Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286)最新文献_第7页

Chitosan inhibits gap junction formation and contraction of an in vitro wound model 壳聚糖抑制体外创面模型缝隙连接的形成和收缩

Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286) Pub Date : 1998-10-29 DOI: 10.1109/IEMBS.1998.746107

R. Mariappan, J.G. Williams, M. Prager, R. Eberhart

{"title":"Chitosan inhibits gap junction formation and contraction of an in vitro wound model","authors":"R. Mariappan, J.G. Williams, M. Prager, R. Eberhart","doi":"10.1109/IEMBS.1998.746107","DOIUrl":"https://doi.org/10.1109/IEMBS.1998.746107","url":null,"abstract":"Wound healing is a process tightly regulated by interactions between cells, cytokines and the extra-cellular matrix. Wound contraction is an important stage in the healing response, mediated by mechanical forces exerted in the matrix by myo-fibroblasts. Chitosan, a polymer of n-acetyl glucosamine, was examined for its wound contraction inhibition effects. Three dimensional collagen gels populated with human dermal fibroblasts (HDFs) were used as wound contraction models. Contraction was measured by surface planimetry. Collagen control gels contracted 87.8/spl plusmn/2.7% (mean/spl plusmn/SD) of their initial surface area whereas collagen-chitosan (3:1) blends contracted only 36.8/spl plusmn/11%. Since wound contraction is mediated by myo-fibroblast transformation, the effect of chitosan on myo-fibroblast transformation was studied. Such transformations are characterized by the formation of gap junctions in fibroblasts. Gap junction formation was measured by a dye transfer assay. The efficiency of gap junction formation was less in fibroblasts plated on collagen-chitosan surfaces (18.7/spl plusmn/5%) when compared to collagen control surfaces (79.1/spl plusmn/8.4%). These data support the hypothesis that chitosan inhibits contraction of a wound model due to the inhibition of gap junction formation and hence the transformation of resting fibroblasts into myo-fibroblasts.","PeriodicalId":156581,"journal":{"name":"Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129796080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-frequency analysis of event-related brain potentials 事件相关脑电位的时频分析

Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286) Pub Date : 1998-10-29 DOI: 10.1109/IEMBS.1998.747167

A. Bianchi, L. Leocani, L. Mainardi, G. Comi, S. Cerutti

引用次数: 2

Design, implementation and bench evaluation of a system for automatic synchronization of chest X-ray radiography with peak lung inflation 胸部x线摄影与肺充气峰值自动同步系统的设计、实现与台架评估

Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286) Pub Date : 1998-10-29 DOI: 10.1109/IEMBS.1998.745521

S. Lampotang, C. Cheung-Seekit, P. Langevin

{"title":"Design, implementation and bench evaluation of a system for automatic synchronization of chest X-ray radiography with peak lung inflation","authors":"S. Lampotang, C. Cheung-Seekit, P. Langevin","doi":"10.1109/IEMBS.1998.745521","DOIUrl":"https://doi.org/10.1109/IEMBS.1998.745521","url":null,"abstract":"The clinical diagnostic data in a chest radiograph is enhanced if chest motion is minimal and X-ray beam exposure occurs at or near peak lung inflation (PLI). Currently, for patients who cannot voluntarily hold a maximal inspiration, beam exposure is manually \"synchronized\" with PLI and is a hit or miss proposition. We implemented a system for automatically synchronizing beam exposure with PLI during chest radiography. Pressure and bi-directional flow at the airway of patients undergoing positive pressure ventilation are monitored by a personal computer. An algorithm coded in C looks for a zero flow crossing and a peak lung pressure to determine PLI. Custom-built interface electronics allow (a) the system to detect, in real time, which buttons on the X-ray machine handswitch are being pressed by the operator and (b) X-ray beam exposure to be triggered via the software. During bench validation using a mechanical test lung, the system worked consistently, without false triggering. Tests with human patients are currently under way, with IRE approval and informed consent. Preliminary human data indicate that higher quality and more consistent chest radiographs are possible with automatic synchronization of X-ray beam exposure with PLI.","PeriodicalId":156581,"journal":{"name":"Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286)","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129838686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Verification of the feasibility of elasticity tomography-simulation study 验证弹性层析模拟研究的可行性

Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286) Pub Date : 1998-10-29 DOI: 10.1109/IEMBS.1998.745562

