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Marathon Health Pitfalls: What Every Runner Needs to Know 马拉松健康陷阱:每个跑步者都需要知道的事
Journal of Education, Health and Sport Pub Date : 2024-06-03 DOI: 10.12775/jehs.2024.73.51692
Daniel Gondko, Patrycja Dębiec, Jakub Roman, Nikodem Pietrzak
{"title":"Marathon Health Pitfalls: What Every Runner Needs to Know","authors":"Daniel Gondko, Patrycja Dębiec, Jakub Roman, Nikodem Pietrzak","doi":"10.12775/jehs.2024.73.51692","DOIUrl":"https://doi.org/10.12775/jehs.2024.73.51692","url":null,"abstract":"Introduction and Purpose: Long-distance running, especially marathons, tests human endurance and physical limits. While the benefits of marathon running are well-documented, the associated health risks often go unnoticed. This review aims to synthesize current knowledge on the health risks and complications faced by marathon runners, providing crucial insights for both amateur and professional athletes.State of Knowledge: Marathon running imposes significant stress on the cardiovascular system, musculoskeletal structure, and metabolic processes. Issues such as acute myocardial injury, overhydration leading to hyponatremia, and musculoskeletal injuries are prevalent. The review also examines less common but severe risks like rhabdomyolysis and marathon-related cardiac arrests. Despite the robust fitness levels of runners, these health risks remain a serious concern, necessitating preventive strategies and proper health monitoring.Summary: Marathon runners must be aware of the potential health risks associated with prolonged endurance activities. Precautionary measures, including tailored training programs, dietary adjustments, and regular medical check-ups, are essential to mitigate these risks. Additionally, further research is required to develop more effective interventions and guidelines that can safeguard the health of marathon participants. This review underscores the need for a balanced approach that respects the physiological demands of marathon running while ensuring the health and safety of the runners.","PeriodicalId":15567,"journal":{"name":"Journal of Education, Health and Sport","volume":"48 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141269854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of creatine supplementation on cognitive function and mood 补充肌酸对认知功能和情绪的影响
Journal of Education, Health and Sport Pub Date : 2024-06-03 DOI: 10.12775/jehs.2024.73.51712
Kamil Walczak, Julia Krasnoborska, Sylwia Samojedny, Maciej Superson, Katarzyna Szmyt, Katarzyna Szymańska, Klaudia Wilk-Trytko
{"title":"Effect of creatine supplementation on cognitive function and mood","authors":"Kamil Walczak, Julia Krasnoborska, Sylwia Samojedny, Maciej Superson, Katarzyna Szmyt, Katarzyna Szymańska, Klaudia Wilk-Trytko","doi":"10.12775/jehs.2024.73.51712","DOIUrl":"https://doi.org/10.12775/jehs.2024.73.51712","url":null,"abstract":"Background: Creatine, a naturally occurring compound plays a crucial role in cellular energy metabolism, particularly in tissues with high energy demands like muscles and the brain. Beyond its well-established role in physical performance enhancement, recent research has revealed its potential benefits for cognitive functions and mood regulation. This review paper aims to comprehensively analyze the existing literature on creatine supplementation's effects on cognitive functions and mood. \u0000State of Knowledge: Findings suggest that creatine supplementation enhances memory, attention, and executive functions, especially under conditions of stress or sleep deprivation. Moreover, it exhibits mood-stabilizing effects, potentially offering relief for symptoms of depression and fatigue. Creatine's ability to augment brain energy metabolism, alongside its neuroprotective properties, underlies its cognitive and mood-enhancing effects. While generally safe, caution is advised, particularly in populations with kidney diseases or those using medications affecting kidney function. \u0000Summary: Creatine emerges as a promising adjunct therapy for enhancing cognitive functions and promoting emotional well-being beyond its traditional role in physical performance.The review underscores the need for further research to elucidate the precise mechanisms of creatine's effects and explore its synergistic potential with other cognitive-enhancing supplements. \u0000 ","PeriodicalId":15567,"journal":{"name":"Journal of Education, Health and Sport","volume":"32 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141270844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements in the Treatment of Diabetic Macular Edema: Current Strategies and Future Directions 糖尿病黄斑水肿的治疗进展:当前策略与未来方向
