Journal of Clinical and Translational Research最新文献

{"title":"Utilizing radiomic features of arterial phase computed tomography for delineating parathyroid adenomas from surrounding anatomical structures","authors":"Chime Ezenekwe, Michael H. Zhang, Irfan Hussain, Yurong Zhang, Daniel T. Ginat","doi":"10.36922/jctr.23.00112","DOIUrl":"https://doi.org/10.36922/jctr.23.00112","url":null,"abstract":"Aim: The study aimed to correlate radiomic data of four-dimensional computed tomography (4D-CT) with pathology-proven parathyroid adenomas to identify and quantitate select dimensional and textural features that predict parathyroid adenomas with a high degree of confidence, with the ultimate goal of improving the reliability of parathyroid adenoma detection so as to facilitate the subsequent unilateral minimally invasive parathyroidectomy (MIP).\u0000Methods: A total of 144 subjects with a history of neck 4D-CT, parathyroidectomy, and intraoperative pathology-proven parathyroid adenoma(s) were retrospectively reviewed. Following the exclusion of patients with a thyroidectomy, unsuccessful surgery, or indeterminate localization of the parathyroid adenoma on 4D-CT, a preliminary sample of 20 patients was obtained. Four anatomical structures (carotid artery, internal jugular vein, thyroid, and parathyroid adenoma) were segmented twice on 25-second arterial phase axial sections of a 4D-CT, and radiomic data of the shape, first-order, and second-order classes (106 variables) were extracted from the four structures for each patient.\u0000Results: Select radiomic variables among the carotid artery, jugular vein, and thyroid groups exhibited overall significant differences when compared to the parathyroid adenoma data (P < 0.05). Further Tukey’s post hoc analysis revealed that, when the parathyroid adenoma group was treated as the reference, 11/16 shape class, 16/18 first-order class, and 46/69 second-order class variables significantly differ from the carotid artery, jugular vein, and/or thyroid group(s). In addition, we found that the thyroid has distinct textural features compared to the parathyroid group, with 1/18 first-order and 19/69 second-order variables differing significantly between the two (P < 0.05). Notably, the texture variables such as dependence non-uniformity, long run emphasis, run percentage, run variance, and busyness exhibited the highest level of differences between the two groups (P < 0.0001).\u0000Conclusion: The parathyroid adenoma group is associated with a unique set of radiomic variables in comparison to surrounding anatomy such as the carotid artery, internal jugular vein, and thyroid.\u0000Relevance for Patients: The distinct, quantifiable differences in dimensional and textural features serve as a set of signature markers distinguishing parathyroid adenomas from their surrounding structures in 4D-CT. These attributes obviate the need for invasively locating parathyroid adenomas preoperatively, thereby enhancing the utilization rate of MIP, which has a favorable implication in the overall clinical outcomes.","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"8 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140654242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of lumbar self-sustained natural apophyseal glides on lumbar spine range of motion and hip muscle flexibility in asymptomatic college students: a crossover study","authors":"Yuto Kikuchi, Kiyokazu Akasaka, Takahiro Otsudo, Hiroshi Hattori, Y. Hasebe, Yuji Hamada, Toby Hall","doi":"10.36922/jctr.23.00091","DOIUrl":"https://doi.org/10.36922/jctr.23.00091","url":null,"abstract":"Background: Patients with low back pain (LBP) tend to have prolonged treatment periods, which increase the cost of medical care. Several studies have reported that lumbar spine range of motion (ROM) and hip muscle flexibility are factors in LBP. Sustained natural apophyseal glides (SNAGs) have reportedly improved the lumbar spine ROM and hip flexibility of LBP patients. Moreover, self- SNAGs can be performed by the patients themselves. \u0000Aim: This study aimed to evaluate the short-term effects of self-SNAGs on lumbar spine ROM compared to a repeated movement procedure in asymptomatic college students.\u0000Methods: A prospective crossover study was conducted on 14 asymptomatic male college students. The asymptomatic participants performed self-SNAGs or repeated movements (i.e., three sets per day, 6 times a day over 1 week), and the compliance rate for both exercises was recorded. The lumbar spine ROM (i.e., flexion, extension, lateral bending, and rotation) was measured using the back ROM instrument, and hip muscle flexibility was measured using the Thomas test, heel-buttock distance, finger-floor distance, and straight leg raise test (SLR). Measurements were taken before commencement, immediately after, and 1 week later.\u0000Results: Left lateral bending and left SLR were excluded from the between-group comparison (self- SNAG and sham) due to a carryover effect (P < 0.05). A comparison between the self-SNAG and sham groups displayed no significant differences in the lumbar spine ROM and hip muscle flexibility (P > 0.05).