Journal of Cutaneous and Aesthetic Surgery最新文献

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Micro-face-lift: A novel biplanar, composite, less-invasive procedure. 微面部提升:一种新型的双平面、复合、微创手术
Journal of Cutaneous and Aesthetic Surgery Pub Date : 2024-01-01 DOI: 10.4103/JCAS.JCAS_71_23
Yoram Wolf, Rami Selinger, Ron Skorochod, Vladimir Mitz
{"title":"Micro-face-lift: A novel biplanar, composite, less-invasive procedure.","authors":"Yoram Wolf, Rami Selinger, Ron Skorochod, Vladimir Mitz","doi":"10.4103/JCAS.JCAS_71_23","DOIUrl":"10.4103/JCAS.JCAS_71_23","url":null,"abstract":"<p><strong>Background: </strong>Facial rejuvenation procedures have been in existence for over a century. Since its first introduction, it improved anatomical understanding and clinical implications and gave rise to numerous techniques and re-ideations of the original face-lift. The increase in popularity of face-lift procedures attracts patients of various ages and with different medical comorbidities. In this paper, we describe the less-invasive facelift procedure, termed the \"Micro-Face-lift,\" with minimal complications, a short recovery period, and few contraindications.</p><p><strong>Materials and methods: </strong>The authors retrospectively analyzed the medical files of 51 patients who underwent the \"Micro-Face-lift\" procedure between 2014 and 2019 by three independent surgeons.</p><p><strong>Results: </strong>Fifty-one patients met the inclusion criteria for the procedure. Forty-nine patients were women (96.1%) and the remainder were men (3.9%). The mean age at the time of the procedure was 60.8 years (range 45-87). Complications were encountered in five patients (9.8%): two hypertrophic scars (3.8%), one hematoma (2%), one surgical wound infection (2%), and one edema (2%), persistent for more than 2 weeks postoperatively. All complications resolved within 6 weeks of postoperatively. Thirty-five patients (68.6%) underwent additional procedures to maximize the aesthetic outcome. Thirty patients (58.8%) underwent submental liposuction and five patients (9.8%) underwent mid-face lipo-filling. The average satisfaction score on the self-reported \"Likert\" scale was 4.27 (range 1-5). All patients were followed for a minimum period of 18 months.</p><p><strong>Conclusions: </strong>The \"Micro-Face-lift\" is a less-invasive procedure that can be performed under local anesthesia and sedation in the outpatient setting. Complication rates and mortality are low, contraindications are rare, and the recovery period is short. In our experience, patient satisfaction is high with the Micro-Face-lift procedure, and the learning curve for the experienced practitioner is short.</p>","PeriodicalId":15415,"journal":{"name":"Journal of Cutaneous and Aesthetic Surgery","volume":" ","pages":"60-65"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44588421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient Perspectives on Hidradenitis Suppurativa-induced Scarring and Laser Therapy. 化脓性汗腺炎致瘢痕形成和激光治疗的患者观点
Journal of Cutaneous and Aesthetic Surgery Pub Date : 2024-01-01 DOI: 10.4103/JCAS.JCAS_83_23
Michelle Toker, Eliza Balazic, Lesley Coe, McCall Torpey, Kristina L Campton, Kseniya Kobets
{"title":"Patient Perspectives on Hidradenitis Suppurativa-induced Scarring and Laser Therapy.","authors":"Michelle Toker, Eliza Balazic, Lesley Coe, McCall Torpey, Kristina L Campton, Kseniya Kobets","doi":"10.4103/JCAS.JCAS_83_23","DOIUrl":"10.4103/JCAS.JCAS_83_23","url":null,"abstract":"","PeriodicalId":15415,"journal":{"name":"Journal of Cutaneous and Aesthetic Surgery","volume":" ","pages":"69-72"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48579988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative evaluation of therapeutic efficacy and safety of black peel versus 25% trichloroacetic acid peel in mild to moderate acne vulgaris: a split face study. 黑果酸换肤与 25% 三氯醋酸换肤对轻中度寻常型痤疮疗效和安全性的比较评估:分脸研究。
Journal of Cutaneous and Aesthetic Surgery Pub Date : 2024-01-01 DOI: 10.4103/JCAS.JCAS_69_23
Neerja Puri, Sumir Kumar, Sameer Kaur, B K Brar
