Journal of Clinical Neuroscience最新文献

{"title":"Clinical and psychological factors associated with fear of relapse in people with multiple sclerosis: A cross-sectional study","authors":"Elham Moases Ghaffary ,&nbsp;Mohammad Yazdan Panah ,&nbsp;Saeed Vaheb ,&nbsp;Hamed Ghoshouni ,&nbsp;Aysa Shaygannejad ,&nbsp;Maedeh Mazloomi ,&nbsp;Vahid Shaygannejad ,&nbsp;Omid Mirmosayyeb","doi":"10.1016/j.jocn.2025.111210","DOIUrl":"10.1016/j.jocn.2025.111210","url":null,"abstract":"<div><h3>Background</h3><div>Fear of relapse (FoR) is one of the main psychological concerns in people with relapsing-remitting multiple sclerosis (PwRRMS). It has disastrous consequences on treatment adherence, quality of life (QoL), and clinical course. Although the issue is closely linked to psychosocial aspects, it is not widely explored despite its overall impact on managing the condition. The determinants of FoR are vital for the optimization of therapeutic intervention toward ensuring patient welfare.</div></div><div><h3>Methods</h3><div>This cross-sectional study, carried out in Isfahan, Iran, from December 2023 to September 2024, investigated demographic, clinical, and psychological characteristics in PwRRMS. The level of FoR was measured by the Fear of Relapse Scale, and for anxiety, depression, and obsessive–compulsive symptoms, the Beck Anxiety Inventory (BAI), Beck Depression Inventory-II (BDI-II), and the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) were used, respectively. Correlation between these factors were analyzed using linear regression.</div></div><div><h3>Results</h3><div>A total of 189 PwRRMS were included. Multivariable linear regression analysis identified significant correlation between the higher annualized relapse rate (ARR) (B = 10.18, standardized 0.14, <em>p</em>-value &lt; 0.05), anxiety (B = 0.32, standardized β = 0.19, <em>p</em>-value &lt; 0.05), depression (B = 0.63, standardized β = 0.42, <em>p</em>-value &lt; 0.001) and Expanded Disability Status Scale (EDSS) (B = 2.19, standardized β = 0.11, <em>p</em>-value &lt; 0.05) with the FoR among PwRRMS. On the other hand, other demographic, clinical, and psychological variables, including disease duration, disability, and obsessive behavior, were found to lack a significant correlation with FoR (<em>p</em>-value &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>This study points out that ARR, anxiety, and depression are among the leading independent risk factors of FoR in PwRRMS. Given the great potential for attenuation with focused treatments and psychological consultation, becoming major contributors to the decrease of FoR and, importantly, to improved overall patient well-being, their proper management and clinical follow-up should be considered an important issue in dealing with such patients.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"135 ","pages":"Article 111210"},"PeriodicalIF":1.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143747102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship between blood urea nitrogen to creatinine ratio and hemorrhagic transformation in stroke patients treated with endovascular thrombectomy","authors":"Fettah EREN,&nbsp;Cahit AYAN,&nbsp;Ayşe AVCI,&nbsp;Omar ELQUTOB,&nbsp;Gokhan OZDEMIR,&nbsp;Şerefnur OZTURK","doi":"10.1016/j.jocn.2025.111217","DOIUrl":"10.1016/j.jocn.2025.111217","url":null,"abstract":"<div><h3>Background</h3><div>This study aimed to determine the parameters associated with hemorrhagic transformation in EVT and its relationship with blood urea nitrogen to creatinine (BUN/Cr) ratio-based dehydration status.</div></div><div><h3>Methods</h3><div>Patients’ data treated with EVT in AIS were evaluated from the years 2018 to 2023.</div><div>Venous blood samples were collected prior to operation and BUN/Cr ratio was calculated. Alberta stroke program early CT (ASPECT) and collateral scores were determined. Hemorrhagic transformation was assessed by brain computed tomography. Mortality and 90-day disability rates were determined. Parameters associated with hemorrhagic transformation were evaluated according to regression analysis models.