Journal of drug delivery最新文献_第6页

Preparation and characterization of liquisolid compacts for improved dissolution of telmisartan. 改善替米沙坦溶出的液固压剂的制备与表征。

Journal of drug delivery Pub Date : 2014-01-01 Epub Date: 2014-10-12 DOI: 10.1155/2014/692793

Naveen Chella, Nataraj Narra, Tadikonda Rama Rao

{"title":"Preparation and characterization of liquisolid compacts for improved dissolution of telmisartan.","authors":"Naveen Chella, Nataraj Narra, Tadikonda Rama Rao","doi":"10.1155/2014/692793","DOIUrl":"https://doi.org/10.1155/2014/692793","url":null,"abstract":"The objective of the present work was to obtain pH independent and improved dissolution profile for a poorly soluble drug, telmisartan using liquisolid compacts. Liquisolid compacts were prepared using Transcutol HP as vehicle, Avicel PH102 as carrier, and Aerosil 200 as a coating material. The formulations were evaluated for drug excipient interactions, change in crystallinity of drug, flow properties, and general quality control tests of tablets using Fourier transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), X-ray diffraction (XRD), angle of repose, and various pharmacopoeial tests. In vitro dissolution studies were performed at three pH conditions (1.2, 4.5 and 7.4). Stability studies were performed at 40°C and 75% RH for three months. The formulation was found to comply with Indian pharmacopoeial limits for tablets. FTIR studies confirmed no interaction between drug and excipients. XRD and DSC studies indicate change/reduction in crystallinity of drug. Dissolution media were selected based on the solubility studies. The optimized formulation showed pH independent release profile with significant improvement (P < 0.005) in dissolution compared to plain drug and conventional marketed formulation. No significant difference was seen in the tablet properties, and drug release profile after storage for 3 months. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/692793","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32793683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Interpenetrating polymer networks as innovative drug delivery systems. 作为创新药物输送系统的互穿聚合物网络。

Journal of drug delivery Pub Date : 2014-01-01 Epub Date: 2014-05-14 DOI: 10.1155/2014/583612

Alka Lohani, Garima Singh, Shiv Sankar Bhattacharya, Anurag Verma

{"title":"Interpenetrating polymer networks as innovative drug delivery systems.","authors":"Alka Lohani, Garima Singh, Shiv Sankar Bhattacharya, Anurag Verma","doi":"10.1155/2014/583612","DOIUrl":"10.1155/2014/583612","url":null,"abstract":"Polymers have always been valuable excipients in conventional dosage forms, also have shown excellent performance into the parenteral arena, and are now capable of offering advanced and sophisticated functions such as controlled drug release and drug targeting. Advances in polymer science have led to the development of several novel drug delivery systems. Interpenetrating polymer networks (IPNs) have shown superior performances over the conventional individual polymers and, consequently, the ranges of applications have grown rapidly for such class of materials. The advanced properties of IPNs like swelling capacity, stability, biocompatibility, nontoxicity and biodegradability have attracted considerable attention in pharmaceutical field especially in delivering bioactive molecules to the target site. In the past few years various research reports on the IPN based delivery systems showed that these carriers have emerged as a novel carrier in controlled drug delivery. The present review encompasses IPNs, their types, method of synthesis, factors which affects the morphology of IPNs, extensively studied IPN based drug delivery systems, and some natural polymers widely used for IPNs. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4052081/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32442791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in delivery systems and therapeutics of cinnarizine: a poorly water soluble drug with absorption window in stomach. 具有胃吸收窗口的低水溶性药物肉桂嗪的给药系统和治疗方法的最新进展。

Journal of drug delivery Pub Date : 2014-01-01 Epub Date: 2014-11-13 DOI: 10.1155/2014/479246

Smita Raghuvanshi, Kamla Pathak

{"title":"Recent advances in delivery systems and therapeutics of cinnarizine: a poorly water soluble drug with absorption window in stomach.","authors":"Smita Raghuvanshi, Kamla Pathak","doi":"10.1155/2014/479246","DOIUrl":"https://doi.org/10.1155/2014/479246","url":null,"abstract":"Low solubility causing low dissolution in gastrointestinal tract is the major problem for drugs meant for systemic action after oral administration, like cinnarizine. Pharmaceutical products of cinnarizine are commercialized globally as immediate release preparations presenting low absorption with low and erratic bioavailability. Approaches to enhance bioavailability are widely cited in the literature. An attempt has been made to review the bioavailability complications and clinical therapeutics of poorly water soluble drug: cinnarizine. The interest of writing this paper is to summarize the pharmacokinetic limitations of drug with special focus on strategies to improvise bioavailability along with effectiveness of novel dosage forms to circumvent the obstacle. The paper provides insight to the approaches to overcome low and erratic bioavailability of cinnarizine by cyclodextrin complexes and novel dosage forms: self-nanoemulsifying systems and buoyant microparticulates. Nanoformulations need to systematically explored in future, for their new clinical role in prophylaxis of migraine attacks in children. Clinical reports have affirmed the role of cinnarizine in migraine prophylaxis. Research needs to be dedicated to develop dosage forms for efficacious bioavailability and drug directly to brain. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/479246","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32884599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 30

