Journal of Diabetes Research最新文献

{"title":"The Relationship Between Postrelease Social Determinants of Health and Glycemic Control in African Americans With Criminal Legal Involvement and Type 2 Diabetes.","authors":"Olaitan Akinboboye, Rebekah J Walker, Jennifer A Campbell, Laura Hawks, Joni S Williams, Leonard E Egede","doi":"10.1155/jdr/3650434","DOIUrl":"10.1155/jdr/3650434","url":null,"abstract":"<p><strong>Background: </strong>Limited literature exists on the relationship between postrelease social determinants of health and glycemic control among African Americans with a history of criminal legal involvement and Type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>Participants were recruited from clinics, community centers, and places of worship in the midwestern United States. Stepwise regression with forward selection was used to evaluate the relationship between postrelease criminal justice system factors, social risk/environmental factors, and glycemic control among African American with history of criminal legal involvement and T2DM.</p><p><strong>Results: </strong>Retained variables from the stepwise regression included age, comorbidity, type of medication, length of incarceration, insurance, and housing insecurity. The analysis revealed statistically significant associations between comorbidity, type of medication, and insurance type with glycemic control. Compared with using only pills or oral hypoglycemic agents, the combination of pills/oral hypoglycemic agents and insulin (β-coefficient: 1.44; 95% CI: 0.77, 2.12) and using insulin or injectables alone (β-coefficient: 0.95; 95% CI: 0.16, 1.73) were associated with an increase in HbA1c. Additionally, each additional comorbidity (β-coefficient: -0.25; 95% CI: -0.40, -0.11) was associated with a decrease in HbA1c. Compared with individuals with private/military/other insurance, those with Medicare (β-coefficient: 1.40; 95% CI: 0.43, 2.37) and Medicaid (β-coefficient: 1.11; 95% CI: 0.12, 2.10) were associated with higher HbA1c.</p><p><strong>Conclusion: </strong>Postrelease criminal justice factors and social/environmental risk factors were not statistically significant. Future studies should evaluate the relationship between insurance type and glycemic control among this population.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2026 1","pages":"e3650434"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13255145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148217422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experience With Intermittent Caloric Restriction in Individuals With Type 1 Diabetes.","authors":"Alison Wong, Raul Herrera, Krista Varady, Qi Wang, Niki Oldenburg, Lisa S Chow","doi":"10.1155/jdr/3581401","DOIUrl":"10.1155/jdr/3581401","url":null,"abstract":"<p><strong>Background: </strong>Little is known about the prevalence and experiences of intermittent caloric restriction (ICR) among individuals with Type 1 diabetes mellitus (T1DM), despite its growing popularity.</p><p><strong>Methods and results: </strong>From September to October 2023, patients diagnosed with T1DM aged 18-89 in Minnesota were invited via the M Health Fairview's electronic health record (EHR) to complete a 10-min online survey. The survey gathered patient-provided data on demographics, clinical data, and questions centered on weight and use of ICR. Out of 124 respondents, 39 reported participating in ICR and completed the survey. These participants, with a mean age of 42.8 years (SD = 12.0) and a mean BMI of 28.2 kg/m² (SD = 5.5), included 22 females and 17 males. Among them, 34 reported practicing time-restricted eating (TRE), whereas 5 reported practicing intermittent fasting (IF). TRE participants reported an average weight loss of 6.0 kg, whereas IF participants reported an average weight loss of 3.5 kg. Hypoglycemia was reported by five TRE participants and one IF participant, with no episodes of diabetic ketoacidosis (DKA) reported. Only six participants reported that their healthcare providers were aware of their fasting program.</p><p><strong>Conclusions: </strong>Individuals with T1DM do engage in ICR, mainly TRE, with rare hypoglycemia and no DKA. Further research is needed on long-term ICR safety in T1DM patients.