Journal of Clinical Psychopharmacology最新文献

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Growing Concerns Over Valproate Teratogenicity Present an Opportunity for Lithium. 对丙戊酸致畸性的日益关注为锂提供了机会。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2025-01-06 DOI: 10.1097/JCP.0000000000001948
Samuel Dotson, Andrew Nierenberg
{"title":"Growing Concerns Over Valproate Teratogenicity Present an Opportunity for Lithium.","authors":"Samuel Dotson, Andrew Nierenberg","doi":"10.1097/JCP.0000000000001948","DOIUrl":"10.1097/JCP.0000000000001948","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"65-66"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protracted Psychiatric Complications Including Psychosis in a Middle-Aged Man After COVID-19 Vaccination: A Case Report. 1例中年男子接种COVID-19疫苗后出现包括精神病在内的长期精神并发症
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-10 DOI: 10.1097/JCP.0000000000001969
Seshagiri Rao Doddi, Francis Pham, Jennifer Wineke, Christopher Marano, Deborah Brooks
{"title":"Protracted Psychiatric Complications Including Psychosis in a Middle-Aged Man After COVID-19 Vaccination: A Case Report.","authors":"Seshagiri Rao Doddi, Francis Pham, Jennifer Wineke, Christopher Marano, Deborah Brooks","doi":"10.1097/JCP.0000000000001969","DOIUrl":"10.1097/JCP.0000000000001969","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"160-162"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vasopressor Requirements in Antipsychotic Overdose: A Poison Center Observational Study. 抗精神病药物过量对血管加压素的需求:一项毒物中心观察性研究。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-10 DOI: 10.1097/JCP.0000000000001965
Natasha Tobarran, Emily K Kershner, Kirk L Cumpston, Andrew Chambers, Avery Michienzi, S Rutherfoord Rose, Nathan Charlton, Brandon K Wills
{"title":"Vasopressor Requirements in Antipsychotic Overdose: A Poison Center Observational Study.","authors":"Natasha Tobarran, Emily K Kershner, Kirk L Cumpston, Andrew Chambers, Avery Michienzi, S Rutherfoord Rose, Nathan Charlton, Brandon K Wills","doi":"10.1097/JCP.0000000000001965","DOIUrl":"10.1097/JCP.0000000000001965","url":null,"abstract":"<p><strong>Purpose/background: </strong>The antipsychotic class of medications has a varying degree of peripheral alpha antagonism resulting vasodilation and potentially hypotension. These hemodynamic changes may require treatment with crystalloids and vasopressors. The primary aim of this study was to evaluate the occurrence of hypotension after antipsychotic overdose and characterize vasopressor use.</p><p><strong>Methods/procedures: </strong>A retrospective cohort study was conducted by chart review of electronic records from 2 regional poison centers from January 1, 2004, to December 31, 2020. Inclusion criteria were single acute antipsychotic exposures evaluated in a health care facility and age >15. Exclusion criteria included missing data, minor or no effect outcomes, and polypharmacy overdose. The primary outcome was hypotension, which was defined as systolic blood pressure <90 mm Hg and/or MAP <65.</p><p><strong>Findings/results: </strong>There were 4488 single acute antipsychotic overdoses that presented to a healthcare facility after the initial search was conducted. After exclusions, there were 2070 cases with moderate or severe outcomes. The mean age was 42 (SD = 16), and 70% were female. There were 169 cases with hypotension. Of the hypotensive cases, 92% involved atypical antipsychotics, with quetiapine being the most common (n = 128, 76%). Vasopressor therapy was administered in 16/169 cases (9.9%). In the cases where vasopressor use was recorded, norepinephrine was used 12 times, dopamine 3 times, and phenylephrine once. No deaths were reported.</p><p><strong>Implications/conclusions: </strong>In antipsychotic overdoses that presented to a healthcare facility, hypotension was present in n = 169 (3.8%).</p><p><strong>Conclusions: </strong>Among patient reports to 2 regional poison centers, we found that hypotension following acute antipsychotic overdose was infrequent and vasopressors are rarely administered.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"92-95"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Second-Generation Antipsychotic-Associated Serious Adverse Events in Women: An Analysis of a National Pharmacoepidemiologic Database. 女性第二代抗精神病药物相关严重不良事件:国家药物流行病学数据库分析。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 DOI: 10.1097/JCP.0000000000001962
