Journal of diabetes & metabolism最新文献_第3页

The Potential Role of GLP-1 Analogues in Cardiovascular Disease Outcome GLP-1类似物在心血管疾病转归中的潜在作用

Journal of diabetes & metabolism Pub Date : 2021-01-01 DOI: 10.35248/2155-6156.21.12.883

Nariman Fahmy Wagih, A. A. El-Sheikh

{"title":"The Potential Role of GLP-1 Analogues in Cardiovascular Disease Outcome","authors":"Nariman Fahmy Wagih, A. A. El-Sheikh","doi":"10.35248/2155-6156.21.12.883","DOIUrl":"https://doi.org/10.35248/2155-6156.21.12.883","url":null,"abstract":"Diabetes prevalence is increasing, according to the International Diabetes Federation report in 2013, 382 Millions have diabetes, and the number is expected to rise beyond 592 million by 2035, an increase of approximately 55%. Type2 Diabetes Mellitus(T2DM) is associated with Obesity, Dyslipidemia, and Hypertension. Hypertension plays a major role in the development of Cardiovascular Disease (CVD). The prevalence of hypertension is higher in people with T2DM than the general public. Macro vascular complications are still the primary cause of death in patients with T2DM.Glucagon like peptide-1 receptor agonists (GLP1-RAs) are a new class of Injectable Anti-diabetes Agents (IADA) that provides blood glucose control with weight reduction ability, systolic blood pressure reduction and a noticeable improvement of lipid profile. GLP1-RAs have proven non-inferiority the CVD outcomes. In this review I will discuss the different available members of GLP1-RAs, modes of action and the role of some GUT hormones in the regulation of glucose metabolism. I will also review landmark trials of different types of GLP1-RAs, cost effectiveness and their potential role in the protection from cardiovascular disease, including evidence on weight reduction, HBA1c reduction, systolic blood pressure control and improvement of both lipid and glycemic profiles.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"11 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73006877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of low-sugar and High-dietary Fiber Noodles on Glycemic Response in Healthy Humans: A Cross-over Trial 低糖高膳食纤维面条对健康人血糖反应的影响:一项交叉试验

Journal of diabetes & metabolism Pub Date : 2020-11-20 DOI: 10.21203/rs.3.rs-111425/v1

K. Kadokura, Tsuyoshi Tomita, S. Hata, Kazuhiko Kamata, K. Suruga

{"title":"Effect of low-sugar and High-dietary Fiber Noodles on Glycemic Response in Healthy Humans: A Cross-over Trial","authors":"K. Kadokura, Tsuyoshi Tomita, S. Hata, Kazuhiko Kamata, K. Suruga","doi":"10.21203/rs.3.rs-111425/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-111425/v1","url":null,"abstract":"\u0000 Background: Low-carbohydrate diets are popular nutritional therapeutics based on recommendations of the American Diabetes Association (2013). In previous reports, we suggested a new diet-intake restriction method using low-sugar, high-dietary fiber noodles containing okara and konjac and reported their effect on blood glucose levels in healthy animals and animal models of type 2 diabetes. This study aimed to compare the effect of low-sugar, high-dietary fiber noodles with that of normal wheat noodles on glycemic response in healthy adult men.Methods: The study was a randomized, cross-over design to investigate the effects of normal wheat noodles versus low-sugar, high-dietary fiber noodles on glucose and insulin responses at 120 min. Plasma glucose and insulin levels were measured at 0, 15, 30, 45, 60, and 120 min after intake of normal wheat noodles or low-sugar, high-dietary fiber noodles.Results: No abnormalities and side effects were observed in the low-sugar, high-dietary fiber noodles group. Additionally, in men who consumed low-sugar, high-dietary fiber noodles, the increase in postprandial blood glucose levels and insulin levels was significantly suppressed compared with that in men who consumed normal wheat noodles. Conclusions: To the best of our knowledge, this is the first report on the effectiveness of low-sugar, high-dietary fiber noodles on postprandial blood glucose levels in healthy humans; our findings also suggest that such type of noodles might be beneficial for patients with diabetes or celiac disease who consume noodles.Trial registration: UMIN000023986","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"113 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2020-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75253732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Glucosinolate Sinigrin Improves Insulin Resistance to Suppress Glutathione Consumption in Type 2 Diabetic Mice 硫代葡萄糖苷苷改善2型糖尿病小鼠胰岛素抵抗抑制谷胱甘肽消耗

