Journal of Cutaneous Medicine and Surgery最新文献

{"title":"A Review on the Mechanisms and Clinical Advances of JAK Inhibitors in the Treatment of Rosacea.","authors":"Yulian Hu, Biyu Li, Runlu Hu, Chuang Huang, Kun Huang","doi":"10.1177/12034754251325482","DOIUrl":"https://doi.org/10.1177/12034754251325482","url":null,"abstract":"<p><p>Rosacea is a chronic inflammatory disease that primarily affects the facial area, with a complex pathogenesis and a variety of treatment options. In recent years, with deeper research into the pathogenesis of rosacea, it has been discovered that the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signalling pathway may be involved in the development of rosacea, and JAK inhibitors are expected to become a new therapeutic approach for rosacea. This paper reviews the mechanisms, clinical efficacy, and safety of JAK inhibitors in the treatment of rosacea.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251325482"},"PeriodicalIF":3.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram for Predicting the Risk of Organ Involvement in Patients With Behcet's Disease.","authors":"Lulu Niu, Huajun Chen, XueJiao Zhang, Qian Liufu, Mukai Chen","doi":"10.1177/12034754251327289","DOIUrl":"https://doi.org/10.1177/12034754251327289","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251327289"},"PeriodicalIF":3.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Incidence of Oral Squamous Cell Carcinoma in Patients With Oral Lichen Planus on Sustained Anti-Inflammatory Therapy: A Single-Centre Retrospective Study of 273 Patients.","authors":"Jose W Ricardo, Max E Oscherwitz, Madison H Read, Angelina H Wiater, Christina Kontzias, Jane B Cleland, Yu Wang, Joseph Jorizzo","doi":"10.1177/12034754251324945","DOIUrl":"https://doi.org/10.1177/12034754251324945","url":null,"abstract":"<p><strong>Background: </strong>Oral lichen planus (OLP), a chronic inflammatory disease, can progress to oral squamous cell carcinoma (OSCC). The malignant transformation rate may be lower in OLP patients receiving anti-inflammatory therapy.</p><p><strong>Objective: </strong>To describe cases of malignant transformation among OLP patients on topical/systemic anti-inflammatory therapy.</p><p><strong>Methods: </strong>The medical records of 273 patients with OLP at an academic institution were retrospectively reviewed. Patients with epithelial dysplasia at OLP diagnosis were excluded. Biopsy-confirmed OSCC cases diagnosed ≥6 months after the initial visit were included. Chi-square and <i>t</i>-tests compared categorical and numerical variables, respectively.</p><p><strong>Results: </strong>The mean age at OLP diagnosis was 63 years (standard deviation [SD]: 12.2, range: 19-92); 79.9% were women and 89.4% were White. Most patients had erosive OLP (EOLP) (61.9%). 16.5% had concurrent genital LP and 10.6% had cutaneous LP. Tacrolimus swish-and-spit was the most frequently prescribed treatment (100%), followed by 10 mg clotrimazole troches (89.4%) and topical corticosteroids (85%). The median duration of clinical follow-up was 2.9 years (interquartile range: 1-5.5). Three (1.1%) patients developed OSCC on average 6.3 years post-OLP diagnosis, all with EOLP. OSCC most frequently affected the tongue (66.7%), followed by the gingiva (33.3%). Out of 3 tumours, one was stage II, one was stage III, and one was stage IV. OLP patients with vs. without OSCC were more often male (<i>P</i> = .04) and more frequently experienced dysphagia (<i>P</i> < .001).</p><p><strong>Conclusion: </strong>OSCC incidence was low in OLP patients on sustained anti-inflammatory therapy, occurring exclusively in those with EOLP. Males and patients with dysphagia more often developed OSCC.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251324945"},"PeriodicalIF":3.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steroid-Induced Rosacea: A Systematic Review.","authors":"Mahek Shergill, Sarah Saud, Ilya Mukovozov","doi":"10.1177/12034754251320643","DOIUrl":"https://doi.org/10.1177/12034754251320643","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251320643"},"PeriodicalIF":3.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Dermatologist is Out? Assessment of Dermatologists in Ontario Accepting Ontario Health Insurance Plan (OHIP) Referrals for Hair Loss Evaluation.","authors":"Victoria Young, Renée A Beach","doi":"10.1177/12034754251324941","DOIUrl":"10.1177/12034754251324941","url":null,"abstract":"<p><strong>Background: </strong>The Ontario Health Insurance Plan (OHIP) insures appointments for the assessment and diagnosis of hair loss, or alopecia. Although anecdotal, discussion suggests that, increasingly, dermatologists decline to see referrals of this nature. There has been a lack of objective surveillance to determine the proportion of dermatologists in practice who accept referrals for this concern.