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2026 1","pages":"e3581401"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148678827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomics Mendelian Randomization Identifies Lactylation-Related Molecular Traits in Type 1 Diabetes.","authors":"Yu Ding, Shiyang Gao, Lingwen Ying, Jie Tang, Guoying Chang, Yiguo Huang, Tingting Yu, Xin Li, Xiumin Wang","doi":"10.1155/jdr/9544974","DOIUrl":"10.1155/jdr/9544974","url":null,"abstract":"<p><strong>Background: </strong>Lactylation is a posttranslational modification involved in cellular metabolic and immune processes. Although dysregulated lactate metabolism has been implicated in type 1 diabetes (T1D), the genetic relevance of lactylation-related molecular traits remains poorly defined.</p><p><strong>Methods: </strong>Summary-data-based Mendelian randomization (SMR) was applied to integrate blood-derived methylation/expression/protein quantitative trait loci (mQTLs/eQTLs/pQTLs) for 353 lactylation-related genes with a T1D genome-wide association study (7467 cases and 10,218 controls). The HEIDI test evaluated heterogeneity. Shared genetic signals were assessed by Bayesian colocalization. Associations identified in the discovery analysis were replicated in the FinnGen_R12_T1D and FinnGen_R9_E4_DM1NEU cohorts. mQTL-eQTL SMR analysis evaluated methylation-expression regulatory relationships. Steiger directionality testing and GTEx tissue eQTL analyses were performed for prioritized genes.</p><p><strong>Results: </strong>SMR prioritized PDAP1, PNKD, and HMGB1 as candidate genes associated with T1D. At the DNA methylation level, methylation at cg05715492 (PDAP1) was positively associated with T1D risk (OR = 1.29, 95% CI: 1.09-1.53), whereas cg05991184 (PNKD) showed an inverse association (OR = 0.73, 95% CI: 0.59-0.90). cg22712983, cg26786924, and cg04880052 in PNKD exhibited positive associations. cg25251738 (HMGB1) methylation was inversely associated with risk (OR = 0.85, 95% CI: 0.75-0.97). At the expression level, genetically predicted PDAP1 (OR = 0.26, 95% CI: 0.10-0.66) and HMGB1 (OR = 0.45, 95% CI: 0.22-0.91) expressions were inversely associated with T1D risk, whereas PNKD expression was positively associated (OR = 1.13, 95% CI: 1.04-1.23). mQTL-eQTL SMR analyses demonstrated significant methylation-expression associations at PDAP1, PNKD, and HMGB1 loci. Steiger directionality testing supported the observed associations. In GTEx datasets, higher PNKD expression was associated with increased T1D risk in both whole blood and spleen.</p><p><strong>Conclusion: </strong>PNKD, PDAP1, and HMGB1 were prioritized as lactylation-related candidate genes associated with T1D risk through integrated genetic analyses. This finding generates hypothesis for future investigations into the potential involvement of lactylation-related pathways in T1D pathogenesis.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2026 1","pages":"e9544974"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148375847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Long-Term Glycemic Control and Clinical Outcomes in Patients With Diabetes Mellitus Hospitalized for Lower Respiratory Tract Infections: A Retrospective Cohort Study.","authors":"Alma Iselin, David Staehli, Fabienne Jaun, Eliska Potlukova, Joerg Daniel Leuppi, Maria Boesing, Giorgia Lüthi-Corridori","doi":"10.1155/jdr/6735488","DOIUrl":"10.1155/jdr/6735488","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes mellitus (DM) increases susceptibility to lower respiratory tract infections (LRTIs) and is associated with higher rates of complications and mortality. Although poor glycemic control is known to increase infection risk, it is unclear whether long-term glycemic status influences outcomes once an LRTI occurs. This study examined whether hemoglobin A1c (HbA1c) predicts clinical outcomes in adults with DM hospitalized for LRTI.</p><p><strong>Methods: </strong>This retrospective, single-center observational study was conducted at Kantonsspital Baselland, Switzerland, and included adult patients with Type 1 and Type 2 DM hospitalized for LRTI between January 2023 and December 2024. Data were extracted from the hospital's electronic medical records system. Long-term glycemic control was assessed by HbA1c values. Outcomes included length of hospital stay (LOHS), readmission, and mortality at 30 and 180 days. Associations were evaluated using multivariable regression models adjusted for age, sex, and number of chronic comorbidities.