Journal of Clinical and Experimental Cardiology最新文献

{"title":"The use of VA-ECMO in the cathlab: STEMI and high risk percutaneous coronary interventions","authors":"F. Brink","doi":"10.4172/2155-9880-C12-121","DOIUrl":"https://doi.org/10.4172/2155-9880-C12-121","url":null,"abstract":"Introduction: Percutaneous coronary intercession (PCI) is a generally applied obtrusive technique intended to treat obstructive injuries in epicardial coronary courses and their significant branches. After the inclusion of a vascular sheath in a fringe corridor (spiral, brachial, or femoral), uniquely molded catheters are progressed to the ostia of coronary conduits and coronary angiography is performed utilizing radio dark difference material. After the obstructive sores have been distinguished and described, satisfactory anticoagulation is given and PCI begins.Initial, a steerable wire is guided through and distal to the block and over it inflatables, goal catheters, atherectomy gadgets, and stents are sent for treatment. ECMO can be utilized as a venovenous (VV-ECMO) circuit for fake aspiratory sidestep or as a venoarterial (VA-ECMO) circuit for fundamental dissemination reclamation. Over late years, a few percutaneous heart intercessions and embed gadgets have been built up that are currently utilized every now and again related to ECMO so as to keep up organ perfusion. Here, we audit the writing on VA-ECMO cannulation area, the utilization of VA-ECMO in intercessions (e.g., coronary mediations and auxiliary heart intercessions), including conclusion and sign for utilization of ECMO support, and percutaneous cardiovascular gadget implantation in VA-ECMO beneficiaries with RCS.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"79 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83783100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial Performance Index in Nephrotic Syndrome","authors":"Salah M. Saleh, Khaled Elmaghraby, Ashraf Mohamed Abdelfadil, Hanem Mohamed","doi":"10.4172/2155-9880.1000585","DOIUrl":"https://doi.org/10.4172/2155-9880.1000585","url":null,"abstract":"Background: Primary or idiopathic nephrotic syndrome (PNS) is the most frequent form of Nephrotic Syndrome in children. There is an increased incidence of heart disease in patients with (PNS). Protein wasting and systemic inflammatory activation during PNS may contribute to cardiac remodeling and dysfunction. Methods: This study was carried out in nephrology unit jointly with cardiology unit in El-Minia University Hospital at the period between March 2015 till December 2016 and included 30 PNS patients as group I and twenty age and sex matched healthy control as group II. Both groups are subjected to full history taking, thorough clinical examination, anthropometric measurements, and lab studies, including serum albumin; renal function tests, 24 h urine protein, and serum cholesterol level. Doppler Echocardiography was used for evaluation of both ventricular hemodynamics, MPI (myocardial performance index) and LV function by LV end systolic diameter, LV end diastolic diameter, LV ejection fraction. Results: The difference between both groups in conventional echo is non-significant, while it is significant in tissue echocardiography in both ventricles including IVRT, IVCT, MPI, E/A, and DT. Ventricular diastolic dysfunction was detected in 30% of patients in whom; diastolic blood pressure (DBP) was significantly higher than those with normal RV diastolic function. Also, DBP not affected by duration of illness and other biochemical parameters.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"9 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88586296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can C-reactive Protein Genetic Variants Identify Patients with Higher and Lower Cardiovascular Risk?","authors":"A. Berezin","doi":"10.4172/2155-9880.1000580","DOIUrl":"https://doi.org/10.4172/2155-9880.1000580","url":null,"abstract":"Recent pre-clinical and clinical studies have revealed the C-reactive protein gene (CRP) is related to the degree of acute rise in plasma C-reactive protein (CRP) levels. Moreover, single nucleotide polymorphisms (SNPs) in the CRP gene could associate with increased risk of cancer, atherosclerosis, diabetes mellitus, bowel disease, rheumatoid arthritis, psoriasis, obstructive pulmonary disease, periodontitis, nonalcoholic fatty liver disease and cardiovascular (CV) diseases. Less is known about the role of variabilities of circulating levels of CRP due to SNPs as an individual biological marker of CV risk and poor clinical outcomes due to CV reasons. The results of clinical trials and some meat-analysis are controversial in this issue. The short commentary is depicted the possible role of SNPs in CRP gene as a personified biological marker of CV risk.