{"title":"THE MOVEMENTS OF THE LARGE INTESTINE OF THE FOWL","authors":"T. Hukuhara, T. Naitoh, H. Kameyama","doi":"10.1540/JSMR1965.10.257","DOIUrl":"https://doi.org/10.1540/JSMR1965.10.257","url":null,"abstract":"","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"306 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127948179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AN ELECTROMYOGRHIC STUDY OF THE STOMACH AFTER SELECTIVE PROXIMAL VAGOTOMY IN DOGS","authors":"S. Misaki, T. Shiratori","doi":"10.1540/jsmr1965.14.43","DOIUrl":"https://doi.org/10.1540/jsmr1965.14.43","url":null,"abstract":"To clarify the gastric motor function after selective proximal vagotomy (SPV) by electromygoraphy in dogs, I designed the following experimental groups; Group I is the control, untreated dogs; Group II is SPV operated dogs; Group III is selective antral vagotomy (SAV) operated dogs.The gastric electromygoram was taken from fasted food stimulated, and insulin stimulated dogs in each groups, and the recording was begun two weeks after theoperation.The results are summarized as follows.1) The were no significant differences in discharge intervals before and after food and insulin stimulation in all groups.2) The propagation velocity was delayed markedly in SPV- and SAV-operated dogs compared to the untreated dogs before stimulation.3) It seemed to be that the delay of propagation velocity at fasting, was more prominent in SAV than in SPV.Therefore, it is suggested that antral branch might play an important role on the gastric motor function.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130129151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yoshiki Tanaka, Y. Shimizu, T. Sato, H. Sasa, Y. Inoue, Y. Murayama, H. Mashiko, Y. Yamazaki, Masayuki Kouyama, T. Koga, T. Matsushima, F. Nagao
{"title":"EXPERIMENTAL STUDIES ON THE INFLUENCE OF VAGUS NERVE ON THE GASTRIC MOTILITY ESPECIALLY ON THE SIGNIFICANCE OF SELECTIVE VAGOTOMY AND SELECTIVE PROXIMAL VAGOTOMY","authors":"Yoshiki Tanaka, Y. Shimizu, T. Sato, H. Sasa, Y. Inoue, Y. Murayama, H. Mashiko, Y. Yamazaki, Masayuki Kouyama, T. Koga, T. Matsushima, F. Nagao","doi":"10.1540/JSMR1965.10.269","DOIUrl":"https://doi.org/10.1540/JSMR1965.10.269","url":null,"abstract":"Eighteen dogs were used for experiments. Electodes were implanted on the stomach after selective vagotomy, selective proximal vagotomy, selective vagotomy with pyloroplasty and laparotomy (control) and electromyograms were recorded until a month after the implantation. Thirty dogs were exmained their gastric motility by means of strain gage meth od under the stimulation of various branches of vagus nerve by square pulses.Results were:1) Both vagotomized dogs showed remarkable increase of anti-peristaltic electrical discharges. In contrast there was no remarkable change on the normo peristaltic discharges.2) On the selectively vagotomized dogs both peristaltic electrical discharges descreased in height contrary to normals.3) After solid diet or hot milk, difference of patterns of normo peristaltic frequency between normal and selectively vagotomized dogs became remarkable. And its pattern in selective proximally vagotomized dogs was resemble to normals'.4) According to results of the stimulation with block or various sections of nerves it is considered that the antral branch of vagus nerve controls also motility of lower corpus. The propagation was very quick differing from anti-peristalsis. And it was considered to be cholinergic.5) By the stimulation of pyloric branch anti-peristalsis was scarcely occured. The pyloroplasty combined with selective vagotomy was not effective to decrease anti-peristaltic discharges after solid diet.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130158687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MEMORIS ON THE STUDY OF THE GASTROINTESTINAL MOTILITY","authors":"T. Hukuhara","doi":"10.1540/JSMR1965.14.145","DOIUrl":"https://doi.org/10.1540/JSMR1965.14.145","url":null,"abstract":"","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"92 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133916405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"CLINICAL STUDIES ON ENDOCSOPIC ELECTROMYOGRAM OF GASTRIC CANCER","authors":"Y. Akasaka, K. Sugawara, I. Niki, K. Kawai","doi":"10.1540/JSMR1965.13.113","DOIUrl":"https://doi.org/10.1540/JSMR1965.13.113","url":null,"abstract":"Endoscopic gastroelectromyograms were obtained from 8 patients with gastric cancer, which was located at the gastric