Journal of Equine Veterinary Science最新文献

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Calcium propionate is an alkalizing agent in exercising Standardbreds 丙酸钙是标准赛马运动中的碱化剂。
IF 1.3 3区 农林科学
Journal of Equine Veterinary Science Pub Date : 2024-10-29 DOI: 10.1016/j.jevs.2024.105212
A.C. Herbst , A.T. Puglia , K. Malinowski, K.H. McKeever
{"title":"Calcium propionate is an alkalizing agent in exercising Standardbreds","authors":"A.C. Herbst ,&nbsp;A.T. Puglia ,&nbsp;K. Malinowski,&nbsp;K.H. McKeever","doi":"10.1016/j.jevs.2024.105212","DOIUrl":"10.1016/j.jevs.2024.105212","url":null,"abstract":"<div><div>The objective of this study was to determine if calcium propionate is an alkalizing agent in exercising Standardbreds and if it alters plasma glucose and serum insulin concentrations. This study used a randomized crossover design to test the hypotheses that calcium propionate alters total CO2 (tCO<sub>2</sub>), Ca<sup>++</sup>, pH, strong ion difference (SID), glucose, and insulin in Standardbreds completing a simulated race test (SRT) on a high-speed equine treadmill. Blood was collected from eight horses (mean age ± SD = 16 ± 2.7 years; range = 13 - 21 years) at 10 and 5 min prior to treatment or control administration, just prior to the subsequent SRT, directly after the SRT, and at 60- and 90-min post SRT. Plasma pH and plasma concentrations of tCO<sub>2,</sub> glucose, Ca<sup>++</sup>, and Na<sup>+</sup>, K<sup>+</sup>, Cl<sup>-</sup>, Lac<sup>-</sup> (for SID calculation) were measured in duplicate by blood gas analyzer and serum insulin by radioimmunoassay. Data were analyzed by two-way repeated-measures ANOVA. For plasma pH, Na<sup>+</sup>, K<sup>+</sup>, Cl<sup>-</sup>, Lac<sup>-</sup>, SID, insulin and glucose, no effects of treatment or treatment by sampling-timepoint interaction were found (p&gt;0.05). Plasma tCO<sub>2</sub>, Ca<sup>++</sup>, pH, Na<sup>+</sup>, SID, and glucose concentrations were significantly lower, and Lac<sup>-</sup> was significantly higher, directly after the SRT compared to all other timepoints (p&lt;0.05). Plasma tCO2, HCO<sub>3</sub><sup>-</sup> and Ca<sup>++</sup> were significantly higher in treated than in control horses at multiple sampling timepoints after treatment/control administration (p&lt;0.05). Serum insulin concentration, measured only pre and 30 min post treatment/control administration, was unaffected by treatment. Calcium propionate is an alkalizing agent in horses.</div></div>","PeriodicalId":15798,"journal":{"name":"Journal of Equine Veterinary Science","volume":"143 ","pages":"Article 105212"},"PeriodicalIF":1.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spermatozoal acrosome dysfunction and its role in stallion subfertility 精子顶体功能障碍及其在公马不育症中的作用
IF 1.3 3区 农林科学
Journal of Equine Veterinary Science Pub Date : 2024-10-26 DOI: 10.1016/j.jevs.2024.105213
Camilo Hernández-Avilés , Luisa Ramírez-Agámez , Dickson D. Varner , Terje Raudsepp , Charles C. Love
{"title":"Spermatozoal acrosome dysfunction and its role in stallion subfertility","authors":"Camilo Hernández-Avilés ,&nbsp;Luisa Ramírez-Agámez ,&nbsp;Dickson D. Varner ,&nbsp;Terje Raudsepp ,&nbsp;Charles C. Love","doi":"10.1016/j.jevs.2024.105213","DOIUrl":"10.1016/j.jevs.2024.105213","url":null,"abstract":"<div><div>Cases of stallion subfertility due to acrosome dysfunction have been recognized since the 1990s. While some of these were observed in stallions with reduced sperm motility and morphology, a more severe form has been reported in stallions with normal-to-excellent sperm quality parameters, which is also uniquely observed in individuals of the Thoroughbred registry. These stallions carry a susceptibility genotype (A/A-A A in the gene <em>FKBP6</em>, exon 5) for Impaired Acrosomal Exocytosis (IAE). Current clinical observations from our group have identified a few highly subfertile stallions from other breed registries that also display a lower ability to undergo acrosomal exocytosis (AE) but do not carry the A/A-A/A genotype. This document provides a concise review of the role of acrosome dysfunction as a cause of stallion subfertility, including methods to estimate acrosome function and clinical descriptions of IAE in TB and non-TB stallions.