\u0000Conclusion: Our study revealed that lumbar self-SNAGs had no significant effect on lumbar spine ROM or hip muscle flexibility in the short term, suggesting that such movements should be avoided when stretching to prevent LBP. However, this study did not include subjects with limited lumbar spine ROM and hip muscle flexibility due to pain, warranting further validation in future studies.\u0000Relevance for Patients: The effects of lumbar self-SNAGs were similar to that of sham exercises in healthy individuals without joint ROM restrictions in the trunk or lower extremities due to LBP","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"12 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140656255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the effects of pulsed microcurrent on pain, depression, and anxiety in patients with herpes zoster","authors":"Li Wang, Jingxuan Liu, Jing Wang, Yurong Zhang, Junwu Zhang","doi":"10.36922/jctr.23.00121","DOIUrl":"https://doi.org/10.36922/jctr.23.00121","url":null,"abstract":"Background: Herpes zoster is a common viral skin infection and has a high incidence rate in China. At present, conventional drugs combined with adjuvant measures are used for treatment. To improve the efficiency and shorten the time of treatment, we propose the use of pulsed microcurrent as a new adjuvant therapy.\u0000Aim: This study aimed to investigate the effects of pulsed microcurrent on pain, depression, and anxiety in patients with herpes zoster.\u0000Methods: A total of 58 patients with herpes zoster who were admitted to our hospital between April and August 2022 were selected as study participants and divided into two groups. The control group (n = 29) received conventional drug therapy, while the experimental group (n = 29) received pulsed microcurrent electrical therapy in combination with conventional drug therapy.\u0000Results: After 14 days of treatment, the scores from the visual analog scale, patient health questionnaire (PHQ) (i.e., PHQ-9), and generalized anxiety disorder (GAD) assessment (i.e., GAD-7) of the experimental group were reportedly significantly lower than those the control group (P < 0.05).\u0000Conclusion: These findings suggested that pulsed microcurrent electrical therapy combined with conventional drug therapy could effectively alleviate the pain, depression, and anxiety symptoms in patients with herpes zoster, highlighting its potential to be widely used in clinical practice.\u0000Relevance for Patients: Patients suffering from herpes zoster may opt for pulsed microcurrent electrical therapy to effectively alleviate the pain, depression, and anxiety symptoms.","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"49 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140750632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue engineering and regenerative medicine in otorhinolaryngology","authors":"Konstantina Dinaki, Nikolaos Grigoriadis, Ioannis Vizirianakis, Jannis Constantinidis, S. Triaridis, Petros Karkos","doi":"10.36922/jctr.22.00151","DOIUrl":"https://doi.org/10.36922/jctr.22.00151","url":null,"abstract":"Background and Aim: Regenerative medicine has been gaining popularity in the field of medicine, and the possibilities for tissue regeneration are immense in the field of otorhinolaryngology, which involves sensory organs and vital functions such as breathing and swallowing. Regenerative strategies offer the potential to restore functions such as hearing, facial expression, olfaction, and speaking, thereby reducing the disadvantages and risks related to traditional reconstruction strategies. This review summarizes the progress of regenerative medicine in otology and hearing, laryngeal surgery, rhinology, and craniofacial reconstruction.\u0000Relevance for Patients: Patients can be informed about the progress of regenerative medicine in the field of otorhinolaryngology and how it has evolved to ameliorate the symptoms of common diseases or cure even more severe ones.","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"64 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between various oral health literacy scales among university students in Jaipur, India","authors":"Poonam Jangid, Naganandini Sampath, S. Mahuli, A. V. Mahuli, R. Yadav","doi":"10.36922/jctr.23.00100","DOIUrl":"https://doi.org/10.36922/jctr.23.00100","url":null,"abstract":"Background: Oral health literacy (OHL) is a multidimensional concept that encompasses reading, writing, speaking, listening, proper decision-making skills, assessment of OHL level, and comparison between scales. Numerous tools are available to measure OHL using a range of indicators.\u0000Aim: The purpose of this study is to compare three OHL scales, namely, Rapid Estimate of Adult Literacy in Medicine and Dentistry-20 (REALMD-20), OHL Adults Questionnaire (OHL-AQ), and Health Literacy in Dentistry (HeLD), among university students in Jaipur, India.