Kenneth L McCall, Emily E Leppien, Brian J Piper, Bridgette M Falco, Kara K Fleck, Jacob C Govel, Gianna N Nasta, Steven R Zheng
{"title":"Second-Generation Antipsychotic-Associated Serious Adverse Events in Women: An Analysis of a National Pharmacoepidemiologic Database.","authors":"Kenneth L McCall, Emily E Leppien, Brian J Piper, Bridgette M Falco, Kara K Fleck, Jacob C Govel, Gianna N Nasta, Steven R Zheng","doi":"10.1097/JCP.0000000000001962","DOIUrl":"10.1097/JCP.0000000000001962","url":null,"abstract":"<p><strong>Purpose: </strong>Women have historically been underrepresented in second-generation antipsychotic (SGA) clinical trials, accounting for less than 35% of participants, which raises concerns about the generalizability of the safety profile for these medications.</p><p><strong>Methods: </strong>The US adverse event reporting system was queried for the dates January 1, 2019, to July 8, 2024, to examine the following 6 SGAs: aripiprazole, clozapine, olanzapine, quetiapine, risperidone, and ziprasidone. Reports were excluded if patients were under 18 years old, contained an unknown age or gender, or were duplicated. Five adverse events were examined: Torsades de pointes (TdP), neuroleptic malignant syndrome (NMS), tardive dyskinesia (TD), agranulocytosis (AG), and cerebrovascular adverse events (CVAE). Counts of these events were noted, and reporting odds ratios (ROR) were calculated.</p><p><strong>Results: </strong>The total study cohort was 87,356 reports, consisting of aripiprazole (n = 10,715, 12.2%), clozapine (n = 25,096, 28.7%), olanzapine (n = 11,587, 13.3%), quetiapine (n = 28,746, 32.9%), risperidone (n = 10,467, 12%), and ziprasidone (n = 745, 0.9%). The cohort's mean age was 48.6 ± 18.5 years and comprised 42,584 females (48.7%). Most cases were reported by healthcare professionals (74,836, 85.7%). A total of 3,754 reports contained at least 1 of the 5 adverse events. The RORs among females compared to males for TdP (5.55, 95% confidence interval [CI] = 3.78-8.47), NMS (0.59, 95% CI = 0.53-0.65), TD (0.88, 95% CI = 0.76-1.02), AG (0.59, 95% CI = 0.51-0.70), and CVAE (1.12, 95% CI = 0.89-1.41) were observed. Females had a significantly higher odds of hospitalization or death with TdP compared to males (ROR = 3.09, 95% CI = 1.36-7.01).</p><p><strong>Conclusions: </strong>Our findings suggest higher odds of TdP and worse TdP-associated outcomes among females exposed to SGAs compared to males. Further studies are needed to confirm these preliminary findings.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":"45 2","pages":"111-115"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ketamine's Altered States Meta-Analysis: The Relationship Between Psychomimetic and Clinical Effects With Focus in Depression. 氯胺酮的改变状态元分析:精神模拟与临床效应之间的关系,聚焦抑郁症。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2024-12-23 DOI: 10.1097/JCP.0000000000001946
Vagner Deuel de O Tavares, Kaike Thiê da Costa Gonçalves, Maria Luiza de Morais Barros, Aldielyson Jorge Cavalcante de Brito, Patrícia Cavalcanti-Ribeiro, Fernanda Palhano-Fontes, Marcelo Falchi-Carvalho, Emerson Arcoverde Nunes, Jerome Sarris, Daniel Perkins, Gisele Fernandes-Osterhold, Draulio Barros de Araujo, Nicole Leite Galvão-Coelho
