临床和实验医学杂志最新文献_第7页

Cytisine parameters measured in the 1.5 Tesla magnetic field 在1.5特斯拉磁场中测量的胞嘧啶参数

临床和实验医学杂志 Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.1.3

Zuzanna Bober, Sabina Galiniak, Dawid Leksa, Klaudia Dynarowicz, D. Aebisher, Elżbieta Ostańska, Anna Czmil, P. Bar, D. Bartusik-Aebisher, P. Tutka

引用次数: 0

Serosurvey and Cellular Immune Status of HTLV-1/2 and HIV Co-infections in Bauchi State, Nigeria 尼日利亚包奇州HTLV-1/2和HIV合并感染的血清调查和细胞免疫状况

临床和实验医学杂志 Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2019.4.1

A. Babayo, Oyebanji Azeez Akande, Y. Sabo, I. Abdullahi, A. Dangana

引用次数: 0

Generation of retractive spine circuits in the process of vitamin B12 deficiency 维生素B12缺乏过程中产生脊柱回缩

临床和实验医学杂志 Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.2.9

P. Mucha, Natalia Leksa, D. Aebisher, Sabina Galiniak, Seweryn Bartosz, Dawid Leksa, D. Bartusik-Aebisher

引用次数: 0

Clinical application of monoclonal antibodies in targeted therapy 单克隆抗体在靶向治疗中的临床应用

临床和实验医学杂志 Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2019.4.9

Maciej Superson, Katarzyna Szmyt, K. Szymanska, K. Walczak, Jeremi Wnorowski, Łukasz Zarębski

{"title":"Clinical application of monoclonal antibodies in targeted therapy","authors":"Maciej Superson, Katarzyna Szmyt, K. Szymanska, K. Walczak, Jeremi Wnorowski, Łukasz Zarębski","doi":"10.15584/ejcem.2019.4.9","DOIUrl":"https://doi.org/10.15584/ejcem.2019.4.9","url":null,"abstract":"Introduction. Recently, monoclonal antibodies (mAbs) have become powerful human therapeutics in the diagnosis and treatment of many diseases. Drugs based on mAbs are approved for the treatment of cardiovascular, respiratory, hematology, autoimmunology, and oncology diseases. Aim. To present the current state of knowledge about the application of mAbs in the therapy of various diseases such as cancer, autoimmune and Alzheimer’s diseases. Material and methods. We conducted a thorough review of the scientific literature from the following databases: EBSCO, PubMed, Science Direct, and Springer Link. Results. Currently, the Food and Drug Administration (FDA) has approved more than 50 therapeutic mAbs which are applied in various clinical trials. Action of mAb are based on various mechanisms, including directly targeting the cells, modifying the host response, recognizing and degrading molecules as well as delivering cytotoxic moieties. Conclusion. Despite some limitations including side effects, and therapeutic challenges, monoclonal antibodies are an attractive option for the development of new therapies and molecular drug targets against a wide range of common diseases due to their specificity and flexibility. MAbs are considered as a great hope for medicine, and effective and safe drugs in the treatment of various diseases.","PeriodicalId":15378,"journal":{"name":"临床和实验医学杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88823269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Multiparametric MRI and other imaging methods suitable to stage prostate carcinoma 多参数MRI等适合前列腺癌分期的影像学方法

临床和实验医学杂志 Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2019.4.7

M. Osuchowski, D. Aebisher, Sabina Galiniak, D. Bartusik-Aebisher, E. Kaznowska

引用次数: 0

Pancreatic tumor metastasis to the navel in a case with three primary tumors – case report and review of the literature 胰腺肿瘤转移至肚脐1例合并三个原发肿瘤的病例报告及文献复习

临床和实验医学杂志 Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.11

F. Dilek, Furkan Tosun, A. Atay, O. Dilek

{"title":"Pancreatic tumor metastasis to the navel in a case with three primary tumors – case report and review of the literature","authors":"F. Dilek, Furkan Tosun, A. Atay, O. Dilek","doi":"10.15584/ejcem.2020.3.11","DOIUrl":"https://doi.org/10.15584/ejcem.2020.3.11","url":null,"abstract":"Introduction. Sister Mary Joseph nodule (SMJN) is a metastasis that can occur in the umbilical region due to many tumors in the abdomen. Most of the cases are of gastrointestinal system origin and are often an indicator of poor prognosis. It can be seen in 1-3% of intraabdominal and pelvic malignancies. In the literature, around 300 studies are presented, mostly in the form of case reports. Very few (7-9%) of the cases with SMJN are from pancreatic origin. In our literature review, we found that in the majority (>90%) of SMJN cases due to pancreatic tumors, the lesions originated from the pancreatic tail and/or body, and tumor marker Ca-19.9 was very high in most cases (>90%). Aim. Here, the case of SMJN seen in a patient with three different primary tumors was discussed in the light of the literature data. Description of the case. Here, our case, whose third primary malignancy was detected in the pancreas in the PET/CT examination performed to investigate the origin of SMJN in a 68-year-old female patient who had undergone surgery due to breast in 2011 and endometrium cancers in 2018 and came with umbilical metastasis, is presented in the light of the literature data. Conclusion. As a result, in our case, which was followed up due to two primary tumors, it became important to know the origin of the SMJN that occurred due to the third primary tumor detected during the CT and PET/CT examination due to the newly emerging SMJN. It is important to know the origin and histopathological features of the SMJN in order to determine the treatment to the patient.","PeriodicalId":15378,"journal":{"name":"临床和实验医学杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82293612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge, perception and child care practices among adolescent mothers in Ibadan Metropolis, Nigeria 尼日利亚伊巴丹大都会青少年母亲的知识、认知和儿童保育做法