</p><p><strong>Results: </strong>A total of 389 patients were included, with a median age of 79 years (IQR 72-84) and 41.1% female. Multimorbidity was highly prevalent, with 76.9% of patients having ≥ 5 chronic conditions. The median HbA1c was 7.2%. The most frequent LRTI admission diagnosis was pneumonia (53.5%), followed by COVID-19 (25.2%) and COPD exacerbation (17.0%). The median LOHS was 8 days (IQR 5-12). Mortality was 5.7% in hospital, 7.5% at 30 days, and 18.2% at 180 days after admission. Rehospitalization occurred in 13.4% of patients within 30 days and 36.7% within 180 days after discharge. Higher HbA1c was modestly associated with longer LOHS (IRR 1.058, p = 0.004) but not with readmission or mortality at any time point.</p><p><strong>Conclusion: </strong>Patients with DM hospitalized for LRTI are typically elderly, multimorbid, and experience high readmission and mortality rates. Long-term glycemic control showed an association with slightly prolonged hospital stay but no association with mortality or readmission. These findings indicate limited prognostic value of HbA1c in the acute LRTI setting and highlight the dominant role of age, sex, and multimorbidity. These findings are primarily applicable to frail, elderly patients with multimorbidity and should be interpreted cautiously in other populations. Prospective studies should investigate the impact of short-term glycemic control and structured inpatient diabetes management on outcomes.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2026 1","pages":"e6735488"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13536487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148874239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationships Between Antihypertensive, Glucose- and Lipid-Lowering Medication Adherence, and Demographic and Clinical Characteristics in American Indian Adults With Type 2 Diabetes.","authors":"Lisa Scarton, Tarah Nelson, Yingwei Yao, Dannielle Branam, Chanler Podany, Anatolia B Legaspi, Marilyn Aguila, Diana Orozco, Amal Almutairi, Aisha Rabie, Tianze Jiao, Ara Jo, William T Donahoo, Richard Segal, R Turner Goins, Spero M Manson, Diana J Wilkie","doi":"10.1155/jdr/5960974","DOIUrl":"10.1155/jdr/5960974","url":null,"abstract":"<p><strong>Objective: </strong>This study examined the relationships between medication adherence and demographic and clinical characteristics in American Indian adults with Type 2 diabetes who live on tribal lands and receive medication at no cost to them.</p><p><strong>Research design and methods: </strong>From tribal electronic health record data, we constructed a cross-sectional cohort of 3042 adults with Type 2 diabetes. Tribal citizens of a federally recognized tribe were included if aged ≥ 18 years, had Type 2 diabetes, had ≥ 1 Choctaw Nation of Oklahoma healthcare encounter in 2018, and were on antihypertensive, glucose- and lipid-lowering medications in 2018. Proportion of days covered (PDC) was used to assess medication adherence with a threshold of ≥ 80%.</p><p><strong>Results: </strong>The cohort mean age was 59.3 ± 11.6 years; the majority were male (52%), married (52%), BMI ≥ 30 (74%), and lived in a rural setting (87%). Overall, 63% of patients were adherent to their medications with a mean PDC across all medication classes of 0.81 ± 0.18. Patients aged > 55 years had a significantly higher PDC across all three medication classes compared with those aged ≤ 55 years (84% vs. 77%, p < 0.001). Also, BMI ≥ 30 (β = 0.033, p < 0.001) or having a comorbid condition (β = 0.040, p < 0.001) were each associated with higher overall PDC. Whereas insulin use (β = -0.023, p = 0.001) and rural residence (β = -0.020, p = 0.03) were associated with lower overall PDC. Additionally, patients with comorbid kidney or heart disease had a higher overall PDC compared with those without these conditions (p < 0.001).