Journal of Clinical Medicine Research最新文献

{"title":"Sudden Cardiac Death in Young Individuals: A Current Review of Evaluation, Screening and Prevention.","authors":"Ramsha Abbas,&nbsp;Aiza Abbas,&nbsp;Talha Kamran Khan,&nbsp;Salal Sharjeel,&nbsp;Khadija Amanullah,&nbsp;Yusra Irshad","doi":"10.14740/jocmr4823","DOIUrl":"https://doi.org/10.14740/jocmr4823","url":null,"abstract":"<p><p>Sudden cardiac death (SCD) can affect all age groups, including young persons. While less common in the age < 35 population, the occurrence of SCD in the young raises concern, with multiple possible etiologies and often unanswered questions. While coronary artery disease is the leading cause in those > 35 years of age, the younger population faces a different subset of pathologies associated with SCD, including arrhythmias and cardiomyopathies. The tragic nature of SCD in the young entails that we explore and implement available screening methods for this population, and perform the necessary investigations such as electrocardiography (ECG) and echocardiography. In this review, we not only explore the vast etiology associated with SCD in those age < 35, but emphasize evaluation methods, who is at risk, and delve into screening of SCD in potential victims and their family members, in an attempt to prevent this traumatic event. Future research must work towards establishing preventative measures in order to reduce SCD, particularly unexplained SCD in the young.</p>","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"15 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0f/8a/jocmr-15-001.PMC9881489.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9237322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the Emergency Department Management of Sickle Cell Vaso-Occlusive Pain Crisis: The Role and Options of Sublingual and Intranasally Administered Analgesia.","authors":"Ademola S Ojo,&nbsp;Olumayowa G Odipe,&nbsp;Oluwanifemi Owoseni","doi":"10.14740/jocmr4841","DOIUrl":"https://doi.org/10.14740/jocmr4841","url":null,"abstract":"<p><p>Vaso-occlusive crisis (VOC), characterized by periods of excruciating pain is the most common clinical manifestation of sickle cell disease (SCD), often resulting in emergency room presentation. These patients often experience long wait times in the emergency department before receiving their first dose of analgesia. This delay results from the complexities of the emergency care system. Using the intranasal or sublingual approach to administering analgesia to SCD patients with VOC offers a fast, safe, noninvasive, atraumatic, and easily accessible route of administration which could reduce the time to first dose of analgesia. With the evolving advances in the development and delivery of analgesic medications, providers should be conversant with the nuances of intranasal and sublingual analgesia in the management of acute vaso-occlusive pain crisis. This review explores the pharmacokinetic profiles, dosages, and administration of intranasal and sublingual analgesics with relevance to the SCD population.</p>","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"15 1","pages":"10-22"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f5/ca/jocmr-15-010.PMC9881494.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9237324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced Time to Procedure for Gastrointestinal Bleeding After Warfarin Reversal With Four-Factor Complex Concentrate as Compared to Plasma.","authors":"Hannah Spector,&nbsp;Hannah L McRae,&nbsp;Tanzy Love,&nbsp;Kalynn Northam,&nbsp;Khaled Refaai,&nbsp;Marian A Rollins-Raval,&nbsp;Majed A Refaai","doi":"10.14740/jocmr4856","DOIUrl":"https://doi.org/10.14740/jocmr4856","url":null,"abstract":"<p><strong>Background: </strong>Bleeding is a serious adverse effect of vitamin K antagonists (VKAs). Anticoagulation reversal is required in some acute cases. This is usually accomplished by plasma transfusion or four-factor prothrombin complex concentrate (4F-PCC). The aim of this study was to gain insight into the clinical course of patients with gastrointestinal (GI) bleeding who require VKA reversal.</p><p><strong>Methods: </strong>Medical records were collected from two centers from patients who presented to the emergency department (ED) for GI bleeding and received 4F-PCC or plasma for VKA reversal between January 2015 and December 2020. ED, hospital, intensive care unit (ICU) length of stay (LOS) as well as time from admission to GI procedure were determined.