Journal of Diabetes Research最新文献

{"title":"The Diabetic Cognitive Impairment Score for Early Screening of Cognitive Impairment in Type 2 Diabetes Patients.","authors":"Shujun Zhang, Xiaoli Shi, Shaolin Zheng, Xiaoli Liang, Fen Wang, Weijie Xu, Xuefeng Yu, Yan Yang","doi":"10.1155/jdr/8029913","DOIUrl":"https://doi.org/10.1155/jdr/8029913","url":null,"abstract":"<p><p><b>Purpose:</b> Diabetes has been associated with an excess risk of cognitive impairment. The hyperphosphorylation of tau protein leads to neurodegeneration and is closely related to Type 2 diabetes (T2D). This study aimed to characterize the association between P-tau181 and diabetic cognitive impairment and to develop a nomogram-based score to screen cognitive impairment in T2D patients. <b>Methods:</b> We used a cohort of 379 patients diagnosed with T2D as a training dataset to develop a predictive model. Risk factors associated with cognitive impairment were identified using stepwise multivariate logistic regressive analysis. A nomogram was established by incorporating these risk factors, and the diabetic cognitive impairment score (DCIS) was built and externally validated in another cohort. <b>Results:</b> In the training cohort, patients with cognitive impairment had higher levels of P-tau181 (13.3 [10.5-18.7] vs. 10.0 [8.0-13.0], <i>p</i> < 0.001). P-tau181 was negatively correlated with MOCA (<i>r</i> = -0.308, <i>p</i> < 0.001) and MMSE (<i>r</i> = -0.289, <i>p</i> < 0.001), and it was independently associated with cognitive impairment in T2D patients (OR, 1.137 [95% CI, 1.080-1.198]; <i>p</i> < 0.001). Other independent risk factors of diabetic cognitive impairment included age, education level, and diabetic retinopathy. The DCIS was built by nomogram based on the four risk factors, which had an area under the receiver operating characteristic curve (AUC) of 0.795 (95% CI, 0.751-0.840). The optimal cut-off of DCIS for the diagnosis of cognitive impairment in T2D patients was 139.5, with a sensitivity of 72.9% and a specificity of 75.3%. In the validation cohort, the AUC of DCIS for screening diabetic cognitive impairment was 0.770 (95% CI, 0.716-0.824). <b>Conclusions:</b> P-tau181 was independently associated with diabetic cognitive impairment. The DCIS, based on P-tau181, age, education level, and diabetic retinopathy, is effective to identify cognitive impairment in T2D patients.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"8029913"},"PeriodicalIF":3.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Simplifying Complex Insulin Regimen on Glycometabolic Parameters and Target Organ Damage in Type 2 Diabetes: A Retrospective Cohort Study.","authors":"Roland Fejes, Csilla Kádár, Róbert Kovács-Huber, Zoltán Taybani, László Juhász, Attila Rutai, Szabolcs Péter Tallósy","doi":"10.1155/jdr/9141564","DOIUrl":"https://doi.org/10.1155/jdr/9141564","url":null,"abstract":"<p><p><b>Background:</b> Fixed-ratio combinations (FRCs) provide an alternative to intensified conservative insulin treatments (ICTs); however, therapy simplification in patients with high total daily insulin dose (TDD) or high HbA_1c is a debated issue; additionally, its influence on target organ damage (TOD) is less known. <b>Methods:</b> Data were retrospectively collected from patients with Type 2 diabetes, including 58 patients who continued ICT and 104 patients who underwent therapy simplification between January 1, 2017, and January 1, 2023. Patient characteristics and therapy details are at baseline and 3, 6, 12, and 24 months after FRC initiation. <b>Results:</b> HbA_1c significantly decreased in both groups (-0.9% [-1.6%, -0.5%] with ICT vs. -1.3% [-2.1%, -0.3%] with FRC), whereas body weight significantly decreased only after simplification (-1 kg [-4, 1] vs. -5 kg [-7, -2]). Diabetes duration was not associated with therapy efficacy. Significant HbA_1c reduction and FRC dose elevation occurred earlier in patients with an initial HbA_1c > 8.0% than in those with an initial HbA_1c < 8.0%. FRC dose