antrum. These cancers include 6 cases of advanced cancers and 2 cases of early cancers with mucosal invasion. On healthy volunteers, the gastroelectromyograms from the gastric antrum showed spike bursts with equal intervals. On the other hand, in the patients with advanced cancers on which muscular layer was completely destroyed by the cancerous invasion, the gastroelectromyograms from the cancerous lesion showed no spike bursts. However, in the patients with mucosal cancers in which the cancerous invasion destroyed neither muscular membrane nor muscular layer, the gastroelectromyogram from the cancerous lesion showed spike bursts similar to those of healthy volunteers.From these results, it is proved that the deeper cancerous invasion disturbed the local motility at the cancerous lesion. In future, endoscopic lead of gastro-electromyogram will become useful for the diagnosis of the degree of cancerous invas-ion and infiltration.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129558125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Kodama, S. Ichikawa, T. Yaegashi, S. Saitoh, K. Miura
{"title":"THE BILE-EXPELLING MECHANISM IN THE GUINEA PIG","authors":"S. Kodama, S. Ichikawa, T. Yaegashi, S. Saitoh, K. Miura","doi":"10.1540/JSMR1965.3.101","DOIUrl":"https://doi.org/10.1540/JSMR1965.3.101","url":null,"abstract":"The terminal portion of the bile duct of the guinea pig was surrounded by the circular muscle fibers which were ramified from the same layer of the duodenum. The orifice of the common bile duct was opened by the rewinding action of the muscle contraction and a small amount of bile which was in the terminal portion of the bile duct was expelled.The intraluminal pressure of the distal end of the common bile duct had an important role on the bile expulsion. When the intraluminal pressure of the ampulla overcame the resistance of the sphincter which was formed by the circular muscle, some bile in the ampulla was forced to expel into the duodenum, but a large amount of bile was pushed back into the common bile duct. The pace-maker area exsisted in the common bile duct near the ampulla.The excitation waves travelled down to the ampulla at the speed of 30-50 mm/sec.It seemed likely that the so-called Oddi's sphincter did not exsist independently with the duodenal muscle, but some sphincter mechanism might exsist.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125253309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"STUDIES ON THE MECHANISM OF THE ONSET OF DELIVERY","authors":"K. Sugimoto","doi":"10.1540/JSMR1965.1.72","DOIUrl":"https://doi.org/10.1540/JSMR1965.1.72","url":null,"abstract":"Still the mechanism of labor is unknown, though Reynolds, Hoff-Bayer and Csapo have some opinions.From the fact that tryptophan, an essential amino acid, is specific to pregnancy, and that Serotonin, a metabolite of tryptophan, has contracting effect to the uterus, it is considered that certain relationship exists between the mechanism of labor and tryptophan. metabolism.The author found that tyrptophan metabolism has some relationship with the mechanism of labor from the results that urinary output of 5-Hydroxyindols has its peak during delivery, and that on paper-chromatogram some indols spots appears during pregnancy and delivery.The author has studied uterine contraction by the drugs concerning tyrptophan-serotonin metabolism. Uterine contraction is intensified by MAO inhibitor, vitamin B6 and Reserpine, and inhibited by decarboxylase inhibitor and desoxypyridoxin.The author also gets favorable results clinically in using vitamin B6 during labor and is trying to find out how tryptophan-serotonin metabolism effects the mechanism of labor.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115484146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"MANOMETRIC AND ELECTROMYOGRAPHIC STUDIES ON THE EFFECT OF TRANSECTION OF CANINE STOMACH ON THE PYLORIC MOTOR FUNCTION","authors":"T. Okabayashi","doi":"10.1540/JSMR1965.3.70","DOIUrl":"https://doi.org/10.1540/JSMR1965.3.70","url":null,"abstract":"To elucidate motor function of the stomach manometric as well as electromyographic study of the pylorus of the canine stomach was carried out following transections and end-to-end anastomoses at various levels such as proximal 1/3, and 1/2, distal 1/3 and 1/4, and 4, 3, 2, and 1 cm from the pyloric ring.The hyperfunction of the pylorus with higher contraction pressure, prolonged discharge interval and more frequent anti-peristalsis appeared following transections between the levels of 1/2 of the organ and 4 cm from the pyloric ring. The most remarkable hyperfunction was noted following the distal 1/3 transection.Following transections within 2 cm from the pyloric ring, hyperfunction of the pyloric ring was still present on electromyogram but the contraction pressure became below the control value.