Journal of Complementary and Integrative Medicine最新文献

{"title":"A new chapter in traditional, complementary, and integrative medicine: Advancing the <i>Journal of Complementary and Integrative medicine</i> through open science, meta-research, artificial intelligence, and early career researcher involvement.","authors":"Jeremy Y Ng","doi":"10.1515/jcim-2024-0364","DOIUrl":"https://doi.org/10.1515/jcim-2024-0364","url":null,"abstract":"","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration of neuroprotective and cognition boosting effects of <i>Mazus pumilus</i> in Alzheimer's disease model.","authors":"Malik Saadullah, Jahan Ara Batool, Muhammad Rashad, Muhammad Asif, Zunera Chauhdary, Asia Bibi","doi":"10.1515/jcim-2024-0231","DOIUrl":"10.1515/jcim-2024-0231","url":null,"abstract":"<p><strong>Objectives: </strong><i>Mazus pumilus</i> (MP) an Asian flowering plant, known for various reported pharmacological activities including antioxidant, anti-nociceptive, anti-inflammatory, anticancer, antibacterial, antifungal, and hepatoprotective effects. This study focused on further exploring <i>Mazus pumilus'</i>s methanol leaf extract (MPM) for bioactive principles and investigating its neuroprotective and cognition-enhancing potential in Alzheimer's disease models.</p><p><strong>Methods: </strong>For the phytochemical screening and identification, TLC, HPLC, and Fourier transform infrared (FTIR) were employed. <i>In-vitro</i> antioxidant potential was assayed by DPPH Free Radical Scavenging method, followed by <i>in-vivo</i> neuroprotective effect of MPM (100, 200, 300 mg/kg) using Wistar-albino rats, sodium azide for induction of AD and rivastigmine as standard. Over 21 days, we observed neurobehavioral changes and performed biochemical (GSH, CAT, SOD, and AchE activity) and histopathological evaluations.</p><p><strong>Results: </strong>Results revealed the presence of alkaloids, flavonoids, amino acids, terpenoids, glycosides, sterols, and saponins. HPLC analysis confirmed the presence of gallic acids, sinapic acid, and caffeic acid. DPPH confirmed the antioxidant effect of MPM, which served as a base for its potential neuroprotective activity. Biochemically, oxidative stress markers improved significantly post-treatment, with decreased GSH, SOD, CAT levels, and increased AchE activity, indicating a reversal of AD-induced changes. Behavioral assessments showed improvements in locomotion, memory, spatial learning, and cognition. Histologically, there was a dose-dependent reduction in neurodegenerative features like neurofibrillary tangles and amyloid beta plaques.</p><p><strong>Conclusions: </strong>Hence, this study concluded MPM is a promising candidate for prophylaxis and treatment of behavioral deficits and cognitive dysfunction in Alzheimer's disease.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"461-471"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A critical review on the active anti-viral metabolites of bioprospecting traditionally used plant species from semi-arid regions of the subcontinent.","authors":"Aliya Naz, Abhiroop Chowdhury, Shubhra Pareek, Pushpendra Kumar, Nitesh Kumar Poddar","doi":"10.1515/jcim-2024-0186","DOIUrl":"10.1515/jcim-2024-0186","url":null,"abstract":"<p><p>Plants are crucial medicinal resources, with 80 % of people relying on them for primary healthcare. The search for natural antiviral compounds is increasing, especially in semi-arid ecosystems where abiotic stress promotes the production of beneficial secondary metabolites. This review highlights semi-arid plants with the potential as functional foods to combat viral diseases and other illnesses. Literature was searched in databases like ScienceDirect to gather information on novel compounds from stress-tolerant semi-arid plant species. These compounds have potential uses in treating viral infections and other health issues such as diabetes and high blood pressure. The review screened 61 semi-arid plants known for their antiviral metabolites. Eight plants were identified with novel antiviral compounds. Key metabolites include agathisflavone, pectic arabinogalactan, azadirachtin, aloin, aloe-emodin, aloesaponarin I, allicin, terpenoids, chlorogenic acids, curcumin, chromones, β-sitosterol, lupeol, oleuropein, carissol, β-amyrin, and ∆-9-tetrahydrocannabinol. Stress-tolerant semi-arid plants are significant sources of metabolites for treating infectious diseases and boosting immune systems. Further research on these metabolites in animal models is needed to verify their efficacy for treating human diseases during endemic and pandemic outbreaks, such as COVID-19.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"412-439"},"PeriodicalIF":0.