Journal of Clinical Psychopharmacology最新文献_第6页

Article Selected to Receive the Mitchell B. Balter Award. 文章被选为米切尔B.巴尔特奖。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1097/JCP.0000000000001992

Anthony J Rothschild, Richard I Shader, Richard Balon, Susan L McElroy

引用次数: 0

Positive Pyramidal Sign as an Unexpected Presentation in Antipsychotic-Induced Acute Dystonia: Case Reports and Literature Review. 在抗精神病药物引起的急性肌张力障碍中，锥体正征是一种意想不到的表现：病例报告和文献回顾。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-03-25 DOI: 10.1097/JCP.0000000000001985

Yi-Hui Liu, Ming Chen, Ye-Kai Huang, Wei-Lin Wang, Jia-Rong Liang, Fu-Jun Jia, Cai-Lan Hou

{"title":"Positive Pyramidal Sign as an Unexpected Presentation in Antipsychotic-Induced Acute Dystonia: Case Reports and Literature Review.","authors":"Yi-Hui Liu, Ming Chen, Ye-Kai Huang, Wei-Lin Wang, Jia-Rong Liang, Fu-Jun Jia, Cai-Lan Hou","doi":"10.1097/JCP.0000000000001985","DOIUrl":"10.1097/JCP.0000000000001985","url":null,"abstract":"Background: Acute drug-induced dystonia (DID) is an extrapyramidal side effect triggered by certain medications, primarily antipsychotics. It presents as acute involuntary muscle contractions, causing twisting, repetitive movements, or abnormal postures. Pyramidal signs, typically from upper motor neuron damage, are characterized by positive pathological reflexes, increased muscle tone, and hyperactive tendon reflexes.Procedures: This study describes 2 cases of acute DID following antipsychotic treatment, both presenting with positive pyramidal sign. A literature review was conducted to find reports of abnormal pyramidal signs in acute DID cases, focusing on medical tests for differential diagnosis and neurological assessments related to DID.Results: After reviewing the detailed medication history and conducting comprehensive tests, it was concluded that risperidone and haloperidol caused DID. Adjusting the medication and providing symptomatic treatment led to significant improvement.Conclusions: These cases highlight the importance of being alert to the possibility of acute DID when using antipsychotics and pyramidal signs appear, providing insights for future research into the mechanisms of these unusual symptoms.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"282-286"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pramipexole Augmentation for Treatment-Resistant Unipolar Depression Not Responding to Aripiprazole Augmentation: An Observational Study. 阿立哌唑增强治疗对难治性单极抑郁症无效：一项观察性研究。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-04-01 DOI: 10.1097/JCP.0000000000001986

Antonio Tundo, Sophia Betro', Rocco de Filippis, Roberto Felici, Chiara Lucangeli, Marica Iommi

{"title":"Pramipexole Augmentation for Treatment-Resistant Unipolar Depression Not Responding to Aripiprazole Augmentation: An Observational Study.","authors":"Antonio Tundo, Sophia Betro', Rocco de Filippis, Roberto Felici, Chiara Lucangeli, Marica Iommi","doi":"10.1097/JCP.0000000000001986","DOIUrl":"10.1097/JCP.0000000000001986","url":null,"abstract":"Background: At least 50% of patients with treatment-resistant depression (TRD) fail to respond to antidepressant augmentation with aripiprazole (AA), currently the augmentation strategy with the best evidence of efficacy. The present observational study investigated whether pramipexole augmentation (PA) might be useful for patients who failed AA.Methods: We compared the short- and long-term effectiveness and safety of PA in 81 consecutively recruited unipolar patients with TRD, 58 (71.6%) not previously treated with AA (UAA) and 23 (28.4%) who previously failed AA (FAA).Results: The FAA and UAA groups did not differ significantly in terms of remission, response, improvement, and general functioning at 12 and 24 weeks and in terms of freedom from relapse at 12 and 24 months. The response rates at 24 weeks were 69.6% (n = 16) and 77.6% (n = 45), and the remission rates were 60.9% (n = 14) and 74.1% (n = 43), respectively. The rates of sustained response at 24 months were 72.7% (n = 8) and 84.2% (n = 16), respectively. The 2 groups did not differ significantly on safety outcomes (acceptability, tolerability, suicidality and suicide attempts) in the short and long term.Conclusions: Our study showed that the off-label use of PA may be a promising treatment for patients with unipolar TRD who had previously failed respond to AA. The present findings are preliminary and should be interpreted with caution due to study limitations, including the flexibility of the add-on schedule and the small sample size of patients followed up for 12 and 24 months, and need to be confirmed in larger studies.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"236-242"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bicytopenia in the Context of Olanzapine Treatment: A Case Report. 奥氮平治疗中的双氧体减少症：1例报告。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-03-26 DOI: 10.1097/JCP.0000000000001977