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"42 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80668777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Liver Dysfunction, Electrocardiographic Abnormalities and Metabolism in Rat","authors":"F. Ketabchi, A. Sepehrinezhad, A. Dehghanian","doi":"10.4172/2155-9880.1000610","DOIUrl":"https://doi.org/10.4172/2155-9880.1000610","url":null,"abstract":"Introduction: Liver disorders may lead to many critical complications such as electrical heart abnormalities. The aim of this study was to investigate the relationship between the severity of liver dysfunctions, electrocardiogram variables and oxygen consumption. Methods: Female Sprague Dawley rats were divided into 4 groups of sham, partial portal vein ligation (PPVL), common bile duct ligation (CBDL), and combination of them (CBDL+ PPVL). 28 days after the first surgery, animals were anesthetized; ECG recorded and right femoral artery and vein cannulated. Blood gas parameters and complete blood count were measured and the arterial-venous oxygen content difference (A-VO2) calculated. Results: QT interval and QTc in the CBDL+PPVL and CBDL groups were longer than those of the sham and PPVL groups. Furthermore, there were abnormal and bizarre T waves in the CBDL and CBDL+PPVL groups. In the CBDL+PPVL group, arterial O2 pressure was lower while arterial CO2 pressure and plasma concentration of HCO3- were higher than those of the other groups. A-VO2 in the CBDL+PPVL group was also lower than those of the other groups, and in the CBDL group was less than that of the PPVL group. Conclusions: In this study, we detected bizarre T waves and increased QT interval and QTc in the ECG of cirrhotic rats, which could be partly linked to the severity of liver dysfunction and reduction of metabolism.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"2 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90691433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Definition Heart Visualization Using Micro-CT Scanning on Experimental Rats","authors":"Ko-Chin Chen, Alon Arad, Zan-Min Song, D. Croaker","doi":"10.4172/2155-9880.1000606","DOIUrl":"https://doi.org/10.4172/2155-9880.1000606","url":null,"abstract":"","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89592375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Major Clinical Considerations for Secondary Hypertension and Treatment Challenges: Systematic Review","authors":"G. Thevenard, Nathalia Dal-Prá, José Zotarelli Filho","doi":"10.4172/2155-9880.1000616","DOIUrl":"https://doi.org/10.4172/2155-9880.1000616","url":null,"abstract":"Introduction: In this context, secondary arterial hypertension (SH) is defined as an increase in systemic arterial pressure (SAP) due to an identifiable cause. Only 5 to 10% of patients suffering from hypertension have a secondary form, while the vast majorities have essential hypertension. Objective: This study aimed to describe, through a systematic review, the main considerations on secondary hypertension, presenting its clinical data and main causes, as well as presenting the types of treatments according to the literary results. Methods: Following the criteria of literary search with the use of the Mesh Terms that were cited in the item below on \"Search strategies\", the total of 76 papers that were submitted to the eligibility analysis were collated and, after that, 23 studies were selected, following the rules of systematic review-PRISMA. In general, as an example, the search strategy in MEDLINE / Pubmed, Web of Science, ScienceDirect Journals (Elsevier), Scopus (Elsevier), OneFile (Gale). Major findings: According to epidemiological data, secondary hypertension (SH) presents an incidence of 5.0 to 10.0% of the world population. In this context, since SH cases are difficult to screen and expensive, only patients with clinical suspicion should be examined. In recent years, some new aspects have gained importance in relation to this screening. Thus, increasing evidence suggests that 24-hour ambulatory blood pressure monitoring plays a central role. The prevalence of SH is related to age and clinical characteristics. In addition, some residual hypertension remains after the pathogenic cause of secondary hypertension has been identified and removed because of the existence of essential hypertension. Conclusion:It was concluded with the present study that secondary hypertension effects on average 7.5% of hypertensive patients. Screening in the diagnosis of secondary hypertension is expensive and laborious and should be performed only in patients with high clinical suspicion.