Journal of Cutaneous Medicine and Surgery最新文献_第3页

Corrigendum to Biomarkers in Pemphigus Vulgaris: A Systematic Review. 寻常性天疱疮生物标志物的勘误表：系统综述。

IF 3.1 4区医学

Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-12-24 DOI: 10.1177/12034754241311342

引用次数: 0

Pachyonychia Congenita. 先天Pachyonychia。

IF 3.1 4区医学

Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2025-01-17 DOI: 10.1177/12034754241308250

Junfeng Du, Yong Luo

引用次数: 0

Idiopathic Scrotal Calcinosis. 特发性阴囊钙化症

IF 3.1 4区医学

Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-11-26 DOI: 10.1177/12034754241303085

Wei Liu, Yu Liu

引用次数: 0

Nodular Pretibial Myxedema. 结节性胫骨前水肿

IF 3.1 4区医学

Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-11-26 DOI: 10.1177/12034754241303062

Lin Wang

引用次数: 0

Scalp Melanoma. 头皮黑色素瘤。

IF 3.1 4区医学

Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-12-22 DOI: 10.1177/12034754241308243

An Jian Leung, Dingyuan Wang

引用次数: 0

Hidradenitis Suppurativa from a Multi-Omic Scope. 从多孔镜观察化脓性扁桃体炎

IF 3.1 4区医学

Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-11-02 DOI: 10.1177/12034754241293138

Patricia Garbayo-Salmons, Ester Saus, Vicente Exposito-Serrano, Mireia Moreno, Mireia Sàbat, Joan Calvet

{"title":"Hidradenitis Suppurativa from a Multi-Omic Scope.","authors":"Patricia Garbayo-Salmons, Ester Saus, Vicente Exposito-Serrano, Mireia Moreno, Mireia Sàbat, Joan Calvet","doi":"10.1177/12034754241293138","DOIUrl":"10.1177/12034754241293138","url":null,"abstract":"Hidradenitis suppurativa (HS) is recognized as a systemic immune-mediated disease (IMID), sharing genetic and environmental risk factors with other IMIDs such as inflammatory bowel disease and psoriasis. Over time, correlating clinical findings with genetic, proteomic, and metabolomic results has been challenging due to diverse sampling methods, analysis techniques, and the use of variable clinical phenotype descriptions across studies. This review aims to summarize the results from various omics fields to explore the etiopathology of HS. Genetic studies highlight defects in Notch and γ-secretase signaling and inflammasome function. Syndromic HS involves specific mutations in autoinflammatory syndromes such as pyogenic sterile arthritis, pyoderma gangrenosum, and acne (PAPA) and pyoderma gangrenosum, acne, and HS (PASH). Proteomic analyses reveal key inflammatory pathways indicating activation of both innate and adaptive immunity. Additionally, microbiome studies show an increased presence of anaerobes like Prevotella in HS lesions and a decreased presence of commensals such as Staphylococcus epidermidis. Gut microbiota dysbiosis, particularly involving Ruminococcus gnavus and Clostridium ramosum, is associated with HS. Moreover, metabolomic profiling indicates dysregulated tryptophan catabolism and lipid metabolism, with increased 5-lipoxygenase-derived metabolites and odd-chain fatty acids suggesting bacterial involvement. In summary, despite advances, robust associations between genetics, proteomics, microbiome, and metabolomics in HS are still lacking. Integrating these datasets could identify new clinical phenotypes, genetic predispositions, microbial signatures, and therapeutic targets, enhancing personalized treatment strategies and biomarker discovery for HS classification, prognosis, and treatment response.","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"159-166"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142564532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Here Comes the Sun! A Study on Sun Exposure and Associated Risks in the Canadian Population. 太阳来了！加拿大人口日晒及相关风险研究》。

IF 3.1 4区医学

Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2025-03-03 DOI: 10.1177/12034754251322778

Thierry Passeron, Henry Lim, Jean Krutmann, Brigitte Dreno, Sonya Abdulla, Patricia Ting, Monica Li, Nadir Chemani, Delphine Kerob, Caroline Le Floch, Nour R Dayeh