Blanca Serra-Sarró, Darío Ramis, Helena Álvarez, Ailin Herrero, Cecilia Mantellini, Miguel Vicente, Rosa Catalán, Miquel Bioque, Vicent Llorca-Bofí

引用次数: 0

N -Acetylcysteine for Nonsuicidal Self-Injurious Behavior in 3 Adults With Williams Syndrome : A Case Series. n -乙酰半胱氨酸对威廉斯综合征3例成人非自杀自伤行为的影响

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI: 10.1097/JCP.0000000000001976

Hagar Kandel, Ava R Cruz, Robyn P Thom, Christopher J McDougle

{"title":"N -Acetylcysteine for Nonsuicidal Self-Injurious Behavior in 3 Adults With Williams Syndrome : A Case Series.","authors":"Hagar Kandel, Ava R Cruz, Robyn P Thom, Christopher J McDougle","doi":"10.1097/JCP.0000000000001976","DOIUrl":"10.1097/JCP.0000000000001976","url":null,"abstract":"Background: Williams syndrome (WS) is a genetic disorder that results from a microdeletion of 25 to 27 genes on chromosome 7q11.23. Individuals with WS often exhibit comorbid neuropsychiatric symptoms, especially anxiety. To our knowledge, nonsuicidal self-injurious behavior (NSSIB) has not been reported in WS. N -acetylcysteine (NAC) is a safe and readily available drug that may modulate glutamate activity in the brain. NAC is effective for treating various neuropsychiatric symptoms and disorders. There are limited reports in the literature where NAC has been used to treat NSSIB effectively, but none in WS.Methods: This report describes using NAC to treat NSSIB in 3 adults with WS.Findings: Nonsuicidal self-injurious behavior was successfully treated in 3 adults with WS using NAC in doses ranging from 2400 to 3600 mg a day, resulting in significant improvement in their daily functioning. Additionally, NAC was well tolerated.Conclusions: NAC was effective for treating NSSIB in 3 adults with WS. By addressing these challenging behaviors, NAC offers a promising pharmacological intervention that can significantly improve the quality of life for patients with WS who engage in NSSIB. Further research and clinical trials are necessary.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"277-281"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of Neutropenia Associated With Duloxetine: A Case Study of an 80-Year-Old Man With Depression Related to Long COVID. 度洛西汀相关中性粒细胞减少的风险：一名80岁男性长期COVID相关抑郁症病例研究

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-03-26 DOI: 10.1097/JCP.0000000000001978

Masahiro Ono, Sachiko Eguchi, Tetsuya Hagiwara, Daimei Sasayama, Shinsuke Washizuka

引用次数: 0

Persistent Psychosis Associated With Intravenous Ketamine in a Patient Using Cannabis: A Case Report and Literature Review. 持续精神病与静脉注射氯胺酮大麻患者：一个病例报告和文献综述。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-03-27 DOI: 10.1097/JCP.0000000000001995

Rachel M Pacilio, Jamarie A Geller

引用次数: 0

Citalopram-Associated Hyponatremia Presenting as Distal Extremity Numbness: A Case Report. 西酞普兰相关低钠血症表现为远端肢体麻木：1例报告。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-03-31 DOI: 10.1097/JCP.0000000000001994

Chenyue Xu, Lingzhuo Kong, Shaohua Hu, Jianbo Lai

引用次数: 0

Antimicrobial Exposure and Risk for Incident Major Depressive Disorder. 抗微生物药物暴露与发生重度抑郁症的风险。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-04-07 DOI: 10.1097/JCP.0000000000002004

