Journal of Cutaneous Medicine and Surgery最新文献

{"title":"A Review on the Mechanisms and Clinical Advances of JAK Inhibitors in the Treatment of Rosacea.","authors":"Yulian Hu, Biyu Li, Runlu Hu, Chuang Huang, Kun Huang","doi":"10.1177/12034754251325482","DOIUrl":"10.1177/12034754251325482","url":null,"abstract":"<p><p>Rosacea is a chronic inflammatory disease that primarily affects the facial area, with a complex pathogenesis and a variety of treatment options. In recent years, with deeper research into the pathogenesis of rosacea, it has been discovered that the Janus Kinase-Signal Transducer and Activator of Transcription (JAK-STAT) signalling pathway may be involved in the development of rosacea, and JAK inhibitors are expected to become a new therapeutic approach for rosacea. This paper reviews the mechanisms, clinical efficacy, and safety of JAK inhibitors in the treatment of rosacea.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"515-519"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Dermoscopic Features of Chronic Lupus Erythematosus Cheilitis: A Prospective Cross-Sectional Study of 35 Patients From a Tertiary Care Hospital in East India.","authors":"Sonika Garg, Madhusmitha Sethy, Vishal Thakur, Biswanath Behera, Pavithra Ayyanar, Shreya K Gowda, Anupam Dey, Amit Satpathy","doi":"10.1177/12034754251336227","DOIUrl":"10.1177/12034754251336227","url":null,"abstract":"<p><strong>Background: </strong>Chronic lupus erythematosus (CLE) cheilitis is a rare entity. There is limited data depicting clinical and dermoscopic aspects of CLE cheilitis. The study aimed to characterize the clinical and dermoscopic features of CLE cheilitis.</p><p><strong>Methods: </strong>This prospective cross-sectional study included all the patients of CLE cheilitis of both genders and all age groups. A detailed description of clinical morphology and associated features was performed. Dermoscopic features were analyzed as per the International Dermoscopic Society criteria. The diagnosis was confirmed by histopathology and direct immunofluorescence test.</p><p><strong>Results: </strong>Of 35 patients, 21 were women. The lower lip was solely involved in 68% of patients, and 28% had isolated lip involvement. Plaque morphology (48.5%) was the most common, followed by ulcero-plaque (34.2%) and atrophic plaque (11.4%). The various associated features were the obliteration of the vermilion border, the presence of peripheral gray to gray-brown pigmentation, radial white and pigment lines, and the sparing of angles of the lips. Under dermoscopic examination, hairpin (74.2%) and linear irregular (65.7%) vessels, reddish to reddish-white structureless area (91.4%), radial white lines (77.1%), and linear brown-gray pigment dots/globules (34.8%) and lines (42.8%) were commonly noted. The study had a few limitations: a small sample size and a lack of a comparison group.</p><p><strong>Conclusion: </strong>This is the largest study characterizing clinical and dermoscopic aspects of CLE cheilitis in patients of skin color. CLE cheilitis is characterized by reddish-white to reddish-gray plaque with/without a peripheral gray rim. Radial white and pigment lines, blurring/obliteration of vermilion border, and sparing of lip angle are additional clinical clues. Dermoscopy shows a reddish to reddish-white structureless area, hairpin and linear vessels, white interlacing, radial and leaf-like lines, and brown-gray linear dots/globules and lines.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"473-479"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144002632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Genetic Characterization of 8 Patients with Syndromic Patterned Cutaneous Hypopigmentation: A Descriptive Study.","authors":"Zhuo Ran Cai, Jean-François Soucy, Frédérique Tihy, Philippe M Campeau, Danielle Marcoux","doi":"10.1177/12034754251336241","DOIUrl":"10.1177/12034754251336241","url":null,"abstract":"<p><strong>Background: </strong>Patterned cutaneous hypopigmentation (PCH) can be associated with an array of extracutaneous findings.</p><p><strong>Objective: </strong>Determine clinical and genetic characteristics of patients with PCH with extracutaneous involvement.</p><p><strong>Method: </strong>Thirty patients were identified, and eight patients with neurological involvement agreed to participate in this study. They were reassessed to collect clinical anomalies associated with their PCH. Exome sequencing was performed on patient blood and lesional skin biopsies as well as blood from both parents when available. Array comparative genomic hybridization was performed on patients' skin and blood samples.</p><p><strong>Results: </strong>Narrow and broad bands along the lines of Blaschko were observed in 8 and 5 patients, respectively. Musculoskeletal, acral; ophthalmologic; and dental anomalies were observed in 7 patients. A chromosomal or monogenic cause of syndromic PCH was identified in all patients: 3 mosaic chromosomal abnormalities found (trisomy 7, trisomy 14, and 13q13-ter deletion) and pathological <i>de novo</i> germline and somatic mutations in 3 (<i>NBEA</i>, <i>USP9X</i>, and <i>DDX3X</i>) and 2 patients (<i>NIPBL</i> and <i>RHOA</i>) respectively.</p><p><strong>Limitations: </strong>Single-centre and retrospective study.</p><p><strong>Conclusion: </strong>Through better clinical characterization of syndromic PCH, we will improve our understanding of these disorders. We believe that all patients with PCH with systemic findings should undergo comprehensive genomic evaluations of lesional skin and peripheral blood.</p>","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"485-490"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prurigo Pigmentosa After Ketogenic Diet.","authors":"Yuxiao Shao, Heng Zhang","doi":"10.1177/12034754251341874","DOIUrl":"10.1177/12034754251341874","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"545"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Favre-Racouchot Syndrome.","authors":"Jun-Zhu Xu, Li Chai","doi":"10.1177/12034754251344212","DOIUrl":"10.1177/12034754251344212","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"543"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatoscopy of Subungual Hemorrhage.","authors":"Marcial Álvarez-Salafranca","doi":"10.1177/12034754251347571","DOIUrl":"10.1177/12034754251347571","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"542"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Self-Healing Langerhans Cell Histiocytosis.","authors":"Catarina Cerqueira, Ana Paula Vieira","doi":"10.1177/12034754251347568","DOIUrl":"10.1177/12034754251347568","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"541"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144248085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"For the Times They are a-Changin\" Bob Dylan 1964.","authors":"Kirk Barber","doi":"10.1177/12034754251365994","DOIUrl":"https://doi.org/10.1177/12034754251365994","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":"29 5","pages":"450-451"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145080944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hidradenitis Suppurativa Disproportionately Affects Marginalized Groups: An All of Us Database Analysis.","authors":"Noelle Desir, Iain Noel Encarnacion, Temitayo A Ogunleye, Susan C Taylor","doi":"10.1177/12034754251320635","DOIUrl":"10.1177/12034754251320635","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"536-537"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Lymphomas as Mimickers of Pyoderma Gangrenosum: A Systematic Review.","authors":"Dea Metko, Shanti Mehta, Eric McMullen, Khalad Maliyar, Laurence Mainville, Shireen Dumont, Vincent Piguet, David Croitoru","doi":"10.1177/12034754251316301","DOIUrl":"10.1177/12034754251316301","url":null,"abstract":"","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"538-539"},"PeriodicalIF":3.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}