Journal of chromatographic science最新文献

Development and validation of stability-indicating RP-HPLC method for simultaneous estimation of clomiphene citrate and co-enzyme Q10 in bulk and pharmaceutical dose. 同时测定枸橼酸克罗米芬和辅酶Q10原料药剂量的反相高效液相色谱法的建立与验证。

IF 1.3 4区化学

Journal of chromatographic science Pub Date : 2026-04-30 DOI: 10.1093/chromsci/bmag013

Malavika Thiruvenkatakumar, Hariprasad Ranganathan, Habibur Rahman S M

{"title":"Development and validation of stability-indicating RP-HPLC method for simultaneous estimation of clomiphene citrate and co-enzyme Q10 in bulk and pharmaceutical dose.","authors":"Malavika Thiruvenkatakumar, Hariprasad Ranganathan, Habibur Rahman S M","doi":"10.1093/chromsci/bmag013","DOIUrl":"https://doi.org/10.1093/chromsci/bmag013","url":null,"abstract":"Clomiphene citrate (CLO) and co-enzyme Q10 (Q10) are \"ovulatory stimulants\" used to treat female infertility and CLO-resistant Polycystic Ovary Syndrome (PCOS). The study aimed to create a unique and well-validated stability-indicating RP-HPLC method for quantifying CLO and Q10 in bulk and tablet formulation, supported by UV analysis. The λ max values of CLO and Q10 were determined at 293 nm and 273 nm, respectively. The chromatographic separation was achieved on a Waters XBridge phenyl 5 μm column (4.6 × 250 mm) using an acetonitrile: tetrahydrofuran (80:20 v/v) with 0.5% triethylamine as a mobile phase at a flow rate of 0.5 mL/min with photodiode array detector at 279 nm (isobestic point). Resveratrol (RES) served as an internal standard (ISTD), with retention durations of 6.504, 9.319 and 5.831 minutes for CLO, Q10 and RES, respectively. Calibration curves were linear (R2 = 0.9987 for CLO and 0.9993 for Q10) and %RSD values for all validation parameters were below 2%, confirming precision and accurate. Forced degradation studies through various stress conditions, assessed the method's stability-indicating nature by exhibiting clear separation of degradation products from the analytes and degradation levels within ICH limits (≤ 20%). The validated method was found to be reliable, specific, and applicable for routine analysis in quality control.","PeriodicalId":15430,"journal":{"name":"Journal of chromatographic science","volume":"64 5","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simultaneous bioanalytical method development and validation of ibuprofen and phenyramidol HCl in human plasma using high-performance liquid chromatography with photodiode array detection and its application in a pharmacokinetic study. 高效液相色谱-光电二极管阵列检测法在人血浆中布洛芬和盐酸苯拉米醇同时生物分析方法的建立和验证及其在药代动力学研究中的应用。

IF 1.3 4区化学

Journal of chromatographic science Pub Date : 2026-04-30 DOI: 10.1093/chromsci/bmag015

Nurgul Kızıltas, Tugrul Cagri Akman, Yasemin Karabayir

{"title":"Simultaneous bioanalytical method development and validation of ibuprofen and phenyramidol HCl in human plasma using high-performance liquid chromatography with photodiode array detection and its application in a pharmacokinetic study.","authors":"Nurgul Kızıltas, Tugrul Cagri Akman, Yasemin Karabayir","doi":"10.1093/chromsci/bmag015","DOIUrl":"10.1093/chromsci/bmag015","url":null,"abstract":"The co-administration of ibuprofen (IBU) and phenyramidol HCl (PHE) is frequently preferred for the management of musculoskeletal disorders to enhance therapeutic efficacy. This study aimed to develop and validate a rapid, sensitive and cost-effective high-performance liquid chromatography-photodiode array (HPLC-PDA) method for the simultaneous determination of IBU and PHE in human plasma and pharmaceutical preparations, and to demonstrate its applicability in pharmacokinetic studies. Chromatographic separation was achieved on a C18 column using a mobile phase consisting of phosphate buffer (pH 6.0 ± 0.05) and methanol (30:70, v/v) at a flow rate of 1.0 mL·min -1. The retention times of IBU and PHE were 3.7 and 2.7 min, respectively, with a total analysis time of 6 min. The method showed excellent linearity within the range of 0.05-40.0 μg·mL -1 for both drugs, with LLOQ values of 0.05 μg·mL-1 for IBU and 0.0025 μg·mL-1 for PHE. The plasma samples were collected at four time points (0.0, 1.0, 4.0 and 8.0 h) after oral administration of IBU and PHE. Cmax, Tmax and AUC0-8 were calculated, with Cmax of 16.14 μg·mL-1 for IBU and 3.71 μg·mL-1 for PHE, while Tmax was 1.0 h for both. Despite limitations in the number of sampling time points, the method proved highly applicable for determining pharmacokinetic profiles and for routine quality control analyses. Its short analysis time, high sensitivity and low sample volume requirement make it a powerful tool for clinical research and therapeutic monitoring. This is the first validated HPLC-PDA method applied to the simultaneous pharmacokinetic evaluation of IBU and PHE in human plasma.","PeriodicalId":15430,"journal":{"name":"Journal of chromatographic science","volume":"64 5","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13130206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Greenness Assessment and Quantitative Profiling of Glycyrrhizic Acid, Piperine and Ursolic Acid Content in Polyherbal Cough Syrup Using High-Performance Liquid Chromatographic Analysis. 高效液相色谱法分析复方止咳糖浆中甘草酸、胡椒碱和熊果酸含量的绿度评价及定量分析