</div></div><div><h3>Results</h3><div>There were 146 patients with a mean age of 67.01 ± 14.34 in the study. The first-pass thrombectomy rate was 32.2 % (n = 47); and 80.8 % (n = 118) of all patients achieved complete recanalization. Symptom-to-puncture and puncture-to-recanalization times were associated with hemorrhagic transformation (p = 0.004, p = 0.012). In addition, initial NIHSS (p &lt; 0.001), number of thrombectomy passes (p &lt; 0.001), intra-arterial thrombolysis (p = 0.008), ASPECT score (p &lt; 0.001), collateral score (p = 0.016), and serum glucose (p = 0.047) levels were associated with hemorrhagic transformation. Decreased glomerular filtration rate (p = 0.007) was associated with symptomatic hemorrhagic transformation. Multivariate regression analysis revealed that the major parameters for hemorrhagic transformation were initial NIHSS and number of thrombectomy passes (p = 0.035, p = 0.046). No relationship was observed between BUN/Cr ratio and hemorrhagic transformation (p = 0.910).</div></div><div><h3>Conclusion</h3><div>In this study, no relationship was detected between BUN/Cr ratio-based dehydration and hemorrhagic transformation in AIS patients treated with EVT. The main predictive factors for hemorrhagic transformation are high initial NIHSS and number of thrombectomy passes.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111217"},"PeriodicalIF":1.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannitol vs placebo for brain relaxation in cerebellopontine angle tumor surgeries: A randomized controlled trial","authors":"Sabina Regmi ,&nbsp;Nidhi Singh ,&nbsp;Kiran Jangra ,&nbsp;Gurucharan Dasari ,&nbsp;Steve Joys ,&nbsp;Hemant Bhagat ,&nbsp;Sandeep Mohindra ,&nbsp;Saurav Mishra","doi":"10.1016/j.jocn.2025.111199","DOIUrl":"10.1016/j.jocn.2025.111199","url":null,"abstract":"<div><h3>Objective</h3><div>Mannitol is widely used for intraoperative brain relaxation, but its benefit in posterior fossa lesions is still debatable. Hence, we aimed to compare mannitol with placebo for brain relaxation score (BRS) in cerebellopontine angle (CPA) tumor surgeries in the supine position and assess secondary outcomes including serum electrolytes, osmolality, hemodynamic parameters, complications, and postoperative acute kidney injury (AKI) and hospital stay.</div></div><div><h3>Methods</h3><div>This single-center, double-blind, randomized controlled trial was initiated after institute review board approval and Clinical Trial registration. Patients undergoing CPA tumor resection in the supine position were randomly assigned to mannitol (Group-M, received 1 g/kg of mannitol) or placebo group (Group-P, received 0.9 % saline). BRS was assessed after dura opening, and serum electrolytes and osmolarity were measured at baseline and postoperatively.</div></div><div><h3>Results</h3><div>Sixty-three patients were analyzed, 33 in group-M and 30 in group-P. The BRS was comparable between group-M [2 (1.5–3)] and group-P [2 (2–3)], <em>P</em> = 0.721. Intraoperatively, serum sodium was significantly lower [139.7 (3.5) vs. 142 (3.6), <em>P</em> = 0.011], serum potassium was higher [3.8 (0.6) vs. 3.4 (0.43), <em>P</em> = 0.003], systolic blood pressure was lower [114 (9.9) vs. 121 (9.7), <em>P</em> = 0.007], and urine output was higher [1162 (488.6) vs. 737 (395.9), <em>P</em> &lt; 0.001] in group-M compared to group-P, respectively.</div></div><div><h3>Conclusion</h3><div>Brain relaxation during posterior fossa surgery is essential for optimizing surgical access and reducing complications. The current study suggests that mannitol may not significantly provide brain relaxation in patients undergoing CPA tumor resection in the supine position. However, further research is needed to establish definitive conclusions regarding its use in posterior fossa surgeries.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111199"},"PeriodicalIF":1.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commenting on: \"The effect of clay therapy on hopelessness and depression levels in chronic stroke patients in addition to physical therapy\".","authors":"Muhammad Zarrar","doi":"10.1016/j.jocn.2025.111212","DOIUrl":"https://doi.org/10.1016/j.jocn.2025.111212","url":null,"abstract":"","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":" ","pages":"111212"},"PeriodicalIF":1.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Degenerative disc disease and isthmic spondylolisthesis have similar outcomes after L5-S1 anterior lumbar interbody fusion","authors":"Bryce A. Basques ,&nbsp;Sapan D. Gandhi ,&nbsp;Samuel S. Rudisill ,&nbsp;Alejandro Perez-Albela ,&nbsp;Frank M. Phillips","doi":"10.1016/j.jocn.2025.111207","DOIUrl":"10.1016/j.jocn.2025.111207","url":null,"abstract":"<div><h3>Background and Objective</h3><div>Anterior lumbar interbody fusion (ALIF) at L5-S1 is commonly performed for both isthmic spondylolisthesis (IS) and degenerative disc disease (DDD). However, the comparative clinical outcomes of ALIF in these two conditions remain unclear. This study aims to compare the clinical outcomes of L5-S1 ALIF for IS and DDD, focusing on patient-reported outcome measures and the achievement of minimum clinically important difference (MCID).