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Compund Index Vol. 765 综合指数第765卷
Journal of Chromatography B: Biomedical Sciences and Applications Pub Date : 2001-12-25 DOI: 10.1016/S0378-4347(01)00536-9
{"title":"Compund Index Vol. 765","authors":"","doi":"10.1016/S0378-4347(01)00536-9","DOIUrl":"https://doi.org/10.1016/S0378-4347(01)00536-9","url":null,"abstract":"","PeriodicalId":15463,"journal":{"name":"Journal of Chromatography B: Biomedical Sciences and Applications","volume":"765 2","pages":"Pages 209-210"},"PeriodicalIF":0.0,"publicationDate":"2001-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0378-4347(01)00536-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136419944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thin-layer chromatography blotting for the fluorescence detection of phospholipid hydroperoxides and cholesteryl ester hydroperoxides 薄层色谱法荧光检测磷脂氢过氧化物和胆固醇酯氢过氧化物
Journal of Chromatography B: Biomedical Sciences and Applications Pub Date : 2001-12-25 DOI: 10.1016/S0378-4347(01)00426-1
Junji Terao, Mariko Miyoshi, Sayuri Miyamoto
{"title":"Thin-layer chromatography blotting for the fluorescence detection of phospholipid hydroperoxides and cholesteryl ester hydroperoxides","authors":"Junji Terao,&nbsp;Mariko Miyoshi,&nbsp;Sayuri Miyamoto","doi":"10.1016/S0378-4347(01)00426-1","DOIUrl":"10.1016/S0378-4347(01)00426-1","url":null,"abstract":"<div><p><span>A blotting technique was developed to specifically detect lipid hydroperoxides in thin-layer chromatography. </span>Phosphatidylcholine<span> hydroperoxides and cholesteryl linoleate<span><span><span> hydroperoxides ranging from 0.1 to 0.5 nmol, which were prepared by reaction with soybean lipoxygenase, were visualized as fluorescent spots on the blotted membrane by immersing the plate into a blotting solvent containing 0.01% (w/v) diphenyl-1-pyrenylphosphine. This technique was applied successfully to monitor </span>lipid peroxidation in human </span>low-density lipoprotein in vitro.</span></span></p></div>","PeriodicalId":15463,"journal":{"name":"Journal of Chromatography B: Biomedical Sciences and Applications","volume":"765 2","pages":"Pages 199-203"},"PeriodicalIF":0.0,"publicationDate":"2001-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0378-4347(01)00426-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77911652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Influence of various biological matrices (plasma, blood microdialysate) on chromatographic performance in the determination of β-blockers using an alkyl-diol silica precolumn for sample clean-up 不同生物基质(血浆、血液微透析液)对样品净化用烷基二醇硅前柱测定β-阻滞剂色谱性能的影响
Journal of Chromatography B: Biomedical Sciences and Applications Pub Date : 2001-12-25 DOI: 10.1016/S0378-4347(01)00423-6
Csilla Mišl’anová , Milan Hutta
{"title":"Influence of various biological matrices (plasma, blood microdialysate) on chromatographic performance in the determination of β-blockers using an alkyl-diol silica precolumn for sample clean-up","authors":"Csilla Mišl’anová ,&nbsp;Milan Hutta","doi":"10.1016/S0378-4347(01)00423-6","DOIUrl":"10.1016/S0378-4347(01)00423-6","url":null,"abstract":"<div><p>A HPLC column-switching system with LiChrospher RP-8 ADS precolumn was applied for the determination of beta-blockers (atenolol, pindolol, propranolol) in human plasma. The influence of biological matrices on the changes of the chromatographic parameters such as retention time, peak symmetry, area and selectivity were investigated. After injection of 5 ml plasma a decrease of retention times of the analytes was observed of up to 25% and an increase of asymmetry factors of up to 5%. Peak areas and selectivities were not changed. The observed effect could indicate changes of chromatographic performance caused by contributions of the analytical column or the ADS precolumn. The experiments with microdialysis excluded the contribution of the analytical column. A detailed investigation of experiments have been discussed in this paper.</p></div>","PeriodicalId":15463,"journal":{"name":"Journal of Chromatography B: Biomedical Sciences and Applications","volume":"765 2","pages":"Pages 167-177"},"PeriodicalIF":0.0,"publicationDate":"2001-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0378-4347(01)00423-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75233657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Quantitative detection of bisphenol A and bisphenol A diglycidyl ether metabolites in human plasma by liquid chromatography–electrospray mass spectrometry 液相色谱-电喷雾质谱法定量检测人血浆中双酚A和双酚A二缩水甘油醚代谢物
