Journal of electrocardiology最新文献

{"title":"Study on the feasibility of distinguishing ventricular and pre-excited arrhythmia rhythms by a new algorithm","authors":"Honglin Ni , Qingcheng Wang , Zhiyong Wang , Wenbo Xu , Xiaowei Pan , Jianfang Zhu , Zhe Liu , Weixun Cai","doi":"10.1016/j.jelectrocard.2024.153817","DOIUrl":"10.1016/j.jelectrocard.2024.153817","url":null,"abstract":"<div><h3>Background</h3><div>The differentiation and diagnosis of ventricular tachycardia (VT) and pre-excited tachycardia (PXT) remains a challenging task, especially when typical AV dissociation is not present. The purpose of this article is to study the feasibility of a new theoretical algorithm for identifying ventricular arrhythmias (VA) and pre-excited arrhythmias (PA) rhythms (which can be used to distinguish VT from PXT, etc.).</div></div><div><h3>Method</h3><div>This study involved the deduction of a new algorithm by combining knowledge of cardiac anatomy, vectorcardiography, and cardiac electrophysiology. The new algorithm evaluated the diagnostic value through intracardiac electrophysiology in 205 cases of VA and PA. The new algorithm diagnoses VA based on the following 4-step process:<ul><li><span>1.</span><span><div>The QRS complex in leads II, III, and aVF shows a unidirectional R wave, and lead aVR shows a QS pattern.</div></span></li><li><span>2.</span><span><div>S waves are predominant in two or more of leads I, aVF, and V6.</div></span></li><li><span>3.</span><span><div>Lead V2 shows ≥3 phase waves or returning branch notching (note: returning branch refers to the band of QRS complexes returning to the baseline).</div></span></li><li><span>4.</span><span><div>Lead V5 shows a negative wave in the initial portion or returning branch notching.</div></span></li></ul></div><div>If none of these criteria are met, the diagnosis is PA. The diagnostic value of the new algorithm is compared with the Steurer algorithm and the Vereckei algorithm (diagnosed based on the QRS waveform characteristics of the two algorithms during electrophysiological verification, excluding the diagnosis of atrioventricular dissociation).</div></div><div><h3>Results</h3><div>The new algorithm showed significant advantages in terms of AUC value (0.83 vs. 0.61 vs. 0.57), sensitivity (83.6 % vs. 23.3 % vs. 24.8 %), and accuracy (82.9 % vs. 48.3 % vs. 46.3 %) compared to the Steurer algorithm and Vereckei algorithm based on QRS waveform characteristics for diagnosing VA (137 cases) and PA (68 cases). This indicates that the new algorithm is more accurate in identifying idiopathic VA. While there was a significant difference in specificity between the New algorithm and Steurer algorithm (82.3 % vs. 98.5 %, <em>p</em> < 0.05), the difference with Vereckei algorithm (82.3 % vs. 89.7 %) was not significant.</div><div>In the New algorithm, the sensitivity and specificity for each step are as follows:<ul><li><span>-</span><span><div>Step 1: Sensitivity 34.3 %, Specificity 94.1 %.</div></span></li><li><span>-</span><span><div>Step 2: Sensitivity 24.1 %, Specificity 98.5 %.</div></span></li><li><span>-</span><span><div>Step 3: Sensitivity 18.3 %, Specificity 100 %.</div></span></li><li><span>-</span><span><div>Step 4: Sensitivity 6.6 %, Specificity 89.7 %.</div></span></li></ul></div><div>Step 1 had the highest AUC value, indicating the best overall diagnostic performan","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"87 ","pages":"Article 153817"},"PeriodicalIF":1.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variability of the PR intervals in Wenckebach atrioventricular block","authors":"S. Serge Barold MD ,&nbsp;Harry G. Mond MD","doi":"10.1016/j.jelectrocard.2024.153815","DOIUrl":"10.1016/j.jelectrocard.2024.153815","url":null,"abstract":"<div><div>The duration of the PR intervals in atypical Wenckebach atrioventricular block before and after a non-conducted P wave can exhibit a wide range of values and patterns. Understanding the different or at times puzzling manifestations of Wenckebach atrioventricular block in terms of its PR intervals can avoid diagnostic errors, especially the erroneous more serious diagnosis of Mobitz type II atrioventricular block.