Journal of Cutaneous Immunology and Allergy最新文献

{"title":"Issue Information","authors":"","doi":"10.1002/we.2748","DOIUrl":"https://doi.org/10.1002/we.2748","url":null,"abstract":"","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47582648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Approach to Identify Receptor Binding Domain of Spike Glycoprotein as A Potential Vaccine Candidate for COVID-19","authors":"Aryan Prajapati","doi":"10.37191/mapsci-2582-6549-4(1)-043","DOIUrl":"https://doi.org/10.37191/mapsci-2582-6549-4(1)-043","url":null,"abstract":"Recent SARS-CoV-2 outbreaks have spurred continuing efforts to exploit different viral protein targets for therapy, but preventing viral proteins, including in therapeutic and vaccine research, has largely failed. In the lack of clear clinical proof for COVID-19 pathogenesis, a comparison of previous pandemic HCoVs-related immune system reactions could provide insight into COVID-19 pathogenesis. Authors summarize the possible genesis and method of spread of COVID-19, in addition to our present understanding of the viral genome integrity of known outbreak viruses against SARS-CoV-2 in this study. The COVID-19 pandemic continues to be a major concern for health-care systems globally. Accurate and timely identification of SARS Coronavirus 2 (SARS-CoV-2) infection is crucial for limiting dissemination and commencing therapy. The gold standard among test procedures is real-time reverse-transcriptase polymerase-chain reaction (rRT-PCR). Despite the fact that this test has a high specificity and sensitivity, the incidence of erroneously negative findings in patients with symptoms and/or having a positive CT scan remains a difficulty. In this article authors analyze the receptor binding domain of spike glycoprotein to be potential vaccine candidates.","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88160790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usage of Novel Analytical Techniques for Treatment of Jamestown Canyon Virus (JCV) Disease-A Review","authors":"G. Prakash","doi":"10.37191/mapsci-2582-6549-4(1)-044","DOIUrl":"https://doi.org/10.37191/mapsci-2582-6549-4(1)-044","url":null,"abstract":"Jamestown Canyon Virus (JCV) is a vector-borne disease that spreads from the bite of an infected Mosquito to humans and resembles the dengue virus in its transmission mode. This disease is rampant in Upper Midwest regions of the US and some provinces of Canada. Research done previously suggests that the clinical diagnosis of the disease can be accomplished by testing the serum isolated from the blood of patients who test positive for the virus. Real-time RT PCR, a rapid molecular detection test, is still being investigated for its usage in the diagnosing JCV. There are different types of Mosquitoes, namely the Snowmelt Aedes mosquito, a known reservoir of the JCV. But some research studies suggest that RT-PCR could be used primarily to diagnose and survey the co-circulation of the JCV or LACV to the epidemiologists and health policymakers for informed public action.","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90405246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous arteritis: Clinicopathological study of 21 cases","authors":"Tomoko Hiraiwa MD,&nbsp;Ko-Ron Chen MD, PhD,&nbsp;Toshiyuki Yamamoto MD, PhD","doi":"10.1002/cia2.12305","DOIUrl":"10.1002/cia2.12305","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We conducted this study to clarify the progress of cutaneous arteritis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We examined 21 cases of cutaneous arteritis that were diagnosed at our hospital between 2005 and 2020. The male-to-female ratio was 1:6 with a mean age of 52.2 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The lower legs were involved in all cases, and the upper extremities or trunk was also involved in some cases. Cutaneous manifestations presented as indurated erythema (<i>n</i> = 15), subcutaneous induration (11), edema (7), livedo (6), and ulcer (3). In addition, extracutaneous conditions including numbness (10), arthritis (8), fever (2), and myalgia (1) were observed. Laboratory tests showed an increase of inflammatory markers in most cases (14). Histopathological features showed necrotizing vasculitis of small-sized arteries at the dermo-subcutaneous junction, and the inflammatory stages of arteritis were histopathologically divided into acute stage (5), subacute stage (5), reparative stage (7), and healed stage (1). The therapies administered were oral prednisolone (11), antiplatelet drug (14), warfarin (1), non-steroidal anti-inflammatory drugs (6), biological drug (1), and other drugs (14). There were no cases showing progression to systemic polyarteritis nodosa during follow-up period. All three patients with ulceration complained of numbness, and one was revealed to have mononeuropathy multiplex. They were treated with low-dose oral prednisolone. Three ulceration cases were histopathologically classified into the acute and subacute stages.