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Isolation of amygdalin epimer at high diastereomeric purity and its structural characterization by spectroscopic and Q-TOF LC-MS methods 高非对映异构体纯度苦杏仁苷表聚体的分离及其光谱和Q-TOF LC-MS表征
IF 1.3
Journal of Chemical Metrology Pub Date : 2021-08-18 DOI: 10.25135/jcm.60.2105.2076
Irfan Capan, S. Servi, A. Aysal, Pshtiwan Raheem Sabır
{"title":"Isolation of amygdalin epimer at high diastereomeric purity and its structural characterization by spectroscopic and Q-TOF LC-MS methods","authors":"Irfan Capan, S. Servi, A. Aysal, Pshtiwan Raheem Sabır","doi":"10.25135/jcm.60.2105.2076","DOIUrl":"https://doi.org/10.25135/jcm.60.2105.2076","url":null,"abstract":"Amygdalin, a cyanogenic glycoside mostly found in the bitter almond kernel, plays an important role in conventional and modern medicine applications. The high diastereomeric purity amygdalin was isolated with chromatographic purification methods and recrystallization. Amygdalin and neoamygdalin were separated chromatographically using the porous graphitic carbon column. Identification and confirmation of each molecule was performed with the ESI Quadrupole Time of Flight system coupled with a reversed phase LC.","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2021-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48189939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Stability indicating liquid chromatographic method for the estimation of remogliflozin etabonate 稳定性指示的液相色谱法测定瑞格列净的含量
IF 1.3
Journal of Chemical Metrology Pub Date : 2020-12-01 DOI: 10.25135/jcm.46.20.07.1734
D. Shah, Ishita I. Gondalia, V. Patel, Ashok Mahajan, U. Chhalotiya
{"title":"Stability indicating liquid chromatographic method for the estimation of remogliflozin etabonate","authors":"D. Shah, Ishita I. Gondalia, V. Patel, Ashok Mahajan, U. Chhalotiya","doi":"10.25135/jcm.46.20.07.1734","DOIUrl":"https://doi.org/10.25135/jcm.46.20.07.1734","url":null,"abstract":": Accurate and precise reverse phase liquid chromatographic method has been developed for the estimation Remogliflozin etabonate in bulk and tablet dosage form. Reverse phase C18 column was used as stationary phase along with mixture of methanol:water (70:30%, v/v) as a mobile phase. Mobile phase flow rate was maintained at 1mL/min and analysis was performed at 229 nm. The method was linear in the concentration range of 1 – 25 μg/mL with correlation coefficient (r 2 ) 0.997. The proposed method was validated with respect to linearity, accuracy, precision and robustness as per ICH Q2 (R1) guideline. To find out the possible degradation pathway, forced degradation studies were performed. The degraded product peaks were well resolved from the pure drug peak with significant difference in their retention time value. The drug was found to be highly susceptible to acid and base hydrolysis. The developed method can be used for analysis of stability samples and routing quality control evaluation of Remogliflozin etabonate in","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42790714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Determination of doxylamine from a tea sample: A claim of drug facilitated crime 茶叶样品中多西胺的测定:毒品促进犯罪的主张
IF 1.3
Journal of Chemical Metrology Pub Date : 2020-06-10 DOI: 10.25135/jcm.40.20.04.1634
M. Kuloglu, T. Tekin, Zeynep Türkmen, Y. T. Demircan, S. Mercan
{"title":"Determination of doxylamine from a tea sample: A claim of drug facilitated crime","authors":"M. Kuloglu, T. Tekin, Zeynep Türkmen, Y. T. Demircan, S. Mercan","doi":"10.25135/jcm.40.20.04.1634","DOIUrl":"https://doi.org/10.25135/jcm.40.20.04.1634","url":null,"abstract":"","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46556303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of a densitometric HPTLC method for determination of 5-HMF in fruit-based baby foods in Turkey 密度计HPTLC法测定土耳其水果类婴儿食品中5-HMF
IF 1.3
Journal of Chemical Metrology Pub Date : 2020-06-10 DOI: 10.25135/jcm.39.20.05.1653
Zeynep Turkmen
{"title":"Development of a densitometric HPTLC method for determination of 5-HMF in fruit-based baby foods in Turkey","authors":"Zeynep Turkmen","doi":"10.25135/jcm.39.20.05.1653","DOIUrl":"https://doi.org/10.25135/jcm.39.20.05.1653","url":null,"abstract":"","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44233930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Primary level electrolytic conductivity measurements at National Metrology Institute of Turkey (TUBITAK UME) 土耳其国家计量研究所(TUBITAK UME)初级电解电导率测量