</p><p><strong>Objectives: </strong>This study investigated the proportion of dermatologists in Ontario accepting OHIP referrals for hair loss. Secondary objectives included wait times, consultation fees for non-OHIP visits, and factors affecting referral acceptance or rejection.</p><p><strong>Methods: </strong>A cross-sectional telephone survey was conducted, in which 284 dermatologists' offices listed by the College of Physicians and Surgeons of Ontario (CPSO) were contacted. The study investigated the acceptance of OHIP referrals for hair loss, wait times, additional referral requirements, and private consultation fees. Descriptive statistics were employed to summarize data.</p><p><strong>Results: </strong>Of the 284 offices contacted, 38.38% (109/284) accepted OHIP referrals for hair loss, 48.59% (138/284) did not, and 13.03% (37/284) were unavailable for contact. The average wait time for offices that accepted referrals was 4.51 ± 4.07 months. Non-OHIP consultation fees ranged from $135 to $299 CAD. Some offices limited acceptance to specific conditions such as alopecia areata and male androgenetic alopecia.</p><p><strong>Conclusion: </strong>A total of 48.59% of dermatologists in Ontario do not accept OHIP referrals for hair loss, while the status of 13.03% remains unknown. This reality raises concerns about accessibility to care. Further research is needed to investigate factors influencing referral acceptance.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251324941"},"PeriodicalIF":3.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Mycosis Fungoides and Sézary Syndrome With Oral Systemic Therapies.","authors":"Jonathan D Greenzaid, Sach Thakker, Ainsley J Ruley, Justin M Eichinger, Lindsay C Strowd","doi":"10.1177/12034754251322881","DOIUrl":"10.1177/12034754251322881","url":null,"abstract":"<p><p>Mycosis fungoides (MF) and Sézary syndrome (SS) are subtypes of cutaneous T-cell lymphoma with numerous topical and systemic therapies. Early-stage MF can be managed with topical corticosteroids, mechlorethamine, and phototherapy. However, patients are often non-responsive to topical therapies, thus requiring systemic therapies. There are few studies summarizing oral (PO) therapies for MF and SS. We aim to discuss the efficacy and safety of FDA-approved, off-label, and investigational oral therapies for MF and SS. FDA-approved oral therapies include bexarotene and vorinostat, both of which are effective in patients who are recalcitrant to prior topical therapies. Off-label oral therapies include methotrexate, acitretin, and chlorambucil. Methotrexate improves MF lesions in both early-stage and late-stage MF and is effective in erythrodermic MF. A combination of acitretin with phototherapy may lead to better response rates compared to acitretin monotherapy. Chlorambucil is mainly used to treat erythrodermic MF. Investigational oral therapies for MF include tenalisib, duvelisib, cerdulatinib, lenalidomide, bortezomib, and azacytidine, and direct comparison studies between these investigational agents and FDA-approved therapies should be undertaken to better understand their role in the management of MF and SS.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251322881"},"PeriodicalIF":3.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should Calcium Supplementation be Abandoned in Patients With Calcinosis Cutis?","authors":"Rose He, Mohammed Osman, Agnieszka Owczarczyk-Saczonek, Robert Gniadecki","doi":"10.1177/12034754251320640","DOIUrl":"https://doi.org/10.1177/12034754251320640","url":null,"abstract":"<p><p>Calcinosis cutis, characterized by the pathological deposition of insoluble calcium salts in the skin, is associated with several disease entities, particularly autoimmune conditions such as scleroderma and dermatomyositis. Lesions of calcinosis are often painful, prone to ulceration, and significantly impair quality of life. Despite the clinical impact, no effective treatments have been established to date, making prevention of this condition a critical priority. In this narrative review, we explore the evidence suggesting that calcium supplementation may contribute to skin calcification. Calcium supplements have been demonstrated to transiently elevate plasma calcium levels, potentially promoting dystrophic tissue calcification-a process that may be exacerbated in a context of magnesium and vitamin K2 deficiencies. Furthermore, calcium supplementation has been associated with an increased risk of adverse cardiovascular events; this concern is particularly relevant in patients with autoimmune diseases who already face elevated cardiovascular comorbidity. Notably, there is no robust evidence supporting the efficacy of calcium supplementation in preventing osteoporosis. Instead, sufficient dietary intake of calcium and protein, along with the supplementation of micronutrients critical for calcium homeostasis (magnesium, zinc, vitamin D₃, and vitamin K₂), should be considered as alternatives to calcium supplementation.