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"19 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73468835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knockdown and Overexpression of Nmnat in the Heart Improve Cardiac Function When Accompanied by Early Repeated Exercise in Aging Drosophila","authors":"Xia Xiaoxuan, Zheng Lan, Tian Xu, Wen Dengtai, Yue Feng, Wang Hui, Xiushan Wu","doi":"10.4172/2155-9880.1000584","DOIUrl":"https://doi.org/10.4172/2155-9880.1000584","url":null,"abstract":"Aim: To determine whether early exercise in the form of instinctive upward walking can mitigate the negative effects of cardiac aging in Drosophila with cardiac-specific Nmnat Knockdown and overexpression. Methods: Flies were given exercise periods of 2 h per day, 5 days a week for 3 weeks starting when they were 2 days old. The heart model was used in conjunction with M-mode echocardiography traces to analyze cardiac function. Exercise capacity was assessed using a climbing index, and the survival rate was calculated with respect to the age of each subject upon death. Results: Cardiac-specific Nmnat knockdown severely compromised cardiac function with age by increased incidence of arrhythmias and decreased fractional with extreme dilation. The repeated exercise regimen was found to mitigate the deterioration of systolic function and rhythm caused by knockdown of myocardial Nmnat. Unexpectedly, hearts overexpressing Nmnat exhibited similar cardiac function to those of flies with normal expression after exercise training, and provided notable benefits with respect to lifespan and age-related locomotor decline. Conclusions: Nmnat plays a critical role in maintaining cardiac function and that beginning a repeated exercise regimen later in life may improve cardiac health. It may provide a basis for further research in mammals.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"9 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78269911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil Gelatinase-Associated Lipocalin (NGAL) as a Predictive Biomarker for Contrast Induced Nephropathy, in Moderate Risk Patients after Cardiac Catheterization","authors":"H. Asklany, N. Taha, Adel Hamdy, S. Magdy","doi":"10.4172/2155-9880.1000599","DOIUrl":"https://doi.org/10.4172/2155-9880.1000599","url":null,"abstract":"Background: Contrast-induced nephropathy (CIN) is an acute kidney insult (AKI) defined as creatinine (SCr) increase 48 to 72 h after intravenous contrast. Because most subjects undergoing invasive cardiac procedures are discharged within 24 h, SCr is unsuitable for CIN detection. This study compares between serum NGAL, and SCr in moderate risk patients after coronary angiography with/without intervention for the occurrence of CIN. Methods: This was a prospective provisional study carried out from January 2015 to July 2016, in the department of Cardiology, El-Minia University Hospital (EGYPT). 42 moderate risk Subjects (Mehran Score 6 to 10 with estimated 14% risk of developing CIN) undergoing elective coronary angiography with/without intervention were enrolled. Serum NGAL was assessed before and 4 h post-procedure. SCr was measured before and 48 h postprocedure. CIN was defined as SCr increase >25% or >0.5 mg/dL from baseline after coronary angiography within 48 h, without explanation or the presence of any cause. Results: 30 males and 12 females with mean age 54.92 ± 10.14 (36-73) years and mean baseline SCr 1.01 ± 0.25 mg/dl (0.6-1.8) were enrolled. A contrast volume with mean 161.9 ± 76.35 mL (100-300) was administered. CIN was found in twelve subjects (28.6%). Included subjects were classified into those with and without CIN, NGAL was significantly elevated in subjects with CIN versus those without 4 h after coronary intervention 172.69 ± 70.48 (50-280 ng/mL) vs. 104.19 ± 53.03 (75-350 ng/mL) (P<0.001). Using a cutoff value of >174 ng/mL, 4-h NGAL was excellent predictor of