Journal of Drug Metabolism and Toxicology最新文献_第7页

Highly Active Antiretroviral Therapy and Anti-tuberculosis Drug Interactions with Associated Clinical Implications: A Review 高活性抗逆转录病毒治疗和抗结核药物相互作用及其相关临床意义:综述

Journal of Drug Metabolism and Toxicology Pub Date : 2016-05-20 DOI: 10.4172/2157-7609.1000207

J. Karanja, Nathan G Kiboi, S. N. Nebere, Achieng Ho

引用次数: 10

Editorial: The International Journal of Pharmacology and Therapeutics 社论:国际药理学和治疗学杂志

Journal of Drug Metabolism and Toxicology Pub Date : 2016-05-18 DOI: 10.4172/2157-7609.1000E130

M. Ďurišová

引用次数: 2

Human Toxicity Photodynamic Therapy Studies on DNA/RNA Complexes as a Promising New Sensitizer for the Treatment of Malignant Tumors Using Bio-Spectroscopic Techniques 利用生物光谱技术研究DNA/RNA复合物作为治疗恶性肿瘤的新型增敏剂的前景

Journal of Drug Metabolism and Toxicology Pub Date : 2016-05-15 DOI: 10.4172/2157-7609.1000E129

A. Heidari

{"title":"Human Toxicity Photodynamic Therapy Studies on DNA/RNA Complexes as a Promising New Sensitizer for the Treatment of Malignant Tumors Using Bio-Spectroscopic Techniques","authors":"A. Heidari","doi":"10.4172/2157-7609.1000E129","DOIUrl":"https://doi.org/10.4172/2157-7609.1000E129","url":null,"abstract":"DNA/RNA complexes play an important role in many biological and catalytic systems. The variety of their functions is due in part to the diversity of metals that bind in the “pocket” of the DNA/RNA complexes system. In this editorial, we discuss synthesis and recognition of DNA/RNA complexes and argue group theory of them. Upon metalation the DNA/RNA complexes system deprotonates, forming a dianionic ligand. The metal ions behave as Lewis acids, accepting lone pairs of electrons from the dianionic DNA/RNA ligand. Unlike most transition metal complexes, their color is due to absorption(s) within the DNA/RNA ligand involving the excitation of electrons from π to π* (π→π*) DNA/RNA complexes orbitals. Most DNA/RNA complexes contain a metal ion in the center of the planner DNA/RNA complexes system, resulting in a kinetically inert complex. If, however, the ionic radius of the metal ions is too large to fit into the hole in the center of the macro cycle, they are located out of the ligand plane, distorting it. These kinetically labile Sitting–Atop (SAT) complexes display characteristic structural and photo induced properties that strongly deviates from those of the regular DNA/RNA complexes [1-26].","PeriodicalId":15537,"journal":{"name":"Journal of Drug Metabolism and Toxicology","volume":"23 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2016-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88229382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 136

Effect of Curcumin on Sulfasalazine Pharmacokinetics in Healthy Volunteers 姜黄素对磺胺氮嗪在健康志愿者体内药代动力学的影响

Journal of Drug Metabolism and Toxicology Pub Date : 2016-05-15 DOI: 10.4172/2157-7609.1000206

Tomoko Tokumoto, Takeshi Hirota, Keisuke Got, M. Kimura, S. Irie, Masato Fukae, I. Ieiri

{"title":"Effect of Curcumin on Sulfasalazine Pharmacokinetics in Healthy Volunteers","authors":"Tomoko Tokumoto, Takeshi Hirota, Keisuke Got, M. Kimura, S. Irie, Masato Fukae, I. Ieiri","doi":"10.4172/2157-7609.1000206","DOIUrl":"https://doi.org/10.4172/2157-7609.1000206","url":null,"abstract":"Curcumin, a commonly used spice, is a naturally occurring polyphenol. It has been reported that curcumin inhibited the transport activity of breast cancer resistance protein (BCRP/ABCG2) in animal studies, and curcumin caused significantly increased plasma concentrations of sulfasalazine (SASP), an in vivo probe for BCRP function in human. In this study, we assessed the influence of prior administration of curcumin on the pharmacokinetics of SASP. An open-label, single-arm and two-phase study was conducted in 34 healthy participants. A single dose of SASP (2,000 mg) was administered orally after overnight fast (phase 1). After seven days washout period, a single oral dose of curcumin (2,000 mg) was administered, and then, 4 days to 5 days after administration of curcumin, 2,000 mg of SASP was administered orally again (phase 2). Plasma concentrations of SASP were assayed by highperformance liquid chromatography. Orally 4 days to 5 days’ time lag between SASP and curcumin intake disappeared the interaction. The disappeared interaction may be responsible for the extremely low bioavailability of curcumin and the disappearance of curcumin in the gastro-intestinal tracts before the administration of SASP. Our findings suggested that 4 days to 5 days’ time lag is necessary to avoid the drug interaction between BCRP substrates and curcumin.","PeriodicalId":15537,"journal":{"name":"Journal of Drug Metabolism and Toxicology","volume":"20 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2016-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88578643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Microbial Transformations of Plant Origin Compounds as a Step in Preparation of Highly Valuable Pharmaceuticals 植物源化合物的微生物转化是制备高价值药物的一个步骤

Journal of Drug Metabolism and Toxicology Pub Date : 2016-05-10 DOI: 10.4172/2157-7609.1000204