</p><p><strong>Results: </strong>4F-PCC patients (n = 49) as compared to plasma (n = 63) patients were found to have a greater number of comorbidities (average of 4.2 vs. 2.7 comorbidities/patient) and more ICU admissions (47% vs. 21%). Time to GI procedure was significantly decreased in the 4F-PCC group (median (interquartile range (IQR)) 19.47 (9.23 - 30.25) vs. 27.88 (21.38 - 45.00) h; P = 0.01). When adjusting for comorbidities, differences in time to GI procedures were also significant in favor of 4F-PCC regardless of any comorbidities (P = 0.014), in atrial fibrillation (P = 0.045) and in hypertension (P = 0.02). The 4F-PCC patients had shorter LOS in the ED and ICU.</p><p><strong>Conclusions: </strong>Our study demonstrated that compared to plasma, 4F-PCC was utilized in more acutely ill patients with higher rates of comorbidities and ICU admission. Nevertheless, the patients who received 4F-PCC had faster access to GI procedure and shorter ED and ICU LOS.</p>","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"15 1","pages":"51-57"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/af/jocmr-15-051.PMC9881491.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9237319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, Hematological, Biochemical and Radiological Characteristics for Patients With Splenic Infarction: Case Series With Literature Review.","authors":"Mariko Hakoshima,&nbsp;Kazuya Kitakaze,&nbsp;Hiroki Adachi,&nbsp;Hisayuki Katsuyama,&nbsp;Hidekatsu Yanai","doi":"10.14740/jocmr4836","DOIUrl":"https://doi.org/10.14740/jocmr4836","url":null,"abstract":"<p><strong>Background: </strong>Splenic infarction is a frequently missed diagnosis in acute clinical conditions and is often under-diagnosed due to the lack of high-quality evidence on pathophysiology of splenic infarction. Due to the scarcity of such evidence, no consensus guidelines regarding the diagnostic approach and management of patients with splenic infarction exist. Most of published articles on splenic infarction are case reports and there was no systematic review on splenic infarction.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of all radiologically confirmed cases of splenic infarction patients with any history of admission at National Center for Global Health and Medicine Kohnodai Hospital, from 2014 to 2020. Further, to understand the pathophysiology that causes splenic infarction, we searched the literatures on splenic infarction.</p><p><strong>Results: </strong>We found 18 patients with splenic infarction. The average age was 78 years, and about half of patients had abdominal pain; however, the other half did not have abdominal pain. One-third of patients with splenic infarction died. Leukocytosis with neutrophilia, a decrease of lymphocytes, anemia, hypoalbuminemia, and liver dysfunction were observed. Fibrinogen was decreased and D-dimer was remarkably elevated. Lactate dehydrogenase (LDH) and C-reactive protein (CRP) were remarkably increased. Six patients (33.3%) had cancer, four patients (22.2%) had atrial fibrillation, and four patients (22.2%) had infection. We found 466 case reports on splenic infarction published from 1975 to 2021. Recently, the number of case reports on splenic infarction due to infection, especially, coronavirus disease 2019 (COVID-19), has been remarkably increasing. Furthermore, we found that leukocytosis, a decrease of lymphocytes, elongated activated partial thromboplastin time, decrease of fibrinogen, liver dysfunction, elevation of LDH and blood urea nitrogen can be the prognosis predicting factors for patients with splenic infarction.</p><p><strong>Conclusion: </strong>Our study elucidated clinical, hematological, biochemical and radiological characteristics for patients with splenic infarction. We newly found significant differences in blood cell counts, coagulation markers, transaminases, LDH and blood urea nitrogen between patients who died and those who survived, suggesting that these parameters can be the prognosis predicting factors for splenic infarction. Further, our systematic review on case reports about splenic infarction showed the etiology of splenic infarction and the trend of the causative diseases.</p>","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"15 1","pages":"38-50"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/4d/jocmr-15-038.PMC9881492.