Journal of Epidemiology最新文献

{"title":"Association between adherence to the Japanese meal-based dietary guideline and all-cause and cause-specific mortalities: A Japan Public Health Center-based Prospective Study.","authors":"Mariko Takano, Junko Ishihara, Ayaka Kotemori, Kumiko Kito, Fumi Hayashi, Yukari Takemi, Hiroyasu Iso, Kazumasa Yamagishi, Taiki Yamaji, Motoki Iwasaki, Manami Inoue, Shoichiro Tsugane, Norie Sawada","doi":"10.2188/jea.JE20240495","DOIUrl":"https://doi.org/10.2188/jea.JE20240495","url":null,"abstract":"<p><strong>Background: </strong>The Ministry of Health, Labour and Welfare in Japan has published a meal-based dietary guideline (Healthy Meal); however, its relationship with health outcomes remains unclear. This observational study examined the association between adherence to Healthy Meal and all-cause and cause-specific mortalities.</p><p><strong>Methods: </strong>We analyzed data from the Japan Public Health Center-based Prospective Study (JPHC Study) with a mean follow-up of 19.0 years, including 40,222 men and 47,350 women aged 45-75 years with no history of cancer, stroke, ischemic heart disease, chronic liver disease, or kidney disease. Adherence to Healthy Meal was scored using dietary intake from a validated food frequency questionnaire. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and cause-specific mortalities across score quartiles.</p><p><strong>Results: </strong>A higher Healthy Meal adherence score was significantly associated with a lower risk of all-cause mortality. The multivariable-adjusted HRs (95% CIs) for the highest versus the lowest adherence group were 0.86 (0.82-0.91, p<0.001 for trend) in men and 0.92 (0.87-0.98, p=0.005 for trend) in women. Significant associations with a lower risk of cerebrovascular disease and respiratory disease mortalities were observed in both sexes. In contrast, significant associations were observed for cancer, cardiovascular disease, and heart disease mortalities in men only.</p><p><strong>Conclusions: </strong>Higher adherence to the Japanese meal-based dietary guideline was associated with a lower risk of all-cause, cerebrovascular disease, and respiratory disease mortalities in Japanese men and women, and cancer, cardiovascular disease, and heart disease mortalities in men only.</p>","PeriodicalId":15799,"journal":{"name":"Journal of Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in thinness, overweight and obesity among Chinese children aged 2-18 years before and during the COVID-19 pandemic in 2010-2020.","authors":"Chengyue Li, Shuai Zhang, Zhidong Zhou, Jianhua Zhang","doi":"10.2188/jea.JE20250061","DOIUrl":"https://doi.org/10.2188/jea.JE20250061","url":null,"abstract":"<p><strong>Introduction: </strong>Changes in nutritional status during the COVID-19 pandemic may be attributed to the obesity-causing environment that had existed before. This paper aimed to investigate trends in thinness, overweight, and obesity among Chinese children aged 2 to 18 from 2010 to 2020 and assess the potential influence of pandemic.</p><p><strong>Methods: </strong>The Chinese Family Panel Studies that were conducted every two years between 2010 and 2020 included 48,642 children between the ages of 2 and 18. Height and mass were reported, and the body mass index (BMI) was calculated. The prevalence of thinness, overweight and obesity was estimated using sex-, and age-specific BMI cut-offs adopted by the International Obesity Task Force and population-weighted procedures. Linear regressions were used to estimate trends.</p><p><strong>Results: </strong>The prevalence of thinness decreased from 25.5% to 22.2% but increased among children aged 2 to 6. The prevalence of overweight and obesity decreased from 24.6% and 14.2% to 22.5% and 10.0%, respectively. However, these decreases in the prevalence of overweight and obesity were attributed mostly to children aged 2 to 6 and the prevalence increased slightly among children aged 13 to 18. The prevalence of obesity in 2020 among only boys aged 13 to 15 was greater than the estimated projections using data from 2010 to 2018.