Journal of Diabetes Research最新文献

{"title":"Identification and Validation of Tryptophan Metabolism-Related Genes in Diabetic Kidney Disease and Construction of a Clinical Prediction Model.","authors":"Shaojie Liu, Qingqing Jiang, Wenli Li, Jinbao Shi, Binxuan Wu, Man Xiong, Liuying Huang","doi":"10.1155/jdr/2736801","DOIUrl":"https://doi.org/10.1155/jdr/2736801","url":null,"abstract":"<p><p><b>Background:</b> Diabetic kidney disease (DKD) is a common microvascular complication of diabetes mellitus (DM). Amino acid (AA) homeostasis has an important impact on renal hemodynamics and glomerular hyperfiltration in patients with DKD, and the metabolite level of tryptophan (TRP), an AA, has been associated with various diseases. <b>Methods:</b> In this study, DKD tubule- and glomerulus-related microarray datasets were collected from the GEO database, and DKD-related modular genes were identified by weighted gene coexpression network analysis (WGCNA). TRP metabolism-related genes (TRGs) were downloaded from the MSigDB database, and the key genes were obtained by taking the intersection of DKD differentially expressed genes, TRGs, and modular genes. Validated with the Nephrseq v5 database and performed clinical prediction model construction. The association of pivotal genes with immune cell infiltration was verified using CIBERSORTx software. The protein expression of the key genes was verified by qPCR, Western blot, immunohistochemistry, and immunofluorescence. <b>Results:</b> Four hundred and seventy seven DEGs were identified in the GSE30529 dataset, 392 DEGs were identified in the GSE30528 dataset, and the intersection of the DEGs in the two datasets, the module with the most significant correlation with DKD obtained by WGCNA, and the TRGs were taken, respectively. Five key genes were finally obtained (AOC1, HAAO, STAT1, OGDHL, and TDO2). Compared with control-group mice, the expression of AOC1, HAAO, and OGDHL was significantly downregulated, and the expression of STAT1 and TDO2 was significantly elevated in DKD mice. The diagnostic model was constructed using the key genes AUC = 0.996. <b>Conclusion:</b> Our study suggests that the AOC1, HAAO, and STAT1 genes may be potential diagnostic biomarkers of tubular injury in DKD. OGDHL and TDO2 may be potential diagnostic biomarkers of glomerular injury in DKD. The model constructed using AOC1, HAAO, STAT1, OGDHL, and TDO2 had good disease differentiation.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"2736801"},"PeriodicalIF":3.6,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12081153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Studies Between Double-Stranded DNA and Diabetes Mellitus.","authors":"Wanli Niu, Zhuo Li, Chunmeng Liu, Ziyan Zhang, Weiwei Chen, Yirui Wang, Xiaofen Guo, Xinyu Feng, Yuge Wang, Guanglei Shi, Yuhang Liu, Haoran Shen, Yang Han, Qi Zhen, Ruimin Wang, Liangdan Sun","doi":"10.1155/jdr/9919456","DOIUrl":"https://doi.org/10.1155/jdr/9919456","url":null,"abstract":"<p><p><b>Background:</b> Diabetes mellitus (DM) is a common chronic endocrine and metabolic disease, and its complications can involve multiple organs and seriously threaten human health. Double-stranded DNA (dsDNA) plays an important role in the autoimmune system; however, the correlation between dsDNA and DM has not been fully studied. <b>Methods:</b> This study recruited 388 diabetic patients and 2970 healthy controls to investigate the relationship between serum dsDNA and DM. The diagnosis of DM was based on the medical diagnostic and treatment standards for DM published by the American Diabetes Association (ADA). The study adhered to ethical principles and obtained informed consent from all participants. We measured serum dsDNA levels in both diabetic patients and healthy controls. The study examined differences in serum dsDNA levels among diabetic patients under various conditions, including different temperatures, ultraviolet (UV) light exposure, seasons, and clinical indicators. Additionally, quantitative PCR was used to assess the