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"25 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114747250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"ULTRASTRUCTURE OF SMOOTH MUSCLE CELL OF CAT NICTITATING MEMBRANE","authors":"Shiro Mito","doi":"10.1540/JSMR1965.1.189","DOIUrl":"https://doi.org/10.1540/JSMR1965.1.189","url":null,"abstract":"The smooth muscle layer of cat nictitating membrane was fixed in permanganate, embedded in epon and observed with electronmicroscope. The smooth muscle cells are enclosed with basement membrane, except where the specialized cell membrane interconnection (intrusion body) is present. This intrusion body is frequently observed in the areas where nerve elements are sparse. Fused membrane or quintuple layered system can not be observed.The unmyelinated nerve endings are distributed among the smooth muscle cells. In the wide extracellular spaces where the nervous elements are rather scant, naked axons are found with basement membrane. But when the nerve terminals are abundant, naked axons keep often intimate relationship with the muscle cells. They are either contact directly with the muscle cells without basement membrane or embedded deep in muscle cells.Occasionally, the smooth muscle cell membrane at the point of contact with the nerve ending shows the presence of endoplasmic reticulum and pinocytotic vesicles. The closest apposition of the axon and the muscle cell is about 80 A. At these contact points, the specialized structure such as secondary synaptic cleft seen in skeletal muscle is not clear. The synaptio vesicles in the axon are divided into two types following their average diameters of 500 A and 800 A. The smaller vesicles with 500 A diameter could further be classified into the granular and agranular types, and they are often found in the same axon. The functional differentiation of them is impossible at present.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124073245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THE ROLE OF INTRAMURAL GANGLION CELLS PLAYED FOR REGULATING THE GASTROINTESTINAL MOTILITY","authors":"T. Hukuhara","doi":"10.1540/JSMR1965.3.1","DOIUrl":"https://doi.org/10.1540/JSMR1965.3.1","url":null,"abstract":"In this review, firstly, the aspects of the normal movements of stomach, small intestine and colon are summarized to be concluded that the movements essentially consist of a kind of the contraction wave. On the basis of the results obtained in the studies on the plexus-containing as well as plexus-free preparations, it is then concluded that acetylcholine released from intramural nervous elements is responsible for maintaining the rhythmic contractions. An evidence has also been presented that the pacemaker is the site, where the intramural nervous elements are distributed much more densely than any other places. Lastly, on the basis of the results obtained recently by Hukuhara and his co-workers the functions of intramural ganglion cells are summarized: The cells consist of excitatory and inhibitory neurones and function as centers of two kinds of intrinsic reflexes; the one is produced by stimulating the mucosa (mucosal intrinsic reflex), while the other by stimulating the muscle coat (muscular intrinsic reflex). The characteristic natures of the reflexes have been described, and evidences that these reflexes play an important role to regulate, on the one hand, the strength and direction of rhythmic contraction waves, and, on the other hand, the transport of contents through the digestive tract, have been presented. When the ganglion cells are completely destroyed, the intrinsic reflexes are completely absolished, and the tone of the muscle remarkably rises. The phenomena are shown to be a primary cause of congenital megacolon and the diseases belonging to the same category. The latter fact, moreover, suggests that in the normal condition the inhibitory neurones persistently discharge to cause a moderate relaxation of the muscle, whereas the excitatory ones are supposed to act only when the mucosa is stimulated.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131948552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}