Journal of diabetes & metabolism Pub Date : 2020-01-01 DOI: 10.35248/2155-6156.20.11.859

Thao T. Truong, T. Koyama

{"title":"Glucosinolate Sinigrin Improves Insulin Resistance to Suppress Glutathione Consumption in Type 2 Diabetic Mice","authors":"Thao T. Truong, T. Koyama","doi":"10.35248/2155-6156.20.11.859","DOIUrl":"https://doi.org/10.35248/2155-6156.20.11.859","url":null,"abstract":"Background: Sinigrin, an aliphatic glucosinolate, is absorbed from the intestine as allyl isothiocyanate (AITC) and conjugated with glutathione (GSH) followed by excretion as an N-acetylcysteine (AITC-NAC) into the urine. AITC is the crucial metabolized form which reflects the occurring bioavailability of dietary sinigrin. However, whether the anti-diabetic effects of dietary sinigrin and the quantitative of metabolic parameters AITC and AITC-NAC remain unknown in the type 2 diabetes model (T2D). Methods: A total of mice were divided into 6 groups: (i) normal control (ii) diabetic control, (iii) normal + 15 (μmol sinigrin/kg BW for all), (iv) diabetes + 15, (v) normal + 30 and (vi) diabetes + 30. After oral administration of sinigrin for 21 days, plasma, tissue, and urine were collected for analysis of metabolic parameters. Results: Administration of sinigrin reduced plasma glucose and significantly improved the insulin resistance of T2D mice. Besides, the treatment of sinigrin induced accumulates AITC levels in the liver and pancreas tissue results in enhancing GSH levels in these tissues (P<0.05). Sinigrin causes less elimination of AITC-NAC in T2D mice urine (below 10% excretion compared to 70% in normal mice P<0.05). These results indicated the collaboration of changeable sinigrin metabolism for its protective effect on T2D mice. Conclusions: Dietary intake of sinigrin possesses anti-diabetes and the changeable amount exposes AITC-NAC and AITC accumulation in the target tissue, enhancing the GSH levels may contribute to its protective effect. These findings may further justify the importance of sinigrin in phytomedicine.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"31 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75230004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Double Blind, Randomised, Four Arm Clinical Study to Evaluate the Safety, Efficacy and Tolerability of Collagen Peptide as a Nutraceutical Therapy in the Management of Type II Diabetes Mellitus 一项双盲、随机、四组临床研究评估胶原肽作为营养品治疗II型糖尿病的安全性、有效性和耐受性

Journal of diabetes & metabolism Pub Date : 2020-01-01 DOI: 10.35248/2155-6156.20.11.839

Sheena Devasia, Suresh Kumar, Stephena Ps, Naoki Inoue, F. Sugihara, Seiko Koizumi, Aya Matsushita, Sriraam Vt

{"title":"A Double Blind, Randomised, Four Arm Clinical Study to Evaluate the Safety, Efficacy and Tolerability of Collagen Peptide as a Nutraceutical Therapy in the Management of Type II Diabetes Mellitus","authors":"Sheena Devasia, Suresh Kumar, Stephena Ps, Naoki Inoue, F. Sugihara, Seiko Koizumi, Aya Matsushita, Sriraam Vt","doi":"10.35248/2155-6156.20.11.839","DOIUrl":"https://doi.org/10.35248/2155-6156.20.11.839","url":null,"abstract":"Dipeptidyl peptidase-4 (DPP-4) inhibitors constitute an innovative class of oral agents for the treatment of Type 2 Diabetes Mellitus (T2DM). DPP-4 inhibitors increase glucagon-like peptide-1 (GLP-1) availability and correct the “incretin defect” seen in T2DM patients. Peptides derived from collagen have been reported to have DPP-4 inhibitory properties. A double blind randomized trial has been conducted to evaluate the effectiveness of Collagen peptides (CPT) as nutritional supplement in subjects with T2DM. Resistant dextrin (RD), a non-digestible dietary polymer, has been used as active comparator in this study. The clinical study was conducted over a total duration of 12 weeks of treatment period. The study was conducted on 66 enrolled subjects randomized in a 2:2:1:1 ratio as a four arm clinical study design. The subjects consumed either CPT (2.5/5 g) or resistant dextrin (2.5/5 g) for 90 days. The results showed that the consumption of 5 g CPT resulted in significant reduction in fasting blood glucose (FBG) and Glycosylated Haemoglobin (HbA1c) in three months study period in subjects. Insulin sensitivity measured in as HOMA IR has also been improved significantly in the group. Thus this study demonstrates the potential role of CPT as add on nutritional supplement for the management of T2DM.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"57 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80433703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Hypoglycemic Effects of Analog Rice Based from Arrowroot (Marantha arundinacea L.) and Cowpea (Vigna unguiculata L.) on Blood Sugar Level and Pancreas Histopathology of Diabetic Rat 竹豆和豇豆类似物对糖尿病大鼠血糖水平和胰腺组织病理学的降血糖作用

