Journal of drug delivery最新文献_第7页

Nanoparticle albumin bound Paclitaxel in the treatment of human cancer: nanodelivery reaches prime-time? 纳米颗粒白蛋白结合紫杉醇治疗人类癌症:纳米递送达到黄金时间?

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-05-02 DOI: 10.1155/2013/905091

Iole Cucinotto, Lucia Fiorillo, Simona Gualtieri, Mariamena Arbitrio, Domenico Ciliberto, Nicoletta Staropoli, Anna Grimaldi, Amalia Luce, Pierfrancesco Tassone, Michele Caraglia, Pierosandro Tagliaferri

引用次数: 62

The sulfatase pathway for estrogen formation: targets for the treatment and diagnosis of hormone-associated tumors. 雌激素形成的硫酸酯酶途径：激素相关肿瘤的治疗和诊断目标。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-02-13 DOI: 10.1155/2013/957605

Lena Secky, Martin Svoboda, Lukas Klameth, Erika Bajna, Gerhard Hamilton, Robert Zeillinger, Walter Jäger, Theresia Thalhammer

{"title":"The sulfatase pathway for estrogen formation: targets for the treatment and diagnosis of hormone-associated tumors.","authors":"Lena Secky, Martin Svoboda, Lukas Klameth, Erika Bajna, Gerhard Hamilton, Robert Zeillinger, Walter Jäger, Theresia Thalhammer","doi":"10.1155/2013/957605","DOIUrl":"10.1155/2013/957605","url":null,"abstract":"The extragonadal synthesis of biological active steroid hormones from their inactive precursors in target tissues is named \"intracrinology.\" Of particular importance for the progression of estrogen-dependent cancers is the in situ formation of the biological most active estrogen, 17beta-estradiol (E2). In cancer cells, conversion of inactive steroid hormone precursors to E2 is accomplished from inactive, sulfated estrogens in the \"sulfatase pathway\" and from androgens in the \"aromatase pathway.\" Here, we provide an overview about expression and function of enzymes of the \"sulfatase pathway,\" particularly steroid sulfatase (STS) that activates estrogens and estrogen sulfotransferase (SULT1E1) that converts active estrone (E1) and other estrogens to their inactive sulfates. High expression of STS and low expression of SULT1E1 will increase levels of active estrogens in malignant tumor cells leading to the stimulation of cell proliferation and cancer progression. Therefore, blocking the \"sulfatase pathway\" by STS inhibitors may offer an attractive strategy to reduce levels of active estrogens. STS inhibitors either applied in combination with aromatase inhibitors or as novel, dual aromatase-steroid sulfatase inhibiting drugs are currently under investigation. Furthermore, STS inhibitors are also suitable as enzyme-based cancer imaging agents applied in the biomedical imaging technique positron emission tomography (PET) for cancer diagnosis.","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":"2013 ","pages":"957605"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31294595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neoplastic meningitis from solid tumors: a prospective clinical study in lombardia and a literature review on therapeutic approaches. 来自实体瘤的肿瘤性脑膜炎:伦巴第的前瞻性临床研究和治疗方法的文献综述。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-01-16 DOI: 10.1155/2013/147325

A Silvani, M Caroli, P Gaviani, V Fetoni, R Merli, M Riva, M De Rossi, F Imbesi, A Salmaggi

{"title":"Neoplastic meningitis from solid tumors: a prospective clinical study in lombardia and a literature review on therapeutic approaches.","authors":"A Silvani, M Caroli, P Gaviani, V Fetoni, R Merli, M Riva, M De Rossi, F Imbesi, A Salmaggi","doi":"10.1155/2013/147325","DOIUrl":"https://doi.org/10.1155/2013/147325","url":null,"abstract":"Neoplastic dissemination to the leptomeninges is an increasingly common occurrence in patients with both haematological and solid tumors arising outside the central nervous system. Both refinement of diagnostic techniques (Magnetic resonance imaging) and increased survival in patients treated with targeted therapies for systemic tumors account for this increased frequency. Cerebrospinal fluid cytological analysis and MRI confirm clinical diagnosis based on multifocal central nervous system signs/symptoms in a patient with known malignancy. Overall survival in patients with leptomeningeal neoplastic dissemination from solid tumors is short, rarely exceeding 3-4 months. However, selected patients may benefit from aggressive therapies, Apart from symptomatic treatment, intrathecal chemotherapy is used, with both free (methotrexate, Thiotepa, AraC) and liposomal antitumor agents (liposomal AraC). Palliative radiotherapy is indicated only in cases of symptomatic bulky disease, surgery is limited to positioning of Ommaya recervoirs or C5F shunting. We report clinical data on a cohort of 26 prospectively followed patients with neoplastic leptomeningitis followed in Lombardia, Italy, in 2011. Prognostic factors and pattern of care are reported.","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":"2013 ","pages":"147325"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/147325","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31323034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Lipid-based nanoparticles in cancer diagnosis and therapy. 基于脂质的纳米粒子在癌症诊断和治疗中的应用。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-07-09 DOI: 10.1155/2013/165981