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10741574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis and Evaluation on the Quality of Pueraria Lobata in the Market Based on High Performance Liquid Chromatography (HPLC)","authors":"Shi-mei Xing","doi":"10.32629/jcmr.v3i4.1087","DOIUrl":"https://doi.org/10.32629/jcmr.v3i4.1087","url":null,"abstract":"Objective: To evaluate the quality of Pueraria lobata sold in the market and establish a HPLC method for the analysis of Pueraria lobata. Method: Acclaim 120 C18 chromatographic column (5 μm. 4.6 * 250mm), acetonitrile-0.1% formic acid aqueous solution was used as the mobile phase for gradient elution, and the contents of 5 components, 3'-methoxy puerarin, puerarin, daidzin, daidzein, and 3'-hydroxypuerarin, were determined in 11 commercial pueraria lobata from different habitats. Results: The contents of these five components in pueraria lobata from different habitats were different. Anhui No. 003 and No. 006 have higher chemical constituents. Conclusion: The method established in this experiment is accurate, with good separation effect, and can be used to detect the content of five different substances in Pueraria lobata. The determination results can provide valuable reference information for the purchase of traditional Chinese medicine stores and provide effective scientific basis for the development of Pueraria lobata resources.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87637748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Huangqi Fuzheng Decoction on Immune Function in Patients with Breast Cancer Undergoing Postoperative Chemotherapy","authors":"Jia Na Er Baokan","doi":"10.32629/jcmr.v3i4.1088","DOIUrl":"https://doi.org/10.32629/jcmr.v3i4.1088","url":null,"abstract":"Objective: To analyze the application effect of Huangqi Fuzheng decoction in postoperative chemotherapy of breast cancer and its influence on immune function of patients. Methods: Eighty breast cancer patients who underwent surgical treatment from January 2021 to August 2022 were selected and randomly divided into two groups. The control group only received conventional chemotherapy regimen.The observation group was added Huangqi Fuzheng decoction on the basis of the control group. The incidence of adverse reactions of chemotherapy was compared between the two groups,the changes of immune indexes, quality of life score and sleep quality score before and after treatment were compared between the two groups. Results: ① The incidence of adverse reactions in the observation group was lower than that in the control group (P < 0.05). ② The changes of CD4+, CD8+, CD4+/CD8+ in the observation group before and after treatment were higher than those in the control group (P < 0.05). ③ The changes of quality of life score and sleep quality score before and after treatment in the observation group were higher than those in the control group (P < 0.05). Conclusion: The application of Huangqi Fuzheng decoction is helpful to reduce the incidence of adverse reactions of chemotherapy and improve the immune function of patients, so as to improve the quality of life and sleep quality of patients.So it can be widely used.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87346866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Phased Radiofrequency Microneedles in Periorbital Rejuvenation","authors":"Min Zhao","doi":"10.32629/jcmr.v3i4.1083","DOIUrl":"https://doi.org/10.32629/jcmr.v3i4.1083","url":null,"abstract":"Objective: For analysis on the application effect of phased radiofrequency microneedles in periorbital rejuvenation. Methods: A total of 106 patients who received orbital repair treatment in the author's unit from 2019 to 2021 were selected as research objects and were divided retrospectively into observation group and control group according to different treatment methods, with 53 patients in each group. The control group was treated with botulinum toxin type A repair therapy, and the observation group was treated with phased radio frequency microneedle repair therapy on the basis of the control group. The periorbital skin texture, wrinkles and static wrinkles before and after treatment were compared between the two groups. Results: After 2 weeks of treatment, the periorbital wrinkle and texture based evaluation value and static wrinkle score of 2 groups were decreased to different degrees, and the observation group was lower than the control group, with statistical significance (P < 0.05). After 1 month and 3 months of treatment, the periorbital wrinkle and texture evaluation value and static wrinkle score of the observation group were lower than those of the control group, with statistical significance (P < 0.001). Conclusion: Phased radiofrequency microneedles are beneficial to the rejuvenation of periorbital skin with satisfactory repair effect.