{"title":"Ketamine's Altered States Meta-Analysis: The Relationship Between Psychomimetic and Clinical Effects With Focus in Depression.","authors":"Vagner Deuel de O Tavares, Kaike Thiê da Costa Gonçalves, Maria Luiza de Morais Barros, Aldielyson Jorge Cavalcante de Brito, Patrícia Cavalcanti-Ribeiro, Fernanda Palhano-Fontes, Marcelo Falchi-Carvalho, Emerson Arcoverde Nunes, Jerome Sarris, Daniel Perkins, Gisele Fernandes-Osterhold, Draulio Barros de Araujo, Nicole Leite Galvão-Coelho","doi":"10.1097/JCP.0000000000001946","DOIUrl":"10.1097/JCP.0000000000001946","url":null,"abstract":"<p><strong>Background: </strong>In recent years, there has been a significant focus on exploring the potential therapeutic impact of altered states of consciousness on treatment outcomes for mental illness, with the goal of enhancing therapeutic strategies and patient results.</p><p><strong>Methods: </strong>This meta-analysis was designed to investigate the potential link between the psychomimetic effects of ketamine and clinical outcomes in mental health, which adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.</p><p><strong>Results: </strong>Eleven studies were selected for meta-analysis, and the main result did not find a significant correlation between the psychoactive effects of ketamine and clinical outcomes either in mental illness (n = 11; n's = 27; r = 0.06 [-0.05, 0.17]; P = 0.268) or depression exclusively (n = 10; n's = 25; r = 0.03 [-0.07, 0.13]; P = 0.561). High heterogeneity was found for general analysis ( I2 = 80.78). Egger's regression did not indicate publication bias (intercept = 1.57; SE = 1.49, P = 0.30). No significant Kendall's rank correlation coefficient was observed ( τ = 0.02, P = 0.88) indicating funnel plot symmetry. The sub-analyses, aimed at minimizing study variability by specifically examining factors such as patient disorders (limited to depression), methods of administration (exclusively intravenous), types of assessment instruments, and the timing of evaluations, also yielded no significant findings.</p><p><strong>Conclusion: </strong>This meta-analysis suggests that the altered states of consciousness experienced during ketamine sessions are not directly linked to clinical outcomes. However, it is important to acknowledge that the limited number of studies and their heterogeneity render this conclusion preliminary, warranting further investigation over time.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"127-139"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clozapine Use in Down Syndrome: A Surprising Paucity of Evidence. 氯氮平在唐氏综合症中的应用:令人惊讶的缺乏证据。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2025-01-14 DOI: 10.1097/JCP.0000000000001953
Mark Ainsley Colijn
{"title":"Clozapine Use in Down Syndrome: A Surprising Paucity of Evidence.","authors":"Mark Ainsley Colijn","doi":"10.1097/JCP.0000000000001953","DOIUrl":"10.1097/JCP.0000000000001953","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"170-171"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of Duloxetine-Related Adverse Events Using the Food and Drug Administration Adverse Event Reporting System: Implications for Monitoring and Management. 使用食品和药物管理局不良事件报告系统分析度洛西汀相关不良事件:对监测和管理的影响。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-13 DOI: 10.1097/JCP.0000000000001966
Meng Zhu, Shengxia Lv, Feiye Zhu, Yongsheng Zhang
{"title":"Analysis of Duloxetine-Related Adverse Events Using the Food and Drug Administration Adverse Event Reporting System: Implications for Monitoring and Management.","authors":"Meng Zhu, Shengxia Lv, Feiye Zhu, Yongsheng Zhang","doi":"10.1097/JCP.0000000000001966","DOIUrl":"10.1097/JCP.0000000000001966","url":null,"abstract":"<p><strong>Background: </strong>The objective of this study was to examine the characteristics of adverse drug reactions of duloxetine and investigate the potential precautions that may exist beyond the drug label.