The effect of polymer content on the non-newtonian behavior of acetaminophen suspension.

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-09-10 DOI:10.1155/2013/907471

Eskandar Moghimipour, Maryam Kouchak, Anayatollah Salimi, Saeed Bahrampour, Somayeh Handali

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引用次数: 4

Abstract

Acetaminophen is used as an analgesic and antipyretic agent. The aim of the study was evaluation of the effect of different polymers on rheological behavior of acetaminophen suspension. In order to achieve controlled flocculation, sodium chloride was added. Then structural vehicles such as carboxymethyl cellulose (CMC), polyvinyl pyrrolidone (PVP), tragacanth, and magnesium aluminum silicate (Veegum) were evaluated individually and in combination. Physical stability parameters such as sedimentation volume (F), redispersibility (n), and growth of crystals of the suspensions were determined. Also, the rheological properties of formulations were studied. The results of this study showed that the combination of suspending agents had the most physical stability and pseudoplastic behavior with some degree of thixotropy. Viscosity of suspensions was increased by adding NaCl 0.02%. Presence of PVP is necessary for improving rheological behavior of suspensions by NaCl. This may be related to the cross-linking between the carbonyl group in the PVP segment and Na(+) ions.

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聚合物含量对对乙酰氨基酚悬浮液非牛顿行为的影响。

对乙酰氨基酚被用作止痛和解热剂。研究了不同聚合物对对乙酰氨基酚混悬液流变行为的影响。为了达到控制絮凝的目的，加入氯化钠。然后分别对羧甲基纤维素(CMC)、聚乙烯吡咯烷酮(PVP)、石蜡、硅酸镁铝(Veegum)等结构载体进行了评价。测定了悬浮液的沉降体积(F)、再分散性(n)和晶体生长等物理稳定性参数。并对配方的流变性能进行了研究。本研究结果表明，该悬浮剂组合具有最好的物理稳定性和假塑性行为，并具有一定的触变性。添加0.02%的NaCl可提高悬浮液的粘度。PVP的存在是改善悬浮液在NaCl作用下的流变性能的必要条件。这可能与PVP段羰基与Na(+)离子的交联有关。

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Journal of drug delivery PHARMACOLOGY & PHARMACY-

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