Journal of Chromatography B: Biomedical Sciences and Applications Pub Date : 2001-12-25 DOI: 10.1016/S0378-4347(01)00393-0
Koichi Inoue , Akiko Yamaguchi , Megumi Wada , Yoshihiro Yoshimura , Tsunehisa Makino , Hiroyuki Nakazawa
{"title":"Quantitative detection of bisphenol A and bisphenol A diglycidyl ether metabolites in human plasma by liquid chromatography–electrospray mass spectrometry","authors":"Koichi Inoue ,&nbsp;Akiko Yamaguchi ,&nbsp;Megumi Wada ,&nbsp;Yoshihiro Yoshimura ,&nbsp;Tsunehisa Makino ,&nbsp;Hiroyuki Nakazawa","doi":"10.1016/S0378-4347(01)00393-0","DOIUrl":"10.1016/S0378-4347(01)00393-0","url":null,"abstract":"<div><p>Due to the ubiquity of epoxy resin compounds and their potential role in increasing the risk for reproductive dysfunction and cancer, the need for an assessment of human exposure is urgent. Therefore, we developed a method for measuring bisphenol A (BPA) and bisphenol A diglycidyl ether (BADGE) metabolites in human blood samples using high-performance liquid chromatography–electrospray ionization mass spectrometry (LC–MS). Human blood samples were processed using enzymatic deconjugation of the glucuronides followed by a novel sample preparation procedure using a solid-phase-cartridge column. This selective analytical method permits rapid detection of the metabolites, free BPA and a hydrolysis product of BADGE (BADGE-4OH) with detection limits in the low nanogram per milliliter range (0.1 ng ml<sup>−1</sup> of BPA and 0.5 ng ml<sup>−1</sup> of BADGE-4OH). The sample extraction was achieved by Oasis HLB column on gradient elution. The recoveries of BPA and BADGE-4OH added to human plasma samples were above 70.0% with a standard deviation of less than 5.0%. This selective, sensitive and accurate method will assist in elucidating potential associations between human exposure to epoxy-based compounds and adverse health effects.</p></div>","PeriodicalId":15463,"journal":{"name":"Journal of Chromatography B: Biomedical Sciences and Applications","volume":"765 2","pages":"Pages 121-126"},"PeriodicalIF":0.0,"publicationDate":"2001-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0378-4347(01)00393-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81275719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 63
Erratum to “Simultaneous determination of the histamine H1-receptor antagonist ebastine and its two metabolites, carebastine and hydroxyebastine, in human plasma using high-performance liquid chromatography” 《高效液相色谱法同时测定人血浆中组胺h1受体拮抗剂依巴斯汀及其两种代谢物卡伐巴斯汀和羟伐巴斯汀》的勘误
Journal of Chromatography B: Biomedical Sciences and Applications Pub Date : 2001-12-25 DOI: 10.1016/S0378-4347(01)00534-5
Michiaki Matsuda, Yasuyuki Mizuki, Yoshiaki Terauchi
{"title":"Erratum to “Simultaneous determination of the histamine H1-receptor antagonist ebastine and its two metabolites, carebastine and hydroxyebastine, in human plasma using high-performance liquid chromatography”","authors":"Michiaki Matsuda,&nbsp;Yasuyuki Mizuki,&nbsp;Yoshiaki Terauchi","doi":"10.1016/S0378-4347(01)00534-5","DOIUrl":"10.1016/S0378-4347(01)00534-5","url":null,"abstract":"","PeriodicalId":15463,"journal":{"name":"Journal of Chromatography B: Biomedical Sciences and Applications","volume":"765 2","pages":"Page 205"},"PeriodicalIF":0.0,"publicationDate":"2001-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0378-4347(01)00534-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85436059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Determination of transdermal sildenafil in nude mouse skin by reversed-phase high-performance liquid chromatography 反相高效液相色谱法测定裸鼠皮肤透皮中西地那非的含量
