Journal of Clinical Psychopharmacology最新文献_第6页

Oculogyric Crisis Associated With Clozapine: Case Report and Review of Literature. 与氯氮平相关的眼科危机：病例报告和文献回顾。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1097/JCP.0000000000001960

Rashmi Shukla, Aleena Thomas

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Blonanserin-Associated Leukopenia: Two Case Reports. blonanserin相关性白细胞减少2例报告。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2024-12-19 DOI: 10.1097/JCP.0000000000001949

Ruyi Zhang, Jia Liu, Shanshan Wang, Dingding Feng, Zhongxuan Ma, Fuquan Zhang

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Recognition of Clozapine-Associated Eosinopenia in Patients With Treatment-Resistant Schizophrenia: A Report of 3 Cases and Literature Review. 难治性精神分裂症患者氯氮平相关性红细胞减少症的识别：附3例报告并文献复习。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2024-12-17 DOI: 10.1097/JCP.0000000000001947

Samuel C Buesking, Carrie R Kriz, Stephen P Jarvis, Leigh Anne Nelson

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COVID-19 and Neuroleptic Malignant Syndrome: A Case Report and Review of Literature. COVID-19与抗精神病药恶性综合征1例报告及文献复习。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI: 10.1097/JCP.0000000000001957

Greg Noe, Kaushal Shah, Samantha Ongchuan-Martin, Sahil Munjal

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Duloxetine-Associated Erosive Gastritis and Gastroesophageal Reflux: A Case Report. 度洛西汀相关糜烂性胃炎及胃食管反流1例

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2025-01-14 DOI: 10.1097/JCP.0000000000001952

Nilgun Oktar Erdogan

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At Last, a Nondopaminergic Agent for the Treatment of Schizophrenia: The Combination of Xanomeline and Trospium (Cobenfy). 最后，一种治疗精神分裂症的非多巴胺能药物：Xanomeline和Trospium （Cobenfy）联合用药。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2025-02-06 DOI: 10.1097/JCP.0000000000001959

Donald C Goff

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A Case of Tacrolimus-Associated Psychosis. 他克莫司相关精神病1例。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-03-01 Epub Date: 2024-12-31 DOI: 10.1097/JCP.0000000000001956

Alexa Joy Hooberman, Nikolas J Martinez, Marko Stojcevski, Bennett Wechsler

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N-Acetylcysteine for Nonsuicidal Self-Injurious Behavior in 3 Adults With Williams Syndrome: A Case Series. n -乙酰半胱氨酸对威廉斯综合征3例成人非自杀自伤行为的影响

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-02-27 DOI: 10.1097/JCP.0000000000001976

Hagar Kandel, Ava R Cruz, Robyn P Thom, Christopher J McDougle

{"title":"N-Acetylcysteine for Nonsuicidal Self-Injurious Behavior in 3 Adults With Williams Syndrome: A Case Series.","authors":"Hagar Kandel, Ava R Cruz, Robyn P Thom, Christopher J McDougle","doi":"10.1097/JCP.0000000000001976","DOIUrl":"https://doi.org/10.1097/JCP.0000000000001976","url":null,"abstract":"Background: Williams syndrome (WS) is a genetic disorder that results from a microdeletion of 25 to 27 genes on chromosome 7q11.23. Individuals with WS often exhibit comorbid neuropsychiatric symptoms, especially anxiety. To our knowledge, nonsuicidal self-injurious behavior (NSSIB) has not been reported in WS. N-acetylcysteine (NAC) is a safe and readily available drug that may modulate glutamate activity in the brain. NAC is effective for treating various neuropsychiatric symptoms and disorders. There are limited reports in the literature where NAC has been used to treat NSSIB effectively, but none in WS.Methods: This report describes using NAC to treat NSSIB in 3 adults with WS.Findings: Nonsuicidal self-injurious behavior was successfully treated in 3 adults with WS using NAC in doses ranging from 2400 to 3600 mg a day, resulting in significant improvement in their daily functioning. Additionally, NAC was well tolerated.Conclusions: NAC was effective for treating NSSIB in 3 adults with WS. By addressing these challenging behaviors, NAC offers a promising pharmacological intervention that can significantly improve the quality of life for patients with WS who engage in NSSIB. Further research and clinical trials are necessary.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Use of Classic Psychedelics for Depressive and Anxiety-Spectrum Disorders: A Comprehensive Review. 经典致幻剂在抑郁和焦虑谱系障碍中的应用：综合综述。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-01-01 Epub Date: 2024-11-22 DOI: 10.1097/JCP.0000000000001941