</div></div>","PeriodicalId":15798,"journal":{"name":"Journal of Equine Veterinary Science","volume":"143 ","pages":"Article 105213"},"PeriodicalIF":1.3,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pneumocephalus due to temporohyoid osteoarthropathy in a 16-year-old Friesian mare 一匹 16 岁的弗里斯兰母马因颞侧骨关节病导致气胸。
IF 1.3 3区 农林科学
Journal of Equine Veterinary Science Pub Date : 2024-10-26 DOI: 10.1016/j.jevs.2024.105210
P. Witt , E.K.L. Stas , L.C. Hardeman , E.R. van Proosdij , E.A.W.S. Weerts , R.A. Lloyd-Edwards , S. Veraa , L.C. Kranenburg , R. van den Boom
{"title":"Pneumocephalus due to temporohyoid osteoarthropathy in a 16-year-old Friesian mare","authors":"P. Witt ,&nbsp;E.K.L. Stas ,&nbsp;L.C. Hardeman ,&nbsp;E.R. van Proosdij ,&nbsp;E.A.W.S. Weerts ,&nbsp;R.A. Lloyd-Edwards ,&nbsp;S. Veraa ,&nbsp;L.C. Kranenburg ,&nbsp;R. van den Boom","doi":"10.1016/j.jevs.2024.105210","DOIUrl":"10.1016/j.jevs.2024.105210","url":null,"abstract":"<div><div>A sixteen-year-old Friesian mare was admitted to the university clinic with the following clinical signs: anorexia, weight loss, fever, bilateral nasal discharge, unilateral facial paralysis and a non-healing corneal lesion. Endoscopic examination of the upper airways showed thickening of the proximal portion of the right stylohyoid bone. Computed tomography imaging showed pneumocephalus due to grade 3 unilateral temporohyoid osteoarthropathy (THO) with fracture of the petrous temporal bone. The horse did not improve following medical treatment. Surgical intervention was declined by the owner and the horse was euthanized due to poor prognosis. Post-mortem examination confirmed the clinical diagnosis. The prevalence of temporal bone fractures is high in horses with severe THO. However, fracture extension into the cranial vault and pneumocephalus has not been described. This is the first reported case of pneumocephalus due to a fracture of the petrous temporal bone in a horse with THO.</div></div>","PeriodicalId":15798,"journal":{"name":"Journal of Equine Veterinary Science","volume":"143 ","pages":"Article 105210"},"PeriodicalIF":1.3,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142568764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unravelling the speed-going relationship: A proof of concept study from British turf flat and jump race meetings 解开速度与速度之间的关系:英国草地平地和障碍赛的概念验证研究。
IF 1.3 3区 农林科学
Journal of Equine Veterinary Science Pub Date : 2024-10-24 DOI: 10.1016/j.jevs.2024.105211
S.J. Hobbs , A. Tatlisulu , A. Johnson , S.D. Rowlands , M. Lucey , J.H. Martin , R.W. Graydon , A.J. Northrop
{"title":"Unravelling the speed-going relationship: A proof of concept study from British turf flat and jump race meetings","authors":"S.J. Hobbs ,&nbsp;A. Tatlisulu ,&nbsp;A. Johnson ,&nbsp;S.D. Rowlands ,&nbsp;M. Lucey ,&nbsp;J.H. Martin ,&nbsp;R.W. Graydon ,&nbsp;A.J. Northrop","doi":"10.1016/j.jevs.2024.105211","DOIUrl":"10.1016/j.jevs.2024.105211","url":null,"abstract":"<div><div>The maximum galloping speeds of racehorses during a race are influenced by the functional performance of the ground (‘going’) amongst other factors. For turf racecourses in Britain, the ground is descriptively classified and numerically quantified on the morning of a race meeting by the clerk of the course and subsequently published to assist decision