Determination of dihydrocapsaicin adulteration in dietary supplements using LC-MS/MS

IF 1.8 Q3 CHEMISTRY, ANALYTICAL
Demet Di̇nçel, Hatice Olgan, Zeynep Canbaloğlu, S. Yalçin, A. Erkuçuk, Gizem Tırıs, A. Gören
{"title":"Determination of dihydrocapsaicin adulteration in dietary supplements using LC-MS/MS","authors":"Demet Di̇nçel, Hatice Olgan, Zeynep Canbaloğlu, S. Yalçin, A. Erkuçuk, Gizem Tırıs, A. Gören","doi":"10.25135/jcm.36.20.01.1532","DOIUrl":null,"url":null,"abstract":"Adulteration of dietary supplements are serious threats to public health in all around of world. Nowadays, in order to obtain the intended effect from natural remedies, the adulteration of natural products via artificial or harmful chemicals are increasing. A rapid LC-MS/MS method for determination of capsaicin and dihydrocapsaicin in dietary supplements via Fortis C18 (150 x 3 mm; 3 μm) column at 25 °C was developed and validated in a mixture of mobile phase A (1 % formic acid solution and 0.1 % ammonium formate in water) and B (1 % formic acid solution and 0.1 % ammonium formate in methanol) with gradient program at a flow rate of 0.35 mL/min. The recoveries of developed methods weytre obtained in the range of % 95.4-106.3 for capsaicin and % 96.3-108.9 for dihydrocapsaicin. This study shows that synthetic compound dihydrocapsaicin is widely use in dietary supplements products for adulteration to increase the effects of product without any declaration.","PeriodicalId":15343,"journal":{"name":"Journal of Chemical Metrology","volume":"1 1","pages":""},"PeriodicalIF":1.8000,"publicationDate":"2020-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Chemical Metrology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.25135/jcm.36.20.01.1532","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ANALYTICAL","Score":null,"Total":0}
引用次数: 5

Abstract

Adulteration of dietary supplements are serious threats to public health in all around of world. Nowadays, in order to obtain the intended effect from natural remedies, the adulteration of natural products via artificial or harmful chemicals are increasing. A rapid LC-MS/MS method for determination of capsaicin and dihydrocapsaicin in dietary supplements via Fortis C18 (150 x 3 mm; 3 μm) column at 25 °C was developed and validated in a mixture of mobile phase A (1 % formic acid solution and 0.1 % ammonium formate in water) and B (1 % formic acid solution and 0.1 % ammonium formate in methanol) with gradient program at a flow rate of 0.35 mL/min. The recoveries of developed methods weytre obtained in the range of % 95.4-106.3 for capsaicin and % 96.3-108.9 for dihydrocapsaicin. This study shows that synthetic compound dihydrocapsaicin is widely use in dietary supplements products for adulteration to increase the effects of product without any declaration.
hplc -MS/MS法测定膳食补充剂中掺假的二氢辣椒素
膳食补充剂掺假严重威胁着世界各地的公众健康。如今,为了从自然疗法中获得预期的效果,通过人工或有害化学物质掺假的天然产品正在增加。hplc -MS/MS快速测定膳食补充剂中辣椒素和二氢辣椒素的方法在流动相a(1%甲酸溶液和0.1%甲酸铵水溶液)和B(1%甲酸溶液和0.1%甲酸铵甲醇)的混合物中,以梯度程序,流速为0.35 mL/min,在25°C下建立了3 μm)的色谱柱并进行了验证。所建立的方法对辣椒素的回收率为95.4 ~ 106.3,对二氢辣椒素的回收率为96.3 ~ 108.9。本研究表明,合成复合二氢辣椒素被广泛应用于膳食补充剂产品中,在没有任何声明的情况下进行掺假,以增加产品的效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Journal of Chemical Metrology
Journal of Chemical Metrology CHEMISTRY, ANALYTICAL-
CiteScore
2.30
自引率
15.40%
发文量
7
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信