Journal of Comparative Pathology最新文献_第4页

Ganglioneuroma in a Meller's chameleon (Trioceros melleri) 在梅勒的变色龙(tricerosmelleri)。

IF 0.9 4区农林科学

Journal of Comparative Pathology Pub Date : 2026-04-01 Epub Date: 2026-03-25 DOI: 10.1016/j.jcpa.2026.01.008

Freelie Mitchell , Mary Ceccolini , Robert V. Jones , Elise E.B. LaDouceur

{"title":"Ganglioneuroma in a Meller's chameleon (Trioceros melleri)","authors":"Freelie Mitchell , Mary Ceccolini , Robert V. Jones , Elise E.B. LaDouceur","doi":"10.1016/j.jcpa.2026.01.008","DOIUrl":"10.1016/j.jcpa.2026.01.008","url":null,"abstract":"<div><div>Nervous system neoplasia is rarely reported in reptiles, with most reports representing gliomas. A captive, 9-year-old Meller's chameleon (<em>Trioceros melleri</em>) was euthanized for weight loss and lethargy. At necropsy, a 2 cm-diameter mass was effacing the right adrenal gland and adhered to the kidney. The skin had two, 0.8–1.0 cm-diameter, firm, pale-yellow masses over the right leg and left shoulder. The fat bodies were small. Histologically, the adrenal gland and peri-adrenal soft tissues were effaced by an expansile, moderately cellular neoplasm entrapping remnant chromaffin and interrenal cells and invading the kidney. The neoplasm was composed of two cell populations resembling well-differentiated neurons and Schwann cell-like peripheral nerve sheath elements. Cellular atypia was minimal. The skin was multifocally elevated and expanded by invasive, unencapsulated neoplasms composed of intersecting streams of neoplastic spindle cells with abundant eosinophilic, finely vacuolated cytoplasm, oval nuclei, marked anisocytosis and anisokaryosis, and occasional mitoses; these were interpreted as sarcomas. The fat bodies had marked atrophy. Immunohistochemistry was non-contributory (glial fibrillary acidic protein, neuron-specific enolase, synaptophysin, NeuN, chromogranin, S100 and vimentin) or negative (AE1/AE3) in neoplastic cells. The adrenal gland mass was diagnosed as a ganglioneuroma, which is a neoplasm of the peripheral nervous system originating from the sympathetic ganglia of the autotomic nervous system. Ganglioneuroma is rarely reported in veterinary species, and this is the first report in a reptile. The origin of this ganglioneuroma was likely neural crest cells of the adrenal gland. It is unknown whether the dermal masses were related to the ganglioneuroma or were unrelated sarcomas.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"226 ","pages":"Pages 38-41"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the pathology of herpesvirus infections in pinnipeds 鳍足类动物疱疹病毒感染的病理学研究进展。

IF 0.9 4区农林科学

Journal of Comparative Pathology Pub Date : 2026-04-01 Epub Date: 2026-03-25 DOI: 10.1016/j.jcpa.2026.01.007

Amy L. Robinson , Laura Bianchessi , Mara S. Rocchi , Mark P. Dagleish

{"title":"A review of the pathology of herpesvirus infections in pinnipeds","authors":"Amy L. Robinson , Laura Bianchessi , Mara S. Rocchi , Mark P. Dagleish","doi":"10.1016/j.jcpa.2026.01.007","DOIUrl":"10.1016/j.jcpa.2026.01.007","url":null,"abstract":"<div><div>Twenty-two herpesviruses, all within the family <em>Orthoherpesviridae</em> and belonging to the <em>Alphaherpesvirinae</em> (n = 3) and <em>Gammaherpesvirinae</em> (n = 19) subfamilies have been reported in 14 different pinniped species (n = 8 phocids, n = 5 otariids and n = 1 odobenid). This review critically assessed the purported pathology reported for herpesvirus infections and found a variety of lesions present dependent on both the herpesvirus and host species. Lesions included hepatic and adrenal necrosis, interstitial pneumonia, thyroid atrophy, lymphodepletion, lymphocytolysis, ulcerative stomatitis, glossitis with tonsilitis and dermatitis, necrotizing keratitis and, potentially, other ocular lesions also. Furthermore, specific individual gammaherpesvirus infections were linked to oncogeneses including urogenital carcinoma, diffuse large B cell lymphoma and B cell lymphoblastic lymphoma. However, for many herpesvirus infections the clinical significance, lesion association and definitive herpesvirus classification remain uncertain, the latter due to lack of sufficient genome data. For these reasons, identification of the definitive host species or even if separately reported herpesviruses are actually the same virus, remain challenging. More extensive genome sequencing is required to definitively identify and classify individual herpesvirus species along with sensitive and specific tools to visualize them within tissues to enable investigation of lesion association.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"226 ","pages":"Pages 42-56"},"PeriodicalIF":0.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147521122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-communicating abomasal (gastric) diverticulum in a 7-day-old bull calf: a case report 7日龄公牛犊牛无交通性皱胃憩室1例。