</p><p><strong>Conclusion: </strong>In a setting with access to no-cost medication, nearly two-thirds of our sample were considered adherent to their medications. Older adults and those with comorbid conditions or BMI ≥ 30 had higher overall adherence to medications, whereas those residing in rural areas or using insulin had lower overall medication adherence.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2026 1","pages":"e5960974"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13170181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147930249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiomics Integration Prioritizes ZFP36L1 as a Candidate Susceptibility Gene Associated With Inflammatory and Angiogenic Pathways in Diabetic Retinopathy.","authors":"Ruiqing Dong, Xiaoli Hui, Chenwen Luo, Shengnan Chen, Ning Gao, Mingqian He, Bingyin Shi, Wei Qiang","doi":"10.1155/jdr/4312504","DOIUrl":"10.1155/jdr/4312504","url":null,"abstract":"<p><strong>Background: </strong>Diabetic retinopathy (DR) is a prevalent microvascular complication of diabetes and a leading cause of blindness despite available therapies, underscoring the need for novel therapeutic targets.</p><p><strong>Methods: </strong>Integrated multiomics analysis combining (1) exploratory single-cell RNA sequencing of rat retinal tissues (three DRs vs. two controls), (2) Mendelian randomization (MR) using whole-blood eQTL data and DR GWAS data (14,584 cases vs. 202,082 controls), and (3) supportive RT-qPCR validation in peripheral-blood clinical samples (30 DRs vs. 30 controls).</p><p><strong>Results: </strong>(1) Genetic causality was as follows: MR analysis demonstrated ZFP36L1 as a novel DR risk gene (OR = 1.156, 95% CI = 1.054-1.269, p = 0.002), with significant upregulation in patient blood samples (p < 0.0001). (2) Inflammatory regulation was as follows: ZFP36L1 showed strong correlations with proinflammatory markers (TNF-α and IL-6) and immune cell infiltration (parainflammation and Tregs), while negatively correlating with B cells. (3) Pathway mechanisms were as follows: Functional enrichment analyses suggested potential links between ZFP36L1 and NF-κB-related inflammatory signaling as well as TGF-β-related angiogenic pathways. Despite its known VEGF mRNA destabilizing function, we observed a positive ZFP36L1-VEGF correlation (r = 0.180, p < 0.001), an unexpected finding under diabetic conditions.</p><p><strong>Conclusions: </strong>ZFP36L1 is a candidate DR susceptibility gene whose genetically regulated expression in blood is associated with DR risk. Retinal single-cell and pathway analyses provide supportive, hypothesis-generating evidence that ZFP36L1 may be linked to inflammatory and angiogenic processes relevant to DR. Further retina-specific and functional studies are required to determine whether ZFP36L1 directly regulates retinal inflammation or angiogenesis in human DR.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2026 1","pages":"e4312504"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13280981/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Nomogram Prediction Model and Validation of Hypoglycemia Risk in Patients With Decompensated Cirrhosis and Type 2 Diabetes.","authors":"Hui Liu, Yang Liu, Qiong Tian, Xiling Hu, Yide Li, Chunfei Wang","doi":"10.1155/jdr/6812038","DOIUrl":"10.1155/jdr/6812038","url":null,"abstract":"<p><strong>Purpose: </strong>This research sought to develop and evaluate a predictive nomogram for determining hypoglycemia likelihood in cases of concurrent decompensated cirrhosis and type 2 diabetes.</p><p><strong>Methods: </strong>This investigation included a cohort of 830 individuals with decompensated cirrhosis and type 2 diabetes in a retrospective design. A random 7:3 split was carried out to create model training and validation sets. Key predictors were selected using LASSO regression followed by multivariate logistic regression to construct the nomogram. Evaluation of the model encompassed both discrimination, quantified by the area under the receiver operating characteristic (ROC) curve (AUC), and calibration, assessed via calibration curves. The model's generalizability was further confirmed using the held-out validation set.