was significantly higher at 3 months in patients with a TDD of > 60 U/day than in those with lower TDD. Relative risk reduction with therapy simplification was 72.1%, 50.6%, 32.3%, and 59.7% for hypoglycemia, renal function decline, microalbuminuria, and macrovascular complications, respectively. Risk of retinopathy, neuropathy, and chronic kidney disease did not significantly change with FRCs. <b>Discussion:</b> FRCs are safe and as effective as ICT even in patients with high initial HbA_1c, high TDD, or long diabetes duration. A protective role of FRCs in diabetic ASCVD has been proven, but their protective role in CKD was not observed. <b>Conclusions:</b> The significant improvements in glycemic and weight control, as well as in TODs, suggest that therapy simplification may represent a more favorable approach compared to the continuation of previous ICT even in patients characterized by high baseline TDD and HbA_1c levels.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"9141564"},"PeriodicalIF":3.6,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimized Effects of Fisetin and Hydroxychloroquine on ER Stress and Autophagy in Nonalcoholic Fatty Pancreas Disease in Mice.","authors":"Mahboobe Sattari, Amin Karimpour, Maryam Akhavan Taheri, Bagher Larijani, Reza Meshkani, Ozra Tabatabaei-Malazy, Ghodratollah Panahi","doi":"10.1155/jdr/2795127","DOIUrl":"https://doi.org/10.1155/jdr/2795127","url":null,"abstract":"<p><p><b>Background:</b> Fat accumulation in the pancreas, known as nonalcoholic fatty pancreatic disease (NAFPD), is associated with obesity and may lead to prediabetes and Type 2 diabetes. Reducing endoplasmic reticulum stress and enhancing autophagy could offer therapeutic benefits. This study examines the effects of fisetin (FSN) and hydroxychloroquine (HCQ) on NAFPD. <b>Method:</b> Forty-eight Male C57BL/6 J mice were assigned to a standard chow diet (SCD) or a high-fat diet (HFD) for 16 weeks. The HFD group was divided into five subgroups; each group contains eight mice: HFD, HFD + V (vehicle), HFD + FSN, HFD + HCQ, and HFD + FSN + HCQ. FSN was given daily at 80 mg/kg, and HCQ was injected IP at 50 mg/kg twice weekly for more 8 weeks. Insulin resistance was assessed through OGTT and HOMA-IR. Histological analysis of pancreatic tissue was conducted, and the protein and mRNA levels of molecules associated with ER stress and autophagy were assessed using PCR and immunoblotting techniques. <b>Result:</b> FSN and HCQ significantly reduced weight gain, pancreatic adipocyte accumulation, and insulin resistance caused by HFD in obese mice, with the combination of the two compounds producing even more pronounced effects. Additionally, the HFD increased the expression of UPR markers ATF4 and CHOP, a response that was further intensified by HCQ. In contrast, FSN attenuated the UPR by regulating GRP78 levels. Furthermore, the HFD resulted in a significant decrease in the LC3II/LC3I ratio and an accumulation of p62 protein due to reduced p-AMPK levels. Following treatment with FSN, these alterations were reversed, leading to decreased mTOR expression and increased levels of autophagy markers such as ATG5 and Beclin1. <b>Conclusion:</b> Our study reveals that FSN and HCQ effectively combat HFD-induced NAFPD, improving insulin sensitivity and addressing pancreatic fat deposition linked to metabolic syndrome. While HCQ may cause endoplasmic reticulum stress, FSN offers protective effects, supporting their combined use for better treatment outcomes.