IF 0.9 4区农林科学

Journal of Comparative Pathology Pub Date : 2026-02-01 Epub Date: 2026-02-27 DOI: 10.1016/j.jcpa.2026.02.002

Cassandra M. Powers

{"title":"Non-communicating abomasal (gastric) diverticulum in a 7-day-old bull calf: a case report","authors":"Cassandra M. Powers","doi":"10.1016/j.jcpa.2026.02.002","DOIUrl":"10.1016/j.jcpa.2026.02.002","url":null,"abstract":"<div><div>A gastric diverticulum (GD) is defined as an outpouching of the gastric wall and is reported rarely in humans, cats and dogs. A congenital GD (true GD) is a full-thickness diverticulum involving all gastric layers. A 7-day-old bull calf with a history of sudden death was presented for post-mortem examination to the Purdue Animal Disease Diagnostic Laboratory. On gross examination, arising from the wall of the caudal aspect of the greater curvature of the abomasum was a soft to firm hollow mass with no gross evidence of communication with the abomasal lumen. Histological sections of the mass revealed a full-thickness GD that possessed all four layers of the abomasum including segments of normal abomasal epithelium. The rumen, reticulum and omasum remain undeveloped at birth and during the first few weeks of life. A calf's rumen usually develops fully at around 12 weeks of age and the abomasum does not reach its maximum volume until around 1.5 years of age. Therefore, it is possible that this calf was either born with this anomaly or it may have developed and closed completely during early post-natal development of the forestomaches. As far as the author is aware, this is the first reported case of an abomasal diverticulum in a bovid.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"225 ","pages":"Pages 10-12"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clear cell squamous cell carcinoma in the third eyelid of a horse 马第三眼睑的透明细胞鳞状细胞癌

IF 0.9 4区农林科学

Journal of Comparative Pathology Pub Date : 2026-02-01 Epub Date: 2026-02-04 DOI: 10.1016/j.jcpa.2026.01.012

Daniel R. Rissi, Ricardo E. Mendes

{"title":"Clear cell squamous cell carcinoma in the third eyelid of a horse","authors":"Daniel R. Rissi, Ricardo E. Mendes","doi":"10.1016/j.jcpa.2026.01.012","DOIUrl":"10.1016/j.jcpa.2026.01.012","url":null,"abstract":"<div><div>Squamous cell carcinoma (SCC) is the most common ocular and periocular neoplasm of horses, typically arising from the limbus, third eyelid mucosa or mucocutaneous junctions of the upper and lower eyelids. Tumours are locally invasive, prone to recurrence and may rarely metastasize. Histological evaluation is required for definitive diagnosis and atypical SCC subtypes may be diagnostically challenging. Here we describe a clear cell SCC in the third eyelid of a 16-year-old female Quarter Horse. The red and invasive mass was surgically excised for histological evaluation. The lesion consisted of a poorly demarcated, exophytic proliferation of neoplastic cells arranged in lobules supported by a scant stroma. Neoplastic cells had round, mostly clear cytoplasm with distinct cell borders and round to oval nuclei with coarse chromatin and a prominent nucleolus. Squamous differentiation was observed throughout. The mitotic count was 23 in 2.37 mm<sup>2</sup> (equivalent to 10 FN22/ × 40 fields). There was one area of vascular infiltration by neoplastic cells. Dysplastic epithelial plaques were observed in the adjacent third eyelid mucosa. Most neoplastic cells had no cytoplasmic staining with periodic acid–Schiff reaction and were negative for mucus and lipid using Mayer mucicarmine and Sudan IV stains, respectively. A mild degree of submucosal elastosis was observed using Verhoeff-van Gieson stain. Neoplastic cells had widespread, robust cytoplasmic labelling for pancytokeratin (AE1/AE3). Ocular or periocular clear cell SCCs have not been previously reported in domestic animals.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"225 ","pages":"Pages 1-3"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146116343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to ‘Multiple congenital pulmonary malformations in a black-capped Bolivian squirrel monkey (Saimiri boliviensis boliviensis)’ [J Comp Pathol, 222 (2025) 3–7] “玻利维亚黑冠松鼠猴（Saimiri boliviensis boliviensis）的多重先天性肺畸形”的勘误[J].动物病理学杂志，222(2025):3-7。

