Open Material Sciences最新文献

{"title":"Mesoporous Biomaterials: a Lexicon and Structured Bibliography of Reviews","authors":"Elizabeth Kennedy, L. Canham, H. Santos","doi":"10.1515/mesbi-2016-0001","DOIUrl":"https://doi.org/10.1515/mesbi-2016-0001","url":null,"abstract":"Accessing mesoporous and nanostructured biomaterial information can be particularly time-consuming and problematic due to the interdisciplinary nature of the field. Relevant papers can be found across a broad range of journals and various key words are needed to comprehensively retrieve information. A keyword lexicon and themed bibliography of over 250 review articles from more than 100 different journals has therefore been assembled to aid students and researchers in this expanding field. Reviews dedicated to fabrication of mesoporous materials and some key characterisation techniques are grouped together. Reviews focussed on specific medical issues like biocompatibility and toxicological testing are also provided. Medical applications that have been the focus of reviews include drug delivery, cancer therapy, medical imaging, orthopaedics, tissue engineering, biofiltration, biosensing and bioanalysis. The following mesoporous materials also have had dedicated reviews on biomedical uses: silica, silicon, silicates, metallic biomaterials, metal organic frameworks, carbonaceous materials, calcium phosphates, titania, and alumina. The academic literature, excluding textbook and textbook chapters, was searched using the lexicon shown in table 1 to capture the field, in conjunction with “review”. Searching was conducted via Google, PubMed, Scopus, Google Scholar and Web of Science. Reviews on mesoporous materials which focussed on non-medical applications were also excluded. Reviews based on nanoscale component structures with mesoporosity, like nanotubes, were included, whilst reviews solely on solid nanoparticles were not. The reviews found have been grouped as shown schematically in figure 1, depending on whether their emphasis is on fabrication, characterisation, medical testing or specific medical uses. General reviews which featured both medical and nonmedical applications have been included, but those focussed solely on non-medical applications have not. Reviewswhich discuss the applicability of various characterization techniques to mesoporous materials in general, or specific mesoporous materials, were included. Most of the reviews that focus on one specificmesoporousmaterial for one specific medical application were grouped within the medical application section, rather than the corresponding dedicated material section.","PeriodicalId":157396,"journal":{"name":"Open Material Sciences","volume":"365 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125825234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesoporous nanotubes as biomaterials","authors":"J. Coffer","doi":"10.1515/mesbi-2015-0005","DOIUrl":"https://doi.org/10.1515/mesbi-2015-0005","url":null,"abstract":"Abstract: This review provides an overview of selected recent research efforts that employ the use of mesoporous nanotubes in a biomaterial context, e.g. principally as a therapeutic or biosensing platform. We focus on the compositions of alumina, boron nitride, silica, silicon, titania, and zinc oxide, along with selected accounts involving single-walled carbon nanotubes. Where known, attention is directed toward the biodegradability and biocompatibility of a given nanotube type, its tunability of size and surface chemistry, and relevance of these parameters to its function as a biomaterial.","PeriodicalId":157396,"journal":{"name":"Open Material Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129727085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesoporous alumina as a biomaterial for biomedical applications","authors":"E. Xifré-Pérez, Josep Ferre-Borull, J. Pallarès, L. Marsal","doi":"10.1515/mesbi-2015-0004","DOIUrl":"https://doi.org/10.1515/mesbi-2015-0004","url":null,"abstract":"Abstract: Porous anodic alumina (PAA) is a biomaterial based on a cost-effective electrochemical anodization of pure aluminum with unique geometrical properties, i.e., self-ordering hexagonal pore distribution, tunable pore diameters and interpore distances, and uniformity of the pores in the vertical direction (nanochannels). These remarkable properties have found important applications in several fields such as energy storage, optics, photonics, magnetism, catalysis and, in particular, in the biomedicine field. In this work, we review the current state of research and key issues on cell culture and implants, drug delivery systems with complex release profiles and specific action, and high efficiency and sensitivity biosensors with different biosensing mechanisms, all of them based on PAA. The biocompatibility, morphology of the surface, nanoestructural engineering in-depth, surface functionalization and coatings are discussed and analyzed in detail.","PeriodicalId":157396,"journal":{"name":"Open Material Sciences","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126555742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alginate/porous silica matrices for the encapsulation of living organisms: tunable properties for biosensors, modular bioreactors, and bioremediation devices","authors":"M. Perullini, Mariano Calcabrini, M. Jobbágy, S. A. Bilmes","doi":"10.1515/mesbi-2015-0003","DOIUrl":"https://doi.org/10.1515/mesbi-2015-0003","url":null,"abstract":"Abstract: The encapsulation of living cells within inorganic silica hydrogels is a promising strategy for the design of biosensors, modular bioreactors, and bioremediation devices, among other interesting applications, attracting