</div></div><div><h3>Materials and Methods</h3><div>This retrospective cohort study analyzed 93 consecutive patients who underwent L5-S1 ALIF with percutaneous posterior instrumentation for IS (n = 37) or stand-alone L5-S1 ALIF for DDD (n = 56). Patient-reported outcomes included Visual Analog Scale (VAS)-back, VAS-leg, Oswestry Disability Index (ODI), Short-Form Health Survey (SF-12), and Veterans RAND 12-item Health Survey (VR-12). Outcomes were assessed preoperatively and at the final postoperative follow-up. Changes between timepoints and the proportion of patients achieving MCID for VAS and ODI were compared between the IS and DDD groups.</div></div><div><h3>Results</h3><div>The two groups were similar in age, sex, and ASA scores, although DDD patients had a slightly higher BMI (29.99 vs. 27.32, p = 0.012). Preoperative VAS-back, VAS-leg, and ODI scores did not differ between groups; however, DDD patients had significantly lower SF-12 and VR-12 scores (p = 0.024 for each). At final follow-up, clinical outcomes for VAS-back, VAS-leg, ODI, and VR-12 were comparable between the groups, though DDD patients had slightly worse SF-12 scores (−6.7, p = 0.021). Improvement from baseline to final follow-up was similar for both groups, and the proportion achieving MCID for VAS-back, VAS-leg, and ODI did not differ significantly.</div></div><div><h3>Conclusion</h3><div>Despite inferior preoperative and final postoperative scores, patients with DDD experienced similar clinical improvement and outcomes after L5-S1 ALIF compared to patients with IS. Moreover, DDD patients were equally likely as IS patients to achieve MCID at final follow-up, suggesting that ALIF is an effective treatment option for both conditions.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"136 ","pages":"Article 111207"},"PeriodicalIF":1.9,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143725628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimally invasive surgery for non-traumatic spontaneous intracerebral Hemorrhage: A network Meta-Analysis of multiple treatment modalities","authors":"Rabeet Tariq ,&nbsp;Salaar Ahmed ,&nbsp;Mohammad Aadil Qamar ,&nbsp;Mohammad Hamza Bajwa ,&nbsp;Abdu R Rahman ,&nbsp;Saad Akhtar Khan ,&nbsp;Roua Nasir ,&nbsp;Jai Kumar Das","doi":"10.1016/j.jocn.2025.111196","DOIUrl":"10.1016/j.jocn.2025.111196","url":null,"abstract":"<div><h3>Introduction</h3><div>Spontaneous Supratentorial Intracerebral Hemorrhage (SICH) is a severe condition with high mortality and morbidity, annually affecting around 2 million people globally. Current treatment guidelines emphasize medical management however, Minimally Invasive Surgery (MIS), including stereotactic and endoscopic approaches, has shown promise in improving outcomes. This network <em>meta</em>-analysis aims to compare the efficacy and safety of MIS with conventional craniotomy, burrhole catheter insertion, and medical treatment for the management of SICH.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, a comprehensive literature search across three databases to identify relevant studies. Data extracted included demographics, treatment outcomes, and adverse effects, while the quality of studies was assessed using the NHLBI tool. A network <em>meta</em>-analysis was performed using RStudio to compare the effectiveness of MIS approaches with other treatment modalities.</div></div><div><h3>Results</h3><div>MIS for SICH was more effective than conservative medical management in reducing mortality (OR: 1.991; 95% CI, 1.364–2.907) but did not show a mortality benefit compared to conventional surgery, external ventricular drainage (EVD), or burr hole procedures. MIS had similar hematoma evacuation rates to conventional surgery and burr hole drainage but required significantly less operating time (SMD: 3.837; 95% CI, 2.851–4.823) and reduced ICU stay (SMD: 4.436; 95% CI, 2.386–6.486). Conventional surgery had higher risks of blood loss, seizures, GI bleed/ulceration, and pneumonia/RTI, while MIS showed a safer profile regarding these complications. There was no significant difference in rebleeding (OR: 1.492; 95% CI, 0.632–3.522) or reoperation rates (OR: 0.494; 95% CI, 0.120–2.039) between MIS, conventional surgery, and conservative treatment.