Journal of drug delivery最新文献_第5页

Polypeptide multilayer self-assembly studied by ellipsometry. 椭圆偏振法研究多肽多层自组装。

Journal of drug delivery Pub Date : 2014-01-01 Epub Date: 2014-02-10 DOI: 10.1155/2014/424697

Marina Craig, Krister Holmberg, Eric Le Ru, Pablo Etchegoin

{"title":"Polypeptide multilayer self-assembly studied by ellipsometry.","authors":"Marina Craig, Krister Holmberg, Eric Le Ru, Pablo Etchegoin","doi":"10.1155/2014/424697","DOIUrl":"https://doi.org/10.1155/2014/424697","url":null,"abstract":"A polypeptide nanofilm made by layer-by-layer (LbL) self-assembly was built on a surface that mimics nonwoven, a material commonly used in wound dressings. Poly-L-lysine (PLL) and poly-L-glutamic acid (PLGA) are the building blocks of the nanofilm, which is intended as an enzymatically degradable lid for release of bactericides to chronic wounds. Chronic wounds often carry infection originating from bacteria such as Staphylococcus aureus and a release system triggered by the degree of infection is of interest. The dry nanofilm was studied with ellipsometry. The thickness of the nanofilm was 60% less in its dry state than in its wet state. The measurements showed that a primer was not necessary to build a stable nanofilm, which is practically important in our case because a nondegradable primer is highly unwanted in a wound care dressing. Added V8 (glutamyl endopeptidase) enzymes only showed adsorption on the nanofilm at room temperature, indicating that the PLL/PLGA \"lid\" may remain intact until the dressing has been filled with wound exudate at the elevated temperature typical of that of the wound. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/424697","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32200118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Interaction Study of an Amorphous Solid Dispersion of Cyclosporin A in Poly-Alpha-Cyclodextrin with Model Membranes by (1)H-, (2)H-, (31)P-NMR and Electron Spin Resonance. 用(1)H-， (2)H-， (31)P-NMR和电子自旋共振研究环孢素A在聚-环糊精中与模型膜的非定形固体分散。

Journal of drug delivery Pub Date : 2014-01-01 Epub Date: 2014-05-05 DOI: 10.1155/2014/575719

Jean-Claude Debouzy, David Crouzier, Fréderic Bourbon, Malika Lahiani-Skiba, Mohamed Skiba

{"title":"Interaction Study of an Amorphous Solid Dispersion of Cyclosporin A in Poly-Alpha-Cyclodextrin with Model Membranes by (1)H-, (2)H-, (31)P-NMR and Electron Spin Resonance.","authors":"Jean-Claude Debouzy, David Crouzier, Fréderic Bourbon, Malika Lahiani-Skiba, Mohamed Skiba","doi":"10.1155/2014/575719","DOIUrl":"https://doi.org/10.1155/2014/575719","url":null,"abstract":"The properties of an amorphous solid dispersion of cyclosporine A (ASD) prepared with the copolymer alpha cyclodextrin (POLYA) and cyclosporine A (CYSP) were investigated by (1)H-NMR in solution and its membrane interactions were studied by (1)H-NMR in small unilamellar vesicles and by (31)P (2)H NMR in phospholipidic dispersions of DMPC (dimyristoylphosphatidylcholine) in comparison with those of POLYA and CYSP alone. (1)H-NMR chemical shift variations showed that CYSP really interacts with POLYA, with possible adduct formation, dispersion in the solid matrix of the POLYA, and also complex formation. A coarse approach to the latter mechanism was tested using the continuous variations method, indicating an apparent 1 : 1 stoichiometry. Calculations gave an apparent association constant of log Ka = 4.5. A study of the interactions with phospholipidic dispersions of DMPC showed that only limited interactions occurred at the polar head group level ((31)P). Conversely, by comparison with the expected chain rigidification induced by CYSP, POLYA induced an increase in the fluidity of the layer while ASD formation led to these effects almost being overcome at 298 K. At higher temperature, while the effect of CYSP seems to vanish, a resulting global increase in chain fluidity was found in the presence of ASD. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/575719","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32387174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Tailor-made pentablock copolymer based formulation for sustained ocular delivery of protein therapeutics. 量身定制的基于五嵌段共聚物的配方，用于持续眼部传递蛋白质疗法。