Journal of diabetes & metabolism Pub Date : 2020-01-01 DOI: 10.35248/2155-6156.20.11.840

M. Pricilla, Effendi Oulan Gustav Hakim Nata Buana

{"title":"Hypoglycemic Effects of Analog Rice Based from Arrowroot (Marantha arundinacea L.) and Cowpea (Vigna unguiculata L.) on Blood Sugar Level and Pancreas Histopathology of Diabetic Rat","authors":"M. Pricilla, Effendi Oulan Gustav Hakim Nata Buana","doi":"10.35248/2155-6156.20.11.840","DOIUrl":"https://doi.org/10.35248/2155-6156.20.11.840","url":null,"abstract":"Diabetes mellitus is the third largest cause of death in Indonesia and 90% of the cases are diabetes mellitus type 2. Diabetes mellitus type 2 can be prevented and controlled by healthy lifestyle, such as consumption of foods with low glycemic index. Indonesia has high dependence on white rice as staple food, while it is relatively high in glycemic index. One alternative to overcome this problem is analog rice from low glycemic index raw materials such as arrowroot and cowpea. The study was in vivo assay using nested design to examine the hypoglycemic properties of analog rice. The analog rice physical properties analysis results showed that all analog rice formulations were acceptable, therefore selected analog rice were the formulation with the highest and lowest arrowroot levels (A1B1C3 and A4B1C3 formulations). The chemical properties analysis results showed that the rice was high in dietary fiber, which are 17.33% (w/w) and 21.30% (w/w). The glycemic index value of analog rice is 39.40 and 37.12. Analog rice had hypoglycemic effect on rat blood sugar by significantly reducing blood sugar for 21 days, which were 18.97% and 25.50%. Analog rice supplementation for 21 days in rats could also improve the pancreatic beta cell profile.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"4 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88155456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of a Fiber-Rich Nutritional Supplement on Postprandial Glycemic Response and Lipid Parameters in Overweight Adults with and without Impaired Fasting Glucose in India 在印度，富含纤维的营养补充剂对空腹血糖受损的超重成年人餐后血糖反应和脂质参数的影响

Journal of diabetes & metabolism Pub Date : 2020-01-01 DOI: 10.35248/2155-6156.20.11.841

R. Bhoite

{"title":"Effects of a Fiber-Rich Nutritional Supplement on Postprandial Glycemic Response and Lipid Parameters in Overweight Adults with and without Impaired Fasting Glucose in India","authors":"R. Bhoite","doi":"10.35248/2155-6156.20.11.841","DOIUrl":"https://doi.org/10.35248/2155-6156.20.11.841","url":null,"abstract":"Objectives: This study evaluated the effects of a fiber-rich nutritional supplement on postprandial glycemic response and lipid parameters in overweight adults with and without impaired fasting glucose (IFG) in India. An ad-hoc analysis assessed the supplement’s effects on glycemic and lipid parameters in overweight adults with and without IFG. Methods: This was a randomized, double-blind, single-center study including 96 subjects. Among them, 26 subjects had IFG (100-125 mg/dL). After an overnight fast and a high-fat standardized breakfast, subjects were stratified according to IFG status and randomized to a fiber-rich drink or an energy-matched non-fiber control drink. Blood was drawn at 10, 20, 30, 40, 50, 60, 75, 90, 105, 120, 150, 180, 210- and 240-min following treatment administration to assess postprandial blood glucose, triglycerides, remnant-like particle-cholesterol (RLP-C) and insulin peaks. There was a 3-day washout period between treatments. Results: Subjects with IFG displayed significantly lowered Cmax for postprandial glucose with the fiber-rich supplement versus control (difference -4.64 mg/dL; p=0.0487). A lower postprandial triglyceride peak was also reported with the fiber-rich supplement; however, this difference was not statistically significant (difference -6.79 mg/dL; p=0.6116). In an ad-hoc analysis, in subjects without IFG, the fiber-rich drink had a larger effect than the control drink on the Cmax for postprandial glucose (difference-4.75 mg/dL [95% CI -7.37, -2.14]), RLP-C (-0.18 mmol/L [-0.35, -0.02] and insulin (-23.33 μIU/mL [-36.54, -10.13]). A single AE, that is mild diarrhea was reported but was not related to the experimental treatment. Conclusion: The fiber-rich nutritional supplement reduced maximum concentrations of postprandial blood glucose levels in overweight subjects with IFG without much influence on postprandial triglycerides.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"73 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80642419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Recent Updates of Irisinandrsquo;s Anti-Obesity Research 鸢尾和鸢尾抗肥胖研究进展