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78014803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Summary of Clinical Syndrome in Treating Spastic Cerebral Palsy from Liver, Spleen and Kidney","authors":"Chenchen Zhang, Hui Wang","doi":"10.32629/jcmr.v3i4.995","DOIUrl":"https://doi.org/10.32629/jcmr.v3i4.995","url":null,"abstract":"Spastic cerebral palsy is mainly caused by dyskinesia and postural abnormality caused by damage of pyramidal tract system. Clinically, the main manifestations are hypertonia, limb joint movement disorder, postural and gait abnormality. At present, Western medicine has not yet developed effective drugs to treat spastic cerebral palsy. In view of the problem that the incidence of spastic cerebral palsy in children is increasing year by year, this paper puts forward the treatment methods of spastic cerebral palsy in children based on the theory of \"liver, spleen and kidney\". The main treatment methods are to strengthen spleen, replenish qi, soften liver and calm wind or nourish liver and kidney, dredge tendons and dredge collaterals. The clinical effect of tonifying deficiency and eliminating pathogenic factors is exact. Attached case 1 is to support it.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89775438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Big Data Analysis Report on Trial of Obstetrics and Gynecology Medical Damage Liability Dispute Cases in China from 2017 to 2021","authors":"Yushu Wu, Jing Li, Yong Zhang, Songyue He, Zhiyong Wang, Changqing Cui","doi":"10.32629/jcmr.v3i4.1085","DOIUrl":"https://doi.org/10.32629/jcmr.v3i4.1085","url":null,"abstract":"Objective: To analyze the data of the trial cases of medical damage liability disputes in obstetrics and gynecology from 2017 to 2021, with a clear understanding of Chinese medical damage liability disputes. Methods: The data of medical damage liability dispute cases in obstetrics and gynecology during 2017-2021 were collected and analyzed. The analysis directions included (1) The trial types of civil litigation cases in each year; (2) Annual distribution of civil litigation cases in obstetrics and gynecology in an annual year basis; (3) Distribution of the amount of the subject matter and the amount of civil compensation; (4) The geographical distribution of litigation cases; (5) Characteristics of the medical institution as defendant; (6) Distribution of litigation departments in medical institutions; (7) Common causes of action in obstetrics and gynecology cases; (8) Results of common injuries in obstetrics and gynecology cases; (9) Court confirmation of disputes over medical records. Results: According to the data analysis results, the distribution of litigation trial types, annual distribution, compensation amount distribution, regional distribution and other basic data were obtained, and based on the analysis of the characteristics of medical institutions, department distribution, causes of litigation, damage structure and court recognition results were systematically discussed. Conclusion: Although the liability disputes for medical damage in obstetrics and gynecology have been declining in recent years, the problems in medical treatment and management can not be ignored. Attention should be paid to them and medical problems should be avoided.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"180 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85444596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Big Data Analysis Report on Trial of Medical Damage Liability Dispute Cases in China in 2021","authors":"Zihui Cheng, Jing Li, Ming Zhou, Lu Zhang, L. Kong, J. Zhang, S. He, Yong Zhang","doi":"10.32629/jcmr.v3i4.1084","DOIUrl":"https://doi.org/10.32629/jcmr.v3i4.1084","url":null,"abstract":"Objective: To analyze the trial process and results of the 2021 medical damage liability dispute cases based on big data to understand the basic situation of the current medical damage liability dispute cases. Methods: The judgment documents of people's courts published from January 1, 2021 to December 31, 2021 were retrieved and searched through the website of China Judgment Documents, and then the relevant data were collected. Results: According to the data summary and data discussion in the same year, the geographical distribution of cases, the characteristics of the defendant's medical structure, the distribution of litigation departments and other data were summarized. Conclusion: According to the results of the basic investigation, the basic characteristics of our current medical dispute cases have been understood, but also the division of responsibility and the problems have been analyzed on the whole, and the corresponding suggestions have been put forward according to the questions, hope to help.","PeriodicalId":15431,"journal":{"name":"Journal of Clinical Medicine Research","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74050516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}