expression of dsDNA receptors, single-stranded RNA (ssRNA) receptors, absent in melanoma factor 2 (AIM2)-related inflammatory factors, and Type I interferon (INF) in the peripheral blood of patients and control groups. <b>Results:</b> Peripheral blood serum dsDNA levels were elevated in diabetic patients compared to controls (mean values 1.09 and 0.97 ng/ml, respectively, <i>p</i> < 0.001). We also found that the gene expression levels of dsDNA receptor, ssRNA receptor, AIM2-related inflammatory factors, and Type I IFN in diabetic patients were upregulated. And serum dsDNA levels correlated with clinical indicators. <b>Conclusions:</b> We have confirmed that DM is closely associated with serum dsDNA levels. Therefore, dsDNA detection shows promise as a novel approach for evaluating DM progression, offering new insights for the future diagnosis and treatment of DM.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"9919456"},"PeriodicalIF":3.6,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12055326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>ADAM9</i> Genetic Variants and Their Role in Modulating Enzyme Activity in Diabetes and Metabolic Traits.","authors":"Hana Drobiova, Fahd Al-Mulla, Rabeah Al-Temaimi","doi":"10.1155/jdr/5519447","DOIUrl":"https://doi.org/10.1155/jdr/5519447","url":null,"abstract":"<p><p>A disintegrin and metalloproteinase Domain 9 (ADAM9) is a zinc-dependent proteinase involved in various biological processes. However, its role in the pathophysiology of metabolic syndrome remains unclear, and studies exploring the association between ADAM9 polymorphisms and metabolic traits are limited. In this study, we investigated the potential link between ADAM9 variants and metabolic syndrome traits in a cohort of adult participants from Kuwait. Using a genome-wide association study (GWAS), followed by a replication study, we identified two ADAM9 variants-ADAM9-E76K (rs61753672) and ADAM9-P750L (rs144750648)-that were associated with various metabolic traits. The replication phase confirmed the association of ADAM9-P750L with HbA1c levels and revealed new associations with systolic blood pressure, waist-to-hip ratio, fasting blood glucose, triglycerides, and cholesterol. Functional analysis showed that both variants exhibited reduced proteolytic activity, potentially contributing to the pathogenesis of Type 2 diabetes. These findings suggest that ADAM9 variants may play a significant role in metabolic health and diabetes risk.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"5519447"},"PeriodicalIF":3.6,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First-Time Usage of SGLT2 Inhibitors in Patients With Type 2 Diabetes Who Are Fasting Ramadan: Efficacy and Safety.","authors":"Hany Ahmed Muhammed Khalil, Sara Kasem Abdelal, Ahmed Faysal El-Rawy, Alshimaa Lotfy Hamed Abodahab","doi":"10.1155/jdr/4321423","DOIUrl":"10.1155/jdr/4321423","url":null,"abstract":"<p><p><b>Introduction:</b> Ramadan fasting claims a necessary role in the management of diabetes. Many people with Type 2 diabetes insist on fasting during the holy month of Ramadan, which represents a challenge to their physicians to provide balance between preventing hypoglycemia or diabetic ketoacidosis (DKA) and good control of hyperglycemia with its short- and long-term complications. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are a glucose-lowering therapy for Type 2 diabetes, which are generally well tolerable but may carry the risk of dehydration and hypoglycemia particularly during the long fasting hours. The study aimed to assess the efficacy and safety of the use of SGLT2i for the first time during Ramadan fasting. <b>Methods:</b> This prospective cohort study was carried out on 61 Egyptian Muslim patients, aged ≥ 18 years old, both sexes, with Type 2 diabetes mellitus (T2DM), prepared to fast during Ramadan, and treated with SGLT2i for the first time as a supplementary to metformin or another oral hypoglycemic drug. The dose of SGLT2i started after Iftar time. During and 