Journal of Chromatography B: Biomedical Sciences and Applications Pub Date : 2001-12-25 DOI: 10.1016/S0378-4347(01)00421-2
Jiahorng Liaw , Ting-Wei Chang
{"title":"Determination of transdermal sildenafil in nude mouse skin by reversed-phase high-performance liquid chromatography","authors":"Jiahorng Liaw ,&nbsp;Ting-Wei Chang","doi":"10.1016/S0378-4347(01)00421-2","DOIUrl":"10.1016/S0378-4347(01)00421-2","url":null,"abstract":"<div><p>A simple and sensitive high-performance liquid chromatographic method was developed for the determination of sildenafil transdermal permeation of nude mouse skin. A reversed-phase column with UV detection at 224 nm was used for chromatographic separation. The mobile phase consisted of 32% acetonitrile with 0.2% phosphoric acid in water at pH 5.3 adjusted with 10 <em>M</em> NaOH with the flow-rate set at 1.0 ml/min. The limit of quantitation achieved was 5 ng/ml, and the calibration curve showed good linearity over the concentration range of 5–500 ng/ml. The relative standard deviations of within- and between-day analyses were all within 15%. Sildenafil was found to be stable between pH 3 and 12 during 24-h incubation with skin. After transdermal administration of 15.8 μg/ml of sildenafil to nude mouse skin, it was detected as early as 15 min. The transport amount of sildenafil could be quantitated and, at pH 8–11, had the highest permeation rate in nude mouse skin.</p></div>","PeriodicalId":15463,"journal":{"name":"Journal of Chromatography B: Biomedical Sciences and Applications","volume":"765 2","pages":"Pages 161-166"},"PeriodicalIF":0.0,"publicationDate":"2001-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0378-4347(01)00421-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82157480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 29
Quantitative analysis of fentanyl in rat plasma by gas chromatography with nitrogen–phosphorus detection 大鼠血浆中芬太尼的氮磷气相色谱定量分析
Journal of Chromatography B: Biomedical Sciences and Applications Pub Date : 2001-12-05 DOI: 10.1016/S0378-4347(01)00405-4
Hak Soo Choi , Ho-Chul Shin , Gilson Khang , John M Rhee , Hai Bang Lee
{"title":"Quantitative analysis of fentanyl in rat plasma by gas chromatography with nitrogen–phosphorus detection","authors":"Hak Soo Choi ,&nbsp;Ho-Chul Shin ,&nbsp;Gilson Khang ,&nbsp;John M Rhee ,&nbsp;Hai Bang Lee","doi":"10.1016/S0378-4347(01)00405-4","DOIUrl":"https://doi.org/10.1016/S0378-4347(01)00405-4","url":null,"abstract":"<div><p>A sensitive assay method was developed to determine fentanyl, an opiate agonist, in rat plasma by gas chromatography with nitrogen–phosphorus detection. For the pretreatment of plasma samples, sodium hydroxide was added to denature protein and <em>n</em>-butyl chloride was used to extract fentanyl. The calibration curve was linear within the concentration range 0.5 to 50 ng/ml (<em>r</em>=0.9997). The limit of detection was 0.1 ng/ml, and 0.5 ng/ml could be quantified with acceptable precision. Furthermore, fentanyl could be determined in only 200 μl of rat plasma. The method has been successfully applied to an intramuscular pharmacokinetic study at a dose of 10 μg/kg. Therefore, the current method is a valuable analytical tool for investigating the pharmacokinetics of fentanyl at low clinical doses.</p></div>","PeriodicalId":15463,"journal":{"name":"Journal of Chromatography B: Biomedical Sciences and Applications","volume":"765 1","pages":"Pages 63-69"},"PeriodicalIF":0.0,"publicationDate":"2001-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0378-4347(01)00405-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91701594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Determination of BMS-284756, a new quinolone, in mouse serum by high-performance liquid chromatography with fluorescence detection. 高效液相色谱-荧光法测定小鼠血清中新型喹诺酮类药物BMS-284756的含量。
Journal of Chromatography B: Biomedical Sciences and Applications Pub Date : 2001-12-05 DOI: 10.1016/S0378-4347(01)00394-2