\u0000Methods: A comparative study was conducted among 180 university students from non-medical courses. Students’ literacy was measured using REALMD-20, OHL-AQ, and HeLD. Independent sample t-test, one-way ANOVA, Kruskal–Wallis test, and Pearson’s correlation test were used for statistical analysis.\u0000Results: A weak positive correlation coefficient was obtained between REALMD-20, OHL-AQ, and HeLD. The mean REALMD-20 scores of Groups 1, 2, and 3 were 16.3, 14.98, and 15.8, respectively. For OHL-AQ, the mean scores obtained for Groups 1, 2, and 3 were 6.77, 7.50, and 6.58, respectively. The mean HeLD scores in Groups 1, 2, and 3 were 104.23, 102.70, and 100.4, respectively. However, the differences between these groups on all three tested scales were not statistically significant.\u0000Conclusion: In the present study, a weak positive correlation was observed between REALMD-20, OHL-AQ, and HeLD, thereby revealing potential shortcomings in each of these tools.\u0000Relevance for Patients: Encouraging patients to articulate their comprehension of their conditions and instructions enables health-care providers to identify gaps and enhance OHL, leading to effective prevention of oral diseases.","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140230183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indiscriminate use of psychotropic drugs by health discipline students at a private university in Colatina","authors":"Sávio Baldotto Covre, Kayki Saib Abi-Habib Guerra, Isabella Rodrigues, Maria Luiza Vidigal Heleodoro, Alessandra Mello Sant’Ana Armani, Fernanda Cristina de Abreu Quintela-Castro, Sarah Fernandes Teixeira","doi":"10.36922/jctr.00093","DOIUrl":"https://doi.org/10.36922/jctr.00093","url":null,"abstract":"Background: Psychotropic drugs are used to treat disorders involving central nervous system. However, several drugs are indiscriminately used by individuals seeking better academic or professional performance or for esthetic or recreational purposes. Indiscriminate utilization of psychotropic drugs is deleterious and can cause insomnia, anxiety, and emotional ability in short term, as well as physical or psychological dependence, cardiovascular, cognitive, and motor alterations in long term, in addition to the risk of overdose.\u0000Aim: This study was designed to characterize the prevalence of indiscriminate use of psychotropic drugs among students in the health disciplines in Colatina, Espírito Santo, to decipher the factors driving this practice. The findings from this study can lend themselves for designing preventive measures, in addition to providing a source of information about the harmful impacts of this habit.\u0000Methods: A descriptive study on a sample of 122 college students from courses in the health disciplines was carried out using online questionnaires. The data were tabulated in GraphPad Prism 9 software, with 95% reliability (P < 0.05), and analyzed using Fisher’s test.\u0000Results: Half of the college students interviewed claimed to have used psychotropic drugs at some points in their lives, and 21.3% had attempted self-medication. Utilization of psychotropic drugs became a common habit among students after entering academic life (62.3%).\u0000Conclusions: Self-medication is a common practice among the interviewed students and academic life, which has an significant impact on mental health, galvanizes this practice. These findings point to the need for better attention to the mental health of the university students and more education regarding the practice of self-medication in the population as a whole.\u0000Relevance for Patients: The study highlights the need for greater attention by health professionals to this practice of self-medication, and more primary preventive measures focused on educating these users to prevent jeopardizing the health of individuals indiscriminately used psychopharmaceuticals and to consequently reduce health system costs.","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"55 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139801055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-medication practice and associated factor among adult household members in Gurage Zone, Southern Ethiopia, Ethiopia, 2022: a cross-sectional study","authors":"Tadesse Sahle Adeba, Fantahun Walle, Tamirat Melis, Ayenew Mose","doi":"10.36922/jctr.00098","DOIUrl":"https://doi.org/10.36922/jctr.00098","url":null,"abstract":"Background: Self-medication refers to the use of medicinal products by the consumers to treat selfrecognized disorders or symptoms, or the intermittent or continued use of medication is not prescribed by a physician for chronic or recurring diseases or symptoms. Globally, the prevalence of selfmedication is estimated to be around 27 – 99.4% according to different studies.\u0000Methods: A cross-sectional study was conducted to assess self-medication practice and associated factors among adult household members of Gubre town from April 28 to June 27, 2022. Data collection from 399 households was conducted by means of a systematic random sampling technique using a pre-tested questionnaire.