making. Importantly, this includes deciding whether a horse should or should not run. The going is also assessed and classified during the meeting by racing analysts using the normalized winning times from each race result. Differences between going assessments are regularly reported, therefore this study aimed to evaluate whether an alternative method of measuring going could better predict going measured from performances. Measurement and performance data from 25 flat and 25 jump meetings were compared using linear and nonlinear regression models. A continuous two-phase polynomial model for cushioning was found to be the best predictor of performance going for all 50 meetings (adjusted <em>r<sup>2</sup></em>=0.819, <em>P</em>&lt;0.001). As cushioning can provide a going related indicator of the forces that the horse will experience at gallop, this measurement may be useful when evaluating racecourse going. This initial model suggests that there is little performance advantage at maximal galloping speeds above a cushioning value of approximately10 kN, possibly due to changes in limb contact timings to manage limb forces limits as the ground becomes firmer. An expansion of objective measurements of going that relate to performance across a wider geographic region, if not internationally are needed to confirm this limit.</div></div>","PeriodicalId":15798,"journal":{"name":"Journal of Equine Veterinary Science","volume":"143 ","pages":"Article 105211"},"PeriodicalIF":1.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physiological responses and agreement between two traditional lunging protocols for physical fitness training in untrained ponies 未经训练的小马在体能训练中的生理反应和两种传统肺活量方案之间的一致性。
IF 1.3 3区 农林科学
Journal of Equine Veterinary Science Pub Date : 2024-10-15 DOI: 10.1016/j.jevs.2024.105207
Onjira Huangsaksri , Thita Wonghanchao , Kanokpan Sanigavatee , Chanoknun Poochipakorn , Patskit Sukhong , Metha Chanda
{"title":"Physiological responses and agreement between two traditional lunging protocols for physical fitness training in untrained ponies","authors":"Onjira Huangsaksri ,&nbsp;Thita Wonghanchao ,&nbsp;Kanokpan Sanigavatee ,&nbsp;Chanoknun Poochipakorn ,&nbsp;Patskit Sukhong ,&nbsp;Metha Chanda","doi":"10.1016/j.jevs.2024.105207","DOIUrl":"10.1016/j.jevs.2024.105207","url":null,"abstract":"<div><div>Lunging is a training technique commonly performed in a round pen or on a lunge line. This study investigated the effort intensity, autonomic responses, and method agreement in applying different lunging protocols to untrained ponies. Sixteen untrained ponies (aged 13.6 ± 6.3 years and weighing 358 ± 47.4 kg) were studied. Each pony underwent the same research-focused lunging program on a lunge line and, subsequently, in a round pen with a two-day interval between sessions. The heart rate variability (HRV) and effort intensity, indicated as a percentage of maximum heart rate (%HRmax), were determined pre-lunging, during lunging at distinct gaits, and at 30 min intervals for 120 min post-lunging. The correlation and method agreement between the two lunging methods were analysed. Ponies ran faster and covered longer distances during exercise on a lunge line than in a round pen. The effort intensity during cantering reached moderate levels (75.10 ± 2.39 % HRmax) with occasional high-intensity levels (88.07 ± 1.29 % HRmax) via both lunging methods. The HRV reached a minimum during cantering and returned to the baseline 120 min post-lunging. The HRV parameters (SDNN, RMSSD, LF, HF, SD1, and SD2) were strongly correlated (<em>r<sub>p</sub></em> ≥ 0.97 and <em>p</em> &lt; 0.001 for all) with a large correlation effect size (R<sup>2</sup> &gt; 0.85) and excellent agreement (average differences were within mean ± 1.96 SD) between the two lunging methods. In conclusion, lunging can elicit high physiological responses in untrained ponies, and both lunging methods demonstrate excellent agreement and yield similar physiological responses in these ponies.