Formulation and evaluation of liquisolid compacts for olmesartan medoxomil. 奥美沙坦美多索米液固紧密剂的研制与评价。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-10-21 DOI: 10.1155/2013/870579

Shailesh T Prajapati, Hitesh H Bulchandani, Dashrath M Patel, Suresh K Dumaniya, Chhaganbhai N Patel

{"title":"Formulation and evaluation of liquisolid compacts for olmesartan medoxomil.","authors":"Shailesh T Prajapati, Hitesh H Bulchandani, Dashrath M Patel, Suresh K Dumaniya, Chhaganbhai N Patel","doi":"10.1155/2013/870579","DOIUrl":"https://doi.org/10.1155/2013/870579","url":null,"abstract":"Olmesartan medoxomil is an angiotensin type II receptor blocker, antihypertensive agent, administered orally. It is highly lipophilic (log P 5.5) and a poorly water-soluble drug with absolute bioavailability of 26%. The poor dissolution rate of water-insoluble drugs is still a major problem confronting the pharmaceutical industry. The objective of the present investigation was to develop liquisolid compacts for olmesartan medoxomil to improve the dissolution rate. Liquisolid compacts were prepared using Acrysol El 135 as a solvent, Avicel PH 102, Fujicalin and Neusilin as carrier materials, and Aerosil as coating material in different ratios. The interaction between drug and excipients was characterized by DSC and FT-IR studies, which showed that there is no interaction between drug and excipients. The powder characteristics were evaluated by different flow parameters to comply with pharmacopoeial limits. The dissolution studies for liquisolid compacts and conventional formulations were carried out, and it was found that liquisolid compacts with 80% w/w of Acrysol EL 135 to the drug showed significant higher drug release rates than conventional tablets. Amongst carriers used Fujicalin and Neusilin were found to be more effective carrier materials for liquid adsorption. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/870579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31864977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 36

Targeted antiepidermal growth factor receptor (cetuximab) immunoliposomes enhance cellular uptake in vitro and exhibit increased accumulation in an intracranial model of glioblastoma multiforme. 靶向抗表皮生长因子受体(西妥昔单抗)免疫脂质体在体外增强细胞摄取，并在颅内多形性胶质母细胞瘤模型中表现出增加的积累。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-09-23 DOI: 10.1155/2013/209205

Joachim Høg Mortensen, Maria Jeppesen, Linda Pilgaard, Ralf Agger, Meg Duroux, Vladimir Zachar, Torben Moos

{"title":"Targeted antiepidermal growth factor receptor (cetuximab) immunoliposomes enhance cellular uptake in vitro and exhibit increased accumulation in an intracranial model of glioblastoma multiforme.","authors":"Joachim Høg Mortensen, Maria Jeppesen, Linda Pilgaard, Ralf Agger, Meg Duroux, Vladimir Zachar, Torben Moos","doi":"10.1155/2013/209205","DOIUrl":"https://doi.org/10.1155/2013/209205","url":null,"abstract":"Therapeutic advances do not circumvent the devastating fact that the survival rate in glioblastoma multiforme (GBM) is less than 5%. Nanoparticles consisting of liposome-based therapeutics are provided against a variety of cancer types including GBM, but available liposomal formulations are provided without targeting moieties, which increases the dosing demands to reach therapeutic concentrations with risks of side effects. We prepared PEGylated immunoliposomes (ILs) conjugated with anti-human epidermal growth factor receptor (EGFR) antibodies Cetuximab ( α -hEGFR-ILs). The affinity of the α -hEGFR-ILs for the EGF receptor was evaluated in vitro using U87 mg and U251 mg cells and in vivo using an intracranial U87 mg xenograft model. The xenograft model was additionally analyzed with respect to permeability to endogenous albumin, tumor size, and vascularization. The in vitro studies revealed significantly higher binding of α -hEGFR-ILs when compared with liposomes conjugated with isotypic nonimmune immunoglobulin. The uptake and internalization of the α -hEGFR-ILs by U87 mg cells were further confirmed by 3D deconvolution analyses. In vivo, the α -hEGFR-ILs accumulated to a higher extent inside the tumor when compared to nonimmune liposomes. The data show that α -hEGFR-ILs significantly enhance the uptake and accumulation of liposomes in this experimental model of GBM suggestive of improved specific nanoparticle-based delivery. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/209205","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40279025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 45