{"title":"Comparative evaluation of therapeutic efficacy and safety of black peel versus 25% trichloroacetic acid peel in mild to moderate acne vulgaris: a split face study.","authors":"Neerja Puri, Sumir Kumar, Sameer Kaur, B K Brar","doi":"10.4103/JCAS.JCAS_69_23","DOIUrl":"10.4103/JCAS.JCAS_69_23","url":null,"abstract":"<p><strong>Introduction: </strong>Peeling has withstood the test of time as a simple, minimally invasive method to renew the skin, despite the introduction of more advanced procedures like lasers.</p><p><strong>Materials and methods: </strong>Thirty patients (or 60 sites) with age ranging from 15 to 45 years with mild-to-moderate acne vulgaris were included in the study. Assessment at baseline was done by the global acne grading system score for including mild and moderate acne patients.</p><p><strong>Results: </strong>On grading the improvement according to the 5-point Global Assessment Scale (GAS), it was found that in area A (black peel), 6.7% of patients showed excellent improvement, 86.7% of patients showed good improvement, and 6.7% of patients showed fair improvement. In area B (25%TCA peel), 6.7% of patients showed excellent improvement, 80% of patients showed good improvement, and 13.3% of patients showed fair improvement.</p><p><strong>Discussion: </strong>None of the patients showed poor or worse outcomes in any of the areas. The difference between the groups was not significant (<i>P =</i> 0.688).</p><p><strong>Conclusion: </strong>There is a paucity of data in the literature regarding the comparison of black peel with other conventional peels in the treatment of acne vulgaris. To the best of our knowledge, this is the first study comparing black peel with TCA peel in the treatment of acne vulgaris.</p>","PeriodicalId":15415,"journal":{"name":"Journal of Cutaneous and Aesthetic Surgery","volume":"17 1","pages":"11-18"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment of Acne Keloidalis Nuchae by Simply Combining Two Conventionally Available Modalities: Ablation with Carbon Dioxide Laser and Intralesional Triamcinolone Acetonide. 将两种传统方法简单地结合起来,治疗瘢痕疙瘩:二氧化碳激光消融术和醋酸曲安奈德皮内注射术。
Journal of Cutaneous and Aesthetic Surgery Pub Date : 2024-01-01 DOI: 10.4103/JCAS.JCAS_112_23
Yogesh M Bhingradia, Tejaswini Salunke
{"title":"Treatment of Acne Keloidalis Nuchae by Simply Combining Two Conventionally Available Modalities: Ablation with Carbon Dioxide Laser and Intralesional Triamcinolone Acetonide.","authors":"Yogesh M Bhingradia, Tejaswini Salunke","doi":"10.4103/JCAS.JCAS_112_23","DOIUrl":"10.4103/JCAS.JCAS_112_23","url":null,"abstract":"<p><p>Acne keloidalis nuchae is a chronic inflammatory condition affecting the occipital area or nape of the neck characterized by fibrotic papules, firm pustules, and nodules that coalesce into keloid like mass or plaques. It was first described by Kaposi in 1969. It is also known as lichen keloidalis nuchae, dermatitis papillaris capillitia, and folliculitis nuchae scleroticans. If not treated in the early stages of the disease it tends to be refractory to conventional methods like topical, intralesional steroids with antibiotics or retinoids. Surgical interventions remain the only choice in such cases. Various surgical modalities including surgical excision with primary or secondary closure, split-thickness skin grafts, and laser-assisted treatments have been tried. Most surgical methods have longer downtime with a higher chance of relapse. We studied the results of a combined treatment option carbon dioxide laser ablation followed by intralesional triamcinolone injection in the same sitting. This outpatient procedure has shown good results with no relapse and less downtime.</p>","PeriodicalId":15415,"journal":{"name":"Journal of Cutaneous and Aesthetic Surgery","volume":"17 1","pages":"25-28"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Wrinkle and Dermal Thickness in the Forearm before and after Picosecond Laser Therapy. 皮秒激光疗法前后对前臂皱纹和真皮厚度的评估
Journal of Cutaneous and Aesthetic Surgery Pub Date : 2024-01-01 DOI: 10.4103/JCAS.JCAS_80_22
Putri Hendria Wardhani, Cita Rosita Sigit Prakoeswa, Muhammad Yulianto Listiawan