IF 1.3 4区化学

Journal of chromatographic science Pub Date : 2026-04-01 DOI: 10.1093/chromsci/bmag009

Payal Chauhan, Falguni Tandel, Aboli Girme, Lal Hingorani, Rakesh Parmar

{"title":"Greenness Assessment and Quantitative Profiling of Glycyrrhizic Acid, Piperine and Ursolic Acid Content in Polyherbal Cough Syrup Using High-Performance Liquid Chromatographic Analysis.","authors":"Payal Chauhan, Falguni Tandel, Aboli Girme, Lal Hingorani, Rakesh Parmar","doi":"10.1093/chromsci/bmag009","DOIUrl":"https://doi.org/10.1093/chromsci/bmag009","url":null,"abstract":"The increasing demand for safe, effective and sustainable alternatives to traditional cough suppressants has brought polyherbal formulations in respiratory ailment management. This report outlines the development and greenness evaluation of a high-performance liquid chromatography method for the simultaneous quantification of glycyrrhizic acid, piperine and ursolic acid from crude plant extracts and commercial polyherbal cough syrups. Chromatographic separation was performed using Agilent Eclipse C18 column (250 × 4.6 mm, 5 μm) under gradient elution using 0.1% formic acid in water and acetonitrile as mobile phases. The optimal absorbance wavelengths during quantification were 254 nm for glycyrrhizic acid, 342 nm for piperine, and 210 nm for ursolic acid at retention times of 21.3, 24.5 and 31.0 min, respectively. Results indicated a method that was sensitive, reproducible and specific to the three analytes quantified as well as validated according to ICH Q2(R1). Evaluating the greenness of the method (using the Analytical GREEnness metric, Green Analytical Procedure Index, and Eco-Scale Assessment confirmed that this method could be considered \"green\". Upon completion of method validation, the method was used to quantify each marker compound from commercially available products in an effort to better understand production methodologies and directed our quality control and standardization efforts. The results of this systematic investigation point to the advantage of applying green analytical techniques for the assessments of polyherbal medicines, potentially establishing them as credible, environmentally friendly therapeutic options for respiratory ailments.","PeriodicalId":15430,"journal":{"name":"Journal of chromatographic science","volume":"64 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of a Reverse-Phase High-Performance Liquid Chromatography Method for Simultaneous Quantification of Tofacitinib Citrate and Berberine Chloride in Bulk, Injection and Plasma. 反相高效液相色谱法同时定量散装、注射剂和血浆中柠檬酸托法替尼和氯化小檗碱的研究

IF 1.3 4区化学

Journal of chromatographic science Pub Date : 2026-04-01 DOI: 10.1093/chromsci/bmag010

Monika, Vikas Jhawat, Mahima Chauhan, Samrat Chauhan, Sonali, Mayank Kumar Singh, Rahul Singh, Rahul Pratap Singh

