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Journal of Cutaneous Medicine and Surgery最新文献

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Corrigendum to Biomarkers in Pemphigus Vulgaris: A Systematic Review. 寻常性天疱疮生物标志物的勘误表：系统综述。
IF 3.1 4区 医学
Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-12-24 DOI: 10.1177/12034754241311342
{"title":"Corrigendum to Biomarkers in Pemphigus Vulgaris: A Systematic Review.","authors":"","doi":"10.1177/12034754241311342","DOIUrl":"10.1177/12034754241311342","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"212"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pachyonychia Congenita. 先天Pachyonychia。
IF 3.1 4区 医学
Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2025-01-17 DOI: 10.1177/12034754241308250
Junfeng Du, Yong Luo
{"title":"Pachyonychia Congenita.","authors":"Junfeng Du, Yong Luo","doi":"10.1177/12034754241308250","DOIUrl":"10.1177/12034754241308250","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"206"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Idiopathic Scrotal Calcinosis. 特发性阴囊钙化症
IF 3.1 4区 医学
Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-11-26 DOI: 10.1177/12034754241303085
Wei Liu, Yu Liu
{"title":"Idiopathic Scrotal Calcinosis.","authors":"Wei Liu, Yu Liu","doi":"10.1177/12034754241303085","DOIUrl":"10.1177/12034754241303085","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"202"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nodular Pretibial Myxedema. 结节性胫骨前水肿
IF 3.1 4区 医学
Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-11-26 DOI: 10.1177/12034754241303062
Lin Wang
{"title":"Nodular Pretibial Myxedema.","authors":"Lin Wang","doi":"10.1177/12034754241303062","DOIUrl":"10.1177/12034754241303062","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"205"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scalp Melanoma. 头皮黑色素瘤。
IF 3.1 4区 医学
Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-12-22 DOI: 10.1177/12034754241308243
An Jian Leung, Dingyuan Wang
{"title":"Scalp Melanoma.","authors":"An Jian Leung, Dingyuan Wang","doi":"10.1177/12034754241308243","DOIUrl":"10.1177/12034754241308243","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"209"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hidradenitis Suppurativa from a Multi-Omic Scope. 从多孔镜观察化脓性扁桃体炎
IF 3.1 4区 医学
Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-11-02 DOI: 10.1177/12034754241293138
Patricia Garbayo-Salmons, Ester Saus, Vicente Exposito-Serrano, Mireia Moreno, Mireia Sàbat, Joan Calvet
{"title":"Hidradenitis Suppurativa from a Multi-Omic Scope.","authors":"Patricia Garbayo-Salmons, Ester Saus, Vicente Exposito-Serrano, Mireia Moreno, Mireia Sàbat, Joan Calvet","doi":"10.1177/12034754241293138","DOIUrl":"10.1177/12034754241293138","url":null,"abstract":"<p><p>Hidradenitis suppurativa (HS) is recognized as a systemic immune-mediated disease (IMID), sharing genetic and environmental risk factors with other IMIDs such as inflammatory bowel disease and psoriasis. Over time, correlating clinical findings with genetic, proteomic, and metabolomic results has been challenging due to diverse sampling methods, analysis techniques, and the use of variable clinical phenotype descriptions across studies. This review aims to summarize the results from various omics fields to explore the etiopathology of HS. Genetic studies highlight defects in Notch and γ-secretase signaling and inflammasome function. Syndromic HS involves specific mutations in autoinflammatory syndromes such as pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) and pyoderma gangrenosum, acne, and HS (PASH). Proteomic analyses reveal key inflammatory pathways indicating activation of both innate and adaptive immunity. Additionally, microbiome studies show an increased presence of anaerobes like <i>Prevotella</i> in HS lesions and a decreased presence of commensals such as <i>Staphylococcus epidermidis</i>. Gut microbiota dysbiosis, particularly involving <i>Ruminococcus gnavus</i> and <i>Clostridium ramosum</i>, is associated with HS. Moreover, metabolomic profiling indicates dysregulated tryptophan catabolism and lipid metabolism, with increased 5-lipoxygenase-derived metabolites and odd-chain fatty acids suggesting bacterial involvement. In summary, despite advances, robust associations between genetics, proteomics, microbiome, and metabolomics in HS are still lacking. Integrating these datasets could identify new clinical phenotypes, genetic predispositions, microbial signatures, and therapeutic targets, enhancing personalized treatment strategies and biomarker discovery for HS classification, prognosis, and treatment response.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"159-166"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Be King of Your Creativity or Slave to Your Words. 做你的创造力之王，还是做你话语的奴隶。