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"2795127"},"PeriodicalIF":3.6,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12011465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in Corneal Nerve Structure and Function in Prediabetes.","authors":"Jun Ma, Junfang Zhang, Mengjia Tan, Min Ji, Jianfeng Yu, Huaijin Guan","doi":"10.1155/jdr/4586856","DOIUrl":"https://doi.org/10.1155/jdr/4586856","url":null,"abstract":"<p><p><b>Background:</b> Although prediabetes increases the risk of developing diabetes, its role in neuropathy remains unclear. We aim to assess alterations in the corneal nerve structure and function in prediabetes and risk factors for corneal nerve loss. <b>Methods:</b> An examination of IVCM and corneal sensitivity was conducted on a cohort of 75 participants, comprising 23 controls, 32 prediabetes, and 20 Type 2 diabetes. Semiautomatic analysis was employed to quantify the corneal nerve fiber length (CNFL), corneal nerve fiber density (CNFD), and dendritic cell (DC) density. <b>Results:</b> CNFL and CNFD were lower in prediabetes and Type 2 diabetes than in the controls, and they were associated with DC density. CNFL and CNFD were lower in Type 2 diabetes than in prediabetes. DC density was higher in prediabetes and Type 2 diabetes than in controls. However, there were no differences in corneal sensitivity between controls and prediabetes. Multivariable regression analysis demonstrated an association between reduced CNFL and age, BMI, fasting plasma glucose (FPG), and uric acid (UA) levels in prediabetes. In Type 2 diabetes, age, HbA1c, blood urea nitrogen (BUN), creatinine (Cr), and triglyceride levels exhibited associations with reduced CNFL. <b>Conclusions:</b> Corneal nerve damage was detected in prediabetes using IVCM. The patients with prediabetes showed signs of nerve structure damage, and the corneal nerve structure damage occurred before the nerve function changes. Immune cells also participate in the occurrence and development of DCN and are related to the corneal neuropathy. Understanding the corneal nerve fiber condition through IVCM may prove crucial in monitoring prediabetic neuropathy.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"4586856"},"PeriodicalIF":3.6,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin <i>β</i>3 in the Glomerulus.","authors":"Shiyuan Liu, Mingyao Meng, Chunkai Huang, Lijia He, Pu Wang, Zhe Tang, Xi Ran, Hui Gao, Yangfan Guo, Yan He, Jian Chen, Haiyan Hu, Shan He, Yiyi Zhao, Zongliu Hou, Lin Li, Wenhong Li, Wenju Wang, Xiaodan Wang","doi":"10.1155/jdr/6683126","DOIUrl":"https://doi.org/10.1155/jdr/6683126","url":null,"abstract":"<p><p>In this study, we investigated the therapeutic effects and mechanisms of umbilical cord mesenchymal stem cells (UCMSCs) in diabetic nephropathy (DN) ZDF (FA/FA) rats. The therapeutic effects were assessed by renal function tests, the urinary albumin-creatinine ratio, PAS staining, electron microscopy, and TGF-<i>β</i>1 expression in renal tissue. Subsequently, podocyte injury in renal tissue was detected by immunofluorescence staining for podocin. To further explore the underlying mechanism, serum Angptl4 levels were measured, and Angptl4, integrin <i>β</i>3, fibronectin, and podocin levels in renal tissue were analysed by Western blotting. In vitro, podocytes are stimulated with high glucose and then treated with UCMSCs, and podocyte activity and the expression of synaptopodin, Angptl4, and integrin <i>β</i>3 were observed. UCMSC significantly improve renal function, pathological injury, and podocyte injury in the ZDF (FA/FA) rats. Western blot revealed increased expression of Angptl4, integrin <i>β</i>3, and fibronectin in renal tissues of the DN group, and UCMSC treatment significantly downregulated those proteins. However, UCMSC showed no effects on serum Angptl4 concentration. Podocin expression in renal tissues was significantly restored by UCMSC treatment. In vitro, podocyte activity was decreased after high glucose stimulation and improved by UCMSC treatment. UCMSC restored the expression of synaptopodin, and Angptl4 and downstream integrin <i>β</i>3 were also inhibited. Our study suggested that UCMSC therapy could improve renal function and renal pathological changes in ZDF (FA/FA) rats. In addition, inhibition of the Angptl4/integrin <i>β</i>3 pathway is the potential mechanism by which UCMSC attenuates podocyte injury in the DN model.