</div></div><div><h3>Conclusion</h3><div>MIS significantly reduces mortality compared to conservative treatment while offering similar outcomes to other surgeries. MIS also has advantages like shorter operating times, reduced ICU stays, and fewer complications, making it a promising alternative for managing SICH.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"135 ","pages":"Article 111196"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary: Coexistence of anti-NMDA receptor (NMDAR) encephalitis and MOGAD","authors":"Vasileios-Periklis Stamatellos","doi":"10.1016/j.jocn.2025.111213","DOIUrl":"10.1016/j.jocn.2025.111213","url":null,"abstract":"","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"135 ","pages":"Article 111213"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trans-arterial approach for neural recording and stimulation: Present and future","authors":"Jian Liu ,&nbsp;Xinjian Yang ,&nbsp;Basel Musmar ,&nbsp;David M. Hasan","doi":"10.1016/j.jocn.2025.111180","DOIUrl":"10.1016/j.jocn.2025.111180","url":null,"abstract":"<div><div>Neural recording and stimulation are fundamental techniques used for brain computer interfaces (BCIs). BCIs have significant potential for use in a range of brain disorders. However, for most BCIs, electrode implantation requires invasive craniotomy procedures, which have a risk of infection, hematoma, and immune responses. Such drawbacks may limit the extensive application of BCIs. There has been a rapid increase in the development of endovascular technologies and devices. Indeed, in a clinical trial, stent electrodes have been endovascularly implanted via a venous approach and provided an effective endovascular BCI to help disabled patients. Several authors have reviewed the use of endovascular recordings or endovascular BCIs. However, there is limited information on the use of <em>trans</em>-arterial BCIs. Herein, we reviewed the literature on the use of <em>trans</em>-arterial neural recording and stimulation for BCIs, and discuss their potential in terms of anatomical features, device innovations, and clinical applications. Although the use of <em>trans</em>-arterial recording and stimulation in the brain remains challenging, we believe it has high potential for both scientists and physicians.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"135 ","pages":"Article 111180"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebral cavernous Malformation Surgery: National trends in Volume, Complications, and costs","authors":"Avi A. Gajjar ,&nbsp;Ilayda Kayir ,&nbsp;Alyssa Lee ,&nbsp;Rashad Jabarkheel ,&nbsp;Mohamed M. Salem ,&nbsp;Lun Li ,&nbsp;Joshua Catapano ,&nbsp;Visish M. Srinivasan ,&nbsp;Jan-Karl Burkhardt","doi":"10.1016/j.jocn.2025.111178","DOIUrl":"10.1016/j.jocn.2025.111178","url":null,"abstract":"<div><h3>Background and Objectives</h3><div>Cerebral cavernous malformations (CCMs) are vascular anomalies that can lead to significant neurological complications, such as hemorrhage or lesion progression. This study analyzes trends in CCM resections across the United States, focusing on morbidity, mortality, and associated costs.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on the National Inpatient Sample who underwent CCM resections from 2016 to 2020. Data were collected from a national database, including patient demographics, outcomes, and costs. Statistical analysis was performed to identify factors associated with in-hospital mortality, complications, length of stay (LOS), and cost.</div></div><div><h3>Results</h3><div>The patient cohort identified 3,300 patients with a mean age of 42.8 years, with a slight female predominance (53.5 %) and a majority identifying as white (66.5 %). Complications occurred in 8.5 % of cases, with acute bleeding significantly increasing the risk of complications (OR = 2.15, p &lt; 0.001), non-home discharge (OR = 2.52, p &lt; 0.001), and extended LOS (OR = 3.21, p &lt; 0.001). Non-elective admissions were associated with higher rates of complications (17.0 % vs. 3.4 %, p &lt; 0.001) and extended LOS (OR = 2.84, p &lt; 0.001). Independent factors for poor outcomes included higher Charlson Comorbidity Index (CCI) scores (OR = 1.417, p &lt; 0.01) and patient demographics such as age and race, with Black race (OR = 6.84, p = 0.0199) and lower household income (OR = 2.17, p &lt; 0.01) being significant predictors of in-hospital mortality.