</div></div>","PeriodicalId":15798,"journal":{"name":"Journal of Equine Veterinary Science","volume":"143 ","pages":"Article 105207"},"PeriodicalIF":1.3,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cortisol concentrations in substance use disorder patients undergoing short-term psychotherapy incorporating equine interaction compared to cognitive behavioral therapy: A preliminary study 与认知行为疗法相比,药物使用障碍患者在接受马匹互动短期心理疗法时的皮质醇浓度:初步研究。
IF 1.3 3区 农林科学
Journal of Equine Veterinary Science Pub Date : 2024-10-09 DOI: 10.1016/j.jevs.2024.105208
E. Farnlacher , M.M. Friend , K. Holtcamp , M.C. Nicodemus , R. Swanson , C. Lemley , C. Cavinder , P. Prince
{"title":"Cortisol concentrations in substance use disorder patients undergoing short-term psychotherapy incorporating equine interaction compared to cognitive behavioral therapy: A preliminary study","authors":"E. Farnlacher ,&nbsp;M.M. Friend ,&nbsp;K. Holtcamp ,&nbsp;M.C. Nicodemus ,&nbsp;R. Swanson ,&nbsp;C. Lemley ,&nbsp;C. Cavinder ,&nbsp;P. Prince","doi":"10.1016/j.jevs.2024.105208","DOIUrl":"10.1016/j.jevs.2024.105208","url":null,"abstract":"<div><div>Psychotherapy incorporating equine interaction (PIE) is emerging as an effective supplemental substance use disorder (SUD) treatment. Benefits are attributed to decreased stress levels associated with the presence of the horse, however, research concerning stress parameters related to short-term equine interaction during SUD treatment is limited. Therefore, the purpose of this preliminary study was to investigate cortisol concentrations in SUD patients participating in PIE for two weeks compared with those in traditional cognitive behavioral therapy (CBT). Salivary cortisol samples were collected from two populations of SUD patients: 1) PIE participants (n = 18) and 2) CBT participants (n = 5). The impacts of the therapy type and the week of sampling were analyzed using a mixed linear model in SAS. Significance level was set at <em>P ≤</em> 0.05. When comparing PIE to CBT, no impact associated with therapy type was determined (<em>P</em> = 0.74). Cortisol concentrations lacked significant changes during the two-week period for both therapeutic interventions. While short-term intervention lacked improvement in cortisol levels for both therapy types, further research is warranted to determine the most effective approach and duration of therapy.</div></div>","PeriodicalId":15798,"journal":{"name":"Journal of Equine Veterinary Science","volume":"143 ","pages":"Article 105208"},"PeriodicalIF":1.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pedigree tracing to determine the origins of the modern Palomino Horse Breeders of America stock-type horse 通过血统追踪,确定现代美国帕洛米诺马饲养者协会(Palomino Horse Breeders of America)畜牧型马的起源。
IF 1.3 3区 农林科学
Journal of Equine Veterinary Science Pub Date : 2024-10-09 DOI: 10.1016/j.jevs.2024.105209
B. Pepper , E. North , M. Foster , J. Culwell , M.C. Nicodemus , C. Cavinder , K. Harvey , T. Williams
{"title":"Pedigree tracing to determine the origins of the modern Palomino Horse Breeders of America stock-type horse","authors":"B. Pepper ,&nbsp;E. North ,&nbsp;M. Foster ,&nbsp;J. Culwell ,&nbsp;M.C. Nicodemus ,&nbsp;C. Cavinder ,&nbsp;K. Harvey ,&nbsp;T. Williams","doi":"10.1016/j.jevs.2024.105209","DOIUrl":"10.1016/j.jevs.2024.105209","url":null,"abstract":"<div><div>Registration numbers for the Palomino Horse Breeders of America (PHBA) have risen with the assistance of new registration guidelines. These changes in guidelines allowed for registration of any horse with a palomino body