Journal of Clinical and Translational Research最新文献

{"title":"Current characteristics of a population of psoriatic arthritis and gender disparities","authors":"Jimmy Menis, Marie Doussière, Estelle Touboul, Vincent Barbier, J. Sobhy-Danial, P. Fardellone, M. Fumery, G. Chaby, V. Goëb","doi":"10.18053/jctres.09.202302.001","DOIUrl":"https://doi.org/10.18053/jctres.09.202302.001","url":null,"abstract":"Background and Aim: Psoriatic arthritis (PsA) is a polymorphic disease associated with numerous comorbidities. The objective of this study was to describe the main clinicobiological and imaging characteristics of a population of PsA and to extract any disparities between men and women. Methods: A total of 132 patients in the rheumatology department of Amiens University Hospital with a confirmed diagnosis of PsA according to the CASPAR criteria were included over a period of 4 months. All data were collected retrospectively in this observational and single-center study. Results: The sex ratio was 1 and the average age at inclusion was 54.9 years. Peripheral PsA was the predominant clinical form. Axial PsA represented 12.1% of cases. Enthesitis was noted in 52.3% of cases while dactylitis was identified in 29.5% of cases. Moreover, 12.1% had a joint symptomatology preceding the appearance of cutaneous signs. HLA-B*27 positivity was found in 33.3% of cases. Chronic hyperuricemia accounted for 10% of our population. Sacroiliitis was observed in 41% of cases. The disparities between men and women are multiple and consistent with the literature: Polyarticular form, enthesitis, obesity, more intensive prescription of s-DMARDs, and b-DMARDs are more associated with the female population. Oligoarticular form, psoriatic nail dystrophy, radiological axial involvement, and chronic hyperuricemia are more encountered in the male population. Conclusions: Our study found a very heterogeneous disease, with marked differences between men and women. Peripheral PsA remains predominant but the search for associated axial involvement, which is probably underestimated, seems essential. Relevance for Patients: This work studied the main characteristics of patients with PsA followed in real life, in a regional university reference center. We have highlighted a very heterogeneous disease as well as some gender disparities, not well described in the literature, which should be taken into account in order to optimize therapeutic management.","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"32 1","pages":"84 - 92"},"PeriodicalIF":0.0,"publicationDate":"2023-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78643148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacopa monnieri supplementation has no effect on serum brain-derived neurotrophic factor (BDNF) levels but beneficially modulates NF-kB and CREB levels in healthy elderly subjects","authors":"","doi":"10.18053/jctres.09.202301.007","DOIUrl":"https://doi.org/10.18053/jctres.09.202301.007","url":null,"abstract":"","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"51 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77241107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological findings in celiac disease patients enrolled for duodenal biopsy in Najran, Saudi Arabia: a five-year retrospective study","authors":"","doi":"10.18053/jctres.09.202304.22-00189","DOIUrl":"https://doi.org/10.18053/jctres.09.202304.22-00189","url":null,"abstract":"","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"62 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82068664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal gait and fatigue do not change when using common at-home gait tasks in patients with Facioscapulohumeral Muscular Dystrophy: a pilot study","authors":"","doi":"10.18053/jctres.09.202302.004","DOIUrl":"https://doi.org/10.18053/jctres.09.202302.004","url":null,"abstract":"","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83416416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNAs in the regulation of Wnt/β-Catenin, NF-kB, PI3K/AKT, STAT3, p53, and Hedgehog pathway","authors":"","doi":"10.18053/jctres.09.202304.22-00195","DOIUrl":"https://doi.org/10.18053/jctres.09.202304.22-00195","url":null,"abstract":"","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"224 4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77968082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in place of death in patients with idiopathic pulmonary fibrosis: a ten-year analysis of the United States National Center for Health Statistics WONDER database","authors":"","doi":"10.18053/jctres.09.202303.002","DOIUrl":"https://doi.org/10.18053/jctres.09.202303.002","url":null,"abstract":"","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74020934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the endoscopic keyhole technique have advantages over the microscopic keyhole technique for treating cervical radiculopathy?","authors":"","doi":"10.18053/jctres.09.202304.23-00023","DOIUrl":"https://doi.org/10.18053/jctres.09.202304.23-00023","url":null,"abstract":"","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83651072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of health-related quality of life in improving cancer outcome","authors":"","doi":"10.18053/jctres.09.202302.006","DOIUrl":"https://doi.org/10.18053/jctres.09.202302.006","url":null,"abstract":"","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"76 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90577768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug-induced liver injury associated with liraglutide use: a case-based review of detection, severity, causality assessment, and clinical outcomes","authors":"","doi":"10.18053/jctres.09.202303.004","DOIUrl":"https://doi.org/10.18053/jctres.09.202303.004","url":null,"abstract":"","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85641139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic outcomes of early and delayed ERCP and PTCD in patients with obstructive severe acute biliary pancreatitis","authors":"","doi":"10.18053/jctres.09.202303.007","DOIUrl":"https://doi.org/10.18053/jctres.09.202303.007","url":null,"abstract":"","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86903209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}