{"title":"Development of a Reverse-Phase High-Performance Liquid Chromatography Method for Simultaneous Quantification of Tofacitinib Citrate and Berberine Chloride in Bulk, Injection and Plasma.","authors":"Monika, Vikas Jhawat, Mahima Chauhan, Samrat Chauhan, Sonali, Mayank Kumar Singh, Rahul Singh, Rahul Pratap Singh","doi":"10.1093/chromsci/bmag010","DOIUrl":"https://doi.org/10.1093/chromsci/bmag010","url":null,"abstract":"The main aim of this study was to develop and validate a new reverse-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous estimation of tofacitinib citrate (TFC) and berberine chloride (BBC) in pharmaceutical injection formulations and blood plasma. An isocratic RP-HPLC method was used with a mobile phase consisting of phosphate buffer saline (pH 5.5) and acetonitrile at a ratio of 70:30, at flow rate of 1 mL/min at 25°C. Both drugs were detected at 306 nm. The proposed method demonstrated excellent linearity over a concentration range of 5-30 μg/mL for both the TFC and BBC, with correlation coefficients (R2) exceeding 0.999. System suitability parameters, including peak area, tailing factor, theoretical plates and resolution, were within acceptable limits, with relative standard deviations <2%. The recovery studies at 50, 100 and 150% showed mean recovery rates of 99.4-100.7% for TFC and 99.9-100.4% for BBC. The method exhibited high sensitivity, with low detection and quantification limits. The robustness was confirmed under slight variations in flow rate and mobile phase composition. The developed RP-HPLC method is accurate, reliable and suitable for simultaneous quantification of TFC and BBC in pharmaceutical and biological matrices, offering potential for routine quality control and pharmacokinetic studies.","PeriodicalId":15430,"journal":{"name":"Journal of chromatographic science","volume":"64 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147592475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical quality by design (AQbD)-assisted bioanalytical method for the estimation of Lasmiditan in human plasma by reverse phase-high performance liquid chromatography (RP-HPLC). 反相高效液相色谱法（RP-HPLC）测定人血浆中拉西米坦的分析质量设计（AQbD）辅助生物分析方法。

IF 1.3 4区化学

Journal of chromatographic science Pub Date : 2026-04-01 DOI: 10.1093/chromsci/bmag012

Ajitha Azhakesan, Burugula Sparsha, Pasupuleti Kishore, Sujatha Kuppusamy

{"title":"Analytical quality by design (AQbD)-assisted bioanalytical method for the estimation of Lasmiditan in human plasma by reverse phase-high performance liquid chromatography (RP-HPLC).","authors":"Ajitha Azhakesan, Burugula Sparsha, Pasupuleti Kishore, Sujatha Kuppusamy","doi":"10.1093/chromsci/bmag012","DOIUrl":"https://doi.org/10.1093/chromsci/bmag012","url":null,"abstract":"Migraine is a complex neurological condition that often involves a severe headache characterized by moderate to severe throbbing. Lasmiditan a novel ditan approved by USFDA in 2011 to treat migraine. This contemporary research elaborates the systematic development and validation of Reverse Phase-High Performance Liquid Chromatography bio analytical method for estimating Lasmiditan in human plasma employing analytical quality by design. Bio analysis employing protein precipitation was performed to extract Lasmiditan from human plasma using Dolutegravir as the internal standard. Design of Experiments was incorporated employing central composite design, and the methodology was assessed for critical analytical attributes by varying the critical quality attributes using Design Expert Software Version 13.0. The chromatographic conditions optimized were symmetry C18 (150 × 4.6 mm, 5 μ) column, mobile phase 0.1% orthophosphoric acid: acetonitrile (70:30 (v/v) with a flow rate of 1.0 mL/min at detection wavelength of 260 nm and column temperature of 30°C. Validation studies indicated linearity between 20 and 800 ng/mL (r2 = 0.999), whereas accuracy and precision portrayed a 98.79% recovery. Succinctly, current work exemplifies the significant merits of analytical quality by design approach toward the holistic process in bioanalytical method validation. Furthermore, the method was evaluated using the Whiteness Assessment Tool (Blue Applicability Grade Index), yielding a high score of 82.5, indicating superior performance in terms of analytical efficiency, environmental friendliness and operator safety. Thus, the developed method can be applied for estimation of preclinical and clinical samples of Lasmiditan with improved accuracy and precision.","PeriodicalId":15430,"journal":{"name":"Journal of chromatographic science","volume":"64 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative analysis of characteristic aroma components in rose hydrosol by reversed-phase liquid chromatography using hydroxypropyl-β-cyclodextrin as mobile-phase additive. 以羟丙基-β-环糊精为流动相添加剂，反相液相色谱法定量分析玫瑰纯露中特征香气成分。

IF 1.3 4区化学

Journal of chromatographic science Pub Date : 2026-04-01 DOI: 10.1093/chromsci/bmag011

