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Ventral Simultanagnosia as an Aura of Posterior Cortex Epilepsy. 作为后皮层癫痫先兆的腹侧单纯性失神。
IF 3.1 3区 医学
Journal of Clinical Neurology Pub Date : 2024-04-02 DOI: 10.3988/jcn.2023.0468
Su Min Park, B. Kim, K. Kang, Jung-Ju Lee
{"title":"Ventral Simultanagnosia as an Aura of Posterior Cortex Epilepsy.","authors":"Su Min Park, B. Kim, K. Kang, Jung-Ju Lee","doi":"10.3988/jcn.2023.0468","DOIUrl":"https://doi.org/10.3988/jcn.2023.0468","url":null,"abstract":"","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140752542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease: A Comparative Study. 肌萎缩侧索硬化症和帕金森病视网膜神经纤维层厚度的纵向变化：比较研究
IF 3.1 3区 医学
Journal of Clinical Neurology Pub Date : 2024-04-02 DOI: 10.3988/jcn.2023.0353
Sharifah Azira Taufik, Norlina Ramli, Ai-Huey Tan, Shen-Yang Lim, Mohd Taufiq Abdul Ghani, N. Shahrizaila
{"title":"Longitudinal Changes in the Retinal Nerve Fiber Layer Thickness in Amyotrophic Lateral Sclerosis and Parkinson's Disease: A Comparative Study.","authors":"Sharifah Azira Taufik, Norlina Ramli, Ai-Huey Tan, Shen-Yang Lim, Mohd Taufiq Abdul Ghani, N. Shahrizaila","doi":"10.3988/jcn.2023.0353","DOIUrl":"https://doi.org/10.3988/jcn.2023.0353","url":null,"abstract":"BACKGROUND AND PURPOSE\u0000There is increasing evidence that the anterior visual pathways are involved in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD). This study investigated longitudinal changes in retinal nerve fiber layer (RNFL) thickness in patients with ALS and PD with the aim of better understanding their roles as biomarkers of disease progression.\u0000\u0000\u0000METHODS\u0000This study recruited 21 ALS patients, 19 age-matched PD patients, and 21 agematched healthy controls. Patient demographics and clinical scores relating to the respective diseases were documented. The RNFL thickness was measured using optical coherence tomography at baseline and after 6 months.\u0000\u0000\u0000RESULTS\u0000At baseline, the RNFL in the superior quadrant was significantly thinner in the patients with ALS than in healthy controls (109.90±22.41 µm vs. 127.81±17.05 µm [mean±standard deviation], p=0.008). The RNFL thickness did not differ significantly between the ALS and PD patients or between the PD patients and healthy controls. At 6 months, there was further significant RNFL thinning in patients with ALS, for both the overall thickness (baseline: median=94.5 µm, range=83.0-106.0 µm; follow-up: median=93.5 µm, range=82.5-104.5 µm, p=0.043) and the thickness in the inferior quadrant (median=126 µm, range=109.5-142.5 µm; and median=117.5 µm, range=98.5-136.5 µm; respectively, p=0.032). However, these changes were not correlated with the ALS functional scores. In contrast, the patients with PD did not demonstrate a significant change in RNFL thickness between the two time points.\u0000\u0000\u0000CONCLUSIONS\u0000The RNFL thickness is a promising biomarker of disease progression in patients with ALS but not in those with PD, which has a slower disease progression.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140755227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnosis, Treatment, and Follow-Up of Giant-Cell Arteritis: A Retrospective Multicenter Study. 巨细胞动脉炎的诊断、治疗和随访：一项回顾性多中心研究
IF 3.1 3区 医学
Journal of Clinical Neurology Pub Date : 2024-04-02 DOI: 10.3988/jcn.2023.0169
Mi-Kyoung Kang, Yooha Hong, Y. Kim, Hong‐Kyun Park, Soo-Kyoung Kim, J. Sohn, Jiyoung Kim, Ki-Han Kwon, Soo-Jin Cho
{"title":"Diagnosis, Treatment, and Follow-Up of Giant-Cell Arteritis: A Retrospective Multicenter Study.","authors":"Mi-Kyoung Kang, Yooha Hong, Y. Kim, Hong‐Kyun Park, Soo-Kyoung Kim, J. Sohn, Jiyoung Kim, Ki-Han Kwon, Soo-Jin Cho","doi":"10.3988/jcn.2023.0169","DOIUrl":"https://doi.org/10.3988/jcn.2023.0169","url":null,"abstract":"BACKGROUND AND PURPOSE\u0000Giant-cell arteritis (GCA) is the most common type of vasculitis in the elderly and is associated with high risks of visual loss and recurrence. Owing to its rarity in Asian populations, the current clinical interventions for these patients are not well known. Here we aimed to characterize the current management status of patients with GCA using Korean multicenter data.\u0000\u0000\u0000METHODS\u0000This retrospective study analyzed medical records of patients with GCA at six Korean university hospitals from February 2009 to November 2022. GCA had originally been diagnosed based on the 1990 American College of Rheumatology (ACR) criteria, and cases were selected for inclusion in this study based on the 2022 ACR/European Alliance of Associations for Rheumatology criteria. We evaluated treatments, follow-up periods, and outcomes (relapse, remission, and adverse drug reactions) in patients with GCA with or without arteritic anterior ischemic optic neuropathy (AAION).