Journal of drug delivery Pub Date : 2014-01-01 Epub Date: 2014-06-22 DOI: 10.1155/2014/401747

Sulabh P Patel, Ravi Vaishya, Gyan Prakash Mishra, Viral Tamboli, Dhananjay Pal, Ashim K Mitra

{"title":"Tailor-made pentablock copolymer based formulation for sustained ocular delivery of protein therapeutics.","authors":"Sulabh P Patel, Ravi Vaishya, Gyan Prakash Mishra, Viral Tamboli, Dhananjay Pal, Ashim K Mitra","doi":"10.1155/2014/401747","DOIUrl":"https://doi.org/10.1155/2014/401747","url":null,"abstract":"The objective of this research article is to report the synthesis and evaluation of novel pentablock copolymers for controlled delivery of macromolecules in the treatment of posterior segment diseases. Novel biodegradable PB copolymers were synthesized by sequential ring-opening polymerization. Various ratios and molecular weights of each block (polyglycolic acid, polyethylene glycol, polylactic acid, and polycaprolactone) were selected for synthesis and to optimize release profile of FITC-BSA, IgG, and bevacizumab from nanoparticles (NPs) and thermosensitive gel. NPs were characterized for particle size, polydispersity, entrapment efficiency, and drug loading. In vitro release study of proteins from NPs alone and composite formulation (NPs suspended in thermosensitive gel) was performed. Composite formulations demonstrated no or negligible burst release with continuous near zero-order release in contrast to NPs alone. Hydrodynamic diameter of protein therapeutics and hydrophobicity of PB copolymer exhibited significant effect on entrapment efficiency and in vitro release profile. CD spectroscopy confirmed retention of structural conformation of released protein. Biological activity of released bevacizumab was confirmed by in vitro cell proliferation and cell migration assays. It can be concluded that novel PB polymers can serve a platform for sustained delivery of therapeutic proteins. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/401747","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32520028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 37

Application of experimental design in preparation of nanoliposomes containing hyaluronidase. 实验设计在制备含透明质酸酶纳米脂质体中的应用。

Journal of drug delivery Pub Date : 2014-01-01 Epub Date: 2014-09-09 DOI: 10.1155/2014/948650

Narayanan Kasinathan, Subrahmanyam Mallikarjuna Volety, Venkata Rao Josyula

{"title":"Application of experimental design in preparation of nanoliposomes containing hyaluronidase.","authors":"Narayanan Kasinathan, Subrahmanyam Mallikarjuna Volety, Venkata Rao Josyula","doi":"10.1155/2014/948650","DOIUrl":"https://doi.org/10.1155/2014/948650","url":null,"abstract":"Hyaluronidase is an enzyme that catalyzes breakdown of hyaluronic acid. This property is utilized for hypodermoclysis and for treating extravasation injury. Hyaluronidase is further studied for possible application as an adjuvant for increasing the efficacy of other drugs. Development of suitable carrier system for hyaluronidase would help in coadministration of other drugs. In the present study, the hyaluronidase was encapsulated in liposomes. The effect of variables, namely, phosphatidylcholine (PC), cholesterol, temperature during film formation (T 1), and speed of rotation of the flask during film formation (SPR) on percentage of protein encapsulation, was first analyzed using factorial design. The study showed that level of phosphatidylcholine had the maximum effect on the outcome. The effect of interaction of PC and SPR required for preparation of nanoliposomes was identified by central composite design (CCD). The dependent variables were percentage protein encapsulation, particle size, and zeta potential. The study showed that ideal conditions for production of hyaluronidase loaded nanoliposomes are PC-140 mg and cholesterol 1/5th of PC when the SPR is 150 rpm and T 1 is 50°C. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/948650","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32729293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Development of Corn Starch-Neusilin UFL2 Conjugate as Tablet Superdisintegrant: Formulation and Evaluation of Fast Disintegrating Tablets. 玉米淀粉- neusilin UFL2偶联片超崩解剂的研制:快速崩解片的配方及评价。

Journal of drug delivery Pub Date : 2014-01-01 Epub Date: 2014-09-23 DOI: 10.1155/2014/827035