IF 1.3
Journal of Chemical Metrology Pub Date : 2020-06-10 DOI: 10.25135/jcm.34.20.01.1524
E. Uysal, L. Liv, F. Fiçicioǧlu, M. Arifoviç
{"title":"Primary level electrolytic conductivity measurements at National Metrology Institute of Turkey (TUBITAK UME)","authors":"E. Uysal, L. Liv, F. Fiçicioǧlu, M. Arifoviç","doi":"10.25135/jcm.34.20.01.1524","DOIUrl":"https://doi.org/10.25135/jcm.34.20.01.1524","url":null,"abstract":"TUBITAK UME (National Metrology Institute of Turkey) Electrochemistry Laboratory established the primary level electrolytic conductivity measurement system in 2018. The objective of this work is to prove the accuracy of the established system with an acceptable uncertainty and to disseminate the traceability for electrolytic conductivity measurements. While the accuracy of the system was tested with the certified conductivity solutions, the accuracy of the software developed at TUBITAK UME was also tested. The cell constant was determined as 0.57986 cm at 25 °C by using certified conductivity solutions. The accuracy of the system was evaluated using the measurement of certified conductivity solutions and it was found that there was no significant difference between the results at 95% confidence level. Finally, “Evaluation of measurement data Guide to the expression of uncertainty in measurement” and “EA-4/02 M: 2013 Evaluation of the Uncertainty of Measurement in Calibration” guides were used to form the uncertainty budget for primary level electrolytic conductivity measurements.","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43165242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Determination of dihydrocapsaicin adulteration in dietary supplements using LC-MS/MS hplc -MS/MS法测定膳食补充剂中掺假的二氢辣椒素
IF 1.3
Journal of Chemical Metrology Pub Date : 2020-06-10 DOI: 10.25135/jcm.36.20.01.1532
Demet Di̇nçel, Hatice Olgan, Zeynep Canbaloğlu, S. Yalçin, A. Erkuçuk, Gizem Tırıs, A. Gören
{"title":"Determination of dihydrocapsaicin adulteration in dietary supplements using LC-MS/MS","authors":"Demet Di̇nçel, Hatice Olgan, Zeynep Canbaloğlu, S. Yalçin, A. Erkuçuk, Gizem Tırıs, A. Gören","doi":"10.25135/jcm.36.20.01.1532","DOIUrl":"https://doi.org/10.25135/jcm.36.20.01.1532","url":null,"abstract":"Adulteration of dietary supplements are serious threats to public health in all around of world. Nowadays, in order to obtain the intended effect from natural remedies, the adulteration of natural products via artificial or harmful chemicals are increasing. A rapid LC-MS/MS method for determination of capsaicin and dihydrocapsaicin in dietary supplements via Fortis C18 (150 x 3 mm; 3 μm) column at 25 °C was developed and validated in a mixture of mobile phase A (1 % formic acid solution and 0.1 % ammonium formate in water) and B (1 % formic acid solution and 0.1 % ammonium formate in methanol) with gradient program at a flow rate of 0.35 mL/min. The recoveries of developed methods weytre obtained in the range of % 95.4-106.3 for capsaicin and % 96.3-108.9 for dihydrocapsaicin. This study shows that synthetic compound dihydrocapsaicin is widely use in dietary supplements products for adulteration to increase the effects of product without any declaration.","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":"1 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41727560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Determination of secondary metabolites of Origanum vulgare subsp. hirtum and O. vulgare subsp. vulgare by LC-MS/MS 牛至次级代谢产物的测定。汗毛和O.vulgare亚种。LC-MS/MS法
IF 1.3
Journal of Chemical Metrology Pub Date : 2020-06-10 DOI: 10.25135/jcm.33.20.04.1610
Züleyha Özer, S. Carikci, H. Yılmaz, T. Kilic, T. Dirmenci, A. Gören
{"title":"Determination of secondary metabolites of Origanum vulgare subsp. hirtum and O. vulgare subsp. vulgare by LC-MS/MS","authors":"Züleyha Özer, S. Carikci, H. Yılmaz, T. Kilic, T. Dirmenci, A. Gören","doi":"10.25135/jcm.33.20.04.1610","DOIUrl":"https://doi.org/10.25135/jcm.33.20.04.1610","url":null,"abstract":"","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44941301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 14
Importance of sample pretreatment step on the bacterial toxicity bioassay of ZnO nanoparticles 样品预处理步骤对ZnO纳米粒子细菌毒性生物测定的重要性
IF 1.3
Journal of Chemical Metrology Pub Date : 2020-06-10 DOI: 10.25135/jcm.37.20.03.1583
A. Baysal, H. Saygin, G. Ustabasi