6 weeks after Ramadan, evaluations were conducted. <b>Results:</b> Glycated hemoglobin (HbA1c), blood pressure (systolic and diastolic), and creatinine were significantly lower after Ramadan than at the beginning of Ramadan. The estimated glomerular filtration rate (eGFR) was significantly higher after Ramadan than at the beginning of Ramadan. Hypoglycemia, dehydration, and DKA did not occur in any patient. There was a significant negative correlation between age and HbA1c (<i>r</i> = -0.267, 95% CI: -0.48 to -0.05; <i>p</i> = 0.037) and eGFR (<i>r</i> = -0.684, 95% CI: -0.79 to -0.54; <i>p</i> < 0.001) after Ramadan, while there was no correlation between the duration of DM and HbA1c before and after Ramadan. HbA1c was significantly lower after Ramadan than during Ramadan in patients with ischemic heart disease (IHD), hypertension (HTN), peripheral neuropathy (PN), and chronic kidney disease (CKD) (<i>p</i> < 0.05). <b>Conclusions:</b> SGLT2i is effective and safe during Ramadan fasting with a significant reduction in HBA1c, blood pressure, and creatinine and a significant elevation of eGFR. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT06370247.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"4321423"},"PeriodicalIF":3.6,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12048193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trial and Participant Characteristics of a Home-Visiting Diabetes Intervention: The <i>Together Overcoming Diabetes</i> Study.","authors":"Melissa L Walls, Kelley J Sittner, Gabby J Gomez, Reagan E Cole, Sylvie R Perkins, Rachel I Steinberg, Angie K Forsberg, Emily E Haroz, Allison Barlow","doi":"10.1155/jdr/6591307","DOIUrl":"https://doi.org/10.1155/jdr/6591307","url":null,"abstract":"<p><p><b>Background:</b> American Indians (AIs) endure the most severe health inequities in the nation, including disproportionately high rates of Type 2 diabetes (T2D). We describe baseline characteristics for AI participants enrolled in a culturally grounded, intergenerational, home-based T2D preventive intervention called <i>Together Overcoming Diabetes</i> (TOD). <b>Methods:</b> This community-based participatory research collaboration between five tribal nations and university-based researchers launched recruitment for a waitlist randomized control trial (RCT) design in 2021. Eligible participants were adults diagnosed with T2D who self-identified as AI, lived on or near participating reservations, and were caregivers to youth aged 10-16 years. Participants completed baseline assessments upon enrollment before being randomized to the intervention or waitlist group. <b>Results:</b> A total of <i>N</i> = 162 individuals (81 adults and 81 youth) enrolled in the study. Most of the adult (Indigenous) sample reported being female (77.8%) and were on average 49.5 years old. Average age of youth participants was 13.2 years, with similar representation of girls and boys. Mean adult HbA1c (primary outcome for the trial) was 7.93 (SD = 1.99) at baseline. Around 19% of youth participants reported a T2D or prediabetes diagnosis. Additional demographic and holistic health results are presented. <b>Conclusion:</b> This study provides comprehensive information about physiological, psychological, behavioral, and sociodemographic characteristics for a sample of AI families enrolled in a T2D intervention study. Findings suggest that intervention goals to improve behaviors like diet and physical activity are warranted and highlight the need for policy changes to address the social determinants of health. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT04734015.