C. Sumi, T. Sudou

{"title":"Verification of the feasibility of elasticity tomography-simulation study","authors":"C. Sumi, T. Sudou","doi":"10.1109/IEMBS.1998.745562","DOIUrl":"https://doi.org/10.1109/IEMBS.1998.745562","url":null,"abstract":"The pathological state of living soft tissue highly correlates with quasi-static mechanical properties, particularly, elasticity. With such consideration in mind, the authors previously developed the iterative 2D ultrasonic RF-echo phase matching method that allowed providing them the considerably accurate estimates of 2D strain distributions generated in vivo in soft tissues by heart motion/extracorporeally applied pressures or very low frequency vibrations. Furthermore, the authors proposed a novel inverse problem that determined a relative shear modulus distribution with respect to reference shear moduli only from measured strain distributions under the assumption that no mechanical source exists in the ROI. However, as previously demonstrated, due to the combination of noise in measurement data and improper configurations of mechanical sources/reference regions, the problem is inevitably ill-conditioned in real-world applications. Thus, to uniquely determine the acceptable approximation to the original target distribution despite their occurrence, the authors developed a robust reconstruction method in conjunction with a so-called regularization method. To verify the feasibility of a whole technique, i.e., elasticity tomography, reconstruction is carried out using RF-echo data simulated on a simple soft tissue model.","PeriodicalId":156581,"journal":{"name":"Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286)","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130485055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A self-organising fuzzy estimator for hypoglycaemia monitoring in diabetic patients 用于糖尿病患者低血糖监测的自组织模糊估计器

Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286) Pub Date : 1998-10-29 DOI: 10.1109/IEMBS.1998.747135

G. Hastings, N. Ghevondian, H. Nguyen

引用次数: 12

Validation of automated arrhythmia detection for Holter ECG 动态心电图心律失常自动检测的验证

Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286) Pub Date : 1998-10-29 DOI: 10.1109/IEMBS.1998.745836

Chun-Lung Chang, Kang-Ping Lin, Terrence Tao, Tsai Kao, W. Chang

{"title":"Validation of automated arrhythmia detection for Holter ECG","authors":"Chun-Lung Chang, Kang-Ping Lin, Terrence Tao, Tsai Kao, W. Chang","doi":"10.1109/IEMBS.1998.745836","DOIUrl":"https://doi.org/10.1109/IEMBS.1998.745836","url":null,"abstract":"This paper describes a fast and very effective feature extraction technique for detection and discrimination of QRS on a microprocessor-based Holter ECG analysis system. The technique converts long term (up to 24 hours) recorded ECG into a positive waveform by signal preprocessing. Three characteristic factors, the duration, the areas, and the original slope of the positive waveform are detected when the onset and end points of each pulse have been detected by dynamic threshold detection. The prominent feature is extracted from a product of these three factors. It is used to identify normal beats and arrhythmias. This method has been examined using 47 different patients' ECG signals on a MIT/BIH database. The accuracy of QRS detection was 99.3% in validation. The identification sensitivity of PVC beats was 95.2% with 14 different arrhythmia patients. The method has also been implemented on a microprocessor based Holter ECG analysis system. A record of the MIT database recorded ECG can be completely analyzed within 30 second for reporting the heart rate variations, heart beat classifications and arrhythmia analysis.","PeriodicalId":156581,"journal":{"name":"Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286)","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1998-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127030607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

A novel finite element method for analyzing viscoelastic dynamics in biological tissues 一种分析生物组织粘弹性动力学的有限元方法

Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286) Pub Date : 1998-10-29 DOI: 10.1109/IEMBS.1998.746076

Cai Kunbao, Jiang Ze-jia, Zhou Shouchang, Yang Ruifang, Yu Jihui

引用次数: 0

An impulse response flow cytometric technique for blood cell characterisation-instrumentation and preliminary evaluation 一种用于血细胞表征的脉冲响应流式细胞术——仪器和初步评价

Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286) Pub Date : 1998-10-29 DOI: 10.1109/IEMBS.1998.746963

Y. Liu, E. Abel, J. Belch, S. Chen

引用次数: 4

Coordinated responses of limb movement during human bipedal locomotion to external perturbation 人双足运动时肢体运动对外部扰动的协调反应

Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286) Pub Date : 1998-10-29 DOI: 10.1109/IEMBS.1998.744919

T. Nomura, M. Kobayashi, J. Kozuka, S. Sato

引用次数: 1

Rate of information processing during simultaneous presentation of auditory and visual information 听觉和视觉信息同时呈现时的信息处理速率

Proceedings of the 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Vol.20 Biomedical Engineering Towards the Year 2000 and Beyond (Cat. No.98CH36286) Pub Date : 1998-10-29 DOI: 10.1109/IEMBS.1998.745231

A. Murata, H. Iwase

引用次数: 2