Journal of Chemical Metrology最新文献_第4页

Development of RP-HPLC PDA method for concurrent quantification of Baloxavir marboxil and its impurities RP-HPLC PDA同时定量巴洛西韦及其杂质方法的建立

IF 1.3

Journal of Chemical Metrology Pub Date : 2022-06-02 DOI: 10.25135/jcm.71.2202.2344

Divya Molleti, A. Pawar

引用次数: 2

A highly selective and sensitive spectrofluorometric method for quantification of meropenem in its dosage form and fresh human plasma 一种高选择性、灵敏的荧光光谱法测定美罗培南剂型和新鲜人血浆的含量

IF 1.3

Journal of Chemical Metrology Pub Date : 2022-06-02 DOI: 10.25135/jcm.70.2202.2363

A. Fahim, Abbas Alshirify, Kasim Hassan

引用次数: 2

Measurement uncertainty assessment for potentiometric determination of trace anionic impurities in graphite post ultrasonic extraction: A bottom-up approach 超声提取后石墨中微量阴离子杂质电位测定的测量不确定度评定:自下而上方法

IF 1.3

Journal of Chemical Metrology Pub Date : 2022-05-07 DOI: 10.25135/jcm.69.2202.2367

H. Parab, Sangita D. Kumar

引用次数: 0

Identification, separation and mass spectral characterization of degradants in Cariprazine HCl by LC-MS/MS/QTOF LC-MS/MS/QTOF法鉴定、分离盐酸卡里吡嗪中降解物及质谱表征

IF 1.3

Journal of Chemical Metrology Pub Date : 2022-05-01 DOI: 10.25135/jcm.68.2201.2338

Pallekona Sushma, A. Pawar

引用次数: 2

LC-HRMS profiling of phytochemicals, antidiabetic, anticholinergic and antioxidant activities of evaporated ethanol extract of Astragalus brachycalyx Fischer LC-HRMS分析短枝黄芪蒸发乙醇提取物的植物化学物质、抗糖尿病、抗胆碱能和抗氧化活性

IF 1.3

Journal of Chemical Metrology Pub Date : 2021-12-26 DOI: 10.25135/jcm.62.2107.2155

I. Gülçin, Hatice Kiziltaş, Zeynebe Bi̇ngöl, A. Gören, S. M. Pinar, S. Alwasel

{"title":"LC-HRMS profiling of phytochemicals, antidiabetic, anticholinergic and antioxidant activities of evaporated ethanol extract of Astragalus brachycalyx Fischer","authors":"I. Gülçin, Hatice Kiziltaş, Zeynebe Bi̇ngöl, A. Gören, S. M. Pinar, S. Alwasel","doi":"10.25135/jcm.62.2107.2155","DOIUrl":"https://doi.org/10.25135/jcm.62.2107.2155","url":null,"abstract":"Astragalus is a perennial plant that has existed for about 2500-3000 years and consists of more than 250 taxonomic parts. Twenty species of Astragalus are endemic to Turkey, as well as the richest genus with 425 taxa. The roots of Astragalus species are used in folk medicine as hepatoprotective, antioxidant, antibacterial, antihypertensive, antidiabetic and diuretic. Also, it is used to treat diabetes mellitus, leukemia, nephritis and uterine cancer. It is known that in Anatolia, Astragalus roots are traditionally used against leukemia and wound healing. For the purpose, the measuring of antioxidant activity of evaporated ethanol extract of Astragalus brachycalyx FISCHER (EEAB), some bioanalytic methods including DPPH and ABTS scavenging effects, ferric ions (Fe) and cupric ions (Cu) reducing abilities, and metal (Fe) chelating activity were realized. α-Tocopherol, ascorbic acid, and BHT were used as the standard antioxidants. On the other hand, some phenolic compounds, which responsible for antioxidant activities of EEAB was determined by liquid chromatography-high resolution mass spectrometry (LC-HRMS). At the similar concentration, EEAB exhibited efficient antioxidant effects when compared to standard compounds. Additionally, EEAB showed IC50 values of 1.985 μg/mL toward acetylcholinesterase (AChE), 0.620 μg/mL on α-glycosidase and 0.306 μg/mL against α-amylase enzymes.","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":"1 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2021-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41930518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Development of a quality control material for the analysis of volatile compounds in alcoholic beverages 用于分析酒精饮料中挥发性化合物的质量控制材料的开发

IF 1.3

Journal of Chemical Metrology Pub Date : 2021-12-26 DOI: 10.25135/jcm.66.2111.2259

S. Charapitsa, S. Sytova, A. Kavalenka, L. Sobolenko, Yauheni Shauchenka, N. Kostyuk, M. Zayats, V. Egorov, S. Leschev, I. Melsitova, Siarhei Vetokhin, N. Zayats

引用次数: 3

SSimultaneous estimation of Pyridoxine HCl and FMOC-Leucine using derivative and chromatographic approach in pharmaceutical dosage form 药物剂型中盐酸吡哆醇和fmoc -亮氨酸的衍生色谱法同时测定

IF 1.3

Journal of Chemical Metrology Pub Date : 2021-12-17 DOI: 10.25135/jcm.65.2109.2205