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"6591307"},"PeriodicalIF":3.6,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12045684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144010510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Bias in Clinical Trials of Sodium-Glucose Cotransporter 2 Inhibitors for the Treatment of Type 2 Diabetes Mellitus: A Systematic Review.","authors":"Santiago José Lora-Escobar, Lupe Rodríguez-de Francisco, Manuel López-Feijoo, Bernardo Santos-Ramos, Virginia Bellido, Rosa Casado-Mejía, Héctor Acosta-García","doi":"10.1155/jdr/3733178","DOIUrl":"https://doi.org/10.1155/jdr/3733178","url":null,"abstract":"<p><p><b>Aims:</b> The study is aimed at assessing gender bias in Phase III clinical trials (CTs) of sodium-glucose cotransporter type 2 (iSGLT2) inhibitors in adults with Type 2 diabetes mellitus (T2DM). <b>Methods:</b> We searched PubMed and EMBASE databases until June 2023. To estimate sex bias in recruitment, the difference between F-Particip (fraction of women recruited) and F-Prev (prevalence fraction of women with T2DM) was calculated. A significant sex bias in recruitment was considered to exist when the difference between F-Particip and F-Prev was greater than 0.05, 0.1, and 0.2. The analysis was considered to have a sex bias when the efficacy variables were not analyzed by sex. Gender of the first, last, and corresponding author was also assessed. <b>Results:</b> In total, 70 articles met all inclusion criteria. Sex bias in recruitment showed variable results depending on the reference value. No significant sex bias in recruitment was found in the total number of included patients. Examining each CT individually, using values of significant sex bias in recruitment of ±0.05, ±0.1, or ±0.2, we found that 41.4%, 20%, and 5.7% of the trials, respectively, showed this bias. In 34.3% of the articles, women were the first, last, or corresponding authors. Sex-based analysis of the results was performed in five studies. <b>Conclusions:</b> Although the proportion of women included in iSGLT2 CTs seems acceptable, gender bias persists in the analysis of variables and in the study authors. However, the lack of gender focus may be explained by the characteristics of the patients included in the CTs.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"3733178"},"PeriodicalIF":3.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041635/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Prediabetes and Diabetes in a European Longitudinal General Population Cohort and Its Associated Factors-Results From the Austrian LEAD Study.","authors":"Amiria Dal Grande, Maarten Van Herck, Robab Breyer-Kohansal, Tobias Mraz, Ahmad Karimi, Mohammad Azizzadeh, Sylvia Hartl, Otto C Burghuber, Emiel F M Wouters, Alexandra Kautzky-Willer, Caspar Schiffers, Marie K Breyer","doi":"10.1155/jdr/5540276","DOIUrl":"https://doi.org/10.1155/jdr/5540276","url":null,"abstract":"<p><p><b>Aims:</b> This study evaluates the incidence of (pre)diabetes in an Austrian population over a broad age span and addresses whether alterations in lifestyle, blood markers, and body composition are associated with the development of (pre)diabetes. <b>Material and Methods:</b> Data from the first and second phases of the Austrian LEAD study, a longitudinal population-based cohort study, were used. Inclusion criteria were a valid glycaemic status (i.e., normoglycaemia, prediabetes, and diabetes) at both phases using American Diabetes Association criteria. Besides blood samples, body composition parameters and an interviewer-administered questionnaire were assessed. A binary logistic regression was performed to answer the research question. <b>Results:</b> In total, 7822 individuals (51% females, 46 ± 19 years with 9.6% aged < 18 years, median follow-up time 4.1 [3.9-4.5] years) were included. The overall incidence rate was estimated at 63.0 (95% CI [59.7; 66.3]) and 8.4 (95% CI [7.4; 9.5]) per 1000 person-years for prediabetes and diabetes, respectively. In the 6-<10-, 10-<20-, and 20-<30-year age bins, an incidence rate of, respectively, 30.2, 16.3, and 13.4 per 1000 person-years (prediabetes) and 2.0, 3.5, and 1.3 (diabetes) was observed. Further, 38.3% of diabetic individuals at Visit 2 were undiagnosed and thus untreated. Factors identified as being significantly associated with progression towards (pre)diabetes included changes in triglycerides, high-density lipoprotein cholesterol, total cholesterol, and visceral adipose tissue mass, besides male sex, older age, low education level, and urban residence. <b>Conclusions:</b> The overall incidence of (pre)diabetes in the Austrian population is high and highlights the need for screening from a young age and on a regular basis so that preventive and treatment strategies can be implemented at an early stage. <b>Trial Registration:</b> ClinicalTrials.gov identifier: NCT01727518.