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251320640"},"PeriodicalIF":3.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Performance of Dermoscopy for Distinguishing Early Melanomas and Intermediate Melanocytic Lesions From Low-Grade Dysplastic Nevi.","authors":"Ceylan Avcı, Meltem Kaşıkçı, Banu Lebe, Sevgi Akarsu, Turna İlknur","doi":"10.1177/12034754251325508","DOIUrl":"https://doi.org/10.1177/12034754251325508","url":null,"abstract":"<p><strong>Background: </strong>Early melanomas, dysplastic melanocytic nevi, and melanocytic tumours of uncertain malignant potential (MELTUMPs) reveal similar clinic and dermoscopic findings leading to underdiagnosis of malign lesions or unnecessary excision of benign ones. High-grade dysplastic nevi and MELTUMPs in the intermediate category should be recognized and completely excised.</p><p><strong>Objectives: </strong>We evaluated the diagnostic performance of pattern analysis, ABCD rule, colour, architecture, symmetry, and homogeneity algorithm, melanoma-specific structures and asymmetry of dermoscopic features in distinguishing early melanomas, high-grade dysplastic nevi, and MELTUMPs from low-grade dysplastic nevi.</p><p><strong>Methods: </strong>We retrospectively assessed dermoscopic images blindly to the histopathological diagnoses in a university hospital.</p><p><strong>Results: </strong>One hundred forty histopathologically confirmed melanocytic lesions were included (93 low-grade dysplastic nevi, 26 thin melanomas, 17 high-grade dysplastic nevi, and 4 MELTUMPs). All dermoscopic methods had poor diagnostic performance in early melanomas and intermediate melanocytic lesions. In the multivariate analyses of dermoscopic findings, the atypical pigment network (OR: 3.58, 95% CI: 1.31-9.72), asymmetry of globules (OR: 3.17, 95% CI: 1.37-7.35), streaks (OR: 6.16, 95% CI: 1.95-19.48) and homogenous structureless areas (OR: 5.92, 95% CI: 2.36-14.92) were the significant predictive factors for melanomas and intermediate melanocytic lesions. Positive predictive values of melanoma-specific structures were shiny white structures (100%), scar-like depigmentation (85.7%), blue-white veil (72.7%), atypical blotch (72.2%), and negative pigment network (71.4%).</p><p><strong>Conclusions: </strong>Shiny white structures, atypical network, asymmetry of globules, streaks, and homogeneous structureless areas were the most significant dermoscopic findings in discriminating early melanomas and intermediate melanocytic lesions from low-grade dysplastic nevi.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251325508"},"PeriodicalIF":3.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143615653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Eczema Education Pictorial Study (PEEPS): A Pilot Investigation.","authors":"Bethany F Wilken, Sonja Molin, Thomas Herzinger, Robert Bobotsis, Anne K Ellis, Yuka Asai","doi":"10.1177/12034754251320645","DOIUrl":"10.1177/12034754251320645","url":null,"abstract":"<p><strong>Background: </strong>For optimal control of atopic dermatitis (AD), patient education is essential to complement traditional therapy. Patient education has proven to benefit AD outcomes, but previous methods of delivery are costly and time-consuming.</p><p><strong>Objective: </strong>To assess the effectiveness of a one-page pictorial education tool at improving AD quality of life (QoL) and disease severity.</p><p><strong>Methods: </strong>Patients with AD and caregivers (if patient <18 years) received education with a pictorial education tool. QoL and disease severity were measured at baseline and in follow-up 2 to 6 months after education.</p><p><strong>Results: </strong>Forty-seven patients and caregivers from speciality clinics in dermatology and allergy received education. At follow-up, there were significant decreases in QoL scores and median disease severity scores.</p><p><strong>Conclusions: </strong>A pictorial education tool for AD is associated with significant benefits for patients and caregivers after 2 to 6 months. This tool may be valuable for health care providers who are in need of an effective and efficient method of AD education; however, further studies are needed to address identified knowledge gaps and expand to other sites and non-specialist clinics.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251320645"},"PeriodicalIF":3.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143605033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Incidence of Prurigo Nodularis: A Systematic Review of Population-Based Studies.","authors":"Ryan S Q Geng, Siddhartha Sood, Martin Heung, Khalad Maliyar, Muskaan Sachdeva, Abrahim Abduelmula, Asfandyar Mufti, Jensen Yeung","doi":"10.1177/12034754251325467","DOIUrl":"https://doi.org/10.1177/12034754251325467","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"12034754251325467"},"PeriodicalIF":3.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}