</p><p><strong>Conclusions: </strong>From 2010 to 2020, the prevalence of all forms of malnutrition among Chinese children decreased, with age disparities. During the pandemic, overweight became more common among pubertal boys. Future interventions as well as policies ought to give high-risk groups priority.</p>","PeriodicalId":15799,"journal":{"name":"Journal of Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Adipose Tissue Insulin Resistance with Risk of Diabetes Incidents in Middle-aged Japanese Workers according to BMI states: 17 years of Follow-up of Aichi Worker's Cohort study.","authors":"Tahmina Akter, Zean Song, Midori Takada, Mohammad Hassan Hamrah, Shuang Wang, Baruck Tegegn Endale, Shalini Enon Perera Paththamesthrige, May Thet Khine, Masaaki Matsunaga, Atsuhiko Ota, Koji Tamakoshi, Hiroshi Yatsuya","doi":"10.2188/jea.JE20250025","DOIUrl":"https://doi.org/10.2188/jea.JE20250025","url":null,"abstract":"<p><p>BackgroundInsulin resistance in adipocytes, manifested as high basal circulating free fatty acid (FFA) is thought to contribute to the development of type 2 diabetes mellitus (T2DM). However, the association between adipocyte insulin resistance (Adipo-IR) index and T2DM has rarely been explored in prospective studies. We examined this association in a middle-aged Japanese workers' cohort. Since the association may differ according to the degree of overall adiposity, the analysis was stratified by the presence of overweight/obesity defined with body mass index (BMI).MethodsA total of 3,257 subjects (men 2501, women 756) aged 35-66 years were followed-up for up to 17 years. T2DM incidence was defined as fasting blood glucose level ≥ 126 mg/dL, glycated hemoglobin level ≥ 6.5 %, or self-reported initiation of glucose-lowering medications. Adipo-IR was calculated as the product of FFA (mmol/L) and insulin (pmol/L) obtained from baseline fasting blood samples and divided into sex- and BMI category (<25 or ≥25 kg/m²)-specific tertiles. Cox-proportional hazards model was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) adjusted for age, BMI, smoking status, physical activity, drinking habit and family history of diabetes.ResultsDuring a median of 14.6 years of follow-up, 365 developed T2DM. Compared with the lowest tertile, T2DM risk was significantly increased among the highest tertile category in overweight/obese men (HR: 2.94, 95% CI, 1.76-4.90) and women (HR: 4.24, 95% CI, 1.08-16.61).ConclusionAdipo-IR was positively associated with T2DM risk in overweight/obese men and women.</p>","PeriodicalId":15799,"journal":{"name":"Journal of Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium.","authors":"Sangjun Lee, Choonghyun Ahn, Sarah Krull Abe, Md Shafiur Rahman, Md Rashedul Islam, Eiko Saito, Seokyung An, Norie Sawada, Xiao-Ou Shu, Woon-Puay Koh, Hui Cai, Atsushi Hozawa, Seiki Kanemura, Chisato Nagata, San-Lin You, Daehee Kang, Rieko Kanehara, Yu-Tang Gao, Jian-Min Yuan, Wanqing Wen, Yumi Sugawara, Keiko Wada, Chien-Jen Chen, Keun-Young Yoo, Habibul Ahsan, Kee Seng Chia, Aesun Shin, Jeongseon Kim, Jung Eun Lee, Keitaro Matsuo, Nathaniel Rothman, You-Lin Qiao, Wei Zheng, Paolo Boffetta, Manami Inoue, Sue K Park","doi":"10.2188/jea.JE20240362","DOIUrl":"10.2188/jea.JE20240362","url":null,"abstract":"<p><strong>Background: </strong>Studies on the association between multimorbidity and mortality in large populations have mainly been conducted in European and North American populations. This study aimed to identify the association between cardiometabolic multimorbidity and all-cause and cardiovascular disease (CVD) mortality in the Asia Cohort Consortium.</p><p><strong>Methods: </strong>In this prospective cohort study, pooled analysis was performed to evaluate the association between cardiometabolic diseases (hypertension, diabetes, ischemic heart disease, and stroke), multimorbidity, and all-cause and CVD mortality, including premature mortality, among participants from 11 Asian cohort studies. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox hazard regression.