Prateek Juneja, Birender Kaur, Oluwatoyin A Odeku, Inderbir Singh

{"title":"Development of Corn Starch-Neusilin UFL2 Conjugate as Tablet Superdisintegrant: Formulation and Evaluation of Fast Disintegrating Tablets.","authors":"Prateek Juneja, Birender Kaur, Oluwatoyin A Odeku, Inderbir Singh","doi":"10.1155/2014/827035","DOIUrl":"https://doi.org/10.1155/2014/827035","url":null,"abstract":"In the present study, corn Starch-Neusilin UFL2 conjugates were prepared by physical, chemical, and microwave methods with the aim of using the conjugates as tablet superdisintegrant. Various powder tests, namely, angle of repose, bulk density, tapped density, Hausner's ratio, Carr's index, swelling index, and powder porosity were conducted on the samples. The conjugates were characterized by ATR-FTIR, XRD, DSC, and SEM techniques. Heckel and Kawakita models were applied to carry out compression studies for the prepared conjugates. Fast disintegrating tablets of domperidone were prepared using corn starch and corn Starch-Neusilin UFL2 conjugates as tablet superdisintegrants in different concentrations. Conjugates were found to possess good powder flow and tabletting properties. Heckel analysis indicated that the conjugates prepared by microwave method showed the slowest onset of plastic deformation while Kawakita analysis indicated that the conjugates prepared by microwave method exhibited the highest amount of total plastic deformation. The study revealed that the corn Starch-Neusilin UFL2 conjugates possess improved powder flow properties and could be a promising superdisintegrant for preparing fast disintegrating tablet. Also, the results sugessted that the microwave method was found to be most effective for the preparation of corn Starch-Neusilin UFL2 conjugates. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/827035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32759321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Preparation and the biopharmaceutical evaluation for the metered dose transdermal spray of dexketoprofen. 右酮洛芬透皮喷雾剂的制备及生物制药评价。

Journal of drug delivery Pub Date : 2014-01-01 Epub Date: 2014-02-11 DOI: 10.1155/2014/697434

Wangding Lu, Huafei Luo, Zhuangzhi Zhu, Yubo Wu, Jing Luo, Hao Wang

{"title":"Preparation and the biopharmaceutical evaluation for the metered dose transdermal spray of dexketoprofen.","authors":"Wangding Lu, Huafei Luo, Zhuangzhi Zhu, Yubo Wu, Jing Luo, Hao Wang","doi":"10.1155/2014/697434","DOIUrl":"https://doi.org/10.1155/2014/697434","url":null,"abstract":"The objective of the present work was to develop a metered dose transdermal spray (MDTS) formulation for transdermal delivery of dexketoprofen (DE). DE release from a series of formulations was assessed in vitro. Various qualitative and quantitative parameters like spray pattern, pump seal efficiency test, average weight per metered dose, and dose uniformity were evaluated. The optimized formulation with good skin permeation and an appropriate drug concentration and permeation enhancer (PE) content was developed incorporating 7% (w/w, %) DE, 7% (v/v, %) isopropyl myristate (IPM), and 93% (v/v, %) ethanol. In vivo pharmacokinetic study indicated that the optimized formulation showed a more sustainable plasma-concentration profile compared with the Fenli group. The antiinflammatory effect of DE MDTS was evaluated by experiments involving egg-albumin-induced paw edema in rats and xylene-induced ear swelling in mice. Acetic acid-induced abdominal constriction was used to evaluate the anti-nociceptive actions of DE MDTS. Pharmacodynamic studies indicated that the DE MDTS has good anti-inflammatory and anti-nociceptive activities. Besides, skin irritation studies were performed using rat as an animal model. The results obtained show that the MDTS can be a promising and innovative therapeutic system used in transdermal drug delivery for DE. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/697434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32202670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Carbon nanotubes: an emerging drug carrier for targeting cancer cells. 碳纳米管：针对癌细胞的新兴药物载体。

Journal of drug delivery Pub Date : 2014-01-01 Epub Date: 2014-04-24 DOI: 10.1155/2014/670815