Wenli Zhang, Mengyi Wen, Junchao Zhu, Yuxia Chen, Wanghui Chen, Shengqiang Tong

{"title":"Quantitative analysis of characteristic aroma components in rose hydrosol by reversed-phase liquid chromatography using hydroxypropyl-β-cyclodextrin as mobile-phase additive.","authors":"Wenli Zhang, Mengyi Wen, Junchao Zhu, Yuxia Chen, Wanghui Chen, Shengqiang Tong","doi":"10.1093/chromsci/bmag011","DOIUrl":"https://doi.org/10.1093/chromsci/bmag011","url":null,"abstract":"Quantitative determination of eight characteristic aroma components, namely, benzyl alcohol, phenylethyl alcohol, eugenol, geraniol, nerol, linalool, citronellol, and methyl eugenol, by reversed-phase high-performance liquid chromatography with hydroxypropyl-β-cyclodextrin as mobile-phase additive was investigated. The proposed method was validated and demonstrated with good linearity of 0.994 to 1.000 with a recovery in the range of 94.97-109.38% and exhibited favorable accuracy, intra and inter-day precision based on relative standard deviation values. Additionally, the inclusion complex between eight characteristic aroma components and hydroxypropyl-β-cyclodextrin was investigated, the complex formation was found at a 1:1 molal ratio for eight characteristic aroma components and hydroxypropyl-β-cyclodextrin, and the apparent formation constant between citronellol and hydroxypropyl-β-cyclodextrin was determined to be 71.86 M-1. In those components, ∆H of linalool and citronellol was found to be +877.03 kJ mol-1 and +1433.67 kJ mol-1, and ∆S were positive, which indicated that transfer from mobile phase to the stationary phase of the two analytes was entropically driven. Furthermore, this method was successfully applied to determination of characteristic aroma components in Rosa damascena Mill. hydrosol and R. rugosa cv. \"Plena\" hydrosol, in which it was found that phenylethyl alcohol, citronellol, and methyl eugenol were principal components.","PeriodicalId":15430,"journal":{"name":"Journal of chromatographic science","volume":"64 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147673814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Planer chromatographic method development and validation of Tadalafil and Mirabegron using fractional factorial design approach. 他达拉非和米拉贝龙的平面色谱方法的建立和应用分数因子设计方法的验证。

IF 1.3 4区化学

Journal of chromatographic science Pub Date : 2026-04-01 DOI: 10.1093/chromsci/bmag014

Ghanshyam B Paladiya, Jinal Tandel, Heta Kachhiya, Usmangani Chhalotiya, Dimal Shah, Devang Tandel

{"title":"Planer chromatographic method development and validation of Tadalafil and Mirabegron using fractional factorial design approach.","authors":"Ghanshyam B Paladiya, Jinal Tandel, Heta Kachhiya, Usmangani Chhalotiya, Dimal Shah, Devang Tandel","doi":"10.1093/chromsci/bmag014","DOIUrl":"https://doi.org/10.1093/chromsci/bmag014","url":null,"abstract":"The present research focuses on developing a high-performance thin-layer chromatographic (HPTLC) method using a design of experiment approach for simultaneously estimating Tadalafil and Mirabegron. Chromatographic separation was achieved on aluminum plates precoated with silica gel 60 F254 using an optimized mobile phase of MeOH: ACN: n-Butanol: TEA (6:2:2:0.1%v/v/v/v). A fractional factorial design was applied for the robustness study and the independent variables selected were chamber saturation time (A), wavelength (B), mobile phase composition (C) and solvent front (D). It was statistically revealed that the volume of MeOH affected the Rf of both drugs resulting in stricter control of MeOH volume compared to the other three variables. Rf for Tadalafil and Mirabegron was 0.75 and 0.45 at 242 nm. Calibration plots were linear for Tadalafil (100-300 ng/band) and Mirabegron (500-1500 ng/band), with recovery rates of 98.15%-100.34% and 98.46%-102.14%, respectively. The method was validated per ICH Q2(R1) guidelines, demonstrating linearity, precision, accuracy and selectivity, with %RSD values below 2% for both drugs. This HPTLC method is simple, accurate, reproducible and suitable for routine quality control of pharmaceutical formulations.","PeriodicalId":15430,"journal":{"name":"Journal of chromatographic science","volume":"64 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of Reverse Phase High-Performance Liquid Chromatographic Method Enabling Simultaneous Estimation of Polmacoxib and its Process-Related Impurities: Exploring Degradation Pathways and Elucidating Degradant Structures via LC-MS/MS and NMR Spectroscopy. 开发和验证反相高效液相色谱法，可同时估计Polmacoxib及其工艺相关杂质：通过LC-MS/MS和NMR探索降解途径和阐明降解结构。