Development of dorzolamide loaded 6-o-carboxymethyl chitosan nanoparticles for open angle glaucoma. dorzolamide负载6-o-羧甲基壳聚糖纳米颗粒治疗开角型青光眼的研制。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-10-10 DOI: 10.1155/2013/562727

Ujwala Shinde, Mohammed Hadi Ahmed, Kavita Singh

{"title":"Development of dorzolamide loaded 6-o-carboxymethyl chitosan nanoparticles for open angle glaucoma.","authors":"Ujwala Shinde, Mohammed Hadi Ahmed, Kavita Singh","doi":"10.1155/2013/562727","DOIUrl":"https://doi.org/10.1155/2013/562727","url":null,"abstract":"Chitosan (CS) is a biodegradable, biocompatible, and mucoadhesive natural polymer soluble in acidic pH only and can be irritating to the eye. Objective of the study was to synthesize water soluble 6-O-carboxymethyl (OCM-CS) derivative of CS, and to develop CS and OCM-CS nanoparticles (NPs) loaded with dorzolamide hydrochloride (DRZ). CS was reacted with monochloroacetic acid (MCA) for OCM-CS synthesis and was characterized by FT-IR, DSC, and (13)C NMR. CS and OCM-CS NPs were prepared by ionic gelation method. Ocular irritation potential were evaluated and therapeutic efficacy was measured by reduction in intraocular pressure (IOP) in normotensive rabbits. Maximum yield was obtained when the ratio of water/isopropyl alcohol was 1/4 at 55°C. The FT-IR, DSC and (13)C NMR confirmed the formation of an ether linkage between hydroxyl groups of CS and MCA. The particle size and zeta potential of optimised CSNPs was 250.3 ± 2.62 nm and +33.47 ± 0.723 mV, whereas those for OCM-CSNPs were 187.1 ± 2.72 nm and 30.87 ± 0.86 mV. The entrapment efficiency was significantly improved for OCM-CSNPs, compared to CSNPs. OCM-CSNPs had tailored drug release and improved bioavailability with reduction in pulse entry as compared to CSNPs. Hence, it can be concluded that DRZ loaded OCM-CSNPs would be better alternative option to available eye drops for glaucoma treatment. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/562727","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31859021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Targeting antigens to dendritic cell receptors for vaccine development. 将抗原靶向树突状细胞受体用于疫苗开发。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-10-08 DOI: 10.1155/2013/869718

Vasso Apostolopoulos, Theresia Thalhammer, Andreas G Tzakos, Lily Stojanovska

引用次数: 130

Polymeric micelles, a promising drug delivery system to enhance bioavailability of poorly water-soluble drugs. 聚合物胶束，一个有前途的药物传递系统，以提高生物利用度的低水溶性药物。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-06-27 DOI: 10.1155/2013/340315

Wei Xu, Peixue Ling, Tianmin Zhang

引用次数: 407

Convection-enhanced delivery for targeted delivery of antiglioma agents: the translational experience. 靶向递送抗胶质瘤药物的对流增强递送:翻译经验。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-02-14 DOI: 10.1155/2013/107573

Jonathan Yun, Robert J Rothrock, Peter Canoll, Jeffrey N Bruce

引用次数: 27

Gene therapy for advanced melanoma: selective targeting and therapeutic nucleic acids. 晚期黑色素瘤的基因治疗:选择性靶向和治疗性核酸。

Journal of drug delivery Pub Date : 2013-01-01 Epub Date: 2013-03-25 DOI: 10.1155/2013/897348

Joana R Viola, Diana F Rafael, Ernst Wagner, Robert Besch, Manfred Ogris

{"title":"Gene therapy for advanced melanoma: selective targeting and therapeutic nucleic acids.","authors":"Joana R Viola, Diana F Rafael, Ernst Wagner, Robert Besch, Manfred Ogris","doi":"10.1155/2013/897348","DOIUrl":"https://doi.org/10.1155/2013/897348","url":null,"abstract":"Despite recent advances, the treatment of malignant melanoma still results in the relapse of the disease, and second line treatment mostly fails due to the occurrence of resistance. A wide range of mutations are known to prevent effective treatment with chemotherapeutic drugs. Hence, approaches with biopharmaceuticals including proteins, like antibodies or cytokines, are applied. As an alternative, regimens with therapeutically active nucleic acids offer the possibility for highly selective cancer treatment whilst avoiding unwanted and toxic side effects. This paper gives a brief introduction into the mechanism of this devastating disease, discusses the shortcoming of current therapy approaches, and pinpoints anchor points which could be harnessed for therapeutic intervention with nucleic acids. We bring the delivery of nucleic acid nanopharmaceutics into perspective as a novel antimelanoma therapeutic approach and discuss the possibilities for melanoma specific targeting. The latest reports on preclinical and already clinical application of nucleic acids in melanoma are discussed.","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/897348","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31398641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26