Vaibhav Rastogi, Pragya Yadav, Shiv Sankar Bhattacharya, Arun Kumar Mishra, Navneet Verma, Anurag Verma, Jayanta Kumar Pandit

引用次数: 0

Mucoadhesive hydrogel films of econazole nitrate: formulation and optimization using factorial design. 硝酸益康唑黏附水凝胶膜的制备及因子设计优化。

Journal of drug delivery Pub Date : 2014-01-01 Epub Date: 2014-06-10 DOI: 10.1155/2014/305863

Balaram Gajra, Saurabh S Pandya, Sanjay Singh, Haribhai A Rabari

{"title":"Mucoadhesive hydrogel films of econazole nitrate: formulation and optimization using factorial design.","authors":"Balaram Gajra, Saurabh S Pandya, Sanjay Singh, Haribhai A Rabari","doi":"10.1155/2014/305863","DOIUrl":"10.1155/2014/305863","url":null,"abstract":"The mucoadhesive hydrogel film was prepared and optimized for the purpose of local drug delivery to oral cavity for the treatment of oral Candidiasis. The mucoadhesive hydrogel film was prepared with the poly(vinyl alcohol) by freeze/thaw crosslinking technique. 3(2) full factorial design was employed to optimize the formulation. Number of freeze/thaw cycles (4, 6, and 8 cycles) and the concentration of the poly(vinyl alcohol) (10, 15, and 20%) were used as the independent variables whereas time required for 50% drug release, cumulative percent of drug release at 8th hour, and \"k\" of zero order equation were used as the dependent variables. The films were evaluated for mucoadhesive strength, in vitro residence time, swelling study, in vitro drug release, and effectiveness against Candida albicans. The concentration of poly(vinyl alcohol) and the number of freeze/thaw cycles both decrease the drug release rate. Mucoadhesive hydrogel film with 15% poly(vinyl alcohol) and 7 freeze/thaw cycles was optimized. The optimized batch exhibited the sustained release of drug and the antifungal studies revealed that the drug released from the film could inhibit the growth of Candida albicans for 12 hours. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2014/305863","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32491853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Carboxymethyl cellulose acetate butyrate: a review of the preparations, properties, and applications. 羧基甲基纤维素乙酸丁酸酯的制备、性能及应用综述。

Journal of drug delivery Pub Date : 2014-01-01 Epub Date: 2014-12-04 DOI: 10.1155/2014/575969

Mohamed El-Sakhawy, Samir Kamel, Ahmed Salama, Hebat-Allah Sarhan

引用次数: 22

Design optimization and in vitro-in vivo evaluation of orally dissolving strips of clobazam. 氯巴扎姆口腔溶解条的优化设计和体内外评估

Journal of drug delivery Pub Date : 2014-01-01 Epub Date: 2014-09-28 DOI: 10.1155/2014/392783

Rajni Bala, Sushil Khanna, Pravin Pawar

{"title":"Design optimization and in vitro-in vivo evaluation of orally dissolving strips of clobazam.","authors":"Rajni Bala, Sushil Khanna, Pravin Pawar","doi":"10.1155/2014/392783","DOIUrl":"10.1155/2014/392783","url":null,"abstract":"Clobazam orally dissolving strips were prepared by solvent casting method. A full 3(2) factorial design was applied for optimization using different concentration of film forming polymer and disintegrating agent as independent variable and disintegration time, % cumulative drug release, and tensile strength as dependent variable. In addition the prepared films were also evaluated for surface pH, folding endurance, and content uniformity. The optimized film formulation showing the maximum in vitro drug release, satisfactory in vitro disintegration time, and tensile strength was selected for bioavailability study and compared with a reference marketed product (frisium5 tablets) in rabbits. Formulation (F6) was selected by the Design-expert software which exhibited DT (24 sec), TS (2.85 N/cm(2)), and in vitro drug release (96.6%). Statistical evaluation revealed no significant difference between the bioavailability parameters of the test film (F6) and the reference product. The mean ratio values (test/reference) of C max (95.87%), t max (71.42%), AUC0-t (98.125%), and AUC0-∞ (99.213%) indicated that the two formulae exhibited comparable plasma level-time profiles. ","PeriodicalId":15575,"journal":{"name":"Journal of drug delivery","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32759320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0