{"title":"Importance of sample pretreatment step on the bacterial toxicity bioassay of ZnO nanoparticles","authors":"A. Baysal, H. Saygin, G. Ustabasi","doi":"10.25135/jcm.37.20.03.1583","DOIUrl":"https://doi.org/10.25135/jcm.37.20.03.1583","url":null,"abstract":"","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2020-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48078421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Investigation of caffeine concentrations in sport supplements and inconsistencies in product labelling 运动补充剂中咖啡因浓度的调查和产品标签的不一致
IF 1.3
Journal of Chemical Metrology Pub Date : 2019-06-23 DOI: 10.25135/JCM.25.19.04.1252
Eda Okuroglu, T. Tekin, M. Kuloglu, S. Mercan, I. Bavunoğlu, M. Acıkkol, Zeynep Türkmen
{"title":"Investigation of caffeine concentrations in sport supplements and inconsistencies in product labelling","authors":"Eda Okuroglu, T. Tekin, M. Kuloglu, S. Mercan, I. Bavunoğlu, M. Acıkkol, Zeynep Türkmen","doi":"10.25135/JCM.25.19.04.1252","DOIUrl":"https://doi.org/10.25135/JCM.25.19.04.1252","url":null,"abstract":"Caffeine is a substance that can be easily consumed in daily nutrition as well as in sport supplements. Exceeding the daily-recommended dose for caffeine may cause serious health problems. Studies illustrated that many concerns have been raising about the incompatibility between labels on sport supplements and their contents. The present study aimed to investigate caffeine contents in sport supplements purchased from Turkey market for the first time and to evaluate label information on products. Caffeine concentrations were determined in 41 sport supplements and possible adverse effects were emphasized considering calculated daily consumption doses. Seventeen samples among 41 products were found to be caffeine containing, ranging from 4.52 to 471 mg/mL. Three of caffeine containing products were undeclared their caffeine ingredients. Although three products were not specified caffeine their amounts, findings were found above the daily-recommended caffeine limit (400 mg/day). Significant differences were observed between the quantities indicated on the labels and the determined caffeine amounts in 7 products (p<0.05). Eight of 17 caffeine labelled products were found between 151-948% higher than stated label information. Overall, 29.4% of caffeine containing products (n=17) were found over the recommended intake. Consuming more than the daily-recommended dose may cause severe adverse reactions and consumers may experience serious health risks such as arterial hypertension, coronary heart disease, as well as sleep problems, irritability, anxiety, headache, and restlessness. Considering these health risks, awareness of consumers and accurate product labels on sport supplements gain more importance to prevent people from undesired consequences.","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2019-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48751527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
High performance liquid chromatographic analysis of lercanidipine in human breast milk 人母乳中雷卡尼地平的高效液相色谱分析
IF 1.3
Journal of Chemical Metrology Pub Date : 2019-06-23 DOI: 10.25135/JCM.23.19.03.1223
Evrim Kepekci Tekkeli, I. Gazioğlu, Gizem Tırıs, C. Önal
{"title":"High performance liquid chromatographic analysis of lercanidipine in human breast milk","authors":"Evrim Kepekci Tekkeli, I. Gazioğlu, Gizem Tırıs, C. Önal","doi":"10.25135/JCM.23.19.03.1223","DOIUrl":"https://doi.org/10.25135/JCM.23.19.03.1223","url":null,"abstract":"A simple, rapid, precise and accurate isocratic reversed phase HPLC method was developed and validated for the determination of lercanidipine hydrochloride in pharmaceutical tablets and spiked human breast milk. The chromatographic separation was achieved on C18 (250×4.6 mm×5μm) column using a mobile phase consisting of acetonitrile and phospate buffer (pH=4) (55:45, v/v) at a flow rate of 1.1 mL/min and UV detection at 237 nm. The linearity of the proposed method was investigated in the range of 1.0-40 μg/mL (r=0.9990). The method was validated in terms of accuracy, precision, reproducibility, specificity, robustness, and detection and quantification limits, in accordance with ICH guidelines. The proposed method is found as suitable for routine quantification of lercanidipine in human breast milk.","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2019-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48987575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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