{"title":"Optimising Local Anaesthesia Techniques in Wide-Awake Skin and Soft Tissue Surgery: A Systematic Review and Meta-Analysis.","authors":"Margaux Maes, Steven D M Colpaert","doi":"10.1177/12034754261492664","DOIUrl":"https://doi.org/10.1177/12034754261492664","url":null,"abstract":"<p><p>This study aimed to provide an easy-to-implement guide with the most important techniques for administering local anaesthesia in wide-awake skin and soft tissue surgery, ensuring minimum pain and maximum efficiency. Until December 2024, several databases (MEDLINE, Embase and The Cochrane Library) were used to identify studies with following eligible interventions: needle and injection techniques, additives, communication methods, additional analgesic measures and environmental factors. Studies missing relevant outcomes, peer review, full-text availability or not written in English were excluded. Data extraction and risk of bias assessment (RoB 2 tool) were conducted independently. Meta-analysis was performed in JASP (v0.19.3) using a random-effects model, with mean differences (MDs) as effect measure. Heterogeneity was assessed (τ<sup>2</sup>, <i>Q</i> and <i>I</i><sup>2</sup>), and meta-regression explored intervention type as moderator. Out of 48 included studies (3664 patients), 16 were eligible for meta-analysis. All interventions consistently showed pain reduction (MD -1.50, <i>P</i> = .010), and heterogeneity was high (<i>I</i><sup>2</sup> = 97.3). Meta-regression did not reveal significant differences between techniques. Techniques like warming, slower injection speeds and cryopreparation showed favourable results, whereas vibration, verbal framing and waiting after epinephrine administration offer promising, low-risk strategies. As wide-awake skin and soft tissue surgery continues to expand in use and scope, this review highlights practical, patient-centred strategies to optimise local anaesthetic injections, ensuring they are no longer perceived as 'the most painful part of the procedure'.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754261492664"},"PeriodicalIF":2.8,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149231077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sanaz Lordfard, Nandi Edwards, Durr Nassir Al-Mohammed, Katya Peri, Rafael Paolo Lansang, Anastasiya Muntyanu
{"title":"Malignant Transformation of Erythema Ab Igne: A Systematic Review.","authors":"Sanaz Lordfard, Nandi Edwards, Durr Nassir Al-Mohammed, Katya Peri, Rafael Paolo Lansang, Anastasiya Muntyanu","doi":"10.1177/12034754261490557","DOIUrl":"https://doi.org/10.1177/12034754261490557","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754261490557"},"PeriodicalIF":2.8,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149216159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diffuse Cutaneous Mastocytosis.","authors":"Ethan Bendayan, Elena Netchiporouk","doi":"10.1177/12034754261492986","DOIUrl":"https://doi.org/10.1177/12034754261492986","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754261492986"},"PeriodicalIF":2.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ethan Bendayan, Joaquim Cohen, Michael Fein, Barbara Miedzybrodzki, Mohammed Kaouache, Moshe Ben-Shoshan, Elena Netchiporouk
{"title":"Increased Anaphylaxis and Venom Allergy in Mastocytosis Compared With Matched Chronic Urticaria Controls: A Retrospective Cohort Study.","authors":"Ethan Bendayan, Joaquim Cohen, Michael Fein, Barbara Miedzybrodzki, Mohammed Kaouache, Moshe Ben-Shoshan, Elena Netchiporouk","doi":"10.1177/12034754261488407","DOIUrl":"https://doi.org/10.1177/12034754261488407","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754261488407"},"PeriodicalIF":2.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J S Griffiths Acha, M Menendez Sanchez, A Pampin Franco, M U Floristán Muruzabal, J L López Estebaranz, R Gamo Villegas
{"title":"Clinical and Dermoscopic Features of Facial and Extrafacial Lentigo Maligna: A Case Series of 225 Lesions.","authors":"J S Griffiths Acha, M Menendez Sanchez, A Pampin Franco, M U Floristán Muruzabal, J L López Estebaranz, R Gamo Villegas","doi":"10.1177/12034754261493502","DOIUrl":"https://doi.org/10.1177/12034754261493502","url":null,"abstract":"<p><strong>Background: </strong>Lentigo maligna (LM) and its invasive counterpart, LM melanoma (LMM), are subtypes of melanoma associated with chronic sun exposure classically described in head and neck. Extrafacial LM is increasingly recognized and may display distinct dermoscopic features that facilitate earlier recognition than those of facial LM.</p><p><strong>Objectives: </strong>To describe and compare the clinical and dermoscopic characteristics of LM and LMM on facial (head and neck) versus extrafacial sites in a large retrospective series from a tertiary center.