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"5540276"},"PeriodicalIF":3.6,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12041627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneously Diabetic Torii Fatty Rat Shows Early Stage of Diabetic Retinopathy Characterized by Capillary Changes and Inflammation.","authors":"Kasumi Kikuchi, Miyuki Murata, Yasushi Kageyama, Masami Shinohara, Tomohiko Sasase, Kousuke Noda, Susumu Ishida","doi":"10.1155/jdr/3800292","DOIUrl":"https://doi.org/10.1155/jdr/3800292","url":null,"abstract":"<p><p><b>Purpose:</b> The Spontaneously Diabetic Torii (SDT) fatty rat is an animal model of obese Type 2 diabetes. We previously reported that the SDT fatty rats develop diabetic cataracts. This study aimed to elucidate early diabetic changes in the retina of the SDT fatty rats. <b>Materials and Methods:</b> The retinal thickness, capillary diameter, and pericyte/endothelial cell (P/E) ratio were assessed in the male SDT fatty rats and Sprague-Dawley (SD) rats at 24 weeks of age. Immunostaining was performed to assess the intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) levels in the retinal capillaries. DNA microarray analysis was performed to detect inflammation-associated molecules in the retina of the SDT fatty rats. Real-time PCR and Magnetic Luminex Assay were performed to validate the results. <b>Results:</b> The retinal thickness in the SDT fatty rats was significantly greater than that in SD rats. The capillary diameter in the retina of the SDT fatty rats was significantly higher than that of SD rats. The P/E ratio in the SDT fatty rats was significantly lower than that in SD rats. ICAM-1 and VCAM-1 were observed in the retinal vessels of the SDT fatty rats. The levels of mRNA and protein of <i>Mcp1</i>, <i>Il1b</i>, <i>Icam1</i>, and <i>Tnf</i> were upregulated in the retinal tissues of the 24-week-old SDT fatty rats. <b>Conclusions:</b> Our study demonstrated that the SDT fatty rats exhibited early diabetic retinal changes, suggesting that the SDT fatty rats may be useful in research on the pathogenesis of early human diabetic retinopathy.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"3800292"},"PeriodicalIF":3.6,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Neuropathy on Well-Being and Health-Related Quality of Life in Adolescents With Type 1 Diabetes.","authors":"Vinni Faber Rasmussen, Mathilde Thrysøe, Páll Karlsson, Jens Randel Nyengaard, Kurt Kristensen, Esben Thyssen Vestergaard","doi":"10.1155/jdr/6620727","DOIUrl":"https://doi.org/10.1155/jdr/6620727","url":null,"abstract":"<p><p><b>Aim:</b> This study is aimed at assesing the impact of neuropathy on well-being and health-related quality of life (HRQoL) in adolescents with Type 1 diabetes (T1D). <b>Methods:</b> In a cross-sectional study, 60 adolescents with T1D (15-18 years, diabetes duration > 5 years) were enrolled. Clinical and biochemical data were collected, and well-being and HRQoL were assessed using the WHO-5 well-being index and DISABKIDS questionnaires, including diabetes-specific modules. Diagnostic tests for large fiber neuropathy (LFN), small fiber neuropathy (SFN), and autonomic neuropathy were performed as part of the T1DANES study. The participants were divided into groups depending on the presence or absence of specific forms of neuropathy. Those with autonomic neuropathy were further divided depending on reported autonomic symptoms (Composite Autonomic Symptom Scale 31 (COMPASS-31) score ≥ 24 or < 24). Additionally, the data was compared to 23 healthy control subjects. <b>Results:</b> The