{"title":"Evaluation of Wrinkle and Dermal Thickness in the Forearm before and after Picosecond Laser Therapy.","authors":"Putri Hendria Wardhani, Cita Rosita Sigit Prakoeswa, Muhammad Yulianto Listiawan","doi":"10.4103/JCAS.JCAS_80_22","DOIUrl":"10.4103/JCAS.JCAS_80_22","url":null,"abstract":"<p><strong>Background: </strong>Skin wrinkles are generated as a result of the aging process. Dermal thickness underneath a wrinkle decreases absolutely. Approximately 20% of dermal thickness disappears as people become elderly. In recent times, people have attempted to reduce wrinkles using various procedures. Currently, available picosecond lasers in dermatology can create mechanical stress and the energy can be fractionated via diffractive lens arrays (DLA). An emerging indication for the picosecond laser includes photorejuvenation. Non-ablative laser skin rejuvenation therapy demonstrates the dermis can be safely reconstructed by only irradiating the skin surface with a laser. The clinical effects of picosecond pulse laser have been frequently reported, but few studies have included histological investigation.</p><p><strong>Aims and objectives: </strong>This study aimed to evaluate wrinkle and dermal thickness in the forearm before and after picosecond laser therapy.</p><p><strong>Materials and methods: </strong>Twenty healthy male and female subjects between 36 and 55 years old with wrinkles in the forearm who met the sample requirements and were willing to participate were recruited in this study. Clinical examination and biopsy for histopathological examination were carried out before and 4 weeks after therapy, then treatment was carried out using a picosecond laser.</p><p><strong>Results: </strong>At 1-month follow-up, a significant improvement was noted in wrinkle and dermal thickness (<i>P</i> < 0.05).</p><p><strong>Conclusions: </strong>This picosecond 755 nm alexandrite laser with DLA was found to be very effective in treating wrinkles, which was confirmed by a dermatologic assessment from forearm photographic assessment scaled and dermal thickness improvement.</p>","PeriodicalId":15415,"journal":{"name":"Journal of Cutaneous and Aesthetic Surgery","volume":"17 1","pages":"7-10"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086935/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A comparative study of fractional CO2 laser with topical triamcinolone acetonide versus intralesional triamcinolone acetonide in the treatment of alopecia areata. 治疗斑秃的二氧化碳点阵激光与局部使用曲安奈德与局部使用曲安奈德的比较研究。
Journal of Cutaneous and Aesthetic Surgery Pub Date : 2024-01-01 DOI: 10.4103/JCAS.JCAS_31_23
Harish Prasanna, Rajashekar Talari Srinivas, Suresh Kumar Kuppuswamy, Hanumanthayya Keloji, Pavithra Thotta Ravikumar
{"title":"A comparative study of fractional CO<sub>2</sub> laser with topical triamcinolone acetonide versus intralesional triamcinolone acetonide in the treatment of alopecia areata.","authors":"Harish Prasanna, Rajashekar Talari Srinivas, Suresh Kumar Kuppuswamy, Hanumanthayya Keloji, Pavithra Thotta Ravikumar","doi":"10.4103/JCAS.JCAS_31_23","DOIUrl":"10.4103/JCAS.JCAS_31_23","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia areata (AA) is a non-scarring alopecia of chronic autoimmune etiology with heterogenous severity against the anagen hair follicle over the scalp, beard, or any part of the body and is associated with a significant psychological morbidity in the mental status of the patients leading the patients to seek treatment for cosmetic reasons. The management of AA is very unpredictable and is associated with various cosmetic adverse effects. This study aimed at comparing the efficacy and safety of a novel procedure of laser-assisted drug delivery system of steroids with the first-line procedure of intralesional steroids (ILS) for the treatment of patchy AA.</p><p><strong>Aims and objectives: </strong>To assess and compare the efficacy and safety of fractional CO<sub>2</sub> laser in combination with topical triamcinolone acetonide aqueous solution and intralesional triamcinolone acetonide as a monotherapy and in the treatment of AA.