Hope Thelander, Brett Heintz, Lucas Watson, Bruce Alexander, Brian C Lund

{"title":"Antimicrobial Exposure and Risk for Incident Major Depressive Disorder.","authors":"Hope Thelander, Brett Heintz, Lucas Watson, Bruce Alexander, Brian C Lund","doi":"10.1097/JCP.0000000000002004","DOIUrl":"10.1097/JCP.0000000000002004","url":null,"abstract":"Background: Antibacterials are among the most frequently prescribed medications. Antibacterial drugs have the unintended consequence of destroying healthy gut flora, which can lead to known adverse events such as Clostridium difficile infection. Given emerging research concerning the role of these microorganisms in the gut-brain axis and some limited epidemiological studies, the objective of this study was to determine if antimicrobial exposure is associated with increased risk for depression.Methods: National Veterans Health Administration administrative data were used to identify 878,405 veteran patients prescribed an incident antimicrobial during calendar year 2018. Sequence symmetry analysis was used to compare the incidence of a depressive disorder in the 6 months before and after antibacterial exposure, with additional analyses conducted with other antimicrobial classes as negative controls including antifungals, antivirals, and nonsystemic antibacterials.Results: Antibacterial initiation was associated with a small but significant increase in the risk of incident depression (symmetry ratio [SR] = 1.04, 95% confidence interval [CI]: 1.03, 1.05), which was limited to the first 8 weeks following exposure. The strength of association varied with categories of antibacterial spectrum, from SR = 0.98 (95% CI: 0.95, 1.01) with the narrowest spectrum regimens, to SR = 1.12 (95% CI: 1.09, 1.15) with the broadest regimens. No significant association with incident depression was observed for antifungals, antivirals, and nonsystemic antibacterials.Conclusions: Antibacterial exposure was associated with increased risk for a depressive disorder. These findings are consistent with emerging literature and support the need for further research investigating a causal relationship between antibacterial exposure and risk for adverse mental health outcomes.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"219-224"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-05-01 Epub Date: 2025-04-09 DOI: 10.1097/JCP.0000000000001997

Madhuri H Nanjundaswamy, Aana Shah, Shraddha Lotlikar, Rashmi Arasappa, Sundarnag Ganjekar, Harish Thippeswamy, Prabha S Chandra, Geetha Desai

{"title":"Lactation-Related Side Effects of Aripiprazole: A Study From Perinatal Psychiatry Services in India.","authors":"Madhuri H Nanjundaswamy, Aana Shah, Shraddha Lotlikar, Rashmi Arasappa, Sundarnag Ganjekar, Harish Thippeswamy, Prabha S Chandra, Geetha Desai","doi":"10.1097/JCP.0000000000001997","DOIUrl":"10.1097/JCP.0000000000001997","url":null,"abstract":"Background: Aripiprazole, a prolactin-sparing antipsychotic, is considered relatively safe during pregnancy and has a better metabolic profile compared to other antipsychotics. However, its impact on lactation has not been adequately studied. This study aimed to assess the relationship between aripiprazole use during pregnancy and the postpartum period with lactation outcomes.Methods: Clinical charts of women attending perinatal psychiatry services between January 2016 and December 2021 were reviewed for details of aripiprazole prescription, clinical information, and lactation outcomes. Lactation failure was defined as the total absence of milk flow or secretion of minimal amounts for at least 7 days.Results: Among the 398 women attending perinatal psychiatry services, 60 were prescribed aripiprazole during pregnancy, with lactation data available for 35 women who continued the drug during the postpartum period. The mean age of women in years was 29 (±4.4) years. The most common diagnosis for aripiprazole prescription was schizophrenia (60%). Approximately 54.2% of the women were primiparous. Of the 35 women with available lactation data, 26 (74%) experienced complete lactation failure, and 4 (11%) had insufficient milk production while on aripiprazole. The mean dose of aripiprazole was 16.4 mg/day, with a mean duration of use of 20 months.Conclusions: In this study, most women who continued aripiprazole through pregnancy and postpartum experienced either lactation failure or insufficient milk production. It is important to discuss lactation issues associated with the use of aripiprazole with women during pregnancy and the postpartum period.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"258-266"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0