Dr Akhil Nagar, Chaitali R Patel, P. Jain, Samadhan J. Shinde, A. Shirkhedkar, Ruchita Bardya

引用次数: 3

Characterization of low-density polyethylene reference material for melt flow rate by collaboration of NIS and a network of competent laboratories NIS和主管实验室网络合作对低密度聚乙烯熔体流动速率参考材料的表征

IF 1.3

Journal of Chemical Metrology Pub Date : 2021-10-10 DOI: 10.25135/jcm.63.2107.2148

H. Moustafa, Ibrahim F. Tahoun, A. Abou‐Kandil, N. Darwish

引用次数: 1

Quantification of antileukemic drug Dasatinib in human plasma: Application of a sensitive liquid chromatographic method 人血浆中抗白血病药物达沙替尼的定量：灵敏液相色谱法的应用

IF 1.3

Journal of Chemical Metrology Pub Date : 2021-10-09 DOI: 10.25135/jcm.64.2108-2174

Avani Chokshi, A. Gajjar, Pooja Bhanushali, Pritesh Desai

{"title":"Quantification of antileukemic drug Dasatinib in human plasma: Application of a sensitive liquid chromatographic method","authors":"Avani Chokshi, A. Gajjar, Pooja Bhanushali, Pritesh Desai","doi":"10.25135/jcm.64.2108-2174","DOIUrl":"https://doi.org/10.25135/jcm.64.2108-2174","url":null,"abstract":"Dasatinib is a tyrosine kinase inhibitor that is approved and prescribed to patients with chronic myelogenous leukemia and Philadelphia chromosome. Present work reports development of reversed-phase high performance liquid chromatographic method for determination of Dasatinib in human plasma and validation of the developed method according to the guidelines provided by European Medicines Agency (EMA). An RP-HPLC method with UV detection and isocratic elution has been developed and validated for analysis of Dasatinib in human plasma over a range of 5-300 ng/mL. Imatinib was used as an internal standard. Both, the drug and the internal standard were separated on the Inertsil C18 column (150 mm×4.6 mm×0.005 mm) using Ammonium Acetate buffer pH 6.4 and acetonitrile at a ratio of 65:35 as mobile phase. The flow rate was adjusted to 0.7 mL min-1. The detection was performed at 310 nm wavelength. Sample pre-purification was performed through simple protein precipitation using acetonitrile followed by sample collection through centrifugation. The developed method was linear in the range of 5-300 ng/mL with correlation coefficients (r) of 0.995. The lower limit of quantification for Dasatinib in plasma was 5 ng/mL. The accuracy and precision of the method were well within the acceptable limits of 15% over the linear range. In general, the developed method is efficient and inexpensive. It is very simple from the extraction of drug from the plasma matrix to the isocratic elution of analytes. From the data, it can be concluded that the developed method is selective, precise and accurate and applicable for the determination of Dasatinib in human plasma samples.","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2021-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44559169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Development of a quick reverse phase liquid chromatographic method with photodiode-array detection for quantitative determination of chlorthalidone, metoprolol succinate and telmisartan in tablet formulation 光电二极管阵列快速反相液相色谱法测定片剂中氯噻酮、琥珀酸美托洛尔和替米沙坦的含量

IF 1.3

Journal of Chemical Metrology Pub Date : 2021-08-24 DOI: 10.25135/jcm.6012106.2098

Avani Chokshi, R. Prajapati, Pritesh Desai, Mehul D. Patel

{"title":"Development of a quick reverse phase liquid chromatographic method with photodiode-array detection for quantitative determination of chlorthalidone, metoprolol succinate and telmisartan in tablet formulation","authors":"Avani Chokshi, R. Prajapati, Pritesh Desai, Mehul D. Patel","doi":"10.25135/jcm.6012106.2098","DOIUrl":"https://doi.org/10.25135/jcm.6012106.2098","url":null,"abstract":"A quick and simple reversed-phase High-Performance Liquid Chromatographic method (RP-HPLC) with isocratic elution has been developed and validated for the concurrent quantitative determination of chlorthalidone, metoprolol succinate and telmisartan in the bulk mixture and tablet dosage form. The chromatographic separation was performed using Inertsil Octadecyl-Silica (ODSC18) Column (150mm×4.6mm, 5μm) stationary phase. The separation and elution was carried out using a mobile phase mixture of phosphate buffer (50 mM, pH 2.5) and acetonitrile at a ratio of 40:60 v/v and 0.7 mL/min flow rate. Chlorthalidone, metoprolol succinate and telmisartan were eluted at 2.96±0.5 min, 4.31±0.5 min and 5.94±0.5 min respectively. The response was recorded using a photodiode array (PDA) detector at 225 nm wavelength. The selected method was linear in the range of 3.21-18.72 μg/mL, 6.25-37.50 μg/mL and 10-60 μg/mL while percentage recovery was in the range from 99.15 to 99.93%, 99.15 to 99.42% and 100.03 to 100.08% for chlorthalidone, metoprolol succinate and telmisartan respectively. The method was found to be sensitive, selective, linear and reproducible and the results obtained suggest the suitability of the developed method for routine analysis of the formulations containing the combination of these drugs.","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2021-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44845319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1