color, including those with unknown pedigrees. While this promoted registry growth, documenting the breed's orgins from those known pedigrees making up the breed's foundation is important with the introduction of unknown pedigrees. This can be accomplished using pedigree tracing, which is of particular value for color registries as the study of coat color patterns is plagued with misunderstandings due to pedigrees with inaccurate color designations. Thus, the objective of this study was to develop an understanding of the historical origins of the modern PHBA stock-type horse through pedigree tracing. Horses (n = 460) were randomly sampled from published entries from 10 years (2012-2022) of the PHBA World Show Championship Horse Show. The All-Breed Database was utilized to obtain documentation of extended pedigrees that included uninterrupted generation-to-generation inheritance patterns of a <em>cream</em> dilution allele-influenced coat color. Pedigrees were traced back to the earliest recorded relative. We observed six foundation sires contributed to the modern PHBA stock-type horse with the majority (58%) tracing back to a sire named Old Fred. Two identified sires, Yellow Jacket (4%) and Cotton Eyed Joe (3%), have conflicts concerning color designation. While these results assist in documenting the breed's origins, genetic testing is required to accurately identify the <em>cream</em> dilution allele within the horses registered to ensure a phenotype-based solely on the <em>cream</em> dilution allele.</div></div>","PeriodicalId":15798,"journal":{"name":"Journal of Equine Veterinary Science","volume":"143 ","pages":"Article 105209"},"PeriodicalIF":1.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reimagining stallion sperm conservation: Combating carbotoxicity through pyruvate-induced Warburg effect to enhance sperm longevity and function 重塑种马精子保护:通过丙酮酸诱导的沃伯格效应对抗碳毒性,提高精子寿命和功能。
IF 1.3 3区 农林科学
Journal of Equine Veterinary Science Pub Date : 2024-10-09 DOI: 10.1016/j.jevs.2024.105204
Fernando J. Peña, Francisco Eduardo Martín-Cano, Laura Becerro-Rey, Eva da Silva-Álvarez, Gemma Gaitskell-Phillips, Cristina Ortega-Ferrusola, Inés M Aparicio, María Cruz Gil
{"title":"Reimagining stallion sperm conservation: Combating carbotoxicity through pyruvate-induced Warburg effect to enhance sperm longevity and function","authors":"Fernando J. Peña,&nbsp;Francisco Eduardo Martín-Cano,&nbsp;Laura Becerro-Rey,&nbsp;Eva da Silva-Álvarez,&nbsp;Gemma Gaitskell-Phillips,&nbsp;Cristina Ortega-Ferrusola,&nbsp;Inés M Aparicio,&nbsp;María Cruz Gil","doi":"10.1016/j.jevs.2024.105204","DOIUrl":"10.1016/j.jevs.2024.105204","url":null,"abstract":"<div><div>Although stallion spermatozoa are now recognized as highly dependent on oxidative phosphorylation for ATP production in the mitochondria, most extenders in use contain supraphysiological concentrations of glucose as the main energy source. While the toxicity of cryoprotectants has been well documented in the literature, the potential toxicity of excessive glucose in extenders is largely ignored. However, the toxicity of excess glucose, known as “carbotoxicity”, is well-established in many areas of medicine. In this paper, we review the basic aspects of stallion spermatozoa metabolism, focusing on factors that significantly impact the lifespan and functionality of spermatozoa during conservation</div></div>","PeriodicalId":15798,"journal":{"name":"Journal of Equine Veterinary Science","volume":"143 ","pages":"Article 105204"},"PeriodicalIF":1.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overexpression of the key metabolic protein Carnitine Palmitoyl Transferase 1A (CPT1A) in equine sarcoid 在马肉瘤中过度表达关键代谢蛋白肉碱棕榈酰转移酶 1A (CPT1A)。
IF 1.3 3区 农林科学