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"87 ","pages":"Article 153815"},"PeriodicalIF":1.3,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrocardiographic correlates of cardiac magnetic resonance findings in women with myocardial infarction with non-obstructive coronary arteries","authors":"Mitchell Pleasure BA ,&nbsp;Vita N. Jaspan MD ,&nbsp;Olivia Liu BA ,&nbsp;Emilie Lin ,&nbsp;Raymond Y. Kwong MD MPH ,&nbsp;Julia Huang BS ,&nbsp;Anais Hausvater MD ,&nbsp;Tara Sedlak MD ,&nbsp;Hayder Hashim MD ,&nbsp;Caitlin Giesler MD ,&nbsp;Kevin R. Bainey MD ,&nbsp;Aun-Yeong Chong MD ,&nbsp;Bobak Heydari MD MPH ,&nbsp;Mobeen Ahmed MD ,&nbsp;Nathaniel R. Smilowitz MD MS ,&nbsp;Harmony R. Reynolds MD","doi":"10.1016/j.jelectrocard.2024.153813","DOIUrl":"10.1016/j.jelectrocard.2024.153813","url":null,"abstract":"<div><h3>Background</h3><div>Myocardial infarction with nonobstructive coronary arteries (MINOCA) occurs in 6–15 % of MI patients. Cardiac magnetic resonance (CMR) imaging identifies MINOCA etiologies, but access may be limited.</div></div><div><h3>Methods</h3><div>We assessed associations between the index electrocardiogram (ECG) and CMR in MINOCA. Women with MI and &lt; 50 % angiographic stenosis in all vessels were prospectively enrolled at 16 sites. CMR (median 6d from MI) was analyzed for late gadolinium enhancement (LGE), myocardial edema, and wall motion. We assessed ECGs for T-wave inversions (TWI), Q-waves (QW), ST-elevations (STE), ST-depressions (STD), and fragmented QRS complexes (fQRS). We calculated the DETERMINE score (# leads TWI + # fQRS +2*[# QW], excluding aVR, V1).</div></div><div><h3>Results</h3><div>Among 112 women with interpretable ECG, 81.3 % (91/112) had abnormal ECG; 50 % (56/112) had ≥1 TWI. CMR was abnormal in 74.1 % (83/112), with LGE in 49.1 % (55/112) and myocardial edema in 61.6 % (69/112). DETERMINE score ≥ 3 was associated with abnormal CMR (adjusted odds ratio [aOR] aOR 6.06 [1.89, 24.6], <em>p</em> = 0.002) and LGE (aOR 3.10 [1.26, 8.00], <em>p</em> = 0.013), but not edema (aOR 1.86 [0.80, 4.43], <em>p</em> = 0.152). TWI was also associated with abnormal CMR and LGE after adjustment (aOR 3.13 [1.08, 10.1], <em>p</em> = 0.036, aOR 3.23 [1.27, 8.63], p = 0.013, respectively), but not edema (aOR 1.26 [0.54, 2.96], <em>p</em> = 0.589). Specificity for abnormal CMR was 0.83 for DETERMINE score ≥ 3 and 0.75 for TWI. No other ECG findings were associated with CMR abnormality.</div></div><div><h3>Conclusion</h3><div>DETERMINE score ≥ 3 and the presence of any TWI were associated with abnormal CMR and with LGE in MINOCA. Our findings demonstrate that the index ECG can provide insight on CMR findings but without sensitivity or specificity required to forgo the CMR. We reaffirm the central role of CMR in elucidating MINOCA pathophysiology.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"87 ","pages":"Article 153813"},"PeriodicalIF":1.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premature ventricular contraction patterns associated with nonsustained ventricular tachycardia","authors":"Juan F. Rodriguez-Riascos MD,&nbsp;Whilman G. Rodriguez MD,&nbsp;Carlos A. Porras-Meza MD","doi":"10.1016/j.jelectrocard.2024.153812","DOIUrl":"10.1016/j.jelectrocard.2024.153812","url":null,"abstract":"<div><h3>Background</h3><div>Occurrence of nonsustained ventricular tachycardia (NSVT) is associated with negative outcomes. It is not clear whether specific electrocardiographic characteristics of premature ventricular contractions (PVCs) are associated with the occurrence of NSVT. The aim of this study was to identify electrocardiographic patterns associated with the presence of NSVT during 24-h electrocardiographic monitoring in patients with &gt;10 PVCs per hour.</div></div><div><h3>Methods</h3><div>This was a retrospective, observational, cross-sectional study. We reviewed consecutive patients who received 24-h ECG monitoring performed at a single outpatient cardiology center. Patients who received 24-h electrocardiographic monitoring, with a PVC burden ≥10 PVCs/h were included. Occurrence of NSVT during 24-h electrocardiographic monitoring was the main outcome.