\u0000\u0000\u0000RESULTS\u0000This study analyzed 18 patients with a median age of 75.5 years that included 12 females (66.7%). Seven patients (38.8%) had AAION. All patients initially received prednisolone treatment, while four (22.2%) underwent adjuvant treatment with methotrexate and azathioprine during prednisolone tapering. During the median follow-up of 3.5 months (interquartile range: 2.0-23.2 months), 4 patients (22.2%) had prednisolone-related adverse reactions, 2 (11.1%) relapsed, and 13 (72.3%) dropped out. Nine patients (50.0%) experienced remission, with this being sustained in four (36.4%).\u0000\u0000\u0000CONCLUSIONS\u0000This study observed high dropout rates and short follow-ups. Adverse effects of prednisolone were common, and relapses occurred in approximately one-tenth of Korean patients with GCA. Thus, optimizing GCA treatment necessitates regular monitoring and long-term follow-up.","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140751276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing Intraoperative Neurophysiological Monitoring With Human Reflexes. 利用人体反射推进术中神经电生理监测。
IF 3.1 3区 医学
Journal of Clinical Neurology Pub Date : 2024-03-01 DOI: 10.3988/jcn.2023.0416
Jongsuk Choi, Alba Díaz-Baamonde, María de Los Ángeles Sánchez Roldán, Ana Mirallave Pescador, Jun-Soon Kim, Maria J Téllez, Kyung Seok Park, Vedran Deletis
{"title":"Advancing Intraoperative Neurophysiological Monitoring With Human Reflexes.","authors":"Jongsuk Choi, Alba Díaz-Baamonde, María de Los Ángeles Sánchez Roldán, Ana Mirallave Pescador, Jun-Soon Kim, Maria J Téllez, Kyung Seok Park, Vedran Deletis","doi":"10.3988/jcn.2023.0416","DOIUrl":"10.3988/jcn.2023.0416","url":null,"abstract":"<p><p>Human reflexes are simple motor responses that are automatically elicited by various sensory inputs. These reflexes can provide valuable insights into the functioning of the nervous system, particularly the brainstem and spinal cord. Reflexes involving the brainstem, such as the blink reflex, laryngeal adductor reflex, trigeminal hypoglossal reflex, and masseter H reflex, offer immediate information about the cranial-nerve functionality and the overall state of the brainstem. Similarly, spinal reflexes such as the H reflex of the soleus muscle, posterior root muscle reflexes, and sacral reflexes provide crucial information about the functionality of the spinal cord and peripheral nerves. One of the critical benefits of reflex monitoring is that it can provide continuous feedback without disrupting the surgical process due to no movement being induced in the surgical field. These reflexes can be monitored in real time during surgical procedures to assess the integrity of the nervous system and detect potential neurological damage. It is particularly noteworthy that the reflexes provide motor and sensory information on the functional integrity of nerve fibers and nuclei. This article describes the current techniques used for monitoring various human reflexes and their clinical significance in surgery. We also address important methodological considerations and their impact on surgical safety and patient outcomes. Utilizing these methodologies has the potential to advance or even revolutionize the field of intraoperative continuous monitoring, ultimately leading to improved surgical outcomes and enhanced patient care.</p>","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921042/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancement of Surgical Precision and Safety by Human Reflex Monitoring: Remembering a Pioneer in Intraoperative Neurophysiology Whose Legacy Lives On. 通过人体反射监测提高手术的精确性和安全性：缅怀一位遗志永存的术中神经生理学先驱。
IF 3.1 3区 医学
Journal of Clinical Neurology Pub Date : 2024-03-01 DOI: 10.3988/jcn.2024.0021
Jongsuk Choi, Maria J Téllez, Kyung Seok Park
{"title":"Enhancement of Surgical Precision and Safety by Human Reflex Monitoring: Remembering a Pioneer in Intraoperative Neurophysiology Whose Legacy Lives On.","authors":"Jongsuk Choi, Maria J Téllez, Kyung Seok Park","doi":"10.3988/jcn.2024.0021","DOIUrl":"10.3988/jcn.2024.0021","url":null,"abstract":"","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921050/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New Directions in Infection-Associated Ischemic Stroke. 感染相关缺血性中风的新方向。
IF 3.1 3区 医学
Journal of Clinical Neurology Pub Date : 2024-03-01 Epub Date: 2024-02-05 DOI: 10.3988/jcn.2023.0056
Jin-Man Jung, András Gruber, Peter Heseltine, Kumar Rajamani, Sebastián F Ameriso, Mark J Fisher