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"6683126"},"PeriodicalIF":3.6,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12008490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Development of Complications Differ Between Adult-Onset and Child-Adolescent-Onset Type 1 Diabetes: A Report From a Tertiary Medical Center in Türkiye.","authors":"Ramazan Çakmak, Özge Telci Çaklılı, Ayşe Merve Ok, Ümmü Mutlu, Göktuğ Sarıbeyliler, Vefa Seferova Nasifova, Ersel Bilgin, Aylin Çoşkun, Damla Yenersu Guzey, Utku Erdem Soyaltin, Servet Yüce, Hülya Hacışahinoğulları, Gülşah Yenidünya Yalın, Özlem Soyluk Selçukbiricik, Nurdan Gül, Ayşe Kubat Üzüm, Kubilay Karşıdağ, Nevin Dinççağ, Mehmet Temel Yılmaz, Ilhan Satman","doi":"10.1155/jdr/8860118","DOIUrl":"https://doi.org/10.1155/jdr/8860118","url":null,"abstract":"<p><p><b>Background and Aims:</b> The age-at-onset is of great importance in the heterogeneity of Type 1 diabetes mellitus (T1DM). This study was designed to define clinical and laboratory differences between child-adolescent-onset and adult-onset T1DM at presentation and during follow-up and determine the predicting factors for developing microvascular and macrovascular complications. <b>Material and Methods:</b> This retrospective observational study evaluated T1DM patients who were followed in the diabetes outpatient clinic between January 1, 2000, and December 31, 2019. <b>Results:</b> The study cohort included 490 individuals with T1DM (54.3% female, 58.8% adult-onset, and median follow-up: 5 years). In the adult-onset group, baseline C-peptide and GADA prevalence were higher, whereas presentation with ketoacidosis was 2.3-fold lower compared to the child-adolescent-onset group (<i>p</i> < 0.001). During follow-up, the adult-onset group had a 2.4-fold higher overweight/obesity (<i>p</i> < 0.001) and 1.7-fold higher dyslipidemia/hyperlipidemia (<i>p</i> = 0.002) than the child-adolescent-onset group. In multivariate analysis, fasting glucose (<i>p</i> = 0.024) in adult-onset, dyslipidemia/hyperlipidemia (<i>p</i> = 0.037) in child-adolescent-onset, and diabetes duration (<i>p</i> = 0.008 and <i>p</i> = 0.007) and hypertension (<i>p</i> = 0.001 and <i>p</i> = 0.01) in both groups were associated with increased risk of microvascular complications, whereas age-at-onset (<i>p</i> = 0.024), dyslipidemia/hyperlipidemia (<i>p</i> = 0.03), nephropathy (<i>p</i> = 0.003), and neuropathy (<i>p</i> = 0.001) in adult-onset and age (<i>p</i> = 0.002) and triglycerides (<i>p</i> = 0.013) in child-adolescent-onset groups were associated with increased risk of macrovascular complications. The cutoff C-peptide levels at baseline predicted microvascular complications in the whole cohort and adult-onset group were defined as 0.383 ng/mL (<i>p</i> < 0.001) and 0.41 ng/mL (<i>p</i> = 0.001), respectively. In the Kaplan-Meier analysis, C-peptide (< 0.383 ng/mL) but not age-at-onset predicted future development of microvascular and macrovascular complications (<i>p</i> = 0.003 and <i>p</i> = 0.032). <b>Conclusion:</b> Clinical presentation and prognosis differ in adult-onset and child-adolescent-onset T1DM. Low initial C-peptide may predict the development of microvascular and macrovascular complications.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"8860118"},"PeriodicalIF":3.6,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HbA1c and the Risk of Lower Limb Ulcers Among Diabetic Patients: An Observational and Genetics Study.","authors":"Guojun Guo, Yunlong Guan, Yuhuan Chen, Yuge Ye, Zeyu Gan, Xi Cao, Zhenbing Chen, Xingjie Hao","doi":"10.1155/jdr/4744194","DOIUrl":"10.1155/jdr/4744194","url":null,"abstract":"<p><p><b>Aims:</b> A lower limb ulcer is a serious complication of diabetes. The association between glycated hemoglobin (HbA1c) and lower limb ulcers needs further clarification. We aimed to comprehensively evaluate the relationship between HbA1c and lower limb ulcer risk in diabetic patients through multivariable-adjusted observational analyses and Mendelian randomization (MR) approaches. <b>Methods:</b> This prospective cohort