CIN with 91.67% sensitivity, 93.33% specificity, 84.6% PPV, 96.6% NPV, 92.86% Accuracy and 92.86 area under (ROC) curve. Baseline demographics show no difference between those with and without CIN among study groups. Serum NGAL at 4 h post procedure (P<0.001) used as a predictor of the occurrence of CIN among study groups. Conclusions: Serum NGAL measured 4 h following coronary angiography with/without intervention after intravenous contrast administration can be used as a novel and helpful biomarker for the occurrence of CIN in moderate risk patient. The percentage of CIN incidence (28.6%) in this study in moderate risk patients highlight the useful use of serum NGAL 4 h post procedure measurement to predict, intervene and may prevent CIN.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"11 1 1","pages":"2-5"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78386830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Short, Medium and Long-term Prognosis of Pulmonary Embolism","authors":"S. A. Sarr","doi":"10.4172/2155-9880.1000615","DOIUrl":"https://doi.org/10.4172/2155-9880.1000615","url":null,"abstract":"Introduction: Pulmonary Embolism (PE) is the most severe form of venous thromboembolic disease. This is a serious condition not only because of its mortality but also its sequelae. Methodology: The aim of this study is to evaluate the prognosis of patients who had an episode of PE, hospitalized in the cardiology department of the Aristide Le Dantec University Hospital in Dakar. We performed a cohort study that included all patients admitted for pulmonary embolism during the period of May 1, 2011 to February 29, 2016. Subjects were contacted for a re-evaluation during the period of August 1st to September 1st 2016. We evaluated the status of patients (death or alive), to look for signs of chronic pulmonary heart based on the electrocardiogram (right atrial and ventricular hypertrophies, aspect S1S2S3, right bundle branch) and especially on the echocardiogram (right cavitary and parietal dimensions, measurement of the PASP). Results: A total of 77 pulmonary embolism cases were counted during the study period; 70 files were retained. It was a predominantly female population, with an average age of 51.2. Low risk forms (PESI I-II) accounted for 85.7% of the sample, versus 14.3% of PESI III-IV-V forms. At the re-evaluation, we counted 18 deaths (25.7%); twenty-two patients were lost to follow up. No recurrence was noted since hospitalization. Two patients had bilateral, noninflammatory edema. Dyspnea was found in 3 patients. No patient had any sign of right heart failure. Doppler echocardiography showed dilatation of the right ventricle along parasternal long axis in 6 cases and along apical section in 5 cases respectively. Right ventricular wall hypertrophy was noted in 6 patients. The systolic function of the right ventricle was normal in all cases. The right atrium was dilated in 5 cases. Pulmonary hypertension and increased pulmonary vascular resistance were noted in 7 cases, respectively. The overall mortality factors were acute circular insufficiency, right ventricular systolic dysfunction, PESI score of at least 1, tachycardia, PASP value greater than 50 mmHg, right heart failure and dilatation of the right atrium. Conclusion: Wall dilatation and hypertrophy of the right ventricle as well as pulmonary hypertension are frequent sequelae. The parameters of the hemodynamic impact of pulmonary embolism constitute the main prognostic factors.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79501303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eagle Syndrome Causing a False Aneurysm of the Internal Carotid Artery","authors":"H. BenJmaà, A. Lagha, N. Farhat, O. Kammoun, S. Masmoudi, N. Elleuch, I. Frikha","doi":"10.4172/2155-9880.1000581","DOIUrl":"https://doi.org/10.4172/2155-9880.1000581","url":null,"abstract":"Eagle syndrome is asyndrome caused by elongation of the styloid process. It may cause recurrent throat and facial pain, foreign body sensation, otalgia, dysphagia. Vascular complications of this syndrome are rare. We report a case of a distal located false aneurysm of the internal carotid artery caused by this syndrome and diagnosed after a cervical trauma.","PeriodicalId":15504,"journal":{"name":"Journal of Clinical and Experimental Cardiology","volume":"74 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77175664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}