{"title":"Here Comes the Sun! A Study on Sun Exposure and Associated Risks in the Canadian Population.","authors":"Thierry Passeron, Henry Lim, Jean Krutmann, Brigitte Dreno, Sonya Abdulla, Patricia Ting, Monica Li, Nadir Chemani, Delphine Kerob, Caroline Le Floch, Nour R Dayeh","doi":"10.1177/12034754251322778","DOIUrl":"10.1177/12034754251322778","url":null,"abstract":"Objective: To evaluate the awareness of and attitudes toward various aspects of sun-exposure risks and protection methods among Canadians.Methods: An online survey conducted from September 28 to October 18, 2021, included 17,001 participants aged 18 years and above from 17 countries across 5 continents; the data presented are those of the Canadian population (n = 1,000). The survey focused on demographics, sun-exposure habits, comprehension of risks, and knowledge of photoprotection. The results were analyzed using descriptive statistics to identify prevalent trends and discrepancies in sun-protective behaviours among Canadians.Results: The majority of Canadian respondents (93%) acknowledged the health risks associated with sun exposure. While 81% of Canadians reported using some form of sun protection, only 10% systematically implemented all recommended protective measures, highlighting a gap in knowledge translation. Misconceptions regarding the safety of tanned skin and the effectiveness of sunscreens were widespread, particularly in younger demographics and in individuals with darker skin. Knowledge and preventive behaviours were markedly better among individuals who regularly consult dermatologists.Conclusions: This study highlights general awareness of sun-protective behaviours but a lack of universal and comprehensive implementation among Canadians. Given the knowledge gaps in younger demographics and darker skin phototypes, targeted educational initiatives are essential to correct prevalent misconceptions about sun exposure and tanned skin. Dermatologists and other health care professionals can play a pivotal role in education and primary prevention strategies for skin cancer and other sun-related comorbidities.","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"3S-12S"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143537262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Off-Label Use of Tildrakizumab in Patients with Hidradenitis Suppurativa. 在湿疹患者中标示外使用替雷珠单抗

IF 3.1 4区医学

Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-10-25 DOI: 10.1177/12034754241291044

Mahan Maazi, Jeffrey Toy, Xi Yao Gui, Vincent Piguet

引用次数: 0

Real-World Effectiveness and Safety of Tildrakizumab for Moderate-to-Severe Plaque Psoriasis in Adult Patients: A 52-Week Multicenter Retrospective Study. 替雷珠单抗治疗成人中重度斑块状银屑病的实际有效性和安全性：一项为期52周的多中心回顾性研究。

IF 3.1 4区医学

Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-10-25 DOI: 10.1177/12034754241291042

Jensen Yeung, Siddhartha Sood

引用次数: 0

Evaluating the Implementation and Impact of BRAF Reflex Mutation Testing in Melanoma, Lung, and Colorectal Cancers. 评估BRAF反射突变检测在黑色素瘤、肺癌和结直肠癌中的实施和影响。

IF 3.1 4区医学

Journal of Cutaneous Medicine and Surgery Pub Date : 2025-03-01 Epub Date: 2024-12-04 DOI: 10.1177/12034754241302821

Daniel Josué Guerra Ordaz, Sera Whitelaw, Mohammed Kaouache, Amina Moustaqim-Barrette, Louise Gresham, Brandon Ramchatesingh, Margaret Redpath, May Chergui, Ivan V Litvinov

{"title":"Evaluating the Implementation and Impact of BRAF Reflex Mutation Testing in Melanoma, Lung, and Colorectal Cancers.","authors":"Daniel Josué Guerra Ordaz, Sera Whitelaw, Mohammed Kaouache, Amina Moustaqim-Barrette, Louise Gresham, Brandon Ramchatesingh, Margaret Redpath, May Chergui, Ivan V Litvinov","doi":"10.1177/12034754241302821","DOIUrl":"10.1177/12034754241302821","url":null,"abstract":"Background: Reflex molecular testing, the process of profiling specimens at diagnosis, is emerging in oncology, allowing for prompt therapy initiation, and potentially improving outcomes. This study evaluates the impact of reflex BRAF testing on treatment timelines and outcomes in melanoma, lung and colorectal cancers at the McGill University Health Center (MUHC).Methods: A retrospective chart review was conducted at the MUHC. The study included patients with melanoma, lung, and colorectal cancers who underwent BRAF testing from 2017 to 2022. Data on demographics, cancer type, stage, test ordering specialist, testing method, and treatment outcomes were extracted. Statistical analyses included descriptive and multivariate regression analyses.Results: 518 BRAF molecular tests were performed, with 173 patients meeting the inclusion criteria [median age 72 (IQR 60-80 years), 46.2% female]. Of these, 75.7% had melanoma, 23.7% colorectal cancer and 0.58% lung cancer. Pathologists ordered 71.1% of BRAF tests, primarily relying on immunohistochemistry. By 2022, all BRAF results were available before oncology consultations. Patients with pre-consultation BRAF results were more likely to receive targeted therapy (59.4% vs 36.4%). The availability of BRAF test results was associated with quicker treatment initiation and better alignment of therapy with mutation status.Conclusion: This study underscores the success of the pathology team at MUHC in implementing reflex BRAF mutation testing, enhancing clinical care by ensuring the timely availability of test results. Delays in testing may adversely affect clinical decision-making and therapy selection, highlighting the need for standardized reflex testing protocols across Canada to optimize patient outcomes in melanoma, lung, and colorectal cancers.","PeriodicalId":15403,"journal":{"name":"Journal of Cutaneous Medicine and Surgery","volume":" ","pages":"150-155"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0