Journal of Clinical Investigation最新文献

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Checkpoint therapy in cancer treatment: progress, challenges, and future directions. 癌症治疗中的检查点疗法:进展、挑战和未来方向。
IF 13.3 1区 医学
Journal of Clinical Investigation Pub Date : 2024-09-17 DOI: 10.1172/JCI184846
Mesude Bicak, Cansu Cimen Bozkus, Nina Bhardwaj
{"title":"Checkpoint therapy in cancer treatment: progress, challenges, and future directions.","authors":"Mesude Bicak, Cansu Cimen Bozkus, Nina Bhardwaj","doi":"10.1172/JCI184846","DOIUrl":"10.1172/JCI184846","url":null,"abstract":"","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"134 18","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11405031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fibrosis uncovered: ADAMTS12 cuts to the core of extracellular matrix drama. 揭秘纤维化ADAMTS12切入细胞外基质剧的核心。
IF 13.3 1区 医学
Journal of Clinical Investigation Pub Date : 2024-09-17 DOI: 10.1172/JCI183115
Bernhard Dumoulin, Katalin Susztak
{"title":"Fibrosis uncovered: ADAMTS12 cuts to the core of extracellular matrix drama.","authors":"Bernhard Dumoulin, Katalin Susztak","doi":"10.1172/JCI183115","DOIUrl":"10.1172/JCI183115","url":null,"abstract":"<p><p>Fibrosis is a common manifestation of most progressive and degenerative diseases, with myofibroblast activation and matrix accumulation playing a key role. In this issue of the JCI, Hoeft et al. identify the important role of ADAMTS12 in fibroblast activation. ADAMTS12, a secreted protein, is involved in extracellular matrix (ECM) remodeling, cell signaling, and inflammation. ADAMTS12 facilitates proteolysis by cleaving various substrates such as ECM components, which are vital for cellular signaling and remodeling. Additionally, it modulates cell-matrix interactions, influencing cell adhesion and migration, and plays an important role in the inflammatory processes. Understanding the role of ADAMTS12 offers potential therapeutic insights for targeting fibrosis in progressive diseases.</p>","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"134 18","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11405032/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Elexacaftor/tezacaftor/ivacaftor's effects on cystic fibrosis infections are maintained, but not increased, after 3.5 years of treatment. Elexacaftor/tezacaftor/ivacaftor对囊性纤维化感染的疗效在治疗3.5年后保持不变,但没有增加。
IF 13.3 1区 医学
Journal of Clinical Investigation Pub Date : 2024-09-05 DOI: 10.1172/JCI184171
Sarah J Morgan, Ellis Coulter, Hannah L Betts, George M Solomon, John P Clancy, Steven M Rowe, David P Nichols, Pradeep K Singh
{"title":"Elexacaftor/tezacaftor/ivacaftor's effects on cystic fibrosis infections are maintained, but not increased, after 3.5 years of treatment.","authors":"Sarah J Morgan, Ellis Coulter, Hannah L Betts, George M Solomon, John P Clancy, Steven M Rowe, David P Nichols, Pradeep K Singh","doi":"10.1172/JCI184171","DOIUrl":"10.1172/JCI184171","url":null,"abstract":"","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":" ","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11473140/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142140266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes sarcoidosis from other skin granulomatous diseases. CXCR4+ 1 型先天性淋巴细胞的募集使肉样瘤病与其他皮肤肉芽肿疾病区分开来。
IF 13.3 1区 医学
Journal of Clinical Investigation Pub Date : 2024-09-03 DOI: 10.1172/JCI178711
Satish Sati, Jianhe Huang, Anna E Kersh, Parker Jones, Olivia Ahart, Christina Murphy, Stephen M Prouty, Matthew L Hedberg, Vaibhav Jain, Simon G Gregory, Denis H Leung, John T Seykora, Misha Rosenbach, Thomas H Leung
{"title":"Recruitment of CXCR4+ type 1 innate lymphoid cells distinguishes sarcoidosis from other skin granulomatous diseases.","authors":"Satish Sati, Jianhe Huang, Anna E Kersh, Parker Jones, Olivia Ahart, Christina Murphy, Stephen M Prouty, Matthew L Hedberg, Vaibhav Jain, Simon G Gregory, Denis H Leung, John T Seykora, Misha Rosenbach, Thomas H Leung","doi":"10.1172/JCI178711","DOIUrl":"10.1172/JCI178711","url":null,"abstract":"<p><p>Sarcoidosis is a multiorgan granulomatous disease that lacks diagnostic biomarkers and targeted treatments. Using blood and skin from patients with sarcoid and non-sarcoid skin granulomas, we discovered that skin granulomas from different diseases exhibit unique immune cell recruitment