IF 0.9 4区农林科学

Journal of Comparative Pathology Pub Date : 2026-02-01 Epub Date: 2026-02-10 DOI: 10.1016/j.jcpa.2026.01.011

Mayane Faccin, Sarah M. Kezar

引用次数: 0

Invasive carcinoma of no special type with medullary pattern in the canine mammary gland: histopathological and immunohistochemical characterization 犬乳腺无特殊类型髓样浸润性癌：组织病理学和免疫组织化学特征

IF 0.9 4区农林科学

Journal of Comparative Pathology Pub Date : 2026-02-01 Epub Date: 2026-02-12 DOI: 10.1016/j.jcpa.2026.01.001

Lize A.B. Borges, Geovanni D. Cassali

{"title":"Invasive carcinoma of no special type with medullary pattern in the canine mammary gland: histopathological and immunohistochemical characterization","authors":"Lize A.B. Borges, Geovanni D. Cassali","doi":"10.1016/j.jcpa.2026.01.001","DOIUrl":"10.1016/j.jcpa.2026.01.001","url":null,"abstract":"<div><div>Medullary carcinoma (MC) is an extremely rare neoplasm of the human mammary gland that is essentially not reported in veterinary literature. The present report describes a case of a 14-year-old female mixed-breed dog presenting with a mammary mass. Histological examination revealed a poorly demarkated, multinodular neoplasm composed predominantly of solid sheets of epithelial cells with high nuclear-to-cytoplasmic ratio, indistinct cytoplasmic borders and marked pleomorphism. A prominent lymphoplasmacytic infiltrate was also observed. Immunohistochemical analysis showed tumour cells were positive for cytokeratin 14, 34βE12 and epidermal growth factor receptor. The tumour cells were negative for HER2 and oestrogen receptor but had diffuse labelling of progesterone receptor. The proliferation index, assessed by Ki-67 labelling, was 22%, and cyclooxygenase-2 labelling was observed in less than 10% of cells. CD3 and CD20 immunolabelling indicated a predominance of T lymphocytes within the inflammatory infiltrate. These findings led to a diagnosis of invasive carcinoma of no special type with medullary pattern and T lymphocyte enriched inflammatory infiltrate. This case reinforces the importance of recognizing MC in dogs as it shares several histopathological and immunohistochemical features with its human counterpart. Further studies with larger cohorts are needed to elucidate the prognostic significance of this rare tumour subtype in dogs.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"225 ","pages":"Pages 5-9"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146191423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intestinal acinar adenocarcinoma in a blue-fronted Amazon parrot (Amazona aestiva) 蓝额亚马逊鹦鹉肠腺泡腺癌

IF 0.9 4区农林科学

Journal of Comparative Pathology Pub Date : 2026-01-01 Epub Date: 2026-01-31 DOI: 10.1016/j.jcpa.2026.01.003

João C. Krueger , Carolina Fontana , Arthur C. Cheng , Vinicius Dahm , Rachel Teixeira Neto , Luana Canavessi , Nelson D. Lucas , Luana C. Stunitz da Silva , Anderson Luiz de Carvalho , Aline de Marco Viott , Manoela M. Piva

{"title":"Intestinal acinar adenocarcinoma in a blue-fronted Amazon parrot (Amazona aestiva)","authors":"João C. Krueger , Carolina Fontana , Arthur C. Cheng , Vinicius Dahm , Rachel Teixeira Neto , Luana Canavessi , Nelson D. Lucas , Luana C. Stunitz da Silva , Anderson Luiz de Carvalho , Aline de Marco Viott , Manoela M. Piva","doi":"10.1016/j.jcpa.2026.01.003","DOIUrl":"10.1016/j.jcpa.2026.01.003","url":null,"abstract":"<div><div>A 54-year-old captive male blue-fronted Amazon parrot <em>(Amazona aestiva)</em> was presented with progressive weight loss, diarrhoea and dyspnoea. Contrast radiographs suggested a neoplastic process by revealing an opaque soft tissue mass occupying most of the coelomic cavity. Post-mortem findings included approximately 80 ml of serous ascitic fluid. The intestines had a diffuse firm consistency, and the serosal surface was covered by multifocal to coalescent, irregularly shaped, white to off-white elevated plaques and nodules, which obscured visualization of the pancreas. Histologically, there was a neoplastic epithelial cell proliferation that extended to the intestine and pancreatic parenchyma. The cells were arranged in acini associated with mild cytoplasmic and extracellular mucin. The neoplastic cells had diffuse immunoreactivity for pancytokeratin, and both intra- and extracellular mucin stained deeply with Alcian blue. Clinical and pathological findings indicated a diagnosis of intestinal acinar adenocarcinoma.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"224 ","pages":"Pages 30-33"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146073856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retroperitoneal T-cell lymphoma with cystitis and megacolon in a young feline leukaemia virus-positive cat 白血病病毒阳性猫腹膜后t细胞淋巴瘤伴膀胱炎和巨结肠