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Understanding and treating baras (vitiligo) in unani medicine: historical perspectives, pathophysiology, and therapeutic approaches\".","authors":"Nadeem A Shah, Rayees A Mir, Sabba Saltanat","doi":"10.1515/jcim-2024-0240","DOIUrl":"10.1515/jcim-2024-0240","url":null,"abstract":"<p><p>Vitiligo, also known as baras in Unani medicine, causes patches of depigmented skin due to the loss of melanocytes. According to ancient Unani scholars, factors like excessive phlegm in the blood and weakened color-controlling power were believed to be the cause. This study dives into the historical insights of luminaries like Majūsī and Hakim Akbar Arzānī, alongside modern medical understanding. It explores the pathophysiology, epidemiology, and clinical features of vitiligo, while also addressing confusing definitions, dietary influences, and demographic patterns. We take a close look at the classification, prognosis, and investigative methods. The aim of this research is to bring together traditional and modern perspectives to fully understand vitiligo, covering its cultural, historical, and scientific aspects. By incorporating epidemiological data, dietary considerations, and insights into the underlying mechanisms, we enhance diagnostic and treatment approaches. In conclusion, this study establishes a cohesive connection between the historical wisdom of Unani medicine and the current scientific discourse on vitiligo. By merging these perspectives, we gain a comprehensive understanding of the condition, enabling a more holistic approach to diagnosis and management. As dermatological research continues to evolve, the integration of traditional and modern insights becomes crucial in effectively addressing complex skin disorders like vitiligo.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"390-401"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological advances in formulation and assay of herbal resources-based topical drug delivery systems.","authors":"Shehara Gunawardana, Bhavantha Dias","doi":"10.1515/jcim-2024-0181","DOIUrl":"10.1515/jcim-2024-0181","url":null,"abstract":"<p><p>Medicinal plants have been utilized for centuries as a source of healing compounds, which consist of thousands of known bioactive molecules with therapeutic potentials. This article aims to explore and emphasize the significance of medicinal plants and bioactive compounds in the development of topical pharmaceutical formulations. The journey from the extraction of phytochemicals to the development of topical pharmaceutical formulations is described with the aid of scientific evidence selected from PubMed, Google Scholar, ScienceDirect, and Web of Science. Articles published in English during 2018-2023 period were considered and selected randomly. The review discusses the extraction process of medicinal plants, solvent selection, and green synthesis of metal nanoparticles. Subsequently, various biological activities of plant extracts are elaborated especially focusing on antimicrobial, antioxidant, anti-inflammatory, and sun protection activities, along with the corresponding <i>in vitro</i> assays commonly employed for the evaluation. The article presents the process of compound isolation through bioactivity-guided fractionation and also the toxicity evaluation of isolated fractions. Finally, the formulation of medicinal plant extracts into topical pharmaceuticals is addressed, emphasizing the stability evaluation procedures necessary for ensuring product quality and efficacy.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"74-86"},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical screening, molecular docking, antifertility investigations, and ADME potential of various extracts of <i>Pandanus odoratissimus</i> leaves.","authors":"Satyender Kumar, Dinesh Kumar, Rakesh K Sindhu, Seema, Manisha Devi, Sneha Sagar","doi":"10.1515/jcim-2024-0099","DOIUrl":"10.1515/jcim-2024-0099","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to explore the molecular docking characteristics and antifertility impacts of petroleum ether extract (PEEPO) and chloroform (CHEPO) derived from <i>Pandanus odoratissimus</i> (PO) leaves.</p><p><strong>Methods: </strong>TriposSybyl-X 2.1 for molecular docking and Swiss ADME for ADME predictions were used. Antifertility activity was determined by using two <i>in vivo</i> animal models, with a focus on estrogenic/antiestrogenic activity and anti-implantation effects.</p><p><strong>Results: </strong>The findings showed that at different doses (100, 200, and 400 mg/kg), PEEPO had more anti-implantation effect than CHEPO. After taking either extract orally for up to 4,000 mg/kg, no acute toxicity was found. Furthermore, both extracts substantially raised blood oestrogen levels while lowering serum cholesterol and LDL levels, improving their antiimplantation and estrogenic activities, whether given alone or in combination with ethinyl estradiol. Molecular docking scores suggested strong interactions between phytochemicals in the extracts and estrogen receptors. ADME studies highlighted four phytochemicals present in PO leaves, showing high gastrointestinal absorption, blood-brain barrier permeability, and negative Log Kp values, indicating their potential as antifertility agents.