Andrew D Miller

引用次数: 0

Development of oral sustained release rifampicin loaded chitosan nanoparticles by design of experiment. 实验设计制备口服利福平壳聚糖纳米颗粒。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-08-18 DOI: 10.1155/2013/370938

Bhavin K Patel, Rajesh H Parikh, Pooja S Aboti

{"title":"Development of oral sustained release rifampicin loaded chitosan nanoparticles by design of experiment.","authors":"Bhavin K Patel, Rajesh H Parikh, Pooja S Aboti","doi":"10.1155/2013/370938","DOIUrl":"https://doi.org/10.1155/2013/370938","url":null,"abstract":"Objective. The main objective of the present investigation was to develop and optimize oral sustained release Chitosan nanoparticles (CNs) of rifampicin by design of experiment (DOE). Methodology. CNs were prepared by modified emulsion ionic gelation technique. Here, inclusion of hydrophobic drug moiety in the hydrophilic matrix of polymer is applied for rifampicin delivery using CN. The 2(3) full-factorial design was employed by selecting the independent variables such as Chitosan concentration (X 1), concentration of tripolyphosphate (X 2), and homogenization speed (X 3) in order to achieve desired particle size with maximum percent entrapment efficiency and drug loading. The design was validated by checkpoint analysis, and formulation was optimized using the desirability function. Results. Particle size, drug entrapment efficiency, and drug loading for the optimized batch were found to be 221.9 nm, 44.17 ± 1.98% W/W, and 42.96 ± 2.91% W/W, respectively. In vitro release data of optimized formulation showed an initial burst followed by slow sustained drug release. Kinetic drug release from CNs was best fitted to Higuchi model. Conclusion. Design of Experiment is an important tool for obtaining desired characteristics of rifampicin loaded CNs. In vitro study suggests that oral sustained release CNs might be an effective drug delivery system for tuberculosis. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":"2013 ","pages":"370938"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/370938","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31723475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 79

MRI-Guided Focused Ultrasound as a New Method of Drug Delivery. mri引导聚焦超声作为一种新的给药方法。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-05-12 DOI: 10.1155/2013/616197

M Thanou, W Gedroyc

{"title":"MRI-Guided Focused Ultrasound as a New Method of Drug Delivery.","authors":"M Thanou, W Gedroyc","doi":"10.1155/2013/616197","DOIUrl":"https://doi.org/10.1155/2013/616197","url":null,"abstract":"Ultrasound-mediated drug delivery under the guidance of an imaging modality can improve drug disposition and achieve site-specific drug delivery. The term focal drug delivery has been introduced to describe the focal targeting of drugs in tissues with the help of imaging and focused ultrasound. Focal drug delivery aims to improve the therapeutic profile of drugs by improving their specificity and their permeation in defined areas. Focused-ultrasound- (FUS-) mediated drug delivery has been applied with various molecules to improve their local distribution in tissues. FUS is applied with the aid of microbubbles to enhance the permeability of bioactive molecules across BBB and improve drug distribution in the brain. Recently, FUS has been utilised in combination with MRI-labelled liposomes that respond to temperature increase. This strategy aims to “activate” nanoparticles to release their cargo locally when triggered by hyperthermia induced by FUS. MRI-guided FUS drug delivery provides the opportunity to improve drug bioavailability locally and therefore improve the therapeutic profiles of drugs. This drug delivery strategy can be directly translated to clinic as MRg FUS is a promising clinically therapeutic approach. However, more basic research is required to understand the physiological mechanism of FUS-enhanced drug delivery.","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":"2013 ","pages":"616197"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/616197","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31483817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 44

The effect of polymer content on the non-newtonian behavior of acetaminophen suspension. 聚合物含量对对乙酰氨基酚悬浮液非牛顿行为的影响。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-09-10 DOI: 10.1155/2013/907471

Eskandar Moghimipour, Maryam Kouchak, Anayatollah Salimi, Saeed Bahrampour, Somayeh Handali