</p><p><strong>Results: </strong>A total of 483,532 participants were followed for a median of 14.3 years. Compared with participants without any disease, those with stroke and diabetes had higher age- and sex-adjusted HRs for all-cause mortality (HR 3.9; 95% CI, 3.28-4.56). Moreover, the age- and sex-adjusted HRs for CVD mortality were highest in participants with stroke, ischemic heart disease, and diabetes (HR 10.6; 95% CI, 6.16-18.25). These patterns remained consistent after additional adjustments for smoking status and body mass index. The risk of premature mortality followed similar trends but was more pronounced.</p><p><strong>Conclusion: </strong>These findings highlight the differential impacts of individual cardiometabolic diseases and their combinations on mortality risks. Stroke and diabetes were associated with the highest risks for all-cause and cardiovascular mortality, underscoring the need for targeted prevention and personalized management strategies tailored to these high-risk conditions in Asian populations.</p>","PeriodicalId":15799,"journal":{"name":"Journal of Epidemiology","volume":" ","pages":"321-329"},"PeriodicalIF":3.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: \"Coffee and green tea consumption with the risk of COVID-19 among the vaccine recipients in Japan: a prospective study\" [J Epidemiol 34(9) (2024) 444-452].","authors":"Zobida Islam, Shohei Yamamoto, Tetsuya Mizoue, Maki Konishi, Norio Ohmagari","doi":"10.2188/jea.JE20250309","DOIUrl":"https://doi.org/10.2188/jea.JE20250309","url":null,"abstract":"","PeriodicalId":15799,"journal":{"name":"Journal of Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity of a Self-administered Food Frequency Questionnaire for Genomic and Omics Research Among Pregnant Women: The Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study.","authors":"Keiko Murakami, Misako Nakadate, Taku Obara, Misato Aizawa, Ippei Takahashi, Mami Ishikuro, Aoi Noda, Hisashi Ohseto, Noriyuki Iwama, Masatoshi Saito, Ribeka Takachi, Shiori Sugawara, Yudai Yonezawa, Takahiro Yamashita, Shigenori Suzuki, Junko Ishihara, Masayuki Yamamoto, Shinichi Kuriyama","doi":"10.2188/jea.JE20240293","DOIUrl":"10.2188/jea.JE20240293","url":null,"abstract":"<p><strong>Background: </strong>The Tohoku Medical Megabank Project has initiated the Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study) including genomic and omics investigations and conducted a self-administered food frequency questionnaire with the response option \"constitutionally unable to eat or drink it\" for individual food items (TMM-FFQ) for pregnant women. This study evaluated the validity of the TMM-FFQ among pregnant women.</p><p><strong>Methods: </strong>Participants comprised 122 pregnant women aged ≥20 years residing in Miyagi Prefecture who completed weighed food records (WFRs) for 3 days as reference intake and the TMM-FFQ during mid-pregnancy. Correlations between nutrient or food group intakes based on the WFR and the TMM-FFQ were calculated using Spearman's rank correlation coefficients (CCs), adjusting for energy intake and correcting for random within-individual variation of WFR. Cross-classification was also conducted according to quintiles using the WFR and TMM-FFQ data.</p><p><strong>Results: </strong>The percentages of participants who chose the \"constitutionally unable to eat or drink it\" option were >3% for seven food and drink items. CCs were >0.30 for 31 nutrients; the median across energy and 44 nutrients was 0.41. CCs were >0.30 for 14 food groups; the median across 20 food groups was 0.35. The median percentages of cross-classification into exact plus adjacent quintiles and extreme quintiles were 63.1% and 3.3% for energy and nutrients and 61.9% and 4.1% for food groups, respectively.</p><p><strong>Conclusion: </strong>The validity of the TMM-FFQ compared with the WFR was reasonable for certain nutrients and food groups among pregnant women in the TMM BirThree Cohort Study.</p>","PeriodicalId":15799,"journal":{"name":"Journal of Epidemiology","volume":" ","pages":"305-312"},"PeriodicalIF":3.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Wako Cohort Study: Design and Profile of Participants at Baseline.","authors":"Yuri Yokoyama, Yu Nofuji, Takumi Abe, Kumiko Nonaka, Yumi Ozone, Yuka Nakamura, Shiina Chiaki, Takumi Suda, Naoko Saito, Mai Takase, Hidenori Amano, Susumu Ogawa, Hiroyuki Suzuki, Hiroshi Murayama","doi":"10.2188/jea.JE20240288","DOIUrl":"10.2188/jea.JE20240288","url":null,"abstract":"<p><strong>Background: </strong>We launched the Wako Cohort Study in 2023 to identify individual and socio-environmental factors related to the extension of healthy life expectancy and the reduction of health disparities among community-dwelling adults and to develop health promotion and care prevention strategies. This study profile aims to describe the study design and participants' profile at baseline.