</p><p><strong>Methods: </strong>We conducted a retrospective, observational, single-center study including 225 histopathologically confirmed cases of LM or LMM diagnosed between 2017 and 2024. Demographic, clinical, dermoscopic, and histological features were collected and compared by anatomical site.</p><p><strong>Results: </strong>Compared with extrafacial lesions, facial LM/LMM were diagnosed at an older age and more often presented as larger, polychromatic lesions with a higher frequency of blue-gray pigmentation on dermoscopy. Facial lesions also showed more regression-related structureless areas and rhomboidal structures. In contrast, extrafacial lesions more often displayed irregular pigmented foci and early features of reticular distortion, including parallel reticular lines, radial perifollicular lines, progressive loss of the reticular pattern, and an erased pigment network. Pink coloration was significantly associated with more invasive lesions, regardless of location.</p><p><strong>Conclusions: </strong>LM and LMM demonstrate distinct dermoscopic patterns depending on anatomical site. Extrafacial LM are generally easier to recognize. Awareness of these site-specific differences may facilitate earlier clinical detection and improve dermoscopic interpretation across different body regions.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754261493502"},"PeriodicalIF":2.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elaine C Dupuis, Patrick Fleming, Rami Abou Zeinab, Bridgette Hartley, Maxime Barakat, Parbeer Grewal
{"title":"Clinical Implications of Interleukin-17 as a Hepato-Dermal Link in Patients With Psoriasis and Concomitant Steatotic Liver Disease.","authors":"Elaine C Dupuis, Patrick Fleming, Rami Abou Zeinab, Bridgette Hartley, Maxime Barakat, Parbeer Grewal","doi":"10.1177/12034754261490554","DOIUrl":"https://doi.org/10.1177/12034754261490554","url":null,"abstract":"<p><p>Psoriasis is increasingly recognized as a systemic inflammatory disease with impacts beyond the skin and joints. Metabolic dysfunction-associated steatotic liver disease (MASLD) and excessive alcohol consumption are common in the psoriasis population, affecting up to two-thirds of patients. Interleukin-17 (IL-17) has been identified as a potential key pro-inflammatory link between psoriasis and MASLD. IL-17 levels have been positively correlated with progression of MASLD to more advanced forms of liver disease, including steatohepatitis, cirrhosis and hepatocellular carcinoma. Given the high prevalence of concurrent psoriasis and liver disease, dermatologists should have an elevated index of suspicion of MASLD in patients with psoriasis, particularly those with concomitant metabolic risk factors and/or excessive alcohol consumption. Using 3 parameters, the Fibrosis-4 index is a validated, non-invasive screening tool that can be implemented in clinical practice. With the wide variety of therapeutics available to treat psoriasis, practitioners should be mindful of systemic agents carrying potential hepatotoxic adverse effects and could consider instead implementation of advanced therapies that have neutral or potentially beneficial effects on the liver. There is emerging data, pending larger prospective confirmatory studies, that support consideration of IL-17 inhibitors as a reasonable option in appropriate patients with or at risk of MASLD.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754261490554"},"PeriodicalIF":2.8,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Glomus Tumor.","authors":"Wei-Chieh Chen, Stephen Chu-Sung Hu","doi":"10.1177/12034754261493494","DOIUrl":"https://doi.org/10.1177/12034754261493494","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754261493494"},"PeriodicalIF":2.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corrigendum to \"Mapping Mohs Surgery Availability in Canada: A Review of Geographic Access\".","authors":"","doi":"10.1177/12034754261489931","DOIUrl":"https://doi.org/10.1177/12034754261489931","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754261489931"},"PeriodicalIF":2.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Monkeypox Lesions.","authors":"Neerja Saraswat, Sivasankari Mariappan","doi":"10.1177/12034754261496283","DOIUrl":"https://doi.org/10.1177/12034754261496283","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754261496283"},"PeriodicalIF":2.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Onychomycosis by <i>Fusarium oxysporum</i>.","authors":"Stefano Veraldi, Anna Grancini","doi":"10.1177/12034754261493000","DOIUrl":"https://doi.org/10.1177/12034754261493000","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754261493000"},"PeriodicalIF":2.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}