Blaga Mutafova, S. Mutafov, P. Fern, Es, S. Berkov

引用次数: 16

Mathematical Modeling Formation of 7-hydroxymethotrexate from Methotrexate in Patients Undergoing Treatment for Psoriasis with Methotrexate 在接受甲氨蝶呤治疗的银屑病患者中，甲氨蝶呤生成7-羟基甲氨蝶呤的数学模型

Journal of Drug Metabolism and Toxicology Pub Date : 2016-05-10 DOI: 10.4172/2157-7609.1000205

M. Ďurišová

引用次数: 5

Opinion: Journal of Drug Metabolism and Toxicology 观点:药物代谢与毒理学杂志

Journal of Drug Metabolism and Toxicology Pub Date : 2016-04-28 DOI: 10.4172/2157-7609.1000E128

M. Ďurišová

引用次数: 2

Emerging Associations of the ALDH2*2 Polymorphism with Disease Susceptibility ALDH2*2多态性与疾病易感性的新关联

Journal of Drug Metabolism and Toxicology Pub Date : 2016-04-20 DOI: 10.4172/2157-7609.1000202

Jennifer Gueldner, C. Sayes, E. Abel, Erica Bruce

{"title":"Emerging Associations of the ALDH2*2 Polymorphism with Disease Susceptibility","authors":"Jennifer Gueldner, C. Sayes, E. Abel, Erica Bruce","doi":"10.4172/2157-7609.1000202","DOIUrl":"https://doi.org/10.4172/2157-7609.1000202","url":null,"abstract":"Ethanol is metabolized by Alcohol Dehydrogenase (ADH) to acetaldehyde and then irreversibly oxidized by Aldehyde Dehydrogenase (ALDH) to nontoxic acetate. In individuals expressing the ALDH2*2 variant enzyme, the rate of conversion from acetaldehyde to acetate is reduced and leads to flushing, nausea, and tachycardia due to increased blood levels of acetaldehyde. The ALDH2*2 variant has a lowered NAD+ coenzyme binding affinity, which results in a lowered clearance capacity toward acetaldehyde. This polymorphism is caused by the substitution of glutamate for lysine at position 487 within the catalytic active site of ALDH2, resulting in effects on subunit and quaternary complex activity. ALDH2*2 alleles are dominant over ALDH2*1 and therefore are expected to contribute to the formation of inactive heterotetramers decreased enzymatic activity in both homozygous and heterozygous individuals. Consequently, a higher susceptibility to various diseases such as Alzheimer’s, osteoporosis, and acute coronary syndrome has been associated with ALDH2*2 carriers. Additionally, the polymorphism seems to affect the efficacy of Glyceryl Trinitrate (GTN), a drug intended to treat coronary heart disease, in carriers of ALDH2*2 alleles. However, the polymorphism is believed to afford a protective effect against alcoholism as the side effects of acetaldehyde build-up are undesirable. Disulfiram, a drug historically used to treat alcohol dependency, induces the same undesirable physiological effects as the variant enzyme in non-carriers by inhibiting the normal functioning of ALDH2 enzyme.","PeriodicalId":15537,"journal":{"name":"Journal of Drug Metabolism and Toxicology","volume":"8 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2016-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85358174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Prediction of Antigenic MHC Peptide Binders and TAP Binder of COX1 Protein through In Silico Approach 利用计算机技术预测COX1蛋白抗原MHC肽结合物和TAP结合物

Journal of Drug Metabolism and Toxicology Pub Date : 2016-04-04 DOI: 10.4172/2157-7609.1000201

Mishra S, G. Vs

引用次数: 5

NRSF and CCR5 Established Neuron-glia Communication during Acute and Chronic Stresses 急性和慢性应激时NRSF和CCR5建立神经元-胶质细胞通讯

Journal of Drug Metabolism and Toxicology Pub Date : 2016-01-10 DOI: 10.4172/2157-7609.1000197

Huilin Mou, Xiaocong Zhao, Xiaojiang Li, Jie Liu, Hanwei Huang, Hui Zhao

{"title":"NRSF and CCR5 Established Neuron-glia Communication during Acute and Chronic Stresses","authors":"Huilin Mou, Xiaocong Zhao, Xiaojiang Li, Jie Liu, Hanwei Huang, Hui Zhao","doi":"10.4172/2157-7609.1000197","DOIUrl":"https://doi.org/10.4172/2157-7609.1000197","url":null,"abstract":"It has been reported that traumatic stress resulted in immune-suppression. Src kinase activation in the prefrontal cortex was believed to initiate cellular-reorganization at the recover stage of trauma. Herein, we reported that NRSF and CCR5 expression were consistently increased in the prefrontal cortex of SD rats when exposed to traumatic stress, in which CCR5 was activated mostly in neurons and targeted by astrocyte NRSF. Moreover, HPA axis activation could be acutely and sustainably triggered by traumatic stress and PSS at post-trauma respectively, both NRSF and CCR5 had inhibitory effect in the former event, while NRSF could block the scenario in the later event. Intriguingly, the effect of NRSF was mostly converged on multiple mechanisms that associated with GR activity, and the optimal preservation of neuroligin-1 formed neuron-astrocyte communication was achieved by NRSF. Therefore, the present results argue for the dichotomy of NRSF regulatory complexes, whose inhibition in HPA hyper-reactivity during acute and chronic stresses have significant potential for the development of therapeutic approaches in posttraumatic stress-related disorders.","PeriodicalId":15537,"journal":{"name":"Journal of Drug Metabolism and Toxicology","volume":"16 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2016-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84606339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8