D. Xuan, C. Turley, C. Nightingale, D. Nicolau
{"title":"Determination of BMS-284756, a new quinolone, in mouse serum by high-performance liquid chromatography with fluorescence detection.","authors":"D. Xuan, C. Turley, C. Nightingale, D. Nicolau","doi":"10.1016/S0378-4347(01)00394-2","DOIUrl":"https://doi.org/10.1016/S0378-4347(01)00394-2","url":null,"abstract":"","PeriodicalId":15463,"journal":{"name":"Journal of Chromatography B: Biomedical Sciences and Applications","volume":"25 1","pages":"37-43"},"PeriodicalIF":0.0,"publicationDate":"2001-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78003001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Stereoselective analysis of fluvastatin in human plasma for pharmacokinetic studies. 立体选择分析氟伐他汀在人血浆中的药代动力学研究。
Journal of Chromatography B: Biomedical Sciences and Applications Pub Date : 2001-12-05 DOI: 10.1016/S0378-4347(01)00407-8
V. Lanchote, A. Rocha, F. U. de Albuquerque, E. Coelho, P. S. Bonato
{"title":"Stereoselective analysis of fluvastatin in human plasma for pharmacokinetic studies.","authors":"V. Lanchote, A. Rocha, F. U. de Albuquerque, E. Coelho, P. S. Bonato","doi":"10.1016/S0378-4347(01)00407-8","DOIUrl":"https://doi.org/10.1016/S0378-4347(01)00407-8","url":null,"abstract":"","PeriodicalId":15463,"journal":{"name":"Journal of Chromatography B: Biomedical Sciences and Applications","volume":"20 1","pages":"81-8"},"PeriodicalIF":0.0,"publicationDate":"2001-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87877114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Liquid chromatography–mass spectrometry assay of a thiadiazole derivative in mice: application to pharmacokinetic studies 小鼠体内噻二唑衍生物的液相色谱-质谱分析:在药代动力学研究中的应用
Journal of Chromatography B: Biomedical Sciences and Applications Pub Date : 2001-12-05 DOI: 10.1016/S0378-4347(01)00403-0
Hong Wong , Lee Jia , Jim B Camden , Steve D Weitman
{"title":"Liquid chromatography–mass spectrometry assay of a thiadiazole derivative in mice: application to pharmacokinetic studies","authors":"Hong Wong ,&nbsp;Lee Jia ,&nbsp;Jim B Camden ,&nbsp;Steve D Weitman","doi":"10.1016/S0378-4347(01)00403-0","DOIUrl":"10.1016/S0378-4347(01)00403-0","url":null,"abstract":"<div><p>Modern atmospheric pressure ionization (API) ion-trap mass spectrometry in connection with fast chromatographic separations using a short narrow-bore C<sub>8</sub> column was developed to determine 5-phenyl-3-thioureido-1,2,4-thiadiazole (301029), a novel virus inhibitor in serum. Both 301029 and an internal standard (I.S.) were separated from serum samples by acetonitrile deproteinization and extraction without time-consuming reconstitution. The chromatographic separation was achieved on a C<sub>8</sub> reversed-phase narrow-bore column using acetonitrile–water–acetic acid (90:10:0.01, v/v/v) as a mobile phase. The mass spectrometric analysis was performed by atmospheric pressure chemical ionization (APCI) mode with positive ion detection. Single ion monitoring (SIM) scan mode of <em>m/z</em> 237 and 158 was used to quantitatively determine 301029 and I.S., respectively. The low limit of quantitation was 25 ng/ml. The assay exhibited a linear range of 25–2500 ng/ml. Recovery from serum proved to be 100–113%. The precision (C.V.) and accuracy (RE) of the method were 2–12% and 94–112%, respectively. The present method was applied to determine the pharmacokinetic parameters of 301029 following oral administration of the agent to mice at 5 g/kg. The results revealed that the elimination half-life of 301029 was 413 min and the area under serum concentration–time curve was 354 μg/ml/min.</p></div>","PeriodicalId":15463,"journal":{"name":"Journal of Chromatography B: Biomedical Sciences and Applications","volume":"765 1","pages":"Pages 55-62"},"PeriodicalIF":0.0,"publicationDate":"2001-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0378-4347(01)00403-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76462318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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