</p><p><strong>Conclusions: </strong>The phytochemicals in both PEEPO and CHEPO demonstrated promising antifertility potential and interactions with estrogen receptors. Isolation of these phytochemicals could lead to the development of effective herbal antifertility formulations.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"490-500"},"PeriodicalIF":0.0,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical analysis and acute toxicity study of seaweed <i>Halimeda macroloba</i> using Wistar albino rats.","authors":"Kavya Rangaraj, Vimala Ananthy, Amrita Singam, Kartik J Salwe, Kumarappan Manimekalai, Shanmuga Samy, Shravan Venkatraman","doi":"10.1515/jcim-2024-0077","DOIUrl":"10.1515/jcim-2024-0077","url":null,"abstract":"<p><strong>Objectives: </strong><i>Halimeda macroloba (H. macroloba)</i> a seaweed commonly known as green macroalgae is a potential source of bioactive compounds utilised in nutraceuticals and pharmaceuticals. However, there are no reliable scientific studies that describe harmful consequences, which attest to its safety. Thus, the current investigation focuses on a 14-day acute toxicity assessment of <i>H. macroloba</i> hydroalcoholic extract (HME).</p><p><strong>Methods: </strong>HME was prepared using 70 % alcohol as solvent by the maceration method for 72 h and Soxhlet method. Phytochemical analysis was done using standard procedures, according to OECD 423 guidelines. Female Wistar albino rats fasted overnight and received a single oral dosage of 50, 300, and 2,000 mg/kg BW (body weight). Further rats were starved for 4 h and watched individually for every 30 minutes, then twice a day for 14 days. To determine the toxicity overall behaviour, BW, haematological, biochemical, histopathology, and gross morphology were examined.</p><p><strong>Results: </strong>Pharmacologically active phytoconstituents were identified by phytochemical analysis. No significant abnormalities/fatalities from single-dose of HME at escalating doses. No BW or behavioural changes. The majority of the haematological and biochemical parameters were normal. Did not show any apparent changes. simultaneously, a few indicated slight variations that may or may not be caused by HME extract no lesions or anomalies in Gross morphology. Histopathological investigations revealed that HME had no adverse effects on organs.</p><p><strong>Conclusions: </strong>HME administration at doses up to 2,000 mg/kg BW didn't result in acute toxicity/impairment to the pancreas, liver or kidney. Nevertheless, the study's limited test dose of 2,000 mg/kg, BW, didn't result in any fatalities/ adverse effects.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"511-519"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disturbance of testosterone cycle in favism-induced male rats is prevented by pracaxi oil oral administration.","authors":"Khaled M M Koriem, Mahmoud S S Arbid","doi":"10.1515/jcim-2024-0161","DOIUrl":"10.1515/jcim-2024-0161","url":null,"abstract":"<p><strong>Objectives: </strong>Favism is a metabolic disease while pracaxi oil is a strong antioxidant agent. This study evaluates anti-infertility activity and assists normal male fertilization of pracaxi oil in favism-induced male rats.</p><p><strong>Methods: </strong>A total of 36 male albino rats of six equal sets were each with 6 rats; Control, Pracaxi oil (1 mL), and Pracaxi oil (2 mL), Favism-induced male rats-, Pracaxi oil (1 mL) + Favism-induced male rats, and Pracaxi oil (2 mL) + Favism-induced male rats groups. Blood parameters, liver function, serum male hormones were determined. Glucose-6-phosphate dehydrogenase, 3β-hydroxysteroid dehydrogenase, total protein, and cholesterol in testis were estimated. Sodium/potassium-ATPase and antioxidants in the hypothalamus, testis, and sperm were assessed. Sperm count, motility, and abnormality, and sperm monoclonal proliferating antibody Ki-67 were evaluated.</p><p><strong>Results: </strong>Favism decreased blood parameters, liver function, superoxide dismutase, glutathione, serum testosterone and dehydroepiandrosterone sulfate, sperm count and motility, sodium/potassium-ATPase activity while increased malondialdehyde, serum follicle stimulating hormone, sex hormone binding globulin, and luteinizing hormone, glucose-6-phosphatedehydrogenase, 3β-hydroxysteroid dehydrogenase, cholesterol, total protein, sperm abnormality, the percentage of spermatogonia, 1st spermatocyte, 2nd spermatocyte, and spermatid in the testis. Furthermore, two doses of pracaxi oil to favism-induced male rats back all of aforementioned parameters to be close control values where a higher dose of pracaxi oil had an efficient impact than a lower dose.</p><p><strong>Conclusions: </strong>Pracaxi oil protects the hypothalamic-pituitary-gonad axis, and preserves sperm quality in favism-induced male rats.