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In conclusion, all 21 patients followed a chronic course with recurrent skin lesions without systemic complications. Cases with ulceration seem to reveal neurological symptoms and need systemic steroid treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12305","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41706296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythematous reaction of the BCG site to Pfizer-BioNTech COVID-19 vaccine","authors":"Yuta Ito MD,&nbsp;Marie Suzuki MD,&nbsp;Marina Seki MD,&nbsp;Takehiro Okusa MD,&nbsp;Tokio Nakada MD","doi":"10.1002/cia2.12307","DOIUrl":"10.1002/cia2.12307","url":null,"abstract":"<p>Our patient developed erythematous reaction of the BCG site to Pfizer-BioNTech COVID-19 vaccine. As COVID-19 vaccination is expanded to younger ages, we have to pay attention to such reactions.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46136702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Granulomatous reaction as a postherpetic isotopic response after primary varicella infection in a healthy adult","authors":"Tomoki Niimura MD,&nbsp;Yuko Watanabe MD, PhD,&nbsp;Michiko Aihara MD, PhD,&nbsp;Yukie Yamaguchi MD, PhD","doi":"10.1002/cia2.12306","DOIUrl":"10.1002/cia2.12306","url":null,"abstract":"<p>We report the first case of post-herpetic isotopic reaction (PHIR) after primary varicella infection in a healthy adult. PHIR refers to the development of new skin lesions at sites where prior herpetic skin lesions have been resolved. Herpes zoster is the most common cause of PHIR; however, only a few cases of PHIR due to primary varicella infections have been reported.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12306","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45506601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The significance of M1-polarized CD163+ macrophages in acute graft-versus-host disease (GVHD): Possible mechanisms of GVHD in the development of skin lesions","authors":"Yusuke Muto MD, PhD,&nbsp;Taku Fujimura MD, PhD,&nbsp;Yumi Kambayashi MD, PhD,&nbsp;Kentaro Ohuchi MD, PhD,&nbsp;Chunbing Lyu MD, PhD,&nbsp;Hitoshi Terui MD, PhD,&nbsp;Masato Mizuashi MD, PhD,&nbsp;Setsuya Aiba MD, PhD,&nbsp;Yoshihide Asano MD, PhD","doi":"10.1002/cia2.12304","DOIUrl":"10.1002/cia2.12304","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Graft-versus-host disease (GVHD) is an important complication of bone marrow transplantation. Recent reports suggest the significance of T-cell subsets (Th1, Th17, and cytotoxic CD8+ T cells) as well as CD163+ macrophages in the development of cutaneous GVHD. CD163+ macrophages produce various chemokines to establish the immunological microenvironment following stimulation by stromal factors in lesional skin. Thus, the purpose of this study is to determine the main source of IFN-inducible chemokines in the lesional skin of GVHD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We employed immunohistochemical (IHC) staining for CD163 as well as interferon (IFN)-inducible chemokines (CXCL9, CXCL10, CXCL11) to determine if the main source of IFN-inducible chemokines in the lesional skin of GVHD was CD163+ macrophages. Moreover, we investigated the possible cytokine profiles of lesional skin in GVHD by evaluating phospho-<i>signal</i> transducer and activator of transcription (pSTAT) expression in epidermal keratinocytes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Immunohistochemical staining of serial sections for CD163 revealed that CXCL9-expressing cells, CXCL10-expressing cells, and CXCL11-expressing cells were detected in adjacent to CD163+ TAMs in the dermis. In contrast, there were no CCL17-expressing cells or CCL22-expressing cells in the dermis. The nuclei of epidermal keratinocytes in GVHD expressed pSTAT1, pSTAT3, and pSTAT5B.