</div></div><div><h3>Results</h3><div>A total of 343 patients were analyzed (mean [SD] age, 69.7 [12.5] years; 177 men [51.6 %]). NSVT occurred in 72 patients who were compared with 271 patients without NSVT. The novel term “premature beat ratio”, which aims to correlate the coupling interval and compensatory pause, was introduced; a value &gt;0.5 was independently associated with NSVT according to the multivariate model (OR = 3.73, 95 % CI = 1.57–8.82; <em>P</em> = 0.002). PVC burden (OR = 1.09, 95 % CI = 1.02–1.17; <em>P</em> = 0.006), and triplets (OR = 18.19, 95 % CI = 7.32–45.18 P = 0.0) were also associated with NSVT in the multivariate model.</div></div><div><h3>Conclusion</h3><div>These findings suggest that patients with a high PVC burden, triplets, and a premature beat ratio greater than 0.5 have an increased probability of presenting with NSVT and may benefit from more rigorous follow-up.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"87 ","pages":"Article 153812"},"PeriodicalIF":1.3,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A change in QT interval and ST-segment after radiofrequency catheter ablation in pediatric patients with Wolff–Parkinson–White syndrome","authors":"Shuhei Fujita M.D., Ph.D ,&nbsp;Eriko Kabata M.D ,&nbsp;Shinichiro Mizutomi M.D ,&nbsp;Kazuo Usuda M.D., Ph.D ,&nbsp;Akio Chikata M.D., Ph.D ,&nbsp;Takeshi Futatani M.D., Ph.D ,&nbsp;Kiyoshi Hatasaki M.D., Ph.D","doi":"10.1016/j.jelectrocard.2024.153814","DOIUrl":"10.1016/j.jelectrocard.2024.153814","url":null,"abstract":"<div><h3>Background</h3><div>Few studies have examined QT, JT interval, and ST-segment changes due to radiofrequency catheter ablation (RFA) in manifest Wolff–Parkinson–White (WPW) syndrome in pediatric patients.</div></div><div><h3>Methods</h3><div>The study involved 27 patients (male-to-female, 13:14; age, 12 (5–16) years) who were diagnosed with WPW syndrome and underwent RFA in our hospital between 2009 and 2022. Electrocardiographic (ECG) changes were compared between the group with ventricular preexcitation due to an accessory pathway (manifest group, <em>n</em> = 16) and those without it (concealed group, <em>n</em> = 11).</div></div><div><h3>Results</h3><div>The QT interval before RFA was significantly longer in the manifest group than in the concealed group (402 [362–482] vs. 344 [323–427]; <em>p</em> = 0.001). The QT interval was significantly shortened in the manifest group before and after RFA (402 [362–482] vs. 360 [298–422] msec; <em>p</em> = 0.01). At 1 month, the QT interval difference between the manifest and concealed groups disappeared (366 [305–437] vs. 335 [301–436] msec; <em>p</em> = 0.001). ST-segment changes were found after RFA in 56 % (9/16) of the patients in the manifest group but not in the concealed group. ECG changes presenting the Brugada-pattern was found in one patient. One month later, ECG abnormalities persisted in only one patient.</div></div><div><h3>Conclusions</h3><div>In pediatric patients, the QT interval was prolonged in manifest WPW syndrome but shortened after RFA. In the manifest group, transient ST-segment change and T-wave abnormalities were often observed after RFA; however, the ECG normalized in approximately 1 month.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"87 ","pages":"Article 153814"},"PeriodicalIF":1.3,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What is Chapman's sign?","authors":"S. Serge Barold","doi":"10.1016/j.jelectrocard.2024.153811","DOIUrl":"10.1016/j.jelectrocard.2024.153811","url":null,"abstract":"<div><div>Chapman's (electrographic) sign is of a notch on the ascending limb of the R wave in leads I, aVL and V6. It has been used in the diagnosis of myocardial infarction (MI) during left bundle branch block (LBBB) and cardiac pacing. A number of studies have yielded divergent results about its diagnostic usefulness. However, the sign can be helpful in the diagnosis of MI during LBBB or pacing in the absence of other manifestations of MI.