IF 1.3 4区化学

Journal of chromatographic science Pub Date : 2026-02-13 DOI: 10.1093/chromsci/bmag006

Hitesh Thumbar, Bhavin Dhaduk

{"title":"Development and Validation of Reverse Phase High-Performance Liquid Chromatographic Method Enabling Simultaneous Estimation of Polmacoxib and its Process-Related Impurities: Exploring Degradation Pathways and Elucidating Degradant Structures via LC-MS/MS and NMR Spectroscopy.","authors":"Hitesh Thumbar, Bhavin Dhaduk","doi":"10.1093/chromsci/bmag006","DOIUrl":"https://doi.org/10.1093/chromsci/bmag006","url":null,"abstract":"A simple, sensitive, and selective reverse phase high-performance liquid chromatography (HPLC) method was developed and validated for the estimation of Polmacoxib (POL) and its process-related impurities. Chromatographic separation was achieved on a Kromasil C18 column (250 mm x 4.6 mm, 5 μm) using gradient elution with mobile phase containing 10 mM ammonium acetate buffer and acetonitrile in the initial ratio of 90:10 (% v/v). Chromatographic parameters were optimized: flow rate of 1.2 mL/min, UV detection at 232 nm, and injection volume of 10 μL. The developed method was validated as per International Council for Harmonization Q2 (R1) guidelines. For the stability study, the drug was subjected to various stress conditions. The results showed that was sensitive to the alkaline and degraded. Under alkaline condition, impurity-I and II were detected at retention time of 2.61 and 21.09 min, respectively. To identify the structures of the detected impurities, were initially isolated using a preparative HPLC and then collected fractions were injected into liquid chromatography with tandem mass spectrometry for structural identification. Further structure elucidation was performed using 1D-NMR (1H and 13C) and 2D-NMR (1H-1H correlation spectroscopy and 1H-13C heteronuclear single quantum coherence), and explore the degradation pathway. The proposed method is applicable for assay estimation of POL in dosage form and is suitable for quality control analysis.","PeriodicalId":15430,"journal":{"name":"Journal of chromatographic science","volume":"64 3","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147463232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of Trimetallic Metal-Organic Frameworks for the Rapid Removal of Bisphenol A from Water. 快速脱除水中双酚A的三金属金属-有机骨架的制备。

IF 1.3 4区化学

Journal of chromatographic science Pub Date : 2026-02-13 DOI: 10.1093/chromsci/bmag003

Rui Xu, Rui Xiao, Ming-Hua Lu

引用次数: 0

Non-targeted HPTLC Fingerprint Profiling for Swift Authentication of trikatu churna Coupled with Chemometric Methods. 非目标HPTLC指纹图谱与化学计量学方法的结合快速鉴别

IF 1.3 4区化学

Journal of chromatographic science Pub Date : 2026-02-13 DOI: 10.1093/chromsci/bmag008

Rinkal Patel, Kunjal L Vegad, Shailvi B Joshi, Sarita J Gagat, Nikunj D Patel

{"title":"Non-targeted HPTLC Fingerprint Profiling for Swift Authentication of trikatu churna Coupled with Chemometric Methods.","authors":"Rinkal Patel, Kunjal L Vegad, Shailvi B Joshi, Sarita J Gagat, Nikunj D Patel","doi":"10.1093/chromsci/bmag008","DOIUrl":"https://doi.org/10.1093/chromsci/bmag008","url":null,"abstract":"\"Trikatu churna,\" very famous herbal formulation which is widely used and prescribed for various disease conditions like hypothyroidism, hyperlipidaemia, atherosclerosis and others. It is having well proven anti-inflammatory, hepatoprotective and anthelmintic activities. The preliminary issues in quality of trikatu churna arise due to numerous factors like replacement, omission and adulteration in key ingredients of trikatu churna with spurious alike ingredients. A novel, simple, swift, precise, robust, non-destructive and non-targeted method based on High Performance Thin layer chromatography (HPTLC) coupled with multicomponent analysis was developed to appraise the quality of the samples of trikatu churna. Ten market samples and one standardized in-house sample was used for quality evaluation. Three in house samples were also prepared by deliberately omitting one key ingredient in each. Various chemometrics methods like Principal Component Analysis, and Cluster Analysis based on Hierarchy for further analysis to evaluate the differences in market samples of trikatu churna. Thus, developed method can be used as an effectual and applied approach for quality assessment of trikatu churna.","PeriodicalId":15430,"journal":{"name":"Journal of chromatographic science","volume":"64 3","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0