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Journal of Clinical Psychopharmacology最新文献

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At Last, a Nondopaminergic Agent for the Treatment of Schizophrenia: The Combination of Xanomeline and Trospium (Cobenfy). 最后，一种治疗精神分裂症的非多巴胺能药物：Xanomeline和Trospium （Cobenfy）联合用药。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-06 DOI: 10.1097/JCP.0000000000001959
Donald C Goff
{"title":"At Last, a Nondopaminergic Agent for the Treatment of Schizophrenia: The Combination of Xanomeline and Trospium (Cobenfy).","authors":"Donald C Goff","doi":"10.1097/JCP.0000000000001959","DOIUrl":"10.1097/JCP.0000000000001959","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"63-64"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Case of Tacrolimus-Associated Psychosis. 他克莫司相关精神病1例。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2024-12-31 DOI: 10.1097/JCP.0000000000001956
Alexa Joy Hooberman, Nikolas J Martinez, Marko Stojcevski, Bennett Wechsler
{"title":"A Case of Tacrolimus-Associated Psychosis.","authors":"Alexa Joy Hooberman, Nikolas J Martinez, Marko Stojcevski, Bennett Wechsler","doi":"10.1097/JCP.0000000000001956","DOIUrl":"10.1097/JCP.0000000000001956","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"152-154"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Use of Classic Psychedelics for Depressive and Anxiety-Spectrum Disorders: A Comprehensive Review. 经典致幻剂在抑郁和焦虑谱系障碍中的应用：综合综述。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-01-01 Epub Date: 2024-11-22 DOI: 10.1097/JCP.0000000000001941
Vivian Kim, Scott M Wilson, Mary E Woesner
{"title":"The Use of Classic Psychedelics for Depressive and Anxiety-Spectrum Disorders: A Comprehensive Review.","authors":"Vivian Kim, Scott M Wilson, Mary E Woesner","doi":"10.1097/JCP.0000000000001941","DOIUrl":"10.1097/JCP.0000000000001941","url":null,"abstract":"<p><strong>Abstract: </strong>Following a decades-long decline in psychedelic research resulting from social, political, and legislative factors, there has been greatly renewed interest in these compounds' ability to treat psychiatric disorders. Classic psychedelics, encompassing both natural and synthetic psychoactive compounds, are characterized by their action as agonists or partial agonists of serotonin 5-hydroxytryptamine 2A receptors. In this comprehensive review, we summarize the latest clinical trials of classic psychedelics on depression and anxiety, attending to the patient demographics and methodology of each study. Overall, studies published since 2020 affirm the potential for classic psychedelics to treat major depressive disorder, treatment-resistant depression, bipolar II, and anxiety-spectrum disorders. However, findings are limited by short follow-up durations and nonstandard dosing and study designs. Given that many of the studies identified were post hoc analyses or follow-up studies from a select few parent studies, it is recommended that more original research be undertaken, with more diverse and larger sample sizes, standardized methodologies including blinding assessment, and long-term follow-up to identify duration of benefits and adverse reactions. It is also important to consider the role of psychological support and the therapeutic alliance in the psychedelic treatment of psychiatric disorders.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":"45 1","pages":"37-45"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of Clozapine Treatment: Study of Variables Affecting Response in Uruguayan Patients With Schizophrenia. 氯氮平治疗的优化：影响乌拉圭精神分裂症患者反应的变量研究。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-01-01 Epub Date: 2024-11-22 DOI: 10.1097/JCP.0000000000001933
Ismael Olmos, Carina Ricciardi, Mauricio Mato, Natalia Guevara, Sabrina Acuña, Cecilia Maldonado, Marta Vázquez, Mauricio Toledo, Clara Menéndez, Valentina Blanco, José L Badano, Alfonso Cayota, Lucia Spangenberg, Magdalena Cardenas-Rodriguez
