Journal of Clinical Neurology最新文献

{"title":"Effect of Induced Hypertension Therapy According to the Mechanism of Single Subcortical Infarction.","authors":"Seung Taek Oh, Jun Young Chang, Dong-Wha Kang, Sun U Kwon, Sang Hee Ha, Bum Joon Kim","doi":"10.3988/jcn.2025.0486","DOIUrl":"10.3988/jcn.2025.0486","url":null,"abstract":"<p><strong>Background and purpose: </strong>Induced hypertension therapy (IHT) is effective for treating early neurological deterioration (END) in patients with single subcortical infarction (SSI). However, the underlying pathophysiology of SSI is diverse and may affect the efficacy of IHT.</p><p><strong>Methods: </strong>We reviewed patients with SSI who experienced END and received IHT were enrolled. END was defined as ≥2-point increase in the National Institutes of Health Stroke Scale (NIHSS) score, ≥1 motor point increase. IHT was performed by using phenylephrine infusion to raise systolic blood pressure by 10%-20% over baseline. SSI was classified into three subtypes: distal (dSSI), proximal (pSSI), and SSI with parental artery disease (SSIPAD; with stenosis at parental artery disease <50%). Responders were defined as patients who showed neurological improvement (decrease of ≥2 points in NIHSS, ≥1 motor point decrease) within one day after IHT initiation. Multivariable analysis identified factors associated with responders.</p><p><strong>Results: </strong>Characteristics were compared between responders and non-responders, and factors associated with response to IHT were investigated. Among 96 patients (mean age, 64.7±12.9 years; 61.5% male), 49 (51.0%) patients were categorized as responders. Multivariable analysis showed that pSSI (adjusted odds ratio [aOR]=18.10, 95% confidence interval [CI] 5.04-80.60, <i>p</i><0.001) and SSIPAD (aOR=4.56, 95% CI 1.31-19.00, p=0.024) were associated with a positive response to IHT compared to dSSI. Additionally, less white matter changes (Fazekas scale 0-1) were associated with a better response to IHT (aOR=0.15, 95% CI 0.03-0.67, <i>p</i>=0.019).</p><p><strong>Conclusions: </strong>Response to IHT varied according to SSI subtypes and the severity of small vessel changes.</p>","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"22 2","pages":"153-159"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956465/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on: \"Association of Clopidogrel Genetic Polymorphism With Efficacy and Safety for Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Updated Meta-Analysis\".","authors":"Shyam Sundar Sah, Abhishek Kumbhalwar","doi":"10.3988/jcn.2025.0655","DOIUrl":"10.3988/jcn.2025.0655","url":null,"abstract":"","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"22 2","pages":"255-256"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Re: Comments on \"Association of Clopidogrel Genetic Polymorphism With Efficacy and Safety for Ischemic Stroke or Transient Ischemic Attack: A Systematic Review and Updated Meta-Analysis\".","authors":"Hyungjong Park, Tae-Jin Song","doi":"10.3988/jcn.2025.0678","DOIUrl":"10.3988/jcn.2025.0678","url":null,"abstract":"","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"22 2","pages":"257-258"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The One-and-a-Half Syndrome of Korean Clinical Training: 1.5 Years of Fracturing.","authors":"Jong Seok Bae, Jeeyoung Oh","doi":"10.3988/jcn.2025.0703","DOIUrl":"10.3988/jcn.2025.0703","url":null,"abstract":"","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"22 2","pages":"143-145"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractory Status Epilepticus as an Initial Manifestation of IgA Nephropathy.","authors":"Dong Won Kwack, Hyelee Hwang, Ju Young Park, Dong Wook Kim","doi":"10.3988/jcn.2025.0662","DOIUrl":"10.3988/jcn.2025.0662","url":null,"abstract":"","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"22 2","pages":"237-239"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Eyes: Diplopia as an Early Manifestation of a Life-Threatening Condition in a Young Adult.","authors":"Hyun-Woo Kang, Jueun Kim, Sun-Uk Lee, Ji-Soo Kim","doi":"10.3988/jcn.2025.0557","DOIUrl":"10.3988/jcn.2025.0557","url":null,"abstract":"","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"22 2","pages":"249-251"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consistent Detection of Aquaporin-4 Antibodies: A Comparative Analysis Between Fixed and Live Cell-Based Assays.","authors":"Jing Wang, Linge Wang, Xiaolin Yang, Zhizhong Li, Jinyu Jiang, Qiao Xu, Siyuan Huang, Qing Fu, Yang Yang, Rongrong Zhang, Lin Yang, Ai Chen, Xiaopeng Zeng, Ke Xu, Peng Zheng, Xinyue Qin, Jinzhou Feng","doi":"10.3988/jcn.2025.0321","DOIUrl":"10.3988/jcn.2025.0321","url":null,"abstract":"<p><strong>Background and purpose: </strong>Live cell-based assays (LCBA) are increasingly used for serological antibody detection due to their ability to preserve antigen conformation, offering moderately higher sensitivity than fixed cell-based assays. However, the clinical necessity of prioritizing LCBA for the detection of aquaporin-4 immunoglobulin G (AQP4-IgG) in neuromyelitis optica spectrum disorder (NMOSD) remains unclear, especially when compared to its established role in diagnosing myelin oligodendrocyte glycoprotein antibody-associated disease.