</p><p><strong>Methods: </strong>The Wako Cohort Study is a prospective study of community-dwelling adults aged ≥40 years living in Wako City, Saitama Prefecture, Japan. The Wako Cohort Study consists of two surveys: a mail-in survey for persons aged ≥40 years and a face-to-face assessment (on-site survey) for those aged ≥65 years. The survey items were designed considering the following points: 1) life course perspective (transition from middle to old age in the life course), 2) health indifference, and 3) employment in older age.</p><p><strong>Results: </strong>A total of 8,824 individuals participated in the mail-in survey (2,395 persons aged 40-64 years and 6,429 aged ≥65 years). Of those aged ≥65 years who returned the mail survey, 1,004 participated in the subsequent on-site survey. Men aged ≥65 years tended to have higher health interests than those aged 40-64 years; however, this was not true for women. In the mail-in survey, 30.4% of those aged ≥65 years were employed.</p><p><strong>Conclusion: </strong>The Wako Cohort Study is expected to provide new insights into the development of strategies to extend healthy life expectancy and reduce health disparities in Japan.</p>","PeriodicalId":15799,"journal":{"name":"Journal of Epidemiology","volume":" ","pages":"341-348"},"PeriodicalIF":3.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-COVID-19 Condition in Hospitalized Survivors After 1 Year of Infection During the Alpha- and Delta-variant Dominant Waves in Japan: COVID-19 Recovery Study II.","authors":"Yoko Muto, Mariko Hosozawa, Miyuki Hori, Arisa Iba, Shuhei Maruyama, Shinichiro Morioka, Katsuji Teruya, Takeshi Nishida, Toshiyuki Harada, Hideki Yoshida, Satoshi Miike, Akira Kawauchi, Hideaki Kato, Junji Hatakeyama, Shigeki Fujitani, Tomohiro Asahi, Kensuke Nakamura, Yuichi Sato, Taku Oshima, Futoshi Nagashima, Kohei Ota, Tatsuya Fuchigami, Nobuyuki Nosaka, Hiroshi Kamijo, Takeshi Hattori, Hayato Taniguchi, Hiroyasu Iso","doi":"10.2188/jea.JE20240179","DOIUrl":"10.2188/jea.JE20240179","url":null,"abstract":"<p><strong>Background: </strong>Evidence of post-COVID-19 condition (PCC) in the Alpha- and Delta-variant dominant waves is limited.</p><p><strong>Methods: </strong>In a nationwide multicenter cohort study in collaboration with 20 hospitals, we collected data using self-administered questionnaires and electronic medical records of participants aged 20 or more diagnosed with COVID-19, hospitalized between April 1, 2021 and September 30, 2021, and discharged alive. Descriptive statistics were analyzed for PCC and mental health (HADS anxiety and depression scores), comparing Alpha- and Delta-variant dominant waves.</p><p><strong>Results: </strong>We analyzed 1,040 patients (median age, 57 [IQR 49-66] years; men, 66.2%). Of the respondents, 45.4% had at least one PCC symptom 1 year after infection. The common symptoms included dyspnea (20.7%), fatigue/malaise (17.6%), muscle weakness (15.4%), decrease in concentration (13.4%), and sleep disorder (13.3%), followed by brain fog (8.4%). Among patients with PCC, 14.0% had anxiety (HADS-Anxiety ≥11), and 18.6% had depression (HADS-Depression ≥11), with four times higher proportions than those without PCC; only small variations by age, sex, and waves were observed. Associated factors for PCC were age 40 years or over, women, severity of COVID-19 during hospitalization, ex-smokers who quit smoking before COVID-19 infection and being infected during the Delta-variant dominant wave.</p><p><strong>Conclusion: </strong>The study described the prevalence of PCC, associated factors, and mental health of COVID-19 survivors hospitalized during the Alpha- and Delta-variant dominant waves in Japan. Further follow-up will be conducted to examine the longer-term impact of COVID-19 on PCC, complications, daily life, and socioeconomic status.