{"title":"Optimization of Clozapine Treatment: Study of Variables Affecting Response in Uruguayan Patients With Schizophrenia.","authors":"Ismael Olmos, Carina Ricciardi, Mauricio Mato, Natalia Guevara, Sabrina Acuña, Cecilia Maldonado, Marta Vázquez, Mauricio Toledo, Clara Menéndez, Valentina Blanco, José L Badano, Alfonso Cayota, Lucia Spangenberg, Magdalena Cardenas-Rodriguez","doi":"10.1097/JCP.0000000000001933","DOIUrl":"10.1097/JCP.0000000000001933","url":null,"abstract":"<p><strong>Purpose/background: </strong>Clozapine is the recommended drug for treatment-resistant schizophrenia. Drug response could be affected by numerous factors such as age, sex, body mass index, co-medication, consumption of xanthine-containing beverages, smoking, and genetic variants of the enzymes involved in clozapine metabolism (CYP1A2, CYP3A4, and, to a lesser extent, CYP2C19 and CYP2D6). This study evaluated genetic and nongenetic variables that may affect clozapine plasma concentrations in Uruguayan patients with schizophrenia.</p><p><strong>Methods/procedures: </strong>Demographic data including sex, age, ethnicity, body weight, smoking habit, concomitant medication, and xanthine consumption were collected through a data collection form. Clozapine and norclozapine concentrations were determined using an HPLC system equipped with a UV detector. Genetic variants were determined through next-generation sequencing using Illumina sequencing technology and a panel of DNA probes.</p><p><strong>Findings/results: </strong>Fifty patients were included in the study. After evaluation, only tobacco use and obesity had a significant impact on clozapine exposure (P < 0.05). The high prevalence of the genetic variant CYP1A2*1F may account for the significant impact that tobacco smoking has on clozapine concentrations. Some common adverse effects observed in this study depend on clozapine plasma concentrations, such as constipation and sialorrhea.</p><p><strong>Implications/conclusions: </strong>These types of studies provide the clinician with tools to optimize clozapine therapy, attempting to use the minimum effective dose and attenuating the burden of concentration-dependent adverse reactions.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":"45 1","pages":"20-27"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining Alternative Inclusion Criteria Based on Core Symptoms of Depression in Antidepressant Clinical Trials. 抗抑郁药临床试验中基于抑郁核心症状的替代纳入标准的研究
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-01-01 Epub Date: 2024-11-18 DOI: 10.1097/JCP.0000000000001926
Evyn M Peters, Saba Aziz, Lloyd Balbuena
{"title":"Examining Alternative Inclusion Criteria Based on Core Symptoms of Depression in Antidepressant Clinical Trials.","authors":"Evyn M Peters, Saba Aziz, Lloyd Balbuena","doi":"10.1097/JCP.0000000000001926","DOIUrl":"10.1097/JCP.0000000000001926","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":"45 1","pages":"46-47"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Broad-Spectrum Micronutrients or Antidepressants for Antenatal Depression: Effect on Maternal and Infant Birth Outcomes in an Observational Secondary Analysis of NUTRIMUM. 广谱微量营养素或抗抑郁药治疗产前抑郁症：NUTRIMUM观察性二级分析对母婴分娩结局的影响。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-01-01 Epub Date: 2024-12-02 DOI: 10.1097/JCP.0000000000001934
Jessica L Heaton, Siobhan A Campbell, Hayley A Bradley, Roger T Mulder, Lesley Dixon, Jacki Henderson, Julia J Rucklidge
{"title":"Broad-Spectrum Micronutrients or Antidepressants for Antenatal Depression: Effect on Maternal and Infant Birth Outcomes in an Observational Secondary Analysis of NUTRIMUM.","authors":"Jessica L Heaton, Siobhan A Campbell, Hayley A Bradley, Roger T Mulder, Lesley Dixon, Jacki Henderson, Julia J Rucklidge","doi":"10.1097/JCP.0000000000001934","DOIUrl":"10.1097/JCP.0000000000001934","url":null,"abstract":"<p><strong>Purpose/background: </strong>One-fifth of women experience antenatal depression. Untreated antenatal depression is associated with increased risk of adverse birth outcomes. This study investigated the effect of broad-spectrum micronutrients (BSM; vitamins and minerals), used to treat antenatal depression (NUTRIMUM trial), on birth outcomes.</p><p><strong>Methods/procedures: </strong>Birth outcomes of 129 mother-infant pairs were obtained from hospital medical records or personal health records for home births. Pairs from NUTRIMUM exposed to ≥8 weeks of BSM antenatally (MN; n = 55) were compared to pairs exposed to antidepressants antenatally (MED; n = 20) and a reference group (REF; n = 54) of pairs not exposed to trial BSM or antidepressants.