IF 3.1 4区 医学
Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2025-04-09 DOI: 10.1177/12034754251326658
Kirk Barber
{"title":"Be King of Your Creativity or Slave to Your Words.","authors":"Kirk Barber","doi":"10.1177/12034754251326658","DOIUrl":"https://doi.org/10.1177/12034754251326658","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":"29 2","pages":"122-123"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Off-Label Use of Tildrakizumab in Patients with Hidradenitis Suppurativa. 在湿疹患者中标示外使用替雷珠单抗
IF 3.1 4区 医学
Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-10-25 DOI: 10.1177/12034754241291044
Mahan Maazi, Jeffrey Toy, Xi Yao Gui, Vincent Piguet
{"title":"Off-Label Use of Tildrakizumab in Patients with Hidradenitis Suppurativa.","authors":"Mahan Maazi, Jeffrey Toy, Xi Yao Gui, Vincent Piguet","doi":"10.1177/12034754241291044","DOIUrl":"10.1177/12034754241291044","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"188-189"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Real-World Effectiveness and Safety of Tildrakizumab for Moderate-to-Severe Plaque Psoriasis in Adult Patients: A 52-Week Multicenter Retrospective Study. 替雷珠单抗治疗成人中重度斑块状银屑病的实际有效性和安全性：一项为期52周的多中心回顾性研究。
IF 3.1 4区 医学
Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-10-25 DOI: 10.1177/12034754241291042
Jensen Yeung, Siddhartha Sood
{"title":"Real-World Effectiveness and Safety of Tildrakizumab for Moderate-to-Severe Plaque Psoriasis in Adult Patients: A 52-Week Multicenter Retrospective Study.","authors":"Jensen Yeung, Siddhartha Sood","doi":"10.1177/12034754241291042","DOIUrl":"10.1177/12034754241291042","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"180-181"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating the Implementation and Impact of BRAF Reflex Mutation Testing in Melanoma, Lung, and Colorectal Cancers. 评估BRAF反射突变检测在黑色素瘤、肺癌和结直肠癌中的实施和影响。
IF 3.1 4区 医学
Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-12-04 DOI: 10.1177/12034754241302821
Daniel Josué Guerra Ordaz, Sera Whitelaw, Mohammed Kaouache, Amina Moustaqim-Barrette, Louise Gresham, Brandon Ramchatesingh, Margaret Redpath, May Chergui, Ivan V Litvinov
{"title":"Evaluating the Implementation and Impact of BRAF Reflex Mutation Testing in Melanoma, Lung, and Colorectal Cancers.","authors":"Daniel Josué Guerra Ordaz, Sera Whitelaw, Mohammed Kaouache, Amina Moustaqim-Barrette, Louise Gresham, Brandon Ramchatesingh, Margaret Redpath, May Chergui, Ivan V Litvinov","doi":"10.1177/12034754241302821","DOIUrl":"10.1177/12034754241302821","url":null,"abstract":"<p><strong>Background: </strong>Reflex molecular testing, the process of profiling specimens at diagnosis, is emerging in oncology, allowing for prompt therapy initiation, and potentially improving outcomes. This study evaluates the impact of reflex BRAF testing on treatment timelines and outcomes in melanoma, lung and colorectal cancers at the McGill University Health Center (MUHC).</p><p><strong>Methods: </strong>A retrospective chart review was conducted at the MUHC. The study included patients with melanoma, lung, and colorectal cancers who underwent BRAF testing from 2017 to 2022. Data on demographics, cancer type, stage, test ordering specialist, testing method, and treatment outcomes were extracted. Statistical analyses included descriptive and multivariate regression analyses.</p><p><strong>Results: </strong>518 BRAF molecular tests were performed, with 173 patients meeting the inclusion criteria [median age 72 (IQR 60-80 years), 46.2% female]. Of these, 75.7% had melanoma, 23.7% colorectal cancer and 0.58% lung cancer. Pathologists ordered 71.1% of BRAF tests, primarily relying on immunohistochemistry. By 2022, all BRAF results were available before oncology consultations. Patients with pre-consultation BRAF results were more likely to receive targeted therapy (59.4% vs 36.4%). The availability of BRAF test results was associated with quicker treatment initiation and better alignment of therapy with mutation status.</p><p><strong>Conclusion: </strong>This study underscores the success of the pathology team at MUHC in implementing reflex <i>BRAF</i> mutation testing, enhancing clinical care by ensuring the timely availability of test results. Delays in testing may adversely affect clinical decision-making and therapy selection, highlighting the need for standardized reflex testing protocols across Canada to optimize patient outcomes in melanoma, lung, and colorectal cancers.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"150-155"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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