{"title":"The effect of polymer content on the non-newtonian behavior of acetaminophen suspension.","authors":"Eskandar Moghimipour, Maryam Kouchak, Anayatollah Salimi, Saeed Bahrampour, Somayeh Handali","doi":"10.1155/2013/907471","DOIUrl":"https://doi.org/10.1155/2013/907471","url":null,"abstract":"Acetaminophen is used as an analgesic and antipyretic agent. The aim of the study was evaluation of the effect of different polymers on rheological behavior of acetaminophen suspension. In order to achieve controlled flocculation, sodium chloride was added. Then structural vehicles such as carboxymethyl cellulose (CMC), polyvinyl pyrrolidone (PVP), tragacanth, and magnesium aluminum silicate (Veegum) were evaluated individually and in combination. Physical stability parameters such as sedimentation volume (F), redispersibility (n), and growth of crystals of the suspensions were determined. Also, the rheological properties of formulations were studied. The results of this study showed that the combination of suspending agents had the most physical stability and pseudoplastic behavior with some degree of thixotropy. Viscosity of suspensions was increased by adding NaCl 0.02%. Presence of PVP is necessary for improving rheological behavior of suspensions by NaCl. This may be related to the cross-linking between the carbonyl group in the PVP segment and Na(+) ions. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":"2013 ","pages":"907471"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/907471","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31793583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Cancer epigenetics: new therapies and new challenges. 癌症表观遗传学:新疗法和新挑战。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-02-26 DOI: 10.1155/2013/529312

Eleftheria Hatzimichael, Tim Crook

引用次数: 76

Liposomal Doxorubicin in the treatment of breast cancer patients: a review. 治疗乳腺癌患者的多柔比星脂质体：综述。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-03-26 DOI: 10.1155/2013/456409

Juan Lao, Julia Madani, Teresa Puértolas, María Alvarez, Alba Hernández, Roberto Pazo-Cid, Angel Artal, Antonio Antón Torres

{"title":"Liposomal Doxorubicin in the treatment of breast cancer patients: a review.","authors":"Juan Lao, Julia Madani, Teresa Puértolas, María Alvarez, Alba Hernández, Roberto Pazo-Cid, Angel Artal, Antonio Antón Torres","doi":"10.1155/2013/456409","DOIUrl":"10.1155/2013/456409","url":null,"abstract":"Drug delivery systems can provide enhanced efficacy and/or reduced toxicity for anticancer agents. Liposome drug delivery systems are able to modify the pharmacokinetics and biodistribution of cytostatic agents, increasing the concentration of the drug released to neoplastic tissue and reducing the exposure of normal tissue. Anthracyclines are a key drug in the treatment of both metastatic and early breast cancer, but one of their major limitations is cardiotoxicity. One of the strategies designed to minimize this side effect is liposome encapsulation. Liposomal anthracyclines have achieved highly efficient drug encapsulation and they have proven to be effective and with reduced cardiotoxicity, as a single agent or in combination with other drugs for the treatment of either anthracyclines-treated or naïve metastatic breast cancer patients. Of particular interest is the use of the combination of liposomal anthracyclines and trastuzumab in patients with HER2-overexpressing breast cancer. In this paper, we discuss the different studies on liposomal doxorubicin in metastatic and early breast cancer therapy.","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":"2013 ","pages":"456409"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31398189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Dendritic Cell-Mediated Antigen-Specific CD4+ T Cell Responses: IFN-Gamma Aids TLR Stimulation. 增强树突状细胞介导的抗原特异性 CD4+ T 细胞反应：IFN-Gamma 有助于 TLR 刺激。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-05-28 DOI: 10.1155/2013/516749

Kuo-Ching Sheng, Stephanie Day, Mark D Wright, Lily Stojanovska, Vasso Apostolopoulos

{"title":"Enhanced Dendritic Cell-Mediated Antigen-Specific CD4+ T Cell Responses: IFN-Gamma Aids TLR Stimulation.","authors":"Kuo-Ching Sheng, Stephanie Day, Mark D Wright, Lily Stojanovska, Vasso Apostolopoulos","doi":"10.1155/2013/516749","DOIUrl":"10.1155/2013/516749","url":null,"abstract":"Phenotypic maturation and T cell stimulation are two functional attributes of DCs critical for immune induction. The combination of antigens, including those from cancer, with Toll-like receptor (TLR) ligands induces far superior cellular immune responses compared to antigen alone. In this study, IFN-gamma treatment of bone marrow-derived DC, followed by incubation with the TLR2, TLR4, or TLR9 agonists, enhanced DC activation compared to TLR ligation alone. Most notably, the upregulation of CD40 with LPS stimulation and CD86 with CpG stimulation was observed in in vitro cultures. Similarly, IFN-gamma coinjected with TLR ligands was able to promote DC activation in vivo, with DCs migrating from the site of immunization to the popliteal lymph nodes demonstrating increased expression of CD80 and CD86. The heightened DC activation translated to a drastic increase in T cell stimulatory capacity in both antigen independent and antigen dependent fashions. This is the first time that IFN-gamma has been shown to have a combined effect with TLR ligation to enhance DC activation and function. The results demonstrate the novel use of IFN-gamma together with TLR agonists to enhance antigen-specific T cell responses, for applications in the development of enhanced vaccines and drug targets against diseases including cancer.","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":"2013 ","pages":"516749"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3679806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31517038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0