</div></div><div><h3>Conclusion</h3><div>This study highlights the significant impact of acute bleeding and non-elective admissions on complications and outcomes following CCM resection. Further research is warranted to analyze socio-economic factors in improving CCM resection outcomes and explore possible pharmacological treatment approaches in high-risk surgical patients.</div></div>","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"135 ","pages":"Article 111178"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non contiguous dual level spinal injuries – A tertiary care centre institutional experience","authors":"Sarvesh Goyal,&nbsp;Mahnaaz Sultana Azeem,&nbsp;Ravi Sharma,&nbsp;Vivek Tandon,&nbsp;Kanwaljeet Garg,&nbsp;Pankaj Kumar Singh,&nbsp;Guru Dutta Satyarthee,&nbsp;Deepak Gupta,&nbsp;Deepak Agrawal,&nbsp;Shashank Sharad Kale","doi":"10.1016/j.jocn.2025.111198","DOIUrl":"10.1016/j.jocn.2025.111198","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;Non-contiguous Dual level spine injuries (NDSI) are not uncommon in cases of high energy trauma and can carry very high morbidity if not recognized and treated. There is lack of literature and proper guidelines on such injuries.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Aim&lt;/h3&gt;&lt;div&gt;In this study, we plan to understand the demographics, clinical characteristics, management, outcome and prognosis of NDSI in patients presenting to our tertiary care trauma centre from 2015 to 2024.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;We retrospectively reviewed the online and offline database of AIIMS to search for cases of NDSI. Total of 38 patients were found whose data were studied.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Statistical analysis&lt;/h3&gt;&lt;div&gt;SPSS version 23 was used to carry out statistical analysis.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;3.01% of total patients with spine injury had NDSI.&lt;/div&gt;&lt;div&gt;28 patients (73.7 %) were male while 10 patients (26.3 %) female. Mean age of patients was 37.86 years (range – 16 years – 60 years).&lt;/div&gt;&lt;div&gt;Out of 38 patients, 22 patients (57.9 percent) had history of Fall from height and 16 patients (42 percent) had history of Road traffic accident (High velocity).&lt;/div&gt;&lt;div&gt;Most common injury pattern was Cervicothoracic (15 patients, 39.5 %) followed by thoracolumbar (13 patients, 34.2 %), cervicocervical (4 patients, 10%), cervicolumbar (2 patient, 5.3 %). Associated injuries included head injury finding in 5 patients, chest injuries in 15, extremity injuries in 7 and abdominal injuries in 2.&lt;/div&gt;&lt;div&gt;Out of 38, 30 patients had total of 2 noncontigous segment involvement, 6 had 3 and 2 had 4 non-contiguous segment involvement. Out of 38, 16 patients were managed with fixation aimed at 1 segment, whereas 21 patients required fixation of both the non-contiguous segments.&lt;/div&gt;&lt;div&gt;Surgical management of unstable cervical, thoracic, and lumbar fractures involved stabilization through spinal fusion, decompression to relieve pressure on neural elements, and instrumentation with screws, rods, or plates. Procedures done included Anterior odontoid screw for odontoid fracture, ACDF (Anterior cervical discectomy and fusion), ACCF (Anterior cervical corpectomy and fusion), posterior LMSRF (Lateral mass screw rod fixation) for cervical fractures, and posterior decompression and pedicle screw fixation for unstable thoracic and lumbar fractures. Minor injuries and stable compression fractures were managed conservatively. The approach depends on fracture type, location, clinical neurology of patient, finally aiming to restore alignment, stabilize the spine, and prevent neurological deficits.&lt;/div&gt;&lt;div&gt;At admission, 13 patients (34%) were ASIA A, 4 ASIA B(10.5%), 6 ASIA C(15.8%), 5 ASIA D (13.2%) and 10 ASIA E(26.3%).&lt;/div&gt;&lt;div&gt;10 patients required tracheostomy. 4 patients developed pneumonia during their hospital course. 36 patients were discharged, but 2 patients died due to associated sepsis, dyselectrolytemia, pneumonia.&lt;/div&gt;&lt;","PeriodicalId":15487,"journal":{"name":"Journal of Clinical Neuroscience","volume":"135 ","pages":"Article 111198"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143704248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}