Journal of Education, Health and Sport Pub Date : 2024-06-03 DOI: 10.12775/jehs.2024.73.51687
Zuzanna Czach, Magdalena Czach, Dominika Bachurska, Wojciech Kopacz, Łukasz Mazurek, Monika Stradczuk, Wojciech Mazurek, Barbara Rękas, Barbara Kruczyk, Mateusz Piętak, Joanna Olędzka
{"title":"Advancements in the Treatment of Diabetic Macular Edema: Current Strategies and Future Directions","authors":"Zuzanna Czach, Magdalena Czach, Dominika Bachurska, Wojciech Kopacz, Łukasz Mazurek, Monika Stradczuk, Wojciech Mazurek, Barbara Rękas, Barbara Kruczyk, Mateusz Piętak, Joanna Olędzka","doi":"10.12775/jehs.2024.73.51687","DOIUrl":"https://doi.org/10.12775/jehs.2024.73.51687","url":null,"abstract":"This narrative review examines current and emerging treatment strategies for diabetic macular edema (DME), a complication of diabetic retinopathy characterised by fluid accumulation in the macula, which can lead to vision impairment. The incidence of DME is particularly high in patients with long-standing diabetes and advanced retinopathy. The current treatment options for DME include anti-vascular endothelial growth factor (anti-VEGF) agents, corticosteroids, and laser therapies. Anti-VEGF agents, including bevacizumab, ranibizumab, aflibercept, and the more recently developed brolucizumab and faricimab, have been demonstrated to reduce macular thickness and improve visual acuity. Brolucizumab offers the advantage of fewer injections due to its longer duration of action, although it carries a higher risk of ocular inflammation compared to other anti-VEGF agents. The dual inhibition of the VEGF and angiopoietin-2 (Ang-2) pathways by faricimab may enhance vascular stability and reduce inflammation, potentially improving patient outcomes. Steroid therapies, including dexamethasone, fluocinolone acetonide, and triamcinolone acetonide, represent an alternative for patients who do not respond adequately to anti-VEGF treatment. Laser therapies, including focal, navigated, and subthreshold laser treatments, remain a crucial component in the management of DME, with the ability to seal leaking vessels and reduce fluid accumulation. In order to achieve the best outcomes for patients, it is essential to continue to advance these treatment modalities and adopt a personalised, multifaceted approach.","PeriodicalId":15567,"journal":{"name":"Journal of Education, Health and Sport","volume":"18 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141271783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What do we know about body dysmorphic disorder - Review of current knowledge 我们对身体畸形障碍了解多少--现有知识回顾
Journal of Education, Health and Sport Pub Date : 2024-05-23 DOI: 10.12775/jehs.2024.71.51251
Aleksandra Brożyna, Arkadiusz Bydliński, Anita Kwiatkowska, Sara Emerla, Natalia Małek, Konrad Karłowicz, Łukasz Ciulkiewicz, Patryk Pluta, Julia Lubomirska, Patrycja Figurowska, Maria Hermanowska
{"title":"What do we know about body dysmorphic disorder - Review of current knowledge","authors":"Aleksandra Brożyna, Arkadiusz Bydliński, Anita Kwiatkowska, Sara Emerla, Natalia Małek, Konrad Karłowicz, Łukasz Ciulkiewicz, Patryk Pluta, Julia Lubomirska, Patrycja Figurowska, Maria Hermanowska","doi":"10.12775/jehs.2024.71.51251","DOIUrl":"https://doi.org/10.12775/jehs.2024.71.51251","url":null,"abstract":"Introduction \u0000Body dysmorphic disorder, also known as dysmorphophobia, is a severe psychiatric disorder characterized by DSM-V as preoccupation with one or more perceived defects or flaws in physical appearance, that are not observable or appear slight to others. BDD can cause significant distress or impairment in social and occupational areas of life. It is often comorbid with other psychiatric conditions like major depressive disorder. Current ways of treatment include a combination of pharmacotherapy and cognitive-behavioral therapy.  \u0000Aim of the study \u0000To summarize current knowledge of body dysmorphic disorder, its pharmacological and non-pharmacological treatment, outline possible areas for further research, and raise the awareness of the disorder.  \u0000Material and methods  \u0000The review was based on the PubMed database and was carried out using keywords to determine the latest publications. \u0000Summary \u0000Body dysmorphic disorder is a relatively common and severe condition that greatly diminishes patients' quality of life. While helpful diagnostic tools exist, BDD diagnosis remains relatively uncommon, posing challenges for patients to receive adequate treatment and continuing their suffering. Despite identifying several factors contributing to the disorder, much remains unknown. Many patients do not respond to standard treatment options, highlighting the need for further studies into the disorder's neurobiology, causes, and alternate treatment approaches to achieve a deeper comprehension of BDD as the number of new cases increases every year.","PeriodicalId":15567,"journal":{"name":"Journal of Education, Health and Sport","volume":"35 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141103960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A review of treatment of relapsing-remitting type of multiple sclerosis (RRMS) 复发缓解型多发性硬化症(RRMS)治疗综述
Journal of Education, Health and Sport Pub Date : 2024-05-23 DOI: 10.12775/jehs.2024.71.51250
Arkadiusz Bydliński, Aleksandra Brożyna, Natalia Małek, Sara Emerla, Anita Kwiatkowska, Konrad Karłowicz, Maria Hermanowska, Julia Lubomirska, Patrycja Figurowska, Łukasz Ciulkiewicz, Patryk Pluta
{"title":"A review of treatment of relapsing-remitting type of multiple sclerosis (RRMS)","authors":"Arkadiusz Bydliński, Aleksandra Brożyna, Natalia Małek, Sara Emerla, Anita Kwiatkowska, Konrad Karłowicz, Maria Hermanowska, Julia Lubomirska, Patrycja Figurowska, Łukasz Ciulkiewicz, Patryk Pluta","doi":"10.12775/jehs.2024.71.51250","DOIUrl":"https://doi.org/10.12775/jehs.2024.71.51250","url":null,"abstract":"Introduction \u0000Multiple sclerosis (SM) is the most common chronic inflammatory-demyelinating disease of the Central Nervous System. In its course, a multifocal damage is done to a nervous tissue - myelin sheaths surrounding axons become disintegrated. This process leads to a dysfunction of the electrical impulses passage along nerve fibers which occurs as various symptoms that hinder the functioning of the patients.  \u0000Aim of the study \u0000This review aims to summarize treatment methods of relapsing-remitting type of multiple sclerosis (RRMS). Following information will be presented: groups of medications, mechanism of its action, its most important side effects and its effectiveness. \u0000Material and method \u0000This review presents the current state of knowledge about relapsing-remitting type of multiple sclerosis (RRMS) treatment - it is based on Pubmed database and was carried out using keywords concerning the issues of multiple sclerosis. Cited articles were selected in order to base on up-to-date investigation results. \u0000Summary \u0000A wide range of therapeutic options let neurologists treat their patients accurately, but the basic knowledge about each substance should be assimilated to choose the best individual therapy. Patients suffering from multiple sclerosis differ from each other and a personal approach is needed to implement appropriate treatment as soon as possible. Early start allows patients to not to lose their everyday functioning areas, as the neurodegenerative process is stopped at the initial stage. If some changes in brain tissue structure are permanently done, neurologists should know the options of symptomatic treatment to alleviate a patient's suffering. ","PeriodicalId":15567,"journal":{"name":"Journal of Education, Health and Sport","volume":"13 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141105116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SGLT2-Inhibitors - significant role in Heart Failure treatment SGLT2 抑制剂--在心力衰竭治疗中发挥重要作用