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"501-510"},"PeriodicalIF":0.0,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142145765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of resveratrol on rheumatic symptoms and hepatic metabolism of arthritic rats.","authors":"Mellina S Simões, Ana Beatriz P Souza, Francielli M S Silva-Comar, Ciomar A Bersani-Amado, Roberto K N Cuman, Rosane M Peralta, Anacharis B Sá-Nakanishi, Lívia Bracht, Adelar Bracht, Jurandir F Comar","doi":"10.1515/jcim-2024-0200","DOIUrl":"10.1515/jcim-2024-0200","url":null,"abstract":"<p><strong>Objectives: </strong>Resveratrol has been studied as a potential agent for treating rheumatic conditions; however, this compound suppresses glucose synthesis and glycogen catabolism when infused in perfused livers of both arthritic and healthy rats. This study investigated the effects of oral administration of resveratrol on inflammation and liver metabolism in rats with arthritis induced by Freund's adjuvant, which serves as rheumatoid arthritis model.</p><p><strong>Methods: </strong>Holtzman rats, both healthy and exhibiting arthritic symptoms, were orally treated with resveratrol at doses varying from 25 to 500 mg/kg for a 5-day period preceding arthritis induction, followed by an additional 20-day period thereafter. Paw edema, arthritic score and hepatic myeloperoxidase activity were assessed to evaluate inflammation. Glycogen catabolism and gluconeogenesis from lactate were respectively evaluated in perfused livers from fed and fasted rats.</p><p><strong>Results: </strong>Resveratrol decreased the liver myeloperoxidase activity at doses above 100 mg/kg, and decreased the paw edema and delayed the arthritic score at doses above 250 mg/kg. The hepatic gluconeogenesis was decreased in arthritic rats and resveratrol did not improve it. However, resveratrol did not negatively modify the gluconeogenesis in livers of healthy and arthritic rats. Glycogen catabolism was in part and slightly modified by resveratrol in the liver of arthritic and healthy rats.</p><p><strong>Conclusions: </strong>It is improbable that resveratrol negatively affects the liver metabolism, especially considering that gluconeogenesis is highly fragile to changes in cellular architecture. The findings suggest that resveratrol could serve as alternative for treating rheumatoid arthritis. Nevertheless, prudence is advised regarding its transient effects on liver metabolism.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"520-531"},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142107952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical characterization, biochemical profiling and evaluation of anticancer potential of methanolic extract of <i>Withania somnifera</i> stem.","authors":"Aditi Srivastava, Rumana Ahmad, Sahabjada Siddiqui, Sudhir Mehrotra, Mohsin A Khan","doi":"10.1515/jcim-2024-0185","DOIUrl":"10.1515/jcim-2024-0185","url":null,"abstract":"<p><strong>Objectives: </strong>Phytotherapy employs phytoconstituents/phytomedicines derived from plants for treating and preventing illnesses. <i>Withania somnifera</i> is known in the Indian Ayurveda Pharmacopoeia for its medicinal applications and pharmacological properties. In this study, we examined the biological activity spectrum of <i>Withania somnifera</i> methanolic extract of stem (WSME), which is valued as a \"Rasayana\" due to its extensive range of medicinal uses.</p><p><strong>Methods: </strong>WSME was subjected to TPC and TFC quantification and bioactive components were characterized using LC-MS. Its antioxidant potential was gauged by DPPH and H₂O₂ radical scavenging assays, while antibacterial efficacy was assessed against <i>S. aureus</i> and <i>E. coli</i> using disc diffusion assay. <i>In vitro</i> anticancer activity was evaluated against human breast cancer MDA-MB-231 cells while toxicity was evaluated against normal Vero cells using MTT assay.</p><p><strong>Results: </strong>WSME, rich in Withaferin A, showed TPC of 4.73 ± 0.15 mg GAE/g and TFC of 94.94 ± 6.15 mg QE/g dry weight of extract. It exhibited significant antioxidant activity (43.28 and 66.8 % inhibition at 1,000 μg/mL using DPPH and H₂O₂ assays, respectively) and mild antibacterial effects against <i>S. aureus</i> (300-500 mg/mL). WSME induced cell death in MDA-MB-231 cells and significantly inhibited their growth (IC₅₀: 66 μg/mL, <i>P</i> value<0.05) without affecting normal Vero cells in the studied range of 25-400 μg/mL (IC₅₀: 6.09 mg/mL, <i>P</i> value>0.05).</p><p><strong>Conclusions: </strong>The present study lends support to further testing of WSME against other cancer cell lines and animal models of cancer. These preclinical studies would provide further validation to its prospective use as an adjunct in human breast cancer therapy.</p>","PeriodicalId":15556,"journal":{"name":"Journal of Complementary and Integrative Medicine","volume":" ","pages":"319-326"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}