{"title":"New Directions in Infection-Associated Ischemic Stroke.","authors":"Jin-Man Jung, András Gruber, Peter Heseltine, Kumar Rajamani, Sebastián F Ameriso, Mark J Fisher","doi":"10.3988/jcn.2023.0056","DOIUrl":"10.3988/jcn.2023.0056","url":null,"abstract":"<p><p>The relationship between infections and stroke has not been fully characterized, probably delaying the development of specific treatments. This narrative review addresses mechanisms of stroke linked to infections, including hypercoagulability, endothelial dysfunction, vasculitis, and impaired thrombolysis. SARS-CoV-2, the virus that causes COVID-19, may promote the development of stroke, which may represent its most severe neurological complication. The development of specific therapies for infection-associated stroke remains a profound challenge. Perhaps the most important remaining issue is the distinction between infections that trigger a stroke versus infections that are truly incidental. This distinction likely requires the establishment of appropriate biomarkers, candidates of which are elevated levels of fibrin D-dimer and anticardiolipin/antiphospholipid antibodies. These candidate biomarkers might have potential use in identifying pathogenic infections preceding stroke, which is a precursor to establishing specific therapies for this syndrome.</p>","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921058/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139706866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Atypical Meningoencephalomyelitis Following Varicella Zoster Virus Infection. 水痘带状疱疹病毒感染后的非典型脑膜脑炎
IF 3.1 3区 医学
Journal of Clinical Neurology Pub Date : 2024-03-01 DOI: 10.3988/jcn.2023.0332
Guorong Zhang, Chen Liu, Jin Song, Yuzhong Wang
{"title":"Atypical Meningoencephalomyelitis Following Varicella Zoster Virus Infection.","authors":"Guorong Zhang, Chen Liu, Jin Song, Yuzhong Wang","doi":"10.3988/jcn.2023.0332","DOIUrl":"10.3988/jcn.2023.0332","url":null,"abstract":"","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial-Membrane-Protein-Associated Neurodegeneration in Longitudinal Magnetic Resonance Imaging Over 11 Years of Follow-Up. 纵向磁共振成像中与线粒体-膜蛋白相关的神经退行性变，随访 11 年。
IF 3.1 3区 医学
Journal of Clinical Neurology Pub Date : 2024-03-01 DOI: 10.3988/jcn.2023.0336
Jiyun Lee, Jin Ju Kim, Chul Hyoung Lyoo, Yun Joong Kim
{"title":"Mitochondrial-Membrane-Protein-Associated Neurodegeneration in Longitudinal Magnetic Resonance Imaging Over 11 Years of Follow-Up.","authors":"Jiyun Lee, Jin Ju Kim, Chul Hyoung Lyoo, Yun Joong Kim","doi":"10.3988/jcn.2023.0336","DOIUrl":"10.3988/jcn.2023.0336","url":null,"abstract":"","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921055/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary Familial Brain Calcification With XPR1 Mutation Presenting With Cognitive Dysfunction. 原发性家族性脑钙化伴 XPR1 基因突变，表现为认知功能障碍。
IF 3.1 3区 医学
Journal of Clinical Neurology Pub Date : 2024-03-01 DOI: 10.3988/jcn.2023.0284
Sojung Yoon, Seok Jong Chung, Yun Joong Kim
{"title":"Primary Familial Brain Calcification With <i>XPR1</i> Mutation Presenting With Cognitive Dysfunction.","authors":"Sojung Yoon, Seok Jong Chung, Yun Joong Kim","doi":"10.3988/jcn.2023.0284","DOIUrl":"10.3988/jcn.2023.0284","url":null,"abstract":"","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140021908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hypothalamic-Pituitary-Adrenal Axis and Epilepsy. 下丘脑-垂体-肾上腺轴与癫痫。
IF 3.1 3区 医学
Journal of Clinical Neurology Pub Date : 2024-03-01 Epub Date: 2024-02-05 DOI: 10.3988/jcn.2023.0308
Xueying Bian, Wenxian Yang, Jiannan Lin, Biao Jiang, Xiaoli Shao
{"title":"Hypothalamic-Pituitary-Adrenal Axis and Epilepsy.","authors":"Xueying Bian, Wenxian Yang, Jiannan Lin, Biao Jiang, Xiaoli Shao","doi":"10.3988/jcn.2023.0308","DOIUrl":"10.3988/jcn.2023.0308","url":null,"abstract":"<p><p>Epilepsy is a recurrent, transient seizure disorder of the nervous system that affects the intellectual development, life and work, and psychological health of patients. People with epilepsy worldwide experience great suffering. Stressful stimuli such as infection, mental stress, and sleep deprivation are important triggers of epilepsy, and chronic stressful stimuli can lead to frequent seizures and comorbidities. The hypothalamic-pituitary-adrenal (HPA) axis is the most important system involved in the body's stress response, and dysfunction thereof is thought to be associated with core epilepsy symptoms and related psychopathology. This article explores the intrinsic relationships of corticotropin-releasing hormone, adrenocorticotropic hormone, and glucocorticoids with epilepsy in order to reveal the role of the HPA axis in the pathogenesis of epilepsy. We hope that this information will yield future possible directions and ideas for fully understanding the pathogenesis of epilepsy and developing antiepileptic drugs.</p>","PeriodicalId":15432,"journal":{"name":"Journal of Clinical Neurology","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10921057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139706865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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