Journal of Education, Health and Sport Pub Date : 2024-05-22 DOI: 10.12775/jehs.2024.71.49418
Karol Wielgus, Piotr Bator, Maria Pawłowska, Karol Magiera, K. Rachwał, Maria Antos, Jan Ramian, Grzegorz Łyko
{"title":"SGLT2-Inhibitors - significant role in Heart Failure treatment","authors":"Karol Wielgus, Piotr Bator, Maria Pawłowska, Karol Magiera, K. Rachwał, Maria Antos, Jan Ramian, Grzegorz Łyko","doi":"10.12775/jehs.2024.71.49418","DOIUrl":"https://doi.org/10.12775/jehs.2024.71.49418","url":null,"abstract":"Heart failure (HF), which has a high morbidity and mortality rate, is nevertheless a common and crippling ailment, especially in older populations. The complicated pathophysiology of heart failure (HF), which includes oxidative stress, endothelial dysfunction, fibrosis, and inflammation, is frequently not sufficiently treated despite advances in medication. Inhibitors of the sodium-glucose co-transporter 2 (SGLT2) have become a key treatment for HF in patients with varying left ventricular ejection fractions (LVEF). SGLT2 inhibitors have been shown in recent clinical trials to considerably lower hospitalization rates for heart failure, cardiovascular mortality, and all-cause mortality. The mechanisms of SGLT2 inhibitors, such as better ventricular loading, increased heart metabolic efficiency, and decreased inflammation and necrosis, are covered in this review. Additionally, we provide an overview of four important clinical trials—DAPA-HF, EMPEROR-Reduced, EMPEROR-Preserved, and DELIVER—highlighting their effectiveness in lowering unfavourable cardiovascular outcomes for patients with heart failure who have preserved (HFpEF), slightly reduced (HFmrEF), or reduced (HFrEF). The results validate the need for SGLT2 inhibitors in all-inclusive HF treatment plans by highlighting their adaptability and safety in a range of clinical contexts.","PeriodicalId":15567,"journal":{"name":"Journal of Education, Health and Sport","volume":"54 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141109186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breast milk – a living superfood. Review of current knowledge 母乳--有生命的超级食品现有知识回顾
Journal of Education, Health and Sport Pub Date : 2024-05-22 DOI: 10.12775/jehs.2024.71.51247
Patrycja Figurowska, Natalia Małek, Sara Emerla, Aleksandra Brożyna, Anita Kwiatkowska, Arkadiusz Bydliński, Konrad Karłowicz, Maria Hermanowska, Julia Lubomirska, Łukasz Ciulkiewicz, Patryk Pluta
{"title":"Breast milk – a living superfood. Review of current knowledge","authors":"Patrycja Figurowska, Natalia Małek, Sara Emerla, Aleksandra Brożyna, Anita Kwiatkowska, Arkadiusz Bydliński, Konrad Karłowicz, Maria Hermanowska, Julia Lubomirska, Łukasz Ciulkiewicz, Patryk Pluta","doi":"10.12775/jehs.2024.71.51247","DOIUrl":"https://doi.org/10.12775/jehs.2024.71.51247","url":null,"abstract":"Introduction: Breastfeeding is considered the best nutrition for infants, including born preterm due to containing optimal ingredients for development and growth. Breast milk is a rich source of nutrients, it also contains diverse types of bacteria, which play a role in infant’s gastrointestinal tract colonization and preserving mammary health. Composition of human milk varies depending on numerous maternal and infant factors. \u0000Aim of the study: The aim of the study was to summarize the current knowledge about the content of nutrients, bioactive factors and microbiota diversity in human milk depending on various factors. \u0000Materials and methods: The work is a review of 26 mainly English-language scientific publications from 1989-2024 posted on the PubMed platform. \u0000Results: Milk composition changes in addition to several factors. Depending on postnatal age: preterm milk has higher content of protein, fat and immunological factors and lower concentration of lactose than term milk. Depending on milk maturity: Colostrum is higher in protein but lower in lactose, fat and energy than mature milk. Human milk is also a source of viable bacteria important for developing infant’s gut microbiota, but the diversity of bacterial strains in milk may vary. Depending on mode of delivery: milk of mothers after spontaneous labour contents more probiotic vaginal- and