</p><p><strong>Methods: </strong>We compared the performance of live cell-based assays using immunofluorescence (LCBA-IF) and fixed cell-based assays using immunofluorescence (FCBA-IF) in detecting AQP4-IgG in 90 cases of NMOSD meeting 2015 International Panel for Neuromyelitis Optica Diagnosis criteria, alongside 40 controls. Additionally, we further investigated the relationship between AQP4-IgG titers as measured by LCBA-IF and FCBA-IF and clinical parameters in NMOSD patients.</p><p><strong>Results: </strong>Results showed 96.9% agreement between LCBA-IF and FCBA-IF (Cohen's κ=0.935), with a strong Spearman correlation (0.977, <i>p</i><0.001). Both methods demonstrated 100% specificity, with LCBA-IF showing slightly higher sensitivity compared to FCBA-IF. Within LCBA-IF-tested groups, statistically significant differences in annualized relapse rates were observed across all pairwise comparisons (low-titer vs. moderate-titer, low-titer vs. high-titer, and moderate-titer vs. high-titer; all <i>p</i><0.050). However, this association reached statistical significance in some FCBA-IF-tested groups.</p><p><strong>Conclusions: </strong>Overall, there is a strong concordance between LCBA-IF and FCBA-IF in detecting AQP4-IgG, where LCBA-IF shows slightly higher sensitivity. Furthermore, there is a potential link between elevated AQP4-IgG titers and an increased risk of relapse, and this correlation may appear more pronounced when using LCBA-IF.</p>","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"22 2","pages":"212-220"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Susceptibility-Weighted Imaging and T2* Gradient-Recalled Echo for Cerebral Microbleeds Detection: A Systematic Review and Meta-Analysis.","authors":"Su Jeong Yang, Jae-Sung Lim, Yangsean Choi, Ho Sung Kim, Sang Joon Kim, Jae-Hong Lee, Chong Hyun Suh","doi":"10.3988/jcn.2025.0324","DOIUrl":"10.3988/jcn.2025.0324","url":null,"abstract":"<p><strong>Background and purpose: </strong>Criteria for amyloid-related imaging abnormalities in anti-amyloid therapy are based on T2* gradient-recalled echo (GRE), but susceptibility-weighted imaging (SWI) is widely used, creating uncertainty. This study quantitatively compared the detectability of SWI and GRE for cerebral microbleeds and established evidence supporting distinct microbleed criteria for each.</p><p><strong>Methods: </strong>A systematic review and meta-analysis were conducted following PRISMA guidelines. PubMed and Embase were searched for studies directly comparing SWI and GRE up to August 8, 2024. Study quality was assessed with QUADAS-2. The pooled proportion of microbleed detection and detection ratio were calculated. Subgroup analyses were performed based on magnetic field strength (1.5 T vs. 3 T) and SWI slice thickness (<2 mm vs. ≥2 mm), equipment vendor, and study quality.</p><p><strong>Results: </strong>Thirteen studies were included. SWI detected cerebral microbleeds approximately 1.6 times more effectively than GRE. At 3.0 T and 1.5 T, SWI exhibited 1.7-fold and 1.5-fold greater detectability, respectively. SWI with thinner slices (<2 mm) showed a 1.9-fold improvement, while thicker slices (≥2 mm) showed a 1.3-fold improvement. Subgroup analyses revealed no significant differences between vendors (0.61 vs. 0.60, <i>p</i>=0.89), or by study quality (0.61 vs. 0.59, <i>p</i>=0.89).</p><p><strong>Conclusions: </strong>SWI detects cerebral microbleeds about 1.6 times more effectively than GRE, highlighting important differences between the two techniques. Cautious exploration of adjusted thresholds may be needed, and prospective validation in therapy-specific cohorts will be essential before clinical application.</p>","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"22 2","pages":"193-202"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the Electroclinical Paradox to Precision Care by Elucidating Seizure Network Dynamics.","authors":"Jung Bin Kim, Byung-Jo Kim","doi":"10.3988/jcn.2026.0050","DOIUrl":"10.3988/jcn.2026.0050","url":null,"abstract":"","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"22 2","pages":"151-152"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Body-First Trajectory: Mapping the Hidden Prologue of Lewy Body Diseases.","authors":"Jae-Sung Lim, Byung-Jo Kim","doi":"10.3988/jcn.2026.0066","DOIUrl":"10.3988/jcn.2026.0066","url":null,"abstract":"","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":"22 2","pages":"146-148"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147348463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}