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The chemokine expression patterns on CD163+ macrophages matched the expected phosphorylation pattern of epidermal STATs. Our present study suggested that CD163 + macrophages may be a therapeutic target in GVHD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49622768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and effectiveness of dupilumab in the real-world treatment of atopic dermatitis in Japan: 1-year interim analysis from a post-marketing surveillance","authors":"Hidehisa Saeki MD, PhD,&nbsp;Hiroyuki Fujita MD, PhD,&nbsp;Katsuhisa Suzuki BSc,&nbsp;Kazuhiko Arima MD, PhD","doi":"10.1002/cia2.12303","DOIUrl":"10.1002/cia2.12303","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Atopic dermatitis (AD) is a common chronic inflammatory skin disorder in Japan. Dupilumab, a fully human monoclonal antibody, targets a shared subunit of the interleukin (IL)-4 and IL-13 receptors. Post-marketing surveillance of the safety and effectiveness of dupilumab in adult AD patients was conducted in Japan, where the drug is also allowed for use in older adolescents (i.e., ≥15 years), and interim results are reported here.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This observational, multicenter study enrolled Japanese patients with AD who initiated dupilumab between July 2018–June 2020 (UMIN-CTR Trials Registry: UMIN000032807). Baseline demographics, clinical history, medication data and dupilumab safety and effectiveness data were collected.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>By the data cut-off date of March 26, 2021, information from 600 patients has been collected. All the available safety and 1-year effectiveness data are presented. The mean (standard deviation) age was 42.0 (15.9) years, the majority (69.1%) were male, and asthma was present in 12.2%. Adverse drug reactions (ADRs) were observed in 98 patients (16.4%), including conjunctivitis (<i>n</i> = 40; 6.7%), conjunctivitis allergic (<i>n</i> = 30; 5.0%), blepharitis (<i>n</i> = 5; 0.8%), headache and eye pruritus (<i>n</i> = 4; 0.7% each) and eosinophilia (<i>n</i> = 3; 0.5%). Six patients experienced asthma, all of whom had a history of, or concurrent, asthma. Disease severity improved remarkably at 4 months in most patients, which was maintained up to 1 year.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Dupilumab appears to be a safe and effective treatment for patients aged ≥15 years with moderate-to-severe AD in routine clinical practice in Japan. Dupilumab was well tolerated, with no new safety signals and no new-onset asthma.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42241324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate exacerbation of atopic dermatitis after switching from upadacitinib to dupilumab: A report of two cases","authors":"Makoto Ito MD,&nbsp;Masahiro Kamata MD, PhD,&nbsp;Hideaki Uchida MD, PhD,&nbsp;Shota Egawa MD, PhD,&nbsp;Saki Fukaya MD,&nbsp;Kotaro Hayashi MD, PhD,&nbsp;Atsuko Fukuyasu MD,&nbsp;Takamitsu Tanaka MD, PhD,&nbsp;Takeko Ishikawa MD, PhD,&nbsp;Yayoi Tada MD, PhD","doi":"10.1002/cia2.12302","DOIUrl":"10.1002/cia2.12302","url":null,"abstract":"<p>Janus kinase (JAK) inhibitors are efficacious for atopic dermatitis (AD). However, some patients receiving JAK inhibitors develop acne, especially younger patients, or herpes zoster, especially elderly patients, and desire to switch to dupilumab. We experienced two patients with immediate exacerbation of AD after switching from upadacitinib to dupilumab, and herein report these cases. This phenomenon is attributed to the difference in elimination half-life of the two drugs and a slower onset of efficacy of dupilumab than upadacitinib. When switching from a JAK inhibitor to dupilumab, short-term concomitant use, intensifying topical treatment, and/or rescue with cyclosporine should be considered.</p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12302","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41875724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nail toxicity with nail bed ulceration associated with pembrolizumab","authors":"Shintaro Maeda MD, PhD,&nbsp;Yasuhito Hamaguchi MD, PhD,&nbsp;Kaori Sawada MD, PhD,&nbsp;Kyoko Shimizu MD,&nbsp;Kyosuke Oishi MD, PhD,&nbsp;Katsushige Taniuchi MD, PhD,&nbsp;Takashi Matsushita MD, PhD","doi":"10.1002/cia2.12301","DOIUrl":"10.1002/cia2.12301","url":null,"abstract":"<p>A 70-year-old Japanese man was diagnosed with bladder cancer and started pembrolizumab. After six courses of pembrolizumab, all fingernails and toenails had fallen off and the nail beds were ulcerated. Pembrolizumab was discontinued, and he was treated with topical steroids and topical prostaglandin E1 ointment.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":15543,"journal":{"name":"Journal of Cutaneous Immunology and Allergy","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2023-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cia2.12301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45065160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}