IF 0.9 4区农林科学

Journal of Comparative Pathology Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1016/j.jcpa.2025.11.002

Gabriela Hartmann , Simone S.M. Cruz , Joanna V.Z. Echenique , Rafael B. Rosa , Gabriela C. Schaefer , Álan G. Pöppl , Saulo P. Pavarini

{"title":"Retroperitoneal T-cell lymphoma with cystitis and megacolon in a young feline leukaemia virus-positive cat","authors":"Gabriela Hartmann , Simone S.M. Cruz , Joanna V.Z. Echenique , Rafael B. Rosa , Gabriela C. Schaefer , Álan G. Pöppl , Saulo P. Pavarini","doi":"10.1016/j.jcpa.2025.11.002","DOIUrl":"10.1016/j.jcpa.2025.11.002","url":null,"abstract":"<div><div>Retroperitoneal neoplasms are rare in both human and veterinary medicine, particularly in cats, where they account for less than 0.1 % of all neoplasms. This report describes a rare case of retroperitoneal T-cell lymphoma in a 7-month-old, feline leukaemia virus (FeLV)-positive Domestic Shorthair cat, leading to urethral and intestinal obstruction and subsequently cystitis and megacolon, respectively. The cat presented with clinical signs of weight loss, vomiting, tenesmus and urinary retention, and was diagnosed with a retroperitoneal mass compressing the colon and the urinary bladder. Due to the poor prognosis, the cat was euthanized during an exploratory laparoscopy and submitted for post-mortem examination. At necropsy, there was a large retroperitoneal, white, soft-to-firm, irregular mass that encompassed and compressed the rectum, colon, urethra and urinary bladder neck, along with megacolon and haemorrhagic cystitis. Histologically, the mass consisted of sheets of medium-sized neoplastic lymphocytes with mild anisocytosis and anisokaryosis. In the urinary bladder, a necrohaemorrhagic cystitis was observed. The cytoplasm of the neoplastic lymphocytes was positive by immunolabelling for CD3; therefore, the neoplasm was classified as a lymphoblastic T-cell lymphoma. Additionally, multifocal cytoplasmic FeLV immunolabelling was observed within the neoplastic cells, suggesting a possible viral involvement in the case's oncogenesis. This is the first reported case of a possibly FeLV-related retroperitoneal lymphoma in a cat. It had both intestinal and urinary tract obstructions as clinical outcomes. Our findings highlight retroperitoneal lymphoma as a new differential diagnosis for cats with lower urinary tract and gastrointestinal tract obstructions.</div></div>","PeriodicalId":15520,"journal":{"name":"Journal of Comparative Pathology","volume":"224 ","pages":"Pages 1-4"},"PeriodicalIF":0.9,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145536902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesoblastic nephroma in a young Entlebucher Mountain Dog 幼犬的中胚层肾瘤。

IF 0.9 4区农林科学

Journal of Comparative Pathology Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1016/j.jcpa.2025.11.001

Sandra Lockow , Layla Johannsen , Nane Schulz , Gerrit Wüstefeld , Anne Tiede , Stefanie Bruhn , Peter Wohlsein

引用次数: 0

Multicentric diffuse large B-cell lymphoma with dural involvement in a nursery piglet 乳猪多中心弥漫性大b细胞淋巴瘤伴硬脑膜受累

IF 0.9 4区农林科学

Journal of Comparative Pathology Pub Date : 2026-01-01 Epub Date: 2026-01-29 DOI: 10.1016/j.jcpa.2026.01.006

Fernanda F. Perosa , Jean C.O. Menegatt , Anderson H. Gris , Manoela M. Piva , Marcele B. Bandinelli , Saulo P. Pavarini , David Driemeier

引用次数: 0