</p><p><strong>Methods: </strong>This study used data from the Food and Drug Administration Adverse Event Reporting System database 2004-2023 and the linked information of duloxetine. Four algorithms used to evaluate the correlation between duloxetine and adverse events include reporting odds ratio, proportional reporting ratio, Bayesian confidence propagation neural network, and multi-item gamma Poisson shrinker.</p><p><strong>Results: </strong>Adverse reactions involving duloxetine were associated with 24 System Organ Classes. Among them, the three most frequent systems affected were psychiatric disorders (reporting odds ratio [ROR] 5.05), nervous system disorders (ROR 2.27), and general medical conditions and administration site conditions (ROR 0.83). Of particular note, the number of reported cases and the risk of occurrence of adverse events of drug withdrawal syndrome (n = 7498), nausea (n = 7942), and headache (n = 5732) were the highest, increasing each year and reached a peak submission in 2017. More importantly, the occurrence of reproductive system and breast disorders (chisq 317.85) was not mentioned in the drug leaflet.</p><p><strong>Conclusions: </strong>Psychiatric and nervous system disorders are the most frequently reported adverse events associated with duloxetine, with drug withdrawal syndrome, nausea, and headache being especially common. The emergence of mood-related symptoms, such as agitation and irritability, underscores the need for vigilant monitoring of mental health. Additionally, potential risks affecting the reproductive system suggest areas for further attention. These findings highlight the importance of proactive monitoring to improve patient safety during duloxetine treatment.</p>","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"96-105"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Question: Is Pimozide Associated With Male Infertility? 问题:匹莫齐特与男性不育有关吗?
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.1097/JCP.0000000000001972
Richard I Shader
{"title":"Question: Is Pimozide Associated With Male Infertility?","authors":"Richard I Shader","doi":"10.1097/JCP.0000000000001972","DOIUrl":"10.1097/JCP.0000000000001972","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"174"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Premature Ejaculation After Discontinuation of Venlafaxine in a Case of Bipolar Depression. 双相抑郁症患者停用文拉法辛后早泄1例。
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-10 DOI: 10.1097/JCP.0000000000001970
Nidhisha Bajaj, Yash Bajaj
{"title":"Premature Ejaculation After Discontinuation of Venlafaxine in a Case of Bipolar Depression.","authors":"Nidhisha Bajaj, Yash Bajaj","doi":"10.1097/JCP.0000000000001970","DOIUrl":"10.1097/JCP.0000000000001970","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"162-163"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacogenetic Variant Related Higher-Than-Expected Clozapine Concentrations and Clozapine/Norclozapine Ratios in a Patient With Treatment-Resistant Schizoaffective Disorder: A Case Report. 难治性分裂情感性障碍患者的药物遗传变异相关氯氮平浓度和氯氮平/去氯氮平比高于预期:一例报告
IF 2.9 3区 医学
Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-12 DOI: 10.1097/JCP.0000000000001973
Nadir Yalçın, İzgi Bayraktar, Asli Akyol, Ilter Deger, Mehmet Fatih İman, Emre Mutlu, Sertaç Ak, Füsun Özmen, Melih Ö Babaoglu
{"title":"Pharmacogenetic Variant Related Higher-Than-Expected Clozapine Concentrations and Clozapine/Norclozapine Ratios in a Patient With Treatment-Resistant Schizoaffective Disorder: A Case Report.","authors":"Nadir Yalçın, İzgi Bayraktar, Asli Akyol, Ilter Deger, Mehmet Fatih İman, Emre Mutlu, Sertaç Ak, Füsun Özmen, Melih Ö Babaoglu","doi":"10.1097/JCP.0000000000001973","DOIUrl":"10.1097/JCP.0000000000001973","url":null,"abstract":"","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":"163-165"},"PeriodicalIF":2.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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