</p><p><strong>Results: </strong>Among the 830 participants included in the analysis, hypoglycemia occurred in 118 cases, corresponding to an incidence rate of 14.22%. Eight variables were significantly associated with hypoglycemia: diabetic peripheral neuropathy, creatinine (Cr), indirect bilirubin (IB), triglycerides (TGs), use of antibiotics within 48 h of admission, duration of diabetes, insulin dosage, and body mass index (BMI). In the training set, the model's discriminative ability was substantial, with an AUC of 0.736 (95% CI: 0.680-0.792). Notably, this performance was well-maintained in the validation set (AUC = 0.709,95% CI: 0.614-0.803), with reliable calibration demonstrated through strong concordance between model forecasts and actual results.</p><p><strong>Conclusions: </strong>We have constructed a nomogram that incorporates eight predictors to estimate hypoglycemia risk in patients with decompensated cirrhosis and type 2 diabetes. It serves as a practical instrument for hypoglycemia risk assessment, providing valuable support for clinical decisions aimed at prevention and management strategies.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2026 1","pages":"e6812038"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13087448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147698971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and Its Association With Microvascular and Macrovascular Complications in Type 2 Diabetes.","authors":"Mariam Wehbi, Ahmad Al-Bitar, Zaynab Alourfi, Younes Kabalan","doi":"10.1155/jdr/2234488","DOIUrl":"10.1155/jdr/2234488","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) and depression frequently co-occur, but the specific clinical factors driving this association remain incompletely understood, particularly in Middle Eastern populations.</p><p><strong>Objective: </strong>This study is aimed at investigating the association between T2DM and depression and identifying which clinical factors (complications, glycemic control, and treatment modality) are most strongly associated with depression risk in a Syrian patient cohort.</p><p><strong>Methods: </strong>A case-control study enrolled 225 patients with T2DM and 226 nondiabetic controls. Depression was assessed using the Hamilton Depression Rating Scale (HDRS) and the Depression, Anxiety, and Stress Scales (DASS-21). Associations were analyzed using chi-square tests and binary logistic regression, with adjustment for age and sex in subgroup analyses.</p><p><strong>Results: </strong>Depression prevalence was significantly higher in the T2DM group (68.4% by HDRS and 68.9% by DASS-21) than in controls (40.3% and 41.6%, respectively). A T2DM diagnosis was associated with approximately threefold increased odds of depression (OR = 3.22, 95% CI [2.19-4.74] for HDRS; OR = 3.12, 95% CI [2.11-4.58] for DASS-21). Microvascular complications were associated with a marked increase in depression odds (OR = 17.05 - 17.89). Achieving glycemic control was strongly protective (OR = 0.116 - 0.125). Complex insulin-based regimens were associated with greater depression severity, even when the binary presence of depression did not differ significantly by treatment type.</p><p><strong>Conclusion: </strong>In this Syrian cohort, T2DM was associated with a threefold higher odds of depression, but this risk was not uniform. The presence of microvascular complications was the strongest associated factor. These findings support the implementation of routine depression screening in diabetes care, particularly for patients with complications or complex treatment regimens, and highlight that intensive diabetes management may also contribute to depression prevention.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2026 1","pages":"e2234488"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13159080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147868457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Narrative Review of Local Therapies in Diabetic Foot Ulcers: Promises, Limitations and Unmet Needs.","authors":"Dured Dardari","doi":"10.1155/jdr/9428774","DOIUrl":"10.1155/jdr/9428774","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot ulcers (DFUs) frequently remain open despite multidisciplinary standard care. Local therapies target different components of the wound microenvironment, but their comparative value and generalisability are uncertain.