scientific and technological interest. These hostguest multifunctional materials (HGFM) combine synergistically specific biologic functions of their guest with those of the host matrix enhancing their performance. Although inorganic immobilization hosts present several advantages over their (bio)polymer-based counterparts in terms of chemical and physical stability, the direct contact of cells with silica precursors during synthesis and the constraints imposed by the inorganic host during operating conditions have proved to influence their biological response. Recently, we proposed an alternative two-step procedure including a pre-encapsulation in biocompatible polymers such as alginates in order to confer protection to the biological guest during the inorganic and more cytotoxic synthesis. By means of this procedure, whole cultures of microorganisms remain confined in small liquid volumes generated inside the inorganic host, providing near conventional liquid culture conditions.Moreover, the fact of protecting the biological guest during the synthesis of the host, allows extending the synthesis parameters beyond biocompatible conditions, tuning the microstructure of the matrix. In turn, the microstructure (porosity at the nanoscale, radius of gyration of particles composing the structure, and fractal dimension of particle clusters) is determinant of macroscopic parameters, such as optical quality and transport properties that govern the encapsulation material’s performance. Here, we review the most interesting applications of the two-step procedure, making special emphasis on the optimization of optical, transport and mechanical properties of the host as well as in the interaction with the guest during operation conditions.","PeriodicalId":157396,"journal":{"name":"Open Material Sciences","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117199149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesoporous Biomaterials – multifunctional materials for future medical therapies and bioanalysis","authors":"L. Canham, H. Santos, G. Palestino","doi":"10.1515/mesbi-2015-0001","DOIUrl":"https://doi.org/10.1515/mesbi-2015-0001","url":null,"abstract":"Nanoscience and nanotechnology – the ability to not only fabricate precisely at the nanoscale, but also fully characterize and understand behaviour at these dimensions, is now having some profound influences on medicine. Richard Feynman is widely credited with prompting this era with his challenging 1959 lecture “There’s Plenty of Room at the Bottom”. When we look at how biomaterials have evolved over many centuries (Figure 1), they have moved from convenience (wooden replacement teeth) to resilience (stainless steel hip implants) to temporary forms (biodegradable implants and tissue engineering) that increasingly utilize nanotechnology. The relative number of new solid biomaterials appearing has also gradually declined at the expense of porous or “nanocomposite” ones, as the material approaches to assisting healing have become more and more biomimetic. Indeed, living organisms rely onpores to function to such an extent that our own bodies are highly porous over widely varying length scales. Blood perfusion around the body is based on conduits of hugely different diameters (arteries, arterioles, capillaries, venules and veins). Our bone remodelling relies on osteoclasts adapting its macroand mesoporosity in-vivo and sensing the local stress fields via fluid flow. At the tissue level, our skin relies on macropores for homeostasis. At the individual cell level we rely on membrane proteins that create micropores for moving molecules in and out. So, what pore sizes are needed for biomaterials? Biomaterial scaffolds for tissue engineering are a clear example where high levels of macroporosity and very large pores (pore diameters normally in excess of 100 microns) are essential for cellular infiltration, but additional mesoporosity can be very beneficial. Indeed, the so-called “hierarchical porosity” of very broad pore size range is increasingly used here. Biomaterials for immunoisolation on the other hand require tightly controlled mesoporosity Figure 1: Biomaterial evolution: more interactive, multifunctional, nanostructured and porous.","PeriodicalId":157396,"journal":{"name":"Open Material Sciences","volume":"27 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2015-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126070889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of porous silica based carriers for lipids and liquid drug formulations","authors":"Y. Choudhari, U. Reddy, F. Monsuur, T. Pauly, H. Hoefer, W. McCarthy","doi":"10.2478/mesbi-2014-0004","DOIUrl":"https://doi.org/10.2478/mesbi-2014-0004","url":null,"abstract":"Abstract Conversion of liquid and semisolid lipids into free flowing powders is an advantageous technique, as the carriers display high surface area, strong adsorption capacity, ease of processing, and ability to generate lipid loaded free flowing powders which can be converted to solid dosage forms like tablets and capsules. A combination of density, adsorption capacity and desorption is found to be of importance in the selection of the right adsorbent. Adsorbents like magnesium aluminium silicates (MAS), granulated fumed silica (GFS) and mesoporous silica gel (MSG) were characterized by flow property measurements, particle size, scanning electron microscopy (SEM) and pore structure by mercury (Hg) intrusion study. SEM results reveal adsorbent morphology, whereas an intrusion-extrusion study reveal pore size distributions. Tablets and capsules of oil loaded adsorbents were prepared by conventional methods. Oil loaded