</p>","PeriodicalId":15799,"journal":{"name":"Journal of Epidemiology","volume":" ","pages":"330-340"},"PeriodicalIF":3.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Number of Teeth and Incidence of Hip Fracture in Older Adults Aged ≥75 Years: The OHSAKA Study.","authors":"Naoko Otsuki, Tomoaki Mameno, Yuya Kanie, Masahiro Wada, Maki Shinzawa, Kazunori Ikebe, Ryohei Yamamoto","doi":"10.2188/jea.JE20240165","DOIUrl":"10.2188/jea.JE20240165","url":null,"abstract":"<p><strong>Background: </strong>Several studies reported an association between the number of teeth and the incidence of hip fractures in observational studies, mainly in middle-aged adults. This retrospective cohort study aimed to clarify the association between the number of teeth and the incidence of hip fractures.</p><p><strong>Methods: </strong>In this retrospective cohort study, a total of 256,772 participants aged 75 years or older who underwent public dental checkups in Japan were evaluated. Exposure in this study was the number of teeth, with a maximum number of 28, excluding third molars. Outcome measures were the incidence of hip fractures needing surgery, using the Japanese procedure codes in medical claims.</p><p><strong>Results: </strong>A total of 190,998 participants met the inclusion criteria and were available for analysis. Adjusted Fine and Gray models identified a significant association between the number of teeth, including sound, filled, and decayed teeth, and the incidence of hip fractures among women but not for men. The continuous net reclassification improvement of the sound and filled teeth count model increased by 0.078 compared with that of the sound, filled, and decayed teeth count model among women.</p><p><strong>Conclusion: </strong>The number of sound and filled teeth predicted the risk of hip fractures in women, whereas no association was observed between the number of teeth and hip fractures in men.</p>","PeriodicalId":15799,"journal":{"name":"Journal of Epidemiology","volume":" ","pages":"313-320"},"PeriodicalIF":3.7,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do not let the guard down on preventable behavioural risk factors.","authors":"Chiara Stival, Anna Odone, Alessandra Lugo, Piet A van den Brandt, Silvio Garattini, Silvano Gallus","doi":"10.2188/jea.JE20250037","DOIUrl":"10.2188/jea.JE20250037","url":null,"abstract":"<p><strong>Background: </strong>Preventable behavioural risk factors account for approximately one third of mortality, morbidity, and disability worldwide. This study aims to quantify the interest in behavioural risk factors within major medical journals in 2022 and to derive trends over the past 30 years in the entire medical literature.</p><p><strong>Methods: </strong>We analysed the proportion of publications dealing with tobacco smoking, alcohol drinking, use of illicit drugs, excess body weight and physical activity among all the 1,128 articles published in JAMA, BMJ, Lancet and New England Journal of Medicine in 2022. A joinpoint analysis was conducted running in PubMed/MEDLINE specific search strings to evaluate trends over the last 30 years in the four journals and in the whole medical literature.</p><p><strong>Results: </strong>In 2022, of all publications from the four considered medical journals, 2.8% dealt with tobacco smoking, 1.6% alcohol drinking, 1.1% use of illicit drugs, 3.8% excess body weight, 2.7% physical activity and 8.0% dealt with any behaviours. The joinpoint analysis on the whole medical literature showed that papers on modifiable risk factors significantly increased from 3.9% in 1993 to 6.2% in 2014 (annual percent change, APC: between +1.83% and +4.09%), and subsequently decreased between 2014 and 2019 (APC=-0.31%), with an acceleration thereafter (APC =-2.41% in 2019-2022).</p><p><strong>Conclusions: </strong>For the first time we quantified the volume of medical research focused on preventable behavioural risk factors. This appears to be limited and declining over the last decade. Research on primary prevention should be a priority to face the emergence of associated non-communicable diseases globally.</p>","PeriodicalId":15799,"journal":{"name":"Journal of Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}