</p><p><strong>Objective: </strong>To critically summarise evidence for seven local approaches-autologous leucocyte-platelet-fibrin patches, placenta-derived products, sucrose octasulfate dressings, fish skin matrices, hyperbaric oxygen therapy (HBOT), topical oxygen therapy (TOT) and negative pressure wound therapy (NPWT)-and to identify limitations and research priorities.</p><p><strong>Methods: </strong>PubMed and the Cochrane Library were searched through 31 July 2026, supplemented by citation tracking. Randomised and prospective comparative studies, systematic reviews or meta-analyses, guidelines and economic analyses were eligible. The narrative synthesis followed SANRA-informed principles. Forty-one publications were included, among them 18 randomised trial reports.</p><p><strong>Results: </strong>An international trial of the leucocyte-platelet-fibrin patch reported healing at 20 weeks in 34% versus 22% with standard care. A meta-analysis of 11 placental-product trials reported complete healing in 66.9% versus 34.1% (risk ratio 2.00). EXPLORER reported 48% versus 30% closure with sucrose octasulfate at 20 weeks. In deep ulcers, ODIN reported 44% versus 26% healing with intact fish skin at 16 weeks. TOT meta-analysis suggested benefit (risk ratio 1.59), whereas HBOT trials were discordant and NPWT evidence was clinically supportive but low certainty. Severe infection, osteomyelitis and critical ischaemia were commonly excluded.</p><p><strong>Conclusions: </strong>Several local therapies improve healing in selected DFUs, but none replaces debridement, offloading, infection control and vascular care. Product-specific selection, durable outcomes, head-to-head pragmatic trials, complex-ulcer populations and independent economic evaluation are priority needs.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2026 1","pages":"e9428774"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13598672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Link Between Serum Copper and Diabetic Kidney Disease: A Plasma Proteomic Perspective.","authors":"Zhenbang Feng, Jinyu Yu, Junzhuo Wang, Sirui Lu, Weixia Sun, Sensen Su, Wei Liu, Hongzhao Xu","doi":"10.1155/jdr/1950326","DOIUrl":"10.1155/jdr/1950326","url":null,"abstract":"<p><strong>Background: </strong>Diabetic kidney disease (DKD) is a significant microvascular complication of diabetes, accounting for the majority of cases of end-stage renal disease. Copper, an essential trace element, has been identified as a factor closely associated with the onset and progression of DKD. However, the precise causal link between serum copper levels and DKD, along with the mechanisms governing their association, remains unclear.</p><p><strong>Methods: </strong>This study employed Mendelian randomization (MR) analysis based on large-scale GWAS data to explore the causal relationship between serum copper levels and DKD. Additionally, mediation analysis was conducted using plasma proteomic data, complemented by enrichment analysis to explore the mediating metabolic pathways or signaling pathways through which serum copper may mediate the development of DKD.</p><p><strong>Results: </strong>MR results demonstrated that elevated serum copper levels significantly increased the risk of DKD (OR = 1.123, p < 0.001). Additionally, no evidence of pleiotropy or heterogeneity was detected, which provides further assurance of the reliability of results. Protein mediation analysis identified 10 plasma proteins, including FABP, Netrin-1, and glutathione S-transferase A4 as critical mediators in copper-driven DKD, with mediation effects ranging from 6.42% to 28.02%. Following the identification of these 10 mediator proteins, 11 intermediary pathways that mediated the effect of serum copper levels on the onset of DKD were identified.</p><p><strong>Conclusion: </strong>This study elucidates the causal effect of copper levels on DKD and reveals the underlying mechanism by which increased serum copper levels lead to the development of DKD, offering novel insights and potential therapeutic targets for DKD prevention and treatment.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2026 1","pages":"e1950326"},"PeriodicalIF":3.5,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13140866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}