median diabetes duration was 8.5 years (range 5-17), and the HbA1c was 60 mmol/mol (7.6%) (range 41-93 [5.9%-10.6%]). Adolescents who had abnormal autonomic function test(s) and a COMPASS-31 score ≥ 24 exhibited lower WHO-5 well-being index compared to the following groups: those with abnormal autonomic test(s) and fewer autonomic symptoms (COMPASS-31 < 24), the remaining adolescents with T1D, and the control subjects (<i>p</i> values < 0.05). There was no significant difference in the total score of DISABKIDS between the groups; however, the subdomain <i>social inclusion</i> was lowest in the group with COMPASS-31 ≥ 24. Gastric motility index (<i>p</i> = 0.04) and uroflow acceleration (<i>p</i> = 0.02) were positively associated with the total score of DISABKIDS. Females reported lower well-being and HRQoL than males (<i>p</i> values < 0.05); in total, 28% had a WHO-5 well-being index < 50. <b>Conclusion:</b> In conclusion, adolescents with diabetic autonomic neuropathy who also reported autonomic symptoms had lower well-being and impaired social inclusion. Adolescents with symptoms of neuropathy and females appear to be at higher risk of lower well-being, and using standardized screening tools helps to identify the subjects at risk.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"6620727"},"PeriodicalIF":3.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144028927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Diabetic Cognitive Impairment Score for Early Screening of Cognitive Impairment in Type 2 Diabetes Patients.","authors":"Shujun Zhang, Xiaoli Shi, Shaolin Zheng, Xiaoli Liang, Fen Wang, Weijie Xu, Xuefeng Yu, Yan Yang","doi":"10.1155/jdr/8029913","DOIUrl":"https://doi.org/10.1155/jdr/8029913","url":null,"abstract":"<p><p><b>Purpose:</b> Diabetes has been associated with an excess risk of cognitive impairment. The hyperphosphorylation of tau protein leads to neurodegeneration and is closely related to Type 2 diabetes (T2D). This study aimed to characterize the association between P-tau181 and diabetic cognitive impairment and to develop a nomogram-based score to screen cognitive impairment in T2D patients. <b>Methods:</b> We used a cohort of 379 patients diagnosed with T2D as a training dataset to develop a predictive model. Risk factors associated with cognitive impairment were identified using stepwise multivariate logistic regressive analysis. A nomogram was established by incorporating these risk factors, and the diabetic cognitive impairment score (DCIS) was built and externally validated in another cohort. <b>Results:</b> In the training cohort, patients with cognitive impairment had higher levels of P-tau181 (13.3 [10.5-18.7] vs. 10.0 [8.0-13.0], <i>p</i> < 0.001). P-tau181 was negatively correlated with MOCA (<i>r</i> = -0.308, <i>p</i> < 0.001) and MMSE (<i>r</i> = -0.289, <i>p</i> < 0.001), and it was independently associated with cognitive impairment in T2D patients (OR, 1.137 [95% CI, 1.080-1.198]; <i>p</i> < 0.001). Other independent risk factors of diabetic cognitive impairment included age, education level, and diabetic retinopathy. The DCIS was built by nomogram based on the four risk factors, which had an area under the receiver operating characteristic curve (AUC) of 0.795 (95% CI, 0.751-0.840). The optimal cut-off of DCIS for the diagnosis of cognitive impairment in T2D patients was 139.5, with a sensitivity of 72.9% and a specificity of 75.3%. In the validation cohort, the AUC of DCIS for screening diabetic cognitive impairment was 0.770 (95% CI, 0.716-0.824). <b>Conclusions:</b> P-tau181 was independently associated with diabetic cognitive impairment. The DCIS, based on P-tau181, age, education level, and diabetic retinopathy, is effective to identify cognitive impairment in T2D patients.</p>","PeriodicalId":15576,"journal":{"name":"Journal of Diabetes Research","volume":"2025 ","pages":"8029913"},"PeriodicalIF":3.6,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12017955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}