\u0000Result: Among 398 respondents, 113 (28.4%) of them were found to practice self-medication. Two hundred and forty-three (61.05%) participants reported to have fallen sick in the 2 weeks before the survey. Being married (adjusted odds ratio [AOR] = 1.599, 95% confidence interval [CI]: 1.09 – 2.621), being literate (AOR = 1.672, 95% CI: 1.032 – 2.01), perceiving self-medication as an acceptable practice (AOR = 1.652, 95% CI: 1.32 – 1.887), peer influence (AOR = 1.54, 95% CI: 1.304 – 2.321), and access to medical information (AOR = 1.452, 95% CI: 1.263 – 1.570) were significantly associated with self-medication practice.\u0000Conclusion: Nearly a quarter of the study participants practice self-medication. Being married, being literate, perceiving self-medication as an acceptable practice, peer influence, and access to medical information were significantly associated with self-medication practice.\u0000Relevance for Patients: Tailored interventions designed by policymakers, program designer, and implementers should aim to reduce or eliminate non-prescribed drug use among the community through the education on the impact of self-medication on individual health.","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"60 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139859931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Indiscriminate use of psychotropic drugs by health discipline students at a private university in Colatina","authors":"Sávio Baldotto Covre, Kayki Saib Abi-Habib Guerra, Isabella Rodrigues, Maria Luiza Vidigal Heleodoro, Alessandra Mello Sant’Ana Armani, Fernanda Cristina de Abreu Quintela-Castro, Sarah Fernandes Teixeira","doi":"10.36922/jctr.00093","DOIUrl":"https://doi.org/10.36922/jctr.00093","url":null,"abstract":"Background: Psychotropic drugs are used to treat disorders involving central nervous system. However, several drugs are indiscriminately used by individuals seeking better academic or professional performance or for esthetic or recreational purposes. Indiscriminate utilization of psychotropic drugs is deleterious and can cause insomnia, anxiety, and emotional ability in short term, as well as physical or psychological dependence, cardiovascular, cognitive, and motor alterations in long term, in addition to the risk of overdose.\u0000Aim: This study was designed to characterize the prevalence of indiscriminate use of psychotropic drugs among students in the health disciplines in Colatina, Espírito Santo, to decipher the factors driving this practice. The findings from this study can lend themselves for designing preventive measures, in addition to providing a source of information about the harmful impacts of this habit.\u0000Methods: A descriptive study on a sample of 122 college students from courses in the health disciplines was carried out using online questionnaires. The data were tabulated in GraphPad Prism 9 software, with 95% reliability (P < 0.05), and analyzed using Fisher’s test.\u0000Results: Half of the college students interviewed claimed to have used psychotropic drugs at some points in their lives, and 21.3% had attempted self-medication. Utilization of psychotropic drugs became a common habit among students after entering academic life (62.3%).\u0000Conclusions: Self-medication is a common practice among the interviewed students and academic life, which has an significant impact on mental health, galvanizes this practice. These findings point to the need for better attention to the mental health of the university students and more education regarding the practice of self-medication in the population as a whole.\u0000Relevance for Patients: The study highlights the need for greater attention by health professionals to this practice of self-medication, and more primary preventive measures focused on educating these users to prevent jeopardizing the health of individuals indiscriminately used psychopharmaceuticals and to consequently reduce health system costs.","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"5 3-4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139861004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-medication practice and associated factor among adult household members in Gurage Zone, Southern Ethiopia, Ethiopia, 2022: a cross-sectional study","authors":"Tadesse Sahle Adeba, Fantahun Walle, Tamirat Melis, Ayenew Mose","doi":"10.36922/jctr.00098","DOIUrl":"https://doi.org/10.36922/jctr.00098","url":null,"abstract":"Background: Self-medication refers to the use of medicinal products by the consumers to treat selfrecognized disorders or symptoms, or the intermittent or continued use of medication is not prescribed by a physician for chronic or recurring diseases or symptoms. Globally, the prevalence of selfmedication is estimated to be around 27 – 99.4% according to different studies.\u0000Methods: A cross-sectional study was conducted to assess self-medication practice and associated factors among adult household members of Gubre town from April 28 to June 27, 2022. Data collection from 399 households was conducted by means of a systematic random sampling technique using a pre-tested questionnaire.