Journal of diabetes & metabolism Pub Date : 2020-01-01 DOI: 10.35248/2155-6156.20.11.843

Y. Zhang, Li-jun Yang, Yousong Ding

引用次数: 0

Plant-Based Diets for Type 1 Diabetes 1型糖尿病的植物性饮食

Journal of diabetes & metabolism Pub Date : 2020-01-01 DOI: 10.35248/2155-6156.20.11.847

H. Kahleová, B. Carlsen, Rick Lopez, N. Barnard

引用次数: 0

Are Human Beings at Risk for Covid-19 Contamination with Type 2 Diabetes? 人类是否有感染2型糖尿病的风险?

Journal of diabetes & metabolism Pub Date : 2020-01-01 DOI: 10.35248/2155-6156.20.11.850

I. Gill

引用次数: 0

Chronic Diabetic Complications and Associated Factors among People with Type-2 Diabetes Mellitus in Debretabor Hospital, Northwest Ethiopia, 2018 2型糖尿病患者慢性糖尿病并发症及相关因素分析，埃塞俄比亚西北部Debretabor医院，2018

Journal of diabetes & metabolism Pub Date : 2020-01-01 DOI: 10.35248/2155-6156.20.11.845

Beselam Gizachew Astatkie, W. Ayele, Yeshimebet Ali Dawed

{"title":"Chronic Diabetic Complications and Associated Factors among People with Type-2 Diabetes Mellitus in Debretabor Hospital, Northwest Ethiopia, 2018","authors":"Beselam Gizachew Astatkie, W. Ayele, Yeshimebet Ali Dawed","doi":"10.35248/2155-6156.20.11.845","DOIUrl":"https://doi.org/10.35248/2155-6156.20.11.845","url":null,"abstract":"Objective: The aim of this study was to assess the proportion of chronic diabetic complications and factors with type-2 diabetes mellitus at Debretabor Hospital, Northwest Ethiopia, 2018. Methods: Institution based cross-sectional study was conducted among 424 systematically selected type-2 diabetes mellitus patients from March 1-April 5/2018. The collected data were entered into EPI INFO 7 and exported to SPSS version 20 for analysis. Variables with P value <0.05 considered statistically significant. Result: A total of 424 study subjects participated in the study. Overall, 222 (52.4%) (95%CI: 48-57%) of patients were diagnosed with at least one chronic complications. Patients who were >50 years of age [AOR=4.23 (95%CI: 1.80-9.89)], those taking both oral and insulin anti-diabetes mellitus medication [AOR=2.42 (95% CI: 1.18-4.94)] and patients >5 years with duration of diabetes [AOR=17.72 (95%CI: 8.25-38.07)] were positively associated, whereas patients with preventive care services [AOR=0.40 (95%CI: 0.24-0.69)] were negatively associated variables. Conclusion: Older age, taking both oral and insulin anti-diabetes mellitus medication, patients with duration of diabetes >5 years, patients with preventive care services were significantly associated with chronic diabetic complications. Providing the necessary information on the preventive care services by health professionals is needed.","PeriodicalId":15597,"journal":{"name":"Journal of diabetes & metabolism","volume":"157 8 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89124421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3