study included 23,434 individuals with prevalent diabetes in the UK Biobank. The Cox proportional hazard model was used to evaluate the association between HbA1c levels and lower limb ulcer risk. Furthermore, a one-sample MR analysis was conducted to explore the potential causal effect. <b>Results:</b>Over a follow-up period of 290,677 person-years (median length: 13.3 years), 1101 lower limb ulcers cases were documented. The multivariable-adjusted hazard ratios across categories of HbA1c of ≤ 42, 42-53, 53-64, 64-75, 75-86, and > 86 mmol/mol were 0.93 (0.76-1.15), 1.00, 1.24 (1.05-1.46), 1.98 (1.65-2.39), 2.68 (2.13-3.37), and 4.52 (3.62-5.65), respectively. The restrictive cubic spline model showed that lower limb ulcer risk increased steeply when HbA1c concentration exceeded 53 mmol/mol. One-sample linear and nonlinear MR analyses provided a positive but not significant association between genetically proxied HbA1c and lower limb ulcer risk among diabetic patients. <b>Conclusions:</b> High HbA1c levels increase the risk of lower limb ulcers in diabetic patients. MR analyses validated the positive but not significant association between genetically proxied HbA1c levels and lower limb ulcer risk. The results recommended an HbA1c goal of < 53 mmol/mol to decrease the incidence of diabetic ulcers.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"4744194"},"PeriodicalIF":3.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health-Related Quality of Life Among Type 2 Diabetes Patients With Depressive Symptoms in Vietnam.","authors":"Nguyen Tran Kien, Nguyen Phuong Hoa, Ha Huu Tung, Kris Van den Broeck, Johan Wens","doi":"10.1155/jdr/6992121","DOIUrl":"10.1155/jdr/6992121","url":null,"abstract":"<p><p><b>Background:</b> This study investigates the impact of Type 2 diabetes mellitus (T2DM) and depressive symptoms on the health-related quality of life (HRQoL) among patients at the Agricultural General Hospital in Hanoi, Vietnam. The research explores the interconnections between chronic physical conditions and mental health within a resource-constrained healthcare environment. <b>Methods:</b> A cross-sectional survey was conducted with 516 T2DM patients using the SF-36 to assess HRQoL and the PHQ-9 to measure depressive symptoms. The study examined the prevalence of depressive symptoms and their correlation with various HRQoL components. <b>Results:</b> Among the participants, 45.2% exhibited depressive symptoms from mild to severe levels. Significant disparities in HRQoL scores were observed, particularly in physical composite and overall quality of life scores between T2DM with and without depressive symptoms. Statistical analysis highlighted that depressive symptoms significantly diminish HRQoL, with the PHQ-9 scores serving as a robust predictor. <b>Conclusion:</b> The findings underscore the critical need for integrated care approaches that include mental health support for T2DM patients. Routine screening for depressive symptoms should be a component of diabetes management protocols to improve overall patient outcomes. Further longitudinal research is needed to confirm these findings and develop effective interventions.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"6992121"},"PeriodicalIF":3.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11971502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of a Health Literacy and Diabetes Self-Management Education (DSME) Improvement Program for People With Type 2 Diabetes Mellitus: A Community-Based Quasiexperimental Study in Thailand.","authors":"Fatima Ibrahim Abdulsalam, Sribud Srichaijaroonpong, Natthida Phoosuwan, Nitikorn Phoosuwan","doi":"10.1155/jdr/2640702","DOIUrl":"10.1155/jdr/2640702","url":null,"abstract":"<p><p><b>Background:</b> This community-based randomised controlled study was aimed at evaluating a health literacy (HL) and diabetes self-management education (DSME) improvement program (HL-DSME program) among people with Type 2 diabetes mellitus. <b>Methods</b>: The