</p><p><strong>Materials and methods: </strong>A total of 60 patchy AA patients were included in this study. Patients were randomized into two equal groups: Group A and Group B with 30 patients in each group using a computer-generated block randomization. Patients in Group A received fractional CO<sub>2</sub> laser with topical triamcinolone acetonide aqueous solution and Group B received ILS. Both groups received treatment for five settings with each setting a gap of 3 weeks. The efficacy and safety of treatment modalities in both groups were assessed using global photograph assessment (GPA)-scale, lesional area density score percentage of improvement (LAD score improvement %), visual discomfort scale (VDS), visual analogue scale, and documentation of adverse effects in each setting.</p><p><strong>Results: </strong>Efficacy of treatment modality-assessed using means score of GPA-scale and LAD score improvement % suggests quicker results to patients in Group B in initial settings but drastic improvement happens to patients in Group A in subsequent settings. At the end of 5th setting, GPA-scale and LAD score improvement % suggest maximum efficacy in patients in Group A and they are statistically significant (<i>P</i>-value < 0.001). The mean VDS in both groups suggests maximum discomfort in Group A, yet the patient satisfaction at the end of 5th setting was maximum with patients in Group A and they are statistically significant (<i>P</i>-value < 0.001). Cosmetic notable adverse effect of atrophy of skin was documented in 30% of patients in Group B.</p><p><strong>Conclusion: </strong>This study showed that fractional CO<sub>2</sub> laser with topical triamcinolone acetonide is a better treatment modality than the intralesional triamcinolone acetonide for the treatment of AA with respect to efficacy, safety, and adverse events.</p>","PeriodicalId":15415,"journal":{"name":"Journal of Cutaneous and Aesthetic Surgery","volume":"17 1","pages":"34-40"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical pearl: Modified hypodermic needle and its cap for guarded prick incision. 外科珍珠改良皮下注射针及其针帽,用于防护性刺入切口。
Journal of Cutaneous and Aesthetic Surgery Pub Date : 2024-01-01 DOI: 10.4103/JCAS.JCAS_62_21
Muhammed Mukhtar
{"title":"Surgical pearl: Modified hypodermic needle and its cap for guarded prick incision.","authors":"Muhammed Mukhtar","doi":"10.4103/JCAS.JCAS_62_21","DOIUrl":"10.4103/JCAS.JCAS_62_21","url":null,"abstract":"<p><p>There are many instruments to prick the comedone before its extraction and scalp during hair transplantation. These instruments are not well guarded, and it can cause deep injury and fear in the patients. Here we described how to guard these needle for safety during procedure.</p>","PeriodicalId":15415,"journal":{"name":"Journal of Cutaneous and Aesthetic Surgery","volume":"17 1","pages":"66-68"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Full Thickness Macular Hole in Aesthetician Occurring Due to Accidental Self-exposure to Cosmetic Laser Machine Trying to Take Special Precautions Against COVID-19. 美容师在尝试对 COVID-19 采取特别防护措施时,意外自行暴露于美容激光机,导致全厚黄斑孔。
Journal of Cutaneous and Aesthetic Surgery Pub Date : 2024-01-01 DOI: 10.4103/JCAS.JCAS_74_21
Alay S Banker, Bansri M Mahadevia, Harita Shah, Ahan A Banker
{"title":"Full Thickness Macular Hole in Aesthetician Occurring Due to Accidental Self-exposure to Cosmetic Laser Machine Trying to Take Special Precautions Against COVID-19.","authors":"Alay S Banker, Bansri M Mahadevia, Harita Shah, Ahan A Banker","doi":"10.4103/JCAS.JCAS_74_21","DOIUrl":"10.4103/JCAS.JCAS_74_21","url":null,"abstract":"<p><p>A 25-year-old aesthetician was operating Q-switch pulse (SPECTRA) cosmetic laser machine of 1,064 nm wavelength, for the purpose of skin bleaching. The probe suddenly slipped over the plastic sheet that had been placed to avoid COVID-19 exposure after which she complained of sudden loss of vision. She was diagnosed as having vitreous hemorrhage in her right eye and was treated conservatively for one month. She then complained of central scotoma and was diagnosed to have developed a full-thickness macular hole, for which she was advised vitrectomy surgery. The purpose of this case report is to emphasize the importance of taking precautions during the COVID-19 era and while doing that making sure how to handle the machines so as not to inflict any accidental injury to the operating physician. Macular Holes following skin bleaching with Nd:YAG laser occurring in operating aesthetician is rare as compared to that occurring in the patients.