enteric-associated bacteria, while milk of mothers after C-section has more skin-associated microbiota. Depending on mother’s weight: milk of overweight mothers is lower in probiotic- and higher in pathogenic bacteria. Alcohol, nicotine, and some medications also have negative impact on produced milk. \u0000Conclusions: Human milk varies from woman to woman and its composition depends on several factors. Postnatal and gestational stage, delivery mode, mother's weight and certain substances have been found to be important factors influencing the constitution of breast milk, including nutrients, microbiota and volume of milk.","PeriodicalId":15567,"journal":{"name":"Journal of Education, Health and Sport","volume":"62 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141110560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultraviolet-Protective Clothing and Sunscreen: Sun-Protection for Healthy Skin 紫外线防护服和防晒霜:为健康皮肤提供防晒保护
Journal of Education, Health and Sport Pub Date : 2024-05-22 DOI: 10.12775/jehs.2024.71.51237
Daria Sieniawska, Patrycja Proszowska, Magda Madoń, Zuzanna Kotowicz, Adrianna Orzeł, Aleksandra Pich-Czekierda, Julia Sieniawska
{"title":"Ultraviolet-Protective Clothing and Sunscreen: Sun-Protection for Healthy Skin","authors":"Daria Sieniawska, Patrycja Proszowska, Magda Madoń, Zuzanna Kotowicz, Adrianna Orzeł, Aleksandra Pich-Czekierda, Julia Sieniawska","doi":"10.12775/jehs.2024.71.51237","DOIUrl":"https://doi.org/10.12775/jehs.2024.71.51237","url":null,"abstract":"Introduction \u0000Prolonged exposure to ultraviolet (UV) radiation from the sun poses numerous risks to the skin, ranging from premature aging to serious health conditions such as skin cancer. UV radiation can penetrate the skin's surface, causing damage to its cells and DNA, which can lead to the formation of wrinkles, sunspots, and other signs of aging. Therefore, consistent and effective sun protection is essential for maintaining the health and vitality of the skin, as well as reducing the risk of sun-related skin damage and diseases. \u0000Aim of the study \u0000The objective of the study is to conduct a thorough investigation into different aspects of photoprotection and its effects on the skin. This entails assessing the effectiveness and safety of sunscreens, as well as evaluating the impact of sun-protection clothing on skin health. \u0000Materials and methods \u0000The purpose of this review is to assess the current literature of the effectiveness of the various sun protection measures. The literature was reviewed in the Pubmed, Google Scholar data base. \u0000Results \u0000Prolonged UV exposure incites photoaging, carcinogenesis, and immunosuppression, amplifying the risk of skin malignancies. Sun-protective clothing, with adequate UPF ratings, emerges as a pivotal element in mitigating UV-induced skin damage, notably reducing the development of pigmented moles and melanoma. Furthermore, effective sunscreen usage, coupled with broad-spectrum protection, is essential in averting UV-induced skin damage and curbing the incidence of skin cancer. These findings emphasize the imperative of comprehensive photoprotection strategies, integrating sunscreen application, sun-protective clothing, and individual risk assessment, to safeguard against solar-induced skin damage and mitigate the prevalence of skin cancer.","PeriodicalId":15567,"journal":{"name":"Journal of Education, Health and Sport","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141110299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Frailty Scale - frailty assessment and rehabilitation potential 临床虚弱量表--虚弱评估和康复潜力
Journal of Education, Health and Sport Pub Date : 2024-05-22 DOI: 10.12775/jehs.2024.71.51507
Szymon Wiśniewski, Weronika Hołownia, Wiktoria Julia Krzesłowska, Paulina Pytel, Kamila Szewczyk, Bartłomiej Szewczyk
