Journal of chemical technology and biotechnology最新文献

{"title":"Molecular dynamics simulations of oleuropein diffusion in chitosan-based nanoparticles","authors":"Bernardino Tirri,&nbsp;Andrea Lorenzoni,&nbsp;Francesco Mercuri,&nbsp;Pietro Calandra","doi":"10.1002/jctb.70153","DOIUrl":"https://doi.org/10.1002/jctb.70153","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>This study explores the diffusion mechanisms of oleuropein (OLE), a promising polyphenolic compound, within chitosan-based nanoparticles using molecular dynamics simulations. Chitosan nanoparticles serve as drug delivery carriers, leveraging biocompatibility and tunable release properties influenced by environmental factors such as pH. Focusing on two systems – acidic and neutral – we analyzed the initial stages of OLE release, assessing interactions between OLE, chitosan, water molecules, and acetate ions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Simulations revealed that acidic nanoparticles, with protonated amino groups, exhibited enhanced electrostatic interactions and hydration, favoring an initial swelling that acts as the primary driver for eventual OLE diffusion. In contrast, neutral nanoparticles demonstrated weaker hydration and slower OLE release. Specifically, the diffusion coefficients for OLE in the acidic bulk was found to be approximately 26 × 10⁻⁷ cm² s⁻¹, significantly higher than in the neutral bulk (13.6 × 10⁻⁷ cm² s⁻¹). Conversely, in the neutral system, a ‘polymer wrapping’ effect hinders diffusion.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>These findings highlight that, in acidic media, matrix expansion takes precedence over molecular diffusion as the primary driver for release. This mechanistic insight suggests that modulating the initial protonation state is a key strategy for optimizing chitosan nanocarriers and controlling burst release profiles. © 2026 The Author(s). <i>Journal of Chemical Technology and Biotechnology</i> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"101 10","pages":"2000-2010"},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jctb.70153","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidative potential of plum oil cake-based coatings for fresh-cut apple preservation","authors":"Jovana Pantić,&nbsp;Sunčica Kocić-Tanackov,&nbsp;Anita Milić,&nbsp;Danijela Šuput,&nbsp;Nevena Hromiš,&nbsp;Marina Savić,&nbsp;Senka Popović","doi":"10.1002/jctb.70079","DOIUrl":"https://doi.org/10.1002/jctb.70079","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>To add value to a food waste, plum oil cake (POC) was used to develop biopolymer coatings enriched with <i>Satureja montana</i> essential oil for preserving fresh-cut apples. The effectiveness of the active POC coating (C) was compared with an ascorbic acid treatment (ASC) and a combined treatment of POC coating and ASC (C-ASC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>The efficacy of the treatments was evaluated on uncoated and coated fresh-cut apples stored at 4 °C for 14 days. Compared to ASC, POC coating – both alone and combined with ASC – showed consistently better results, especially in the inhibition of lactic acid bacteria, <i>Enterobacteriaceae</i>, aerobic mesophilic bacteria and molds. While ASC was most effective in preserving total flavonoids (197.60–73.97 mg 100 g⁻¹ dry matter, from the first to the last storage day), the C-ASC treatment maintained the highest and most stable antioxidant activity throughout the storage (0.90–0.95 mg Trolox g⁻¹ dry matter), showing a synergistic effect of POC coating and ASC in the preservation of antioxidant compounds. Additionally, the C-ASC treatment showed the lowest browning index (39.42) at the end of storage. The texture, sugar content, titratable acidity and total phenolic content were also better preserved with C-ASC than with POC coating.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>These results show a double benefit: food waste valorization through synthesis of POC coatings and the enhanced preservation of fresh-cut apples with natural preservatives that outperform conventional ASC treatment. Even as stand-alone treatment, POC coating extends the shelf life of fresh-cut apples, while the combination with ASC enhances this effect through its synergistic action. © 2025 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"101 10","pages":"2011-2023"},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148903750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic enhancement of TiO2 photocatalysis by tourmaline for efficient tetracycline hydrochloride degradation","authors":"Tian Yu,&nbsp;Qiaoling Zhou,&nbsp;Xinyi Dai,&nbsp;Xin Guo,&nbsp;Yao Chen","doi":"10.1002/jctb.70230","DOIUrl":"https://doi.org/10.1002/jctb.70230","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>The widespread discharge of antibiotic residues, particularly tetracycline hydrochloride (