发布求助
文献互助 智能选刊 最新文献

Journal of Clinical Investigation最新文献

筛选
英文 中文
Particulate matter air pollution: effects on the respiratory system. 颗粒物空气污染：对呼吸系统的影响。
IF 13.6 1区 医学
Journal of Clinical Investigation Pub Date : 2025-09-02 DOI: 10.1172/JCI194312
Robert B Hamanaka, Gökhan M Mutlu
{"title":"Particulate matter air pollution: effects on the respiratory system.","authors":"Robert B Hamanaka, Gökhan M Mutlu","doi":"10.1172/JCI194312","DOIUrl":"10.1172/JCI194312","url":null,"abstract":"<p><p>Air pollution comprises a complex mixture of gaseous and particulate components. Particulate matter (PM) air pollution is associated with 4.7 million premature deaths per year. Among modifiable risk factors, air pollution exposure contributes to 8% of disability adjusted life years and ranks above factors such as high blood pressure, smoking, and high fasting plasma glucose. As the site of entry, exposure to PM air pollution causes respiratory symptoms and is a significant cause of respiratory morbidity and mortality. In this Review, we discuss the studies that link air pollution exposure with respiratory diseases. We review the epidemiological evidence linking PM exposure and lung diseases including asthma, chronic obstructive pulmonary disease, pulmonary fibrosis, pneumonia, acute respiratory distress syndrome, and lung cancer. We also provide an overview of current knowledge about the mechanisms by which PM exerts its biological effects leading to adverse health effects in the respiratory system.</p>","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"135 17","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging concepts and shifting paradigms for understanding the microbial basis of inflammatory bowel diseases. 理解炎症性肠病微生物基础的新兴概念和转变范式。
IF 13.6 1区 医学
Journal of Clinical Investigation Pub Date : 2025-09-02 DOI: 10.1172/JCI193969
Megan S Kennedy, Eugene B Chang
{"title":"Emerging concepts and shifting paradigms for understanding the microbial basis of inflammatory bowel diseases.","authors":"Megan S Kennedy, Eugene B Chang","doi":"10.1172/JCI193969","DOIUrl":"10.1172/JCI193969","url":null,"abstract":"<p><p>Inflammatory bowel diseases (IBDs) are complex immune disorders that arise at the intersection of genetic susceptibility, environmental exposures, and dysbiosis of the gut microbiota. Our understanding of the role of the microbiome in IBD has greatly expanded over the past few decades, although efforts to translate this knowledge into precision microbiome-based interventions for the prevention and management of disease have thus far met limited success. Here we survey and synthesize recent primary research in order to propose an updated conceptual framework for the role of the microbiome in IBD. We argue that accounting for gut microbiome context - elements such disease regionality, phase of disease, diet, medication use, and patient lifestyle - is essential for the development of a clear and mechanistic understanding of the microbiome's contribution to pathogenesis or health. Armed with better mechanistic and contextual understanding, we will be better prepared to translate this knowledge into effective and precise strategies for microbiome restitution.</p>","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"135 17","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models. 在移植物抗宿主病模型中，自噬对不同靶器官的组织耐受性有差异调节。
IF 13.6 1区 医学
Journal of Clinical Investigation Pub Date : 2025-09-02 DOI: 10.1172/JCI198274
Katherine Oravecz-Wilson, Emma Lauder, Austin Taylor, Laure Maneix, Jeanine L Van Nostrand, Yaping Sun, Lu Li, Dongchang Zhao, Chen Liu, Pavan Reddy
{"title":"Corrigendum to Autophagy differentially regulates tissue tolerance of distinct target organs in graft-versus-host disease models.","authors":"Katherine Oravecz-Wilson, Emma Lauder, Austin Taylor, Laure Maneix, Jeanine L Van Nostrand, Yaping Sun, Lu Li, Dongchang Zhao, Chen Liu, Pavan Reddy","doi":"10.1172/JCI198274","DOIUrl":"10.1172/JCI198274","url":null,"abstract":"","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"135 17","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12435629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144955991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A pathogenic variant of AMOT leads to isolated X-linked congenital hydrocephalus due to N-terminal truncation. AMOT的致病性变异导致孤立的x连锁先天性脑积水由于n端截断。
IF 13.6 1区 医学
Journal of Clinical Investigation Pub Date : 2025-09-02 DOI: 10.1172/JCI179438
Nurcan Hastar, Hagit Daum, Nikoletta Kardos-Török, Gael Ganz, Leon Obendorf, Peter Vajkoczy, Orly Elpeleg, Petra Knaus
{"title":"A pathogenic variant of AMOT leads to isolated X-linked congenital hydrocephalus due to N-terminal truncation.","authors":"Nurcan Hastar, Hagit Daum, Nikoletta Kardos-Török, Gael Ganz, Leon Obendorf, Peter Vajkoczy, Orly Elpeleg, Petra Knaus","doi":"10.1172/JCI179438","DOIUrl":"10.1172/JCI179438","url":null,"abstract":"<p><p>Congenital hydrocephalus is a life-threatening condition that might affect brain development by increasing the pressure on the brain parenchyma. Here, we describe 6 male patients from 1 family, all presenting with an isolated X-linked congenital hydrocephalus. Exome sequencing identified a likely pathogenic variant of angiomotin (AMOT) that segregated with the phenotype in the extended family. We show that the variant, affecting the first methionine, translated into a shorter AMOT protein lacking 91 amino acids from the N-terminus. Mechanistically, we unraveled that the absence of the N-terminus leads to abnormally increased AMOT protein levels due to the loss of both the N-degron degradation signal and the tankyrase-binding domain. Altered degradation of AMOT disrupted the barrier integrity of the cells. Thus, the identified AMOT variant likely underlies the clinical presentation of isolated X-linked hydrocephalus in this family, and our data underscore the importance of tight regulation of AMOT protein level in the brain. AMOT now joins the list of genes involved in congenital hydrocephalus in humans. These findings are instrumental for the genetic counseling of affected families.</p>","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"135 17","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When more isn't better: the surprising superiority of glycoprotein-only Marburg vaccines. 当更多不是更好时：仅含糖蛋白的马尔堡疫苗的惊人优势。
IF 13.6 1区 医学
Journal of Clinical Investigation Pub Date : 2025-09-02 DOI: 10.1172/JCI195933
Pablo Penaloza-MacMaster
{"title":"When more isn't better: the surprising superiority of glycoprotein-only Marburg vaccines.","authors":"Pablo Penaloza-MacMaster","doi":"10.1172/JCI195933","DOIUrl":"10.1172/JCI195933","url":null,"abstract":"","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"135 17","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebrospinal fluid flow modulates brain health. 脑脊液流动调节大脑健康。
IF 13.6 1区 医学
Journal of Clinical Investigation Pub Date : 2025-09-02 DOI: 10.1172/JCI197202
Lauren M Hablitz, Maiken Nedergaard
{"title":"Cerebrospinal fluid flow modulates brain health.","authors":"Lauren M Hablitz, Maiken Nedergaard","doi":"10.1172/JCI197202","DOIUrl":"10.1172/JCI197202","url":null,"abstract":"<p><p>Cerebrospinal fluid dynamics play an important role in maintaining brain health and clearing metabolic waste from the brain. In this issue of the JCI, Gursky et al. investigate how CSF distribution is affected when its primary efflux pathway - the deep cervical lymph nodes - is disrupted by cauterization. This timely study reveals compensatory fluid drainage routes from the skull, age-dependent adaptations in CSF homeostasis, and the emergence of neuroinflammation when an efflux pathway is occluded. The findings underscore the need to better understand the physiological mechanisms governing CSF clearance, how these pathways evolve with aging, and whether CSF influx and efflux exhibit region-specific dynamics shaped by neuroanatomy. Additionally, the study raises important questions about whether peripheral injury can influence central nervous system states. A more complete understanding of CSF flow regulation may offer new perspectives on the origins of neuropathology.</p>","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"135 17","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of Concern for Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction. 肥胖和糖尿病患者循环淀粉样蛋白浓度升高可促进血管功能障碍