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"87 ","pages":"Article 153811"},"PeriodicalIF":1.3,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified torso vs distal limb electrode placement for performing ECGs in children: A method comparison study","authors":"Ivor B. Asztalos MD, MSCE, MBMI ,&nbsp;Amanda S. Artis MS, MPH ,&nbsp;Alexis E. Zavez PhD ,&nbsp;Victoria L. Vetter MD, MSHP, MPH","doi":"10.1016/j.jelectrocard.2024.153810","DOIUrl":"10.1016/j.jelectrocard.2024.153810","url":null,"abstract":"<div><h3>Background</h3><div>The electrocardiogram (ECG) is routinely performed in children with the limb electrodes positioned on the torso, but few studies have investigated the effects of this modification on the pediatric ECG. Our objective was to assess the agreement between the standard limb lead configuration and a modified torso electrode configuration in normal, healthy children, and to assess the effect of height on that agreement.</div></div><div><h3>Methods</h3><div>185 children aged 5–18 years underwent two consecutive 12‑lead ECGs, one with standard distal limb lead placement and one with the limb leads placed on the torso. Agreement was assessed for 17 ECG parameters (intervals, axes, and amplitudes) using Bland-Altman plots, height-dependent mean error, and false positive rates.</div></div><div><h3>Results</h3><div>The torso configuration systematically biased the QRS and P wave axes rightwards (towards aVF). Adequate agreement was observed for PR interval and QRS duration, but QTc limits of agreement (±40 ms) were wide. The torso configuration overestimated left-precordial Q, R, and S wave amplitudes and underestimated right-precordial R and S wave amplitudes compared to the distal limb placement. Mean measurement errors increased with the magnitude of the ECG parameter. Mean and variance of measurement errors were more pronounced in shorter children. False positive rates did not differ between the torso and distal limb configurations.</div></div><div><h3>Conclusion</h3><div>Modified placement of the limb electrodes onto the torso resulted in multiple differences in the pediatric ECG signals. This may lead to misclassification of electrocardiographic abnormalities, particularly in children with measurement values at the upper limits of normal.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"87 ","pages":"Article 153810"},"PeriodicalIF":1.3,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to the Letter by doctor Mazen M. Kawji “Reversal of left arm and left leg rather alternating left fascicular block” [J Electrocardiol 2024;86:153774]","authors":"Paolo Alboni","doi":"10.1016/j.jelectrocard.2024.153809","DOIUrl":"10.1016/j.jelectrocard.2024.153809","url":null,"abstract":"","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"87 ","pages":"Article 153809"},"PeriodicalIF":1.3,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142323187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aslanger's pattern with acute lesion in the left coronary system: A case report","authors":"Marco Antônio Vinciprova Dall Agnese ,&nbsp;Alana Sangalli Copetti ,&nbsp;Sérgio Ferreira de Ferreira Filho ,&nbsp;Pedro Rotta de Ferreira ,&nbsp;Tiago Luiz Luz Leiria","doi":"10.1016/j.jelectrocard.2024.153807","DOIUrl":"10.1016/j.jelectrocard.2024.153807","url":null,"abstract":"<div><div>Acute Coronary Syndrome (ACS) is characterized by the suspicion or confirmation of acute ischemia or acute myocardial infarction (MI). The presence of ST segment elevation (STE) consists in the main criterion for indication of immediate reperfusion therapy due to acute coronary occlusion, although significant part of the acute coronary occlusion cases do not fit the ST-segment elevation myocardial infarction (STEMI) criteria.</div><div>A case report of a 50 year-old male presenting typical anginal pain, whose electrocardiogram (EKG) presented Aslanger's pattern. The patient had severe lesion of the left anterior descending artery (ADA) and chronic occlusion of the right coronary artery on cardiac catheterization, with important collateral flow from branches of the left coronary artery to the right coronary artery.