临床和实验医学杂志 Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.4

O. Oyewole, Christiana Mautin Todowede, I. Dipeolu

{"title":"Knowledge, perception and child care practices among adolescent mothers in Ibadan Metropolis, Nigeria","authors":"O. Oyewole, Christiana Mautin Todowede, I. Dipeolu","doi":"10.15584/ejcem.2020.3.4","DOIUrl":"https://doi.org/10.15584/ejcem.2020.3.4","url":null,"abstract":"Introduction. There is little information regarding childcare practices among adolescent mothers in the study areas. Aim. This study was aimed at investigating knowledge, perception and childcare practices among adolescent mothers. Material and methods. A descriptive cross-sectional survey was conducted on randomly select 382 adolescent mothers. A validated semi-structured questionnaire was used to collect data, which were analysed using, descriptive and multivariate analyses with p-value set at 0.05. Age of respondents was 18.5±0.7 years. Results. Majority (80.6%) had poor knowledge of when to start ante-natal care. Also, 70.0% of the respondents could not perceive growth monitoring as a necessary strategy for child survival and 86.4% perceived diarrhoea as normal for children during the teething period. Many (58.4%) did not practise exclusive breastfeeding. Respondents with secondary education were less likely to have poor knowledge than those with primary education (OR: 0.2, CI: 0.6-0.9, 95%). Respondents, who received supervision from older women during childcare, were less likely to have poor childcare practice than those who did not (OR: 0.2, CI: 0.4-0.7, 95%). Conclusion. Respondents had poor knowledge of childcare practices when childcare survival strategies were used as the yardstick for evaluation. Involvement of older women is suggested to assist adolescent mothers improve their knowledge and practices of childcare.","PeriodicalId":15378,"journal":{"name":"临床和实验医学杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76061471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Behaviors, attitudes and opinions of medical students in the field of smoking and anti-smoking counseling in two countries of Central and Eastern Europe 中欧和东欧两国医学生在吸烟和反吸烟咨询方面的行为、态度和意见

临床和实验医学杂志 Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.8

Paulina Hejda, A. Hubert-Lutecka, Z. Chmiel, A. Sidor, G. Iwanowicz-Palus, Marcin Żal, Agnieszka Koryl, M. Binkowska-Bury

引用次数: 1

Morphology of extensor digitorum longus of Wistar rats after remobilization by vibratory platform 振动平台复位后Wistar大鼠指长伸肌形态学变化

临床和实验医学杂志 Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2019.4.2

Izabela Rodrigues Izabela Rodrigues Camilo, M. Wutzke, R. M. Costa, G. Bertolini, L. F. Ribeiro

引用次数: 1

Knowledge of modifiable risk factors for cardiovascular diseases among university undergraduates in Ibadan, Nigeria 尼日利亚伊巴丹大学本科生对心血管疾病可改变危险因素的了解

临床和实验医学杂志 Pub Date : 2020-01-01 DOI: 10.15584/ejcem.2020.3.7

O. Oyewole, Ayodele Solabi

{"title":"Knowledge of modifiable risk factors for cardiovascular diseases among university undergraduates in Ibadan, Nigeria","authors":"O. Oyewole, Ayodele Solabi","doi":"10.15584/ejcem.2020.3.7","DOIUrl":"https://doi.org/10.15584/ejcem.2020.3.7","url":null,"abstract":"Introduction. Undergraduates in many institutions live a lifestyle that could predispose them to non-communicable diseases (NCDs) including cardiovascular-related. Previous studies on modifiable risk factors (MRFs) against NCDs had focused mainly on adults, whereas young people should be prime targets for prevention programmes. Aim. This study was aimed at investigating knowledge of MRFs against cardiovascular diseases (CVDs) among university undergraduates in Ibadan, Nigeria. Material and methods. A descriptive cross-sectional design was adopted, where 500 undergraduates participated. Data were collected using Focus Group Discussion (FGD) guide and validated questionnaire. Data analyses were conducted using thematic approach and bivariate methods at 5% levels of significance, respectively. Results. Mean age was 22.8 }3.0 years and 51.4% were females. The majority reported that their fathers (82.8%) and mothers (83.0%) had no hypertension history. The FGD revealed that students were knowledgeable of MRFs and preventive behaviours but still engaged in unhealthy lifestyle practices. The MRFs identified included excessive alcohol consumption (85.4%), unhealthy diet (77.6%), physical inactivity (75.2%) and smoking (70.2%). Respondents (56.4%) had good knowledge of MRFs against CVDs; 57.0% had fair lifestyle practices and 54.8% had good knowledge of preventive behaviour against CVDs. Conclusion. Gender was significantly associated with knowledge of CVDs preventive behaviours. Institutional-based lifestyle modification programmes, using peer group education is suggested.","PeriodicalId":15378,"journal":{"name":"临床和实验医学杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80348931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1