{"title":"Clinical Frailty Scale - frailty assessment and rehabilitation potential","authors":"Szymon Wiśniewski, Weronika Hołownia, Wiktoria Julia Krzesłowska, Paulina Pytel, Kamila Szewczyk, Bartłomiej Szewczyk","doi":"10.12775/jehs.2024.71.51507","DOIUrl":"https://doi.org/10.12775/jehs.2024.71.51507","url":null,"abstract":"Background: Studies show a significant increase in frailty prevalence among older adults worldwide. Fortunately, several well-established and user-friendly screening tools can effectively identify frailty in older adults. \u0000Objectives: This article examines the Clinical Frailty Scale's effectiveness in informing treatment decisions for older adults in ambulatory care settings, analyzing its potential to improve patient care. \u0000Methods: On April 1, 2024, the PubMed database was searched for articles on the Clinical Frailty Scale in elderly patients. The 116 most pertinent and current articles, written in English and published within the past few years, were analyzed, and 38 were selected and categorized by content and topic. \u0000  \u0000Limitations: This study is limited because it is not a meta-analysis and thus does not examine the quality of the evidence presented in each article. \u0000Conclusions: Frailty research has illuminated aging and its potential biological causes. The Clinical Frailty Scale effectively identifies vulnerable individuals. By using the CFS to assess frailty risk, healthcare providers can personalize treatment plans and improve overall care for older adults.","PeriodicalId":15567,"journal":{"name":"Journal of Education, Health and Sport","volume":"59 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141113158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How can caffeine alleviate the motor symptoms of Parkinson’s disease? – the implications of adenosine 2A receptor antagonism 咖啡因如何缓解帕金森病的运动症状?- 腺苷 2A 受体拮抗剂的影响
Journal of Education, Health and Sport Pub Date : 2024-05-22 DOI: 10.12775/jehs.2024.71.49808
Anna Wójcik, Aleksander Górny, Justyna Chwiejczak, Julita Młynarska, Jan Kościan, Karolina Szczerkowska, Anna Seroka, Maria Mitkowska, Maria Rybicka, Michał Obrębski
{"title":"How can caffeine alleviate the motor symptoms of Parkinson’s disease? – the implications of adenosine 2A receptor antagonism","authors":"Anna Wójcik, Aleksander Górny, Justyna Chwiejczak, Julita Młynarska, Jan Kościan, Karolina Szczerkowska, Anna Seroka, Maria Mitkowska, Maria Rybicka, Michał Obrębski","doi":"10.12775/jehs.2024.71.49808","DOIUrl":"https://doi.org/10.12775/jehs.2024.71.49808","url":null,"abstract":"Introduction and purpose: Parkinson’s disease (PD) is the second most common neurodegenerative disease, mainly characterized by motor impairment with symptoms including rigidity, bradykinesia, rest tremor and imbalance. It develops upon degeneration of dopaminergic neurons in the substantia nigra associated with neuroinflammatory process initiated by alpha-synuclein deposits. Although, levodopa replacement therapy is the gold-standard treatment, majority of the treated patients develop dyskinesia as the side effect, resulting from altered function of dopamine receptors. It is thought that the abnormal pulsate release of dopamine can be prevented by antagonism of adenosine 2A receptors (A2ARs).\u0000Aim of the study: This review aims to outline the action mechanism of A2AR antagonism on motor performance, and thus evaluate the suggested implications of coffee consumption in PD. Material and method: The involvement of A2ARs in the pathology and treatment of PD has been analyzed based on the findings of many published studies examining the effects of A2AR modulation.\u0000Results: Blockage of A2ARs enhances the action of dopamine via D2 receptors on striatopallidal neurons, decreasing their hyperactivity, and exerts neuroprotective effect, suppressing the neuroinflammation.\u0000Conclusions: Istradefylline, being the only approved A2AR antagonist, was able to reduce total cumulative dose of levodopa, improve motor control, alleviate postural abnormalities, and provide a reduction in daily ‘off’ time experienced by patients. Recent findings suggest the effects of drinking one cup of coffee are comparable with ones obtained by the newly introduced medication, presumably via shared action mechanism by A2AR inhibition.","PeriodicalId":15567,"journal":{"name":"Journal of Education, Health and Sport","volume":"26 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141112271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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