adsorbents were evaluated for the ability to convert oil into powder, easy of processing into tablets and capsules, and release of the loaded oil (Vitamin E) or active (Glyburide). All adsorbents possess good flow property while MSG has higher density than GFS and MAS. This helps to deliver maximum active per unit volume. A wider pore size distribution of MAS was observed in comparison to MSG and GFS. MAS exhibited poor oil release from powder and its formulations, whereas GFS demonstrated closely similar release to MSG. Maximum 70% oil loaded MSG can be delivered in tablet dosage form andMSG can deliver the highest amount in limited volume capsules due to its high density. Hence, lower density and poor oil release from MAS limit its applications in solid oral drug delivery,while both MSG and GFS proved to be suitable.","PeriodicalId":157396,"journal":{"name":"Open Material Sciences","volume":"53 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116418930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bubbles: A review of their relationship to the formation of thin films and porous materials","authors":"K. Kolasinski","doi":"10.2478/mesbi-2014-0003","DOIUrl":"https://doi.org/10.2478/mesbi-2014-0003","url":null,"abstract":"Abstract Bubbles arise at the intersection of gases with other phases. Their role in the formation and applications of thin films and porous materials is complex. At times they are to be avoided. In other cases they are essential to the desired properties and outcomes. In many cases their function, form and production are misunderstood or disregarded. This review seeks to connect a diverse array of technical and fundamental aspects of bubbles so as to facilitate more control and understanding of their functions and utility","PeriodicalId":157396,"journal":{"name":"Open Material Sciences","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132033557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celecoxib confinement within mesoporous silicon for enhanced oral bioavailability","authors":"Feng Wang, T. Barnes, C. Prestidge","doi":"10.2478/mesbi-2013-0001","DOIUrl":"https://doi.org/10.2478/mesbi-2013-0001","url":null,"abstract":"Abstract We investigate the physicochemical characteristics of celecoxib (CEL) entrapped within particles of an oxidized porous silicon matrix (pSiox); determine the oral dose response of CEL compared to pure drug and innovator formulation; develop in vivo-in vitro correlation (IVIVC). CEL was loaded into a pSiox matrix by solvent partitioning, with the physical state of the CEL characterized by FTIR, DSC, TGA and XRD, and correlated with in vitro dissolution behavior. Single dose pharmacokinetic parameters of orally dosed CEL were determined in fasted rats for aqueous suspensions of pure CEL, Celebrexr and CEL-pSiox microparticles. Physicochemical testing of CEL-pSiox formulation confirmed the entrapment of CEL within porous nanostructure in an amorphous or non-crystalline form. CEL-pSiox demonstrated superior pharmacokinetics compared with CEL particles or Celebrexr, i.e. increased absolute bioavailability (96.2% vs. 65.2% vs. 88.1%), increased Cmax (0.91 ± 0.09 μg/mL vs. 0.50 ± 0.16 μg/mL vs. 0.73 ± 0.23 μg/mL) and reduced Tmax (1.0 ± 0.0 h vs. 2.8 ± 0.8 h vs. 3.4 ± 1.0 h). Single point correlation was established between in vitro dissolution efficiency (% DE) and in vivo absolute bioavailability or Cmax . Porous silicon microparticles can be formulated as an effective orally dosed solid dispersion preparation for celecoxib","PeriodicalId":157396,"journal":{"name":"Open Material Sciences","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126451578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design considerations for mesoporous silica nanoparticulate systems in facilitating biomedical applications","authors":"D. Desai, D. Karaman, N. Prabhakar, S. Tadayon, Alain Duchanoy, D. Toivola, S. Rajput, Tuomas Näreoja, J. Rosenholm","doi":"10.2478/mesbi-2014-0001","DOIUrl":"https://doi.org/10.2478/mesbi-2014-0001","url":null,"abstract":"Abstract Mesoporous silica nanoparticles (MSNs) have advanced to the forefront of multifunctional nanoparticulate systems in nanomedicine, owing to this highly fexible materials platform enabling a multitude of design options, often in a modular fashion. Drug delivery ability, detectability via diferent imaging modalities, and stimuliresponsiveness are often combined into one particle system. Very sophisticated and versatile designs along with impressive demonstrations of applicability have been reported to date, but a common ground when it comes to some critical considerations valid for any nanoparticle intended for biomedical purposes is lacking to some degree. In this study, we attempt to take a glance at some of the most crucial aspects of biomedical nanoparticulate design and relate how they apply specifically toMSNs. These considerations include fuorophore labeling and leaching with respect to immobilization to MSNs, the surrounding conditions, carrier biodegradability, and surface coating. Surface modifcation strategies and surface charge tuning are further considered in conjunction to the relative amount of cellular uptake and serum protein adsorption. Cellular internalization routes and biological techniques used to evaluate especially in vitro biobehavior are discussed. Our attempt is hereby to draw attention to some of the most frequently occurring issues to be considered in the design of MSN systems for biomedical applications","PeriodicalId":157396,"journal":{"name":"Open Material Sciences","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127666906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}