Journal of Equine Veterinary Science Pub Date : 2024-10-02 DOI: 10.1016/j.jevs.2024.105205
Manuela Martano , Karen Power , Bianca Cuccaro , Elisabetta Razzuoli , Paola Maiolino , Brunella Restucci
{"title":"Overexpression of the key metabolic protein Carnitine Palmitoyl Transferase 1A (CPT1A) in equine sarcoid","authors":"Manuela Martano ,&nbsp;Karen Power ,&nbsp;Bianca Cuccaro ,&nbsp;Elisabetta Razzuoli ,&nbsp;Paola Maiolino ,&nbsp;Brunella Restucci","doi":"10.1016/j.jevs.2024.105205","DOIUrl":"10.1016/j.jevs.2024.105205","url":null,"abstract":"<div><div>The equine sarcoid is the most common skin neoplasia of fibroblastic origin in horses, characterized by an excessive accumulation of extracellular matrix produced by sarcoid fibroblasts under hypoxic condition. Neoplastic cells can adapt to hypoxia by using alternative energy sources, particularly those that arise from fatty acid oxidation (FAO). The Carnitine Palmitoyl Transferase 1A (CPT1A) belongs to Carnitine System (CS) and promotes the entrance of fatty acids into the mitochondria for β-oxidation. In this study, CPT1A expression was comparatively addressed in 25 equine sarcoids and 5 normal skin samples using immunohistochemistry (IHC). Specificity of CPT1A antibody was validated by Western Blotting (WB). In normal skin samples IHC staining was weak and mainly confined to basal epidermis and few dermal fibroblasts. Sarcoid fibroblast exhibited a strong cytoplasmic and nuclear signal in 60% of the tumor samples. Cytoplasmic CPT1A expression in sarcoid fibroblasts indicates that the protein is actively involved in metabolic reprogramming processes. Nuclear CPT1A expression suggests that the protein may also be involved in the regulation of neoplastic proliferation.</div></div>","PeriodicalId":15798,"journal":{"name":"Journal of Equine Veterinary Science","volume":"143 ","pages":"Article 105205"},"PeriodicalIF":1.3,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142372030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Update on surgical cosmetic solutions in equine ophthalmology 马眼科手术美容解决方案的最新进展。
IF 1.3 3区 农林科学
Journal of Equine Veterinary Science Pub Date : 2024-10-02 DOI: 10.1016/j.jevs.2024.105206
J. Jarry , A. Dugdale , J.M. Vandeweerd
{"title":"Update on surgical cosmetic solutions in equine ophthalmology","authors":"J. Jarry ,&nbsp;A. Dugdale ,&nbsp;J.M. Vandeweerd","doi":"10.1016/j.jevs.2024.105206","DOIUrl":"10.1016/j.jevs.2024.105206","url":null,"abstract":"<div><div>Following eye removal surgery, ocular cosmetic solutions exist for the equine patient. The objective of this review is to summarize the current best evidence on equine ophthalmic cosmetic solutions. A literature review of ophthalmic cosmetic solutions in horses was conducted. Four cosmetic solutions are described. Cosmetic outcome, return to work, owner satisfaction, complication rates, implant choice and future perspectives are discussed under the light of most recent publications. Seventeen peer-reviewed articles were selected: five retrospective studies, four case series, five case reports and three narrative reviews. Additionally, two congress proceedings were included. Recent publications identify intrascleral prosthesis and intraorbital implants adjoined to a corneoscleral shell as cosmetically superior. The orbital meshwork implant requires improvement to be cosmetically acceptable. Return to work is deemed feasible and standing sedation is an option for orbital implant placement beneath sutured eyelids. 3D printing creates new possibilities for implant development.</div></div>","PeriodicalId":15798,"journal":{"name":"Journal of Equine Veterinary Science","volume":"143 ","pages":"Article 105206"},"PeriodicalIF":1.3,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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