program conducted in Sakonnakhon Province in northeastern Thailand comprised 1 day of theory and a 4-week period of follow-up. There were 72 participants (36 participants for each intervention and control group) in the program. Independent <i>t</i>-tests, one-way analysis of variance and, paired-sample <i>T</i>-tests were used to predict HL and self-management scores. <b>Results</b>: The participants in the intervention group increased their total HL score and four dimensions of the HL score significantly in comparison to those in the control group. Total self-management score and the score related to the dimension of exercise behaviour among the participants in the intervention group improved significantly in comparison to those in the control group. <b>Conclusion</b>: The HL-DSME program could increase the total score of HL, scores of four dimensions of HL, the total score of self-management, and the score related to exercise behaviour. Healthcare providers who try to enhance diabetes patients' self-management practices should consider diabetes patients' HL and provide health education regularly. Diabetes management approach should be scalable, efficacious, sustainable, and affordable for patients. <b>Trial Registration:</b> Thai Registry of Clinical Trials: TCTR20241120002.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"2640702"},"PeriodicalIF":3.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Empagliflozin on Serum Ferritin and Its Relationship With Inflammatory Markers in Prediabetic and Diabetic Patients.","authors":"Mojgan Sanjari, Narges Sadeghi, Azade Ramezannezhad, Zohre Safi, Ahmad Naghibzadeh-Tahami, Ladan Amirkhosravi","doi":"10.1155/jdr/8835829","DOIUrl":"10.1155/jdr/8835829","url":null,"abstract":"<p><p><b>Background:</b> This research is aimed at evaluating the effects of the SGLT2 inhibitor empagliflozin on inflammatory markers, some iron metabolism markers, and their interrelationships before and after using empagliflozin. <b>Methods:</b> A quasiexperimental study was conducted on 44 prediabetic and Type 2 diabetic patients aged 18-65 years. The participants were among those treated at the clinic affiliated with Kerman Medical Sciences University between 2022 and 2023. The study included diabetic patients with HbA1c levels of 0.5%-1% higher than the therapeutic target who were not using blood sugar control medication. Each patient received a daily dose of 10 mg of empagliflozin for 3 months. Changes in serum levels of iron, total iron-binding capacity (TIBC), ferritin, transferrin saturation, inflammatory markers IL-6, C-reactive protein (CRP), and uric acid were measured before and 3 months after commencing empagliflozin. <b>Results:</b> Three months after starting empagliflozin, the mean FPG and Hb A1c levels showed a drop (<i>p</i> < 0.05). The serum ferritin level decreased, and TIBC increased significantly (<i>p</i> < 0.05) following empagliflozin treatment. Additionally, the serum levels of CRP (<i>p</i> < 0.05), IL-6 (<i>p</i> < 0.001), and uric acid (<i>p</i> < 0.001) declined. Analysis of the correlation between serum ferritin level and IL-6 and uric acid before and after empagliflozin use revealed a positive correlation between serum ferritin and IL-6 (<i>p</i> = 0.04) and uric acid (<i>p</i> = 0.03). However, no significant correlation was observed between the change in ferritin and CRP levels (<i>p</i> = 0.22). <b>Conclusion:</b> Following empagliflozin treatment, serum levels of ferritin and inflammatory markers interleukin-6, CRP, and uric acid declined, indicating a significant relationship between SGLT2 inhibition, inflammation, and iron metabolism. Furthermore, the correlation between ferritin and inflammatory markers suggests that reduced ferritin levels may result from reduced inflammation. <b>Trial Registration:</b> ClinicalTrials.gov identifier: IRCT20090317001774N10.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"8835829"},"PeriodicalIF":3.6,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}