</p><p><strong>Findings/results: </strong>Groups were comparable on demographic variables. At study entry, MN and MED had depression scores in the moderate range, statistically higher than REF (nonclinical range). MN and REF did not differ significantly for gestational age, preterm births, infant size, or infant resuscitation. There were significantly lower rates of postpartum hemorrhage in MN relative to REF (7.7% vs 30%; RR = 0.26, 95% CI [0.08-0.84]). Gestational age at birth was higher for MN (39.5 weeks) than MED (38.5 weeks; d = 0.67, 95% CI [0.15-1.20], P = 0.03) as well as infant birth length (52.2 vs 50.0 cm; d = 0.77, 95% CI [0.21-1.33], P = 0.02), and rates of infant resuscitation were lower (14.5% vs 45%; RR = 0.33, 95% CI [0.15-0.73]). Days of BSM exposure was positively associated with birth weight ( r = 0.32, P = 0.008) and length ( r = 0.25, P = 0.04).</p><p><strong>Implications/conclusions: </strong>Micronutrients used to alleviate antenatal depression may mitigate negative effects of depression on birth outcomes and showed more favorable birth outcomes compared with antidepressants.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"4-15"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Citalopram Associated with the Development of Tinnitus in an Adolescent Girl: A Case Report. 西酞普兰与青春期女孩耳鸣的发展有关：一例报告。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-01-01 Epub Date: 2024-11-22 DOI: 10.1097/JCP.0000000000001937
Hasibe Ağır, Fatma Coşkun
{"title":"Citalopram Associated with the Development of Tinnitus in an Adolescent Girl: A Case Report.","authors":"Hasibe Ağır, Fatma Coşkun","doi":"10.1097/JCP.0000000000001937","DOIUrl":"10.1097/JCP.0000000000001937","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":"45 1","pages":"57-58"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recurrent Clozapine-Associated Pneumonia: A Case Report. 复发性氯氮平相关性肺炎1例报告。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-01-01 Epub Date: 2024-11-22 DOI: 10.1097/JCP.0000000000001942
Carolanne Wartman, Melodie Vick, Bethany Thomas
{"title":"Recurrent Clozapine-Associated Pneumonia: A Case Report.","authors":"Carolanne Wartman, Melodie Vick, Bethany Thomas","doi":"10.1097/JCP.0000000000001942","DOIUrl":"10.1097/JCP.0000000000001942","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":"45 1","pages":"52-54"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ischemic Priapism With Therapeutic Serum Concentrations of Psychotropic Medications. 血清中精神药物浓度达到治疗水平的缺血性尿崩症。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-01-01 Epub Date: 2024-11-27 DOI: 10.1097/JCP.0000000000001940
Fumiya Inoue, Yuji Okazaki, Kyungo Huh, Toshihisa Ichiba, Akira Namera
{"title":"Ischemic Priapism With Therapeutic Serum Concentrations of Psychotropic Medications.","authors":"Fumiya Inoue, Yuji Okazaki, Kyungo Huh, Toshihisa Ichiba, Akira Namera","doi":"10.1097/JCP.0000000000001940","DOIUrl":"10.1097/JCP.0000000000001940","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"54-55"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142729112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noncardiac Chest Pain and Hypertensive Urgency During Long-term Intravenous Racemic Ketamine for Treatment-Resistant Depression. 长期静脉外消旋氯胺酮治疗难治性抑郁症期间的非心源性胸痛和高血压急症。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-01-01 Epub Date: 2024-11-18 DOI: 10.1097/JCP.0000000000001939
Liliana Patarroyo-Rodriguez, Jennifer L Vande Voort, Simon Kung, Sarah K Brown, Stefanie Cavalcanti, Matthew J Ritter, Balwinder Singh
{"title":"Noncardiac Chest Pain and Hypertensive Urgency During Long-term Intravenous Racemic Ketamine for Treatment-Resistant Depression.","authors":"Liliana Patarroyo-Rodriguez, Jennifer L Vande Voort, Simon Kung, Sarah K Brown, Stefanie Cavalcanti, Matthew J Ritter, Balwinder Singh","doi":"10.1097/JCP.0000000000001939","DOIUrl":"10.1097/JCP.0000000000001939","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":"45 1","pages":"49-52"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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