Vivian Kim, Scott M Wilson, Mary E Woesner

{"title":"The Use of Classic Psychedelics for Depressive and Anxiety-Spectrum Disorders: A Comprehensive Review.","authors":"Vivian Kim, Scott M Wilson, Mary E Woesner","doi":"10.1097/JCP.0000000000001941","DOIUrl":"10.1097/JCP.0000000000001941","url":null,"abstract":"Abstract: Following a decades-long decline in psychedelic research resulting from social, political, and legislative factors, there has been greatly renewed interest in these compounds' ability to treat psychiatric disorders. Classic psychedelics, encompassing both natural and synthetic psychoactive compounds, are characterized by their action as agonists or partial agonists of serotonin 5-hydroxytryptamine 2A receptors. In this comprehensive review, we summarize the latest clinical trials of classic psychedelics on depression and anxiety, attending to the patient demographics and methodology of each study. Overall, studies published since 2020 affirm the potential for classic psychedelics to treat major depressive disorder, treatment-resistant depression, bipolar II, and anxiety-spectrum disorders. However, findings are limited by short follow-up durations and nonstandard dosing and study designs. Given that many of the studies identified were post hoc analyses or follow-up studies from a select few parent studies, it is recommended that more original research be undertaken, with more diverse and larger sample sizes, standardized methodologies including blinding assessment, and long-term follow-up to identify duration of benefits and adverse reactions. It is also important to consider the role of psychological support and the therapeutic alliance in the psychedelic treatment of psychiatric disorders.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":"45 1","pages":"37-45"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of Clozapine Treatment: Study of Variables Affecting Response in Uruguayan Patients With Schizophrenia. 氯氮平治疗的优化：影响乌拉圭精神分裂症患者反应的变量研究。

IF 2.9 3区医学

Journal of Clinical Psychopharmacology Pub Date : 2025-01-01 Epub Date: 2024-11-22 DOI: 10.1097/JCP.0000000000001933

Ismael Olmos, Carina Ricciardi, Mauricio Mato, Natalia Guevara, Sabrina Acuña, Cecilia Maldonado, Marta Vázquez, Mauricio Toledo, Clara Menéndez, Valentina Blanco, José L Badano, Alfonso Cayota, Lucia Spangenberg, Magdalena Cardenas-Rodriguez

{"title":"Optimization of Clozapine Treatment: Study of Variables Affecting Response in Uruguayan Patients With Schizophrenia.","authors":"Ismael Olmos, Carina Ricciardi, Mauricio Mato, Natalia Guevara, Sabrina Acuña, Cecilia Maldonado, Marta Vázquez, Mauricio Toledo, Clara Menéndez, Valentina Blanco, José L Badano, Alfonso Cayota, Lucia Spangenberg, Magdalena Cardenas-Rodriguez","doi":"10.1097/JCP.0000000000001933","DOIUrl":"10.1097/JCP.0000000000001933","url":null,"abstract":"Purpose/background: Clozapine is the recommended drug for treatment-resistant schizophrenia. Drug response could be affected by numerous factors such as age, sex, body mass index, co-medication, consumption of xanthine-containing beverages, smoking, and genetic variants of the enzymes involved in clozapine metabolism (CYP1A2, CYP3A4, and, to a lesser extent, CYP2C19 and CYP2D6). This study evaluated genetic and nongenetic variables that may affect clozapine plasma concentrations in Uruguayan patients with schizophrenia.Methods/procedures: Demographic data including sex, age, ethnicity, body weight, smoking habit, concomitant medication, and xanthine consumption were collected through a data collection form. Clozapine and norclozapine concentrations were determined using an HPLC system equipped with a UV detector. Genetic variants were determined through next-generation sequencing using Illumina sequencing technology and a panel of DNA probes.Findings/results: Fifty patients were included in the study. After evaluation, only tobacco use and obesity had a significant impact on clozapine exposure (P < 0.05). The high prevalence of the genetic variant CYP1A2*1F may account for the significant impact that tobacco smoking has on clozapine concentrations. Some common adverse effects observed in this study depend on clozapine plasma concentrations, such as constipation and sialorrhea.Implications/conclusions: These types of studies provide the clinician with tools to optimize clozapine therapy, attempting to use the minimum effective dose and attenuating the burden of concentration-dependent adverse reactions.","PeriodicalId":15455,"journal":{"name":"Journal of Clinical Psychopharmacology","volume":"45 1","pages":"20-27"},"PeriodicalIF":2.9,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0