</div><div>The dichotomy between STEMI and Non-ST segment elevation myocardial infarction (NSTEMI) must be contested, owing to the evidence that one third of the NSTEMI patients presents a total coronary occlusion. There are other electrocardiographic patterns which must be considered to diagnose ACS. Our case report outlines a different clinical presentation of Aslanger pattern, that shows a ADA acute occlusion, instead of the lesion being in the right coronary system.</div><div>There is evidence that, in addition to the STEMI vs NSTEMI criteria, the Aslanger pattern and other electrocardiographic patterns characterize occlusive ACS. Recognizing those patterns in clinical practice is essential to improve the diagnosis and early treatment of patients with ACS.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"87 ","pages":"Article 153807"},"PeriodicalIF":1.3,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationship between Brugada syndrome and electrocardiogram traits: A bidirectional Mendelian randomization study","authors":"Changxi Li ,&nbsp;Xinquan Wu ,&nbsp;Xudong Song ,&nbsp;Hanfang Liu ,&nbsp;Xuemin Xian ,&nbsp;Peihua Cao ,&nbsp;Yuhang Chen ,&nbsp;Fei Miao ,&nbsp;Xiuli Zhang","doi":"10.1016/j.jelectrocard.2024.153805","DOIUrl":"10.1016/j.jelectrocard.2024.153805","url":null,"abstract":"<div><h3>Introduction</h3><div>Observational studies have suggested associations between Brugada syndrome (BrS) and electrocardiograms traits. Nonetheless, the causal relationships remains uncertain in observational studies. This study aims to investigate the causal relationships between BrS phenotypic risk and electrocardiogram traits using Mendelian randomization (MR) analysis and colocalization analysis.</div></div><div><h3>Methods</h3><div>MR analysis was performed to investigate the causal relationships between BrS phenotype risk and electrocardiogram traits (P wave duration, PR interval, QRS wave duration, ST segment duration, T wave duration, QT interval, heart rate (HR) and heart rate variability). The genetic instruments for BrS (number of cases = 12,821) were obtained from the latest GWAS. GWAS summary data of electrocardiogram traits were obtained from the MRC-IEU and GWAS catalog databases. The causal relationships were obtained through MR methods, and sensitivity analyses (e.g. Cochran's Q test, MR-PRESSO). Furthermore, the causal relationships were evaluated whether they were driven by one linkage disequilibrium using colocalization analysis.</div></div><div><h3>Results</h3><div>We found that there are positive causal relationships between BrS phenotypic risk and P wave duration, PR interval, QRS wave duration and QT interval, respectively (IVW_P: β = 1.238, 95 % CI = 0.857–1.619, <em>P</em>&lt;0.001; IVW_PR: β = 2.199, 95 % CI = 1.358–3.039, <em>P</em>&lt;0.001; IVW_QRS: β = 0.157, 95 % CI = 0.115–0.198, <em>P</em>&lt;0.001; IVW_QT: β = 0.593, 95 % CI = 0.391–0.796, <em>P</em>&lt;0.001), and there is a negative causal relationship between BrS phenotypic risk and heart rate (IVW_HR: β = −0.023, 95 % CI = −0.03 ∼ −0.015, <em>P</em>&lt;0.001). Additionally, there are bidirectional causal relationships between BrS phenotypic risk and P wave duration and PR interval, respectively (IVW_P: OR = 1.217, 95 % CI = 1.118–1.325, <em>P</em>&lt;0.001; IVW_PR: OR = 1.02, 95 % CI = 1.008–1.032, <em>P</em> = 0.001). Furthermore, colocalization analysis identified that the causal relationships between BrS phenotype risk and P wave duration, PR interval and QRS wave duration were driven by rs6790396, rs6801957 and rs6801957, respectively.</div></div><div><h3>Conclusions</h3><div>Bidirectional causal relationships were identified between BrS phenotypic risk and P wave duration and PR interval, respectively. There were positive causal relationships between BrS phenotypic risk and QRS wave duration and QT interval, respectively, and there is a negative causal relationship between BrS phenotypic risk and heart rate.</div></div>","PeriodicalId":15606,"journal":{"name":"Journal of electrocardiology","volume":"87 ","pages":"Article 153805"},"PeriodicalIF":1.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}