\u0000Result: Among 398 respondents, 113 (28.4%) of them were found to practice self-medication. Two hundred and forty-three (61.05%) participants reported to have fallen sick in the 2 weeks before the survey. Being married (adjusted odds ratio [AOR] = 1.599, 95% confidence interval [CI]: 1.09 – 2.621), being literate (AOR = 1.672, 95% CI: 1.032 – 2.01), perceiving self-medication as an acceptable practice (AOR = 1.652, 95% CI: 1.32 – 1.887), peer influence (AOR = 1.54, 95% CI: 1.304 – 2.321), and access to medical information (AOR = 1.452, 95% CI: 1.263 – 1.570) were significantly associated with self-medication practice.\u0000Conclusion: Nearly a quarter of the study participants practice self-medication. Being married, being literate, perceiving self-medication as an acceptable practice, peer influence, and access to medical information were significantly associated with self-medication practice.\u0000Relevance for Patients: Tailored interventions designed by policymakers, program designer, and implementers should aim to reduce or eliminate non-prescribed drug use among the community through the education on the impact of self-medication on individual health.","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"54 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139800197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PD-L1 expression and prognosis in definitive radiotherapy patients with neuroendocrine cervical carcinoma.","authors":"Huiling Li,&nbsp;Xiuhua Li,&nbsp;Meichun Yang,&nbsp;Huiyan Su,&nbsp;Jianqiu Zhang,&nbsp;Chunmiao Hu,&nbsp;Yingming Sun,&nbsp;Dan Hu,&nbsp;Li Chen","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Neuroendocrine carcinoma of the cervix (NECC) is more prone to lymphatic infiltration, lymph node involvement, local recurrence, and distant metastasis. Using concurrent chemoradiotherapy (CCRT) with or without adjuvant chemotherapy as the standard treatment for locally advanced NECCs and CCRT for patients with early lesions confined to the cervix. However, the prognosis of NECC patients treated with definitive radiotherapy (RT) is unknown. Immune checkpoint inhibitors are a promising therapeutic strategy for locally advanced cervical cancer. Some reports suggest that the expression of PD-L1 in solid tumors correlates with prognosis.</p><p><strong>Aim: </strong>This study investigates prognostic factors for survival in patients with neuroendocrine cervical carcinoma (NECC) treated with definitive RT and the relationship between PD-L1 expression and prognosis in these patients.</p><p><strong>Methods: </strong>This retrospective study included 66 patients with histologically confirmed NECC who received RT with or without chemotherapy. From January 2015 to December 2020, patients received routine extended-field irradiation (EFI), and PD-L1 expression was assessed by immunohistochemistry. The most commonly used chemotherapy agents were etoposide-platinum and paclitaxel-platinum.</p><p><strong>Results: </strong>PD-L1 expression was positive in 17 of 45 (37.8%) patients. There were 52 cases of pure NECC and 14 cases of mixed carcinoma. Sixty stage IB-III patients received definitive RT. The 3- and 5-year progression-free survival (PFS) was 39.8% and 34.1%, and 3- and 5-year overall survival (OS) was 48.0% and 40.2%, respectively. There was no significant difference in 3 and 5-year PFS and 3 and 5-year OS between patients with pure and mixed carcinoma. Positive PD-L1 expression was associated with higher 3-year PFS in patients with mixed histology. Univariate analysis showed that lymph node metastasis (LNM) and the International Federation of Gynecology and Obstetrics stages predicted 3- and 5-year PFS in patients who received definitive RT. The median OS in patients receiving less than four cycles and at least four cycles of chemotherapy (CT) was 26.0 and 44.0 months, respectively (<i>P</i> = 0.038); moreover, 3- and 5-year PFS was 34.1% and 25.7% in the former and 46.4% and 40.4% in the latter. There were no significant differences in OS and PFS between pelvic irradiation and prophylactic EFI in patients treated with definitive RT. There were no significant differences in para-aortic failure rate after concurrent chemoradiotherapy between patients who underwent pelvic irradiation or prophylactic EFI (<i>P</i> = 0.147).</p><p><strong>Conclusion: </strong>In patients with mixed NECC, positive PD-L1 expression is correlated with higher 3-year PFS. Chemoradiotherapy was effective for NECCs. The LNM and stage predicted PFS. Four or more cycles of chemotherapy improve prognosis. Prophylactic EFI did not significantly improve ","PeriodicalId":15482,"journal":{"name":"Journal of Clinical and Translational Research","volume":"9 4","pages":"272-281"},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/34/jclintranslres-2023-9-4-272.PMC10431195.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10403527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}