</p>","PeriodicalId":15415,"journal":{"name":"Journal of Cutaneous and Aesthetic Surgery","volume":"17 1","pages":"75-77"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11086931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140911823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anaphylactic shock secondary to topical EMLA 继发于外用 EMLA 的过敏性休克
Journal of Cutaneous and Aesthetic Surgery Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_30_23
V. M. V. Gowda, S. Shenoi, K. M. Augustine
{"title":"Anaphylactic shock secondary to topical EMLA","authors":"V. M. V. Gowda, S. Shenoi, K. M. Augustine","doi":"10.4103/jcas.jcas_30_23","DOIUrl":"https://doi.org/10.4103/jcas.jcas_30_23","url":null,"abstract":"The eutectic mixture of local anesthetics (EMLAs) is an anesthetic cream frequently used by dermatologists for various aesthetic procedures on a daily basis. Although side effects of EMLA are usually mild local skin reactions, rare complications such as methemoglobinemia, central nervous system toxicity, and cardiotoxicity can occur. Herein, we are reporting a case of anaphylactic shock to topical application of EMLA.","PeriodicalId":15415,"journal":{"name":"Journal of Cutaneous and Aesthetic Surgery","volume":"127 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139197344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spontaneous and induced degradation of dermal fillers: A review 皮肤填充剂的自发降解和诱导降解:综述
Journal of Cutaneous and Aesthetic Surgery Pub Date : 2023-11-30 DOI: 10.4103/jcas.jcas_137_23
Uwe Wollina, A. Goldman
{"title":"Spontaneous and induced degradation of dermal fillers: A review","authors":"Uwe Wollina, A. Goldman","doi":"10.4103/jcas.jcas_137_23","DOIUrl":"https://doi.org/10.4103/jcas.jcas_137_23","url":null,"abstract":"Dermal fillers are among the most versatile tools in esthetic medicine. A broad range of temporary, semipermanent, and permanent filler products is on the market. We performed a narrative review on spontaneous and induced degradation of dermal fillers in vitro and in vivo. Hyaluronic acid-based fillers are the most frequently used temporary fillers. The products differ in their hyaluronic acid content, cross-linking, and rheological parameters. Endogenous hyaluronidase and reactive oxygen species are responsible for the spontaneous degradation of these fillers. Hyaluronidase digests the filler material by cleavage of the β-1,4 glycosidic linkage between N-acetyl-glucosamine and d-glucuronic acid. The enzyme can be used for treatment of medical and cosmetic adverse events due to hyaluronic acid-based filler. Higher hyaluronidase content and higher degree of cross-linking are major factors contributing to filler persistence over time. Semipermanent fillers are poly-(d),l-lactic acid and calcium hydroxylapatite. These filler types are decomposed by hydrolysis and osteoclastic enzymes. They usually persist up to 2 years, in single patients even more than 5 years. Sodium thiosulfate can stimulate degradation of calcium hydroxylapatite, but it is slow acting and not effective in case of emergency. Permanent fillers may show some kind of modification in situ, but spontaneous or induced degradation has not been documented. Once implanted the permanent fillers remain lifelong. Intralesional laser treatment supports the removal of permanent filler material as an alternative to surgery. Besides biocompatibility and toxicity, filler materials should also be assessed for degradation to improve patient safety.","PeriodicalId":15415,"journal":{"name":"Journal of Cutaneous and Aesthetic Surgery","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139201751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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