and molecular signatures. Sarcoid skin granulomas were specifically enriched for type 1 innate lymphoid cells (ILC1s) and B cells and exhibited molecular programs associated with formation of mature tertiary lymphoid structures (TLSs), including increased CXCL12/CXCR4 signaling. Lung sarcoidosis granulomas also displayed similar immune cell recruitment. Thus, granuloma formation was not a generic molecular response. In addition to tissue-specific effects, patients with sarcoidosis exhibited an 8-fold increase in circulating ILC1s, which correlated with treatment status. Multiple immune cell types induced CXCL12/CXCR4 signaling in sarcoidosis, including Th1 T cells, macrophages, and ILCs. Mechanistically, CXCR4 inhibition reduced sarcoidosis-activated immune cell migration, and targeting CXCR4 or total ILCs attenuated granuloma formation in a noninfectious mouse model. Taken together, our results show that ILC1s are a tissue and circulating biomarker that distinguishes sarcoidosis from other skin granulomatous diseases. Repurposing existing CXCR4 inhibitors may offer a new targeted treatment for this devastating disease.</p>","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"134 17","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer therapy-related salivary dysfunction. 癌症治疗相关的唾液功能障碍。
IF 13.3 1区 医学
Journal of Clinical Investigation Pub Date : 2024-09-03 DOI: 10.1172/JCI182661
Cristina Paz, Annemarie Glassey, Abigail Frick, Sarah Sattar, Nicholas G Zaorsky, Grace C Blitzer, Randall J Kimple
{"title":"Cancer therapy-related salivary dysfunction.","authors":"Cristina Paz, Annemarie Glassey, Abigail Frick, Sarah Sattar, Nicholas G Zaorsky, Grace C Blitzer, Randall J Kimple","doi":"10.1172/JCI182661","DOIUrl":"10.1172/JCI182661","url":null,"abstract":"<p><p>Salivary gland dysfunction is a common side effect of cancer treatments. Salivary function plays key roles in critical daily activities. Consequently, changes in salivary function can profoundly impair quality of life for cancer patients. We discuss salivary gland anatomy and physiology to understand how anticancer therapies such as chemotherapy, bone marrow transplantation, immunotherapy, and radiation therapy impair salivary function. We discuss approaches to quantify xerostomia in the clinic, including the advantages and limitations of validated quality-of-life instruments and approaches to directly measuring salivary function. Current and emerging approaches to treat cancer therapy-induced dry mouth are presented using radiation-induced salivary dysfunction as a model. Limitations of current sialagogues and salivary analogues are presented. Emerging approaches, including cellular and gene therapy and novel pharmacologic approaches, are described.</p>","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"134 17","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatic lipopolysaccharide binding protein partially uncouples inflammation from fibrosis in MAFLD. 肝脂多糖结合蛋白部分解除了 MAFLD 中炎症与纤维化之间的联系。
IF 13.3 1区 医学
Journal of Clinical Investigation Pub Date : 2024-09-03 DOI: 10.1172/JCI179752
Dan Wang, Ania Baghoomian, Zhengyi Zhang, Ya Cui, Emily C Whang, Xiang Li, Josue Fraga, Rachel Ariana Spellman, Tien S Dong, Wei Li, Arpana Gupta, Jihane N Benhammou, Tamer Sallam
{"title":"Hepatic lipopolysaccharide binding protein partially uncouples inflammation from fibrosis in MAFLD.","authors":"Dan Wang, Ania Baghoomian, Zhengyi Zhang, Ya Cui, Emily C Whang, Xiang Li, Josue Fraga, Rachel Ariana Spellman, Tien S Dong, Wei Li, Arpana Gupta, Jihane N Benhammou, Tamer Sallam","doi":"10.1172/JCI179752","DOIUrl":"10.1172/JCI179752","url":null,"abstract":"","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":" ","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364399/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141766184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models. 在实体瘤模型中,药理 LDH 抑制可重定向瘤内葡萄糖摄取并提高抗肿瘤免疫力。
IF 13.3 1区 医学
Journal of Clinical Investigation Pub Date : 2024-09-03 DOI: 10.1172/JCI177606
Svena Verma, Sadna Budhu, Inna Serganova, Lauren Dong, Levi M Mangarin, Jonathan F Khan, Mamadou A Bah, Anais Assouvie, Yacine Marouf, Isabell Schulze, Roberta Zappasodi, Jedd D Wolchok, Taha Merghoub