IF 13.6 1区 医学
Journal of Clinical Investigation Pub Date : 2025-09-02 DOI: 10.1172/JCI199125
Paul J Meakin, Bethany M Coull, Zofia Tuharska, Christopher McCaffery, Ioannis Akoumianakis, Charalambos Antoniades, Jane Brown, Kathryn J Griffin, Fiona Platt, Claire H Ozber, Nadira Y Yuldasheva, Natallia Makava, Anna Skromna, Alan Prescott, Alison D McNeilly, Moneeza Siddiqui, Colin Na Palmer, Faisel Khan, Michael Lj Ashford
{"title":"Expression of Concern for Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.","authors":"Paul J Meakin, Bethany M Coull, Zofia Tuharska, Christopher McCaffery, Ioannis Akoumianakis, Charalambos Antoniades, Jane Brown, Kathryn J Griffin, Fiona Platt, Claire H Ozber, Nadira Y Yuldasheva, Natallia Makava, Anna Skromna, Alan Prescott, Alison D McNeilly, Moneeza Siddiqui, Colin Na Palmer, Faisel Khan, Michael Lj Ashford","doi":"10.1172/JCI199125","DOIUrl":"10.1172/JCI199125","url":null,"abstract":"","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"135 17","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis. 泛素特异性蛋白酶7维持DNA损伤反应并促进宫颈癌的发生。
IF 13.6 1区 医学
Journal of Clinical Investigation Pub Date : 2025-09-02 DOI: 10.1172/JCI197926
Dongxue Su, Shuai Ma, Lin Shan, Yue Wang, Yuejiao Wang, Cheng Cao, Beibei Liu, Chao Yang, Liyong Wang, Shanshan Tian, Xiang Ding, Xinhua Liu, Na Yu, Nan Song, Ling Liu, Shangda Yang, Qi Zhang, Fuquan Yang, Kai Zhang, Lei Shi
{"title":"Corrigendum to Ubiquitin-specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis.","authors":"Dongxue Su, Shuai Ma, Lin Shan, Yue Wang, Yuejiao Wang, Cheng Cao, Beibei Liu, Chao Yang, Liyong Wang, Shanshan Tian, Xiang Ding, Xinhua Liu, Na Yu, Nan Song, Ling Liu, Shangda Yang, Qi Zhang, Fuquan Yang, Kai Zhang, Lei Shi","doi":"10.1172/JCI197926","DOIUrl":"10.1172/JCI197926","url":null,"abstract":"","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"135 17","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404761/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. IL-17对小鼠皮肤金黄色葡萄球菌感染的宿主防御至关重要。
IF 13.6 1区 医学
Journal of Clinical Investigation Pub Date : 2025-09-02 DOI: 10.1172/JCI198106
John S Cho, Eric M Pietras, Nairy C Garcia, Romela Irene Ramos, David M Farzam, Holly R Monroe, Julie E Magorien, Andrew Blauvelt, Jay K Kolls, Ambrose L Cheung, Genhong Cheng, Robert L Modlin, Lloyd S Miller
{"title":"Corrigendum to IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice.","authors":"John S Cho, Eric M Pietras, Nairy C Garcia, Romela Irene Ramos, David M Farzam, Holly R Monroe, Julie E Magorien, Andrew Blauvelt, Jay K Kolls, Ambrose L Cheung, Genhong Cheng, Robert L Modlin, Lloyd S Miller","doi":"10.1172/JCI198106","DOIUrl":"10.1172/JCI198106","url":null,"abstract":"","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"135 17","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404742/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prostate tumor-mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL10 signaling. 前列腺肿瘤介导的IFNG信号启动骨转移前生态位骨髓细胞免疫抑制IL10信号。
IF 13.6 1区 医学
Journal of Clinical Investigation Pub Date : 2025-08-28 DOI: 10.1172/JCI196347
Mindy K Graham, Sarki A Abdulkadir
{"title":"Prostate tumor-mediated IFNG signaling primes myeloid cells in bone premetastatic niche for immunosuppressive IL10 signaling.","authors":"Mindy K Graham, Sarki A Abdulkadir","doi":"10.1172/JCI196347","DOIUrl":"https://doi.org/10.1172/JCI196347","url":null,"abstract":"","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":" ","pages":""},"PeriodicalIF":13.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信