{"title":"Pharmacologic LDH inhibition redirects intratumoral glucose uptake and improves antitumor immunity in solid tumor models.","authors":"Svena Verma, Sadna Budhu, Inna Serganova, Lauren Dong, Levi M Mangarin, Jonathan F Khan, Mamadou A Bah, Anais Assouvie, Yacine Marouf, Isabell Schulze, Roberta Zappasodi, Jedd D Wolchok, Taha Merghoub","doi":"10.1172/JCI177606","DOIUrl":"10.1172/JCI177606","url":null,"abstract":"<p><p>Tumor reliance on glycolysis is a hallmark of cancer. Immunotherapy is more effective in controlling glycolysis-low tumors lacking lactate dehydrogenase (LDH) due to reduced tumor lactate efflux and enhanced glucose availability within the tumor microenvironment (TME). LDH inhibitors (LDHi) reduce glucose uptake and tumor growth in preclinical models, but their impact on tumor-infiltrating T cells is not fully elucidated. Tumor cells have higher basal LDH expression and glycolysis levels compared with infiltrating T cells, creating a therapeutic opportunity for tumor-specific targeting of glycolysis. We demonstrate that LDHi treatment (a) decreases tumor cell glucose uptake, expression of the glucose transporter GLUT1, and tumor cell proliferation while (b) increasing glucose uptake, GLUT1 expression, and proliferation of tumor-infiltrating T cells. Accordingly, increasing glucose availability in the microenvironment via LDH inhibition leads to improved tumor-killing T cell function and impaired Treg immunosuppressive activity in vitro. Moreover, combining LDH inhibition with immune checkpoint blockade therapy effectively controls murine melanoma and colon cancer progression by promoting effector T cell infiltration and activation while destabilizing Tregs. Our results establish LDH inhibition as an effective strategy for rebalancing glucose availability for T cells within the TME, which can enhance T cell function and antitumor immunity.</p>","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"134 17","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 1 innate lymphoid cells: a biomarker and therapeutic candidate in sarcoidosis. 1型先天性淋巴细胞:肉样瘤病的生物标志物和候选疗法。
IF 13.3 1区 医学
Journal of Clinical Investigation Pub Date : 2024-09-03 DOI: 10.1172/JCI183708
Inchul Cho, Andrew L Ji
{"title":"Type 1 innate lymphoid cells: a biomarker and therapeutic candidate in sarcoidosis.","authors":"Inchul Cho, Andrew L Ji","doi":"10.1172/JCI183708","DOIUrl":"10.1172/JCI183708","url":null,"abstract":"<p><p>Sarcoidosis is an inflammatory disease characterized by immune cell-rich granulomas that form in multiple organs. In this issue of the JCI, Sati and colleagues used scRNA-seq and spatial transcriptomics of skin samples from patients with sarcoidosis and non-sarcoidosis granulomatous disease to identify upregulation of a stromal-immune CXCL12/CXCR4 axis and accumulation of type 1 innate lymphoid cells (ILC1s) in sarcoidosis. The accumulation of ILC1s in skin and blood was specific to patients with sarcoidosis and not observed in other granulomatous diseases. The authors used a mouse model of lung granuloma to show that ILCs contribute to granuloma formation and that blockade of CXCR4 reduced the formation of granulomas, providing a proof of concept that sarcoidosis may be treated by CXCR4 blockade to prevent the progression of disease in patients. These results suggest ILC1s could serve as a diagnostic biomarker in sarcoidosis and a potential therapeutic target.</p>","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"134 17","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell analysis of breast cancer metastasis reveals epithelial-mesenchymal plasticity signatures associated with poor outcomes. 乳腺癌转移的单细胞分析揭示了与不良预后相关的上皮-间质可塑性特征。
IF 13.3 1区 医学
Journal of Clinical Investigation Pub Date : 2024-09-03 DOI: 10.1172/JCI164227
Juliane Winkler, Weilun Tan, Catherine Mm Diadhiou, Christopher S McGinnis, Aamna Abbasi, Saad Hasnain, Sophia Durney, Elena Atamaniuc, Daphne Superville, Leena Awni, Joyce V Lee, Johanna H Hinrichs, Patrick S Wagner, Namrata Singh, Marco Y Hein, Michael Borja, Angela M Detweiler, Su-Yang Liu, Ankitha Nanjaraj, Vaishnavi Sitarama, Hope S Rugo, Norma Neff, Zev J Gartner, Angela Oliveira Pisco, Andrei Goga, Spyros Darmanis, Zena Werb
{"title":"Single-cell analysis of breast cancer metastasis reveals epithelial-mesenchymal plasticity signatures associated with poor outcomes.","authors":"Juliane Winkler, Weilun Tan, Catherine Mm Diadhiou, Christopher S McGinnis, Aamna Abbasi, Saad Hasnain, Sophia Durney, Elena Atamaniuc, Daphne Superville, Leena Awni, Joyce V Lee, Johanna H Hinrichs, Patrick S Wagner, Namrata Singh, Marco Y Hein, Michael Borja, Angela M Detweiler, Su-Yang Liu, Ankitha Nanjaraj, Vaishnavi Sitarama, Hope S Rugo, Norma Neff, Zev J Gartner, Angela Oliveira Pisco, Andrei Goga, Spyros Darmanis, Zena Werb","doi":"10.1172/JCI164227","DOIUrl":"10.1172/JCI164227","url":null,"abstract":"<p><p>Metastasis is the leading cause of cancer-related deaths. It is unclear how intratumor heterogeneity (ITH) contributes to metastasis and how metastatic cells adapt to distant tissue environments. The study of these adaptations is challenged by the limited access to patient material and a lack of experimental models that appropriately recapitulate ITH. To investigate metastatic cell adaptations and the contribution of ITH to metastasis, we analyzed single-cell transcriptomes of matched primary tumors and metastases from patient-derived xenograft models of breast cancer. We found profound transcriptional differences between the primary tumor and metastatic cells. Primary tumors upregulated several metabolic genes, whereas motility pathway genes were upregulated in micrometastases, and stress response signaling was upregulated during progression. Additionally, we identified primary tumor gene signatures that were associated with increased metastatic potential and correlated with patient outcomes. Immune-regulatory control pathways were enriched in poorly metastatic primary tumors, whereas genes involved in epithelial-mesenchymal transition were upregulated in highly metastatic tumors. We found that ITH was dominated by epithelial-mesenchymal plasticity (EMP), which presented as a dynamic continuum with intermediate EMP cell states characterized by specific genes such as CRYAB and S100A2. Elevated expression of an intermediate EMP signature correlated with worse patient outcomes. Our findings identified inhibition of the intermediate EMP cell state as a potential therapeutic target to block metastasis.</p>","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"134 17","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GLP-1R-positive neurons in the lateral septum mediate the anorectic and weight-lowering effects of liraglutide in mice. 侧隔膜中的 GLP-1R 阳性神经元介导了利拉鲁肽对小鼠厌食和降低体重的作用。
IF 13.3 1区 医学
Journal of Clinical Investigation Pub Date : 2024-09-03 DOI: 10.1172/JCI178239
Zijun Chen, Xiaofei Deng, Cuijie Shi, Haiyang Jing, Yu Tian, Jiafeng Zhong, Gaowei Chen, Yunlong Xu, Yixiao Luo, Yingjie Zhu
{"title":"GLP-1R-positive neurons in the lateral septum mediate the anorectic and weight-lowering effects of liraglutide in mice.","authors":"Zijun Chen, Xiaofei Deng, Cuijie Shi, Haiyang Jing, Yu Tian, Jiafeng Zhong, Gaowei Chen, Yunlong Xu, Yixiao Luo, Yingjie Zhu","doi":"10.1172/JCI178239","DOIUrl":"10.1172/JCI178239","url":null,"abstract":"<p><p>Liraglutide, a glucagon-like peptide-1 (GLP-1) analog, is approved for obesity treatment, but the specific neuronal sites that contribute to its therapeutic effects remain elusive. Here, we show that GLP-1 receptor-positive (GLP-1R-positive) neurons in the lateral septum (LSGLP-1R) play a critical role in mediating the anorectic and weight-loss effects of liraglutide. LSGLP-1R neurons were robustly activated by liraglutide, and chemogenetic activation of these neurons dramatically suppressed feeding. Targeted knockdown of GLP-1 receptors within the LS, but not in the hypothalamus, substantially attenuated liraglutide's ability to inhibit feeding and lower body weight. The activity of LSGLP-1R neurons rapidly decreased during naturalistic feeding episodes, while synaptic inactivation of LSGLP-1R neurons diminished the anorexic effects triggered by liraglutide. Together, these findings offer critical insights into the functional role of LSGLP-1R neurons in the physiological regulation of energy homeostasis and delineate their instrumental role in mediating the pharmacological efficacy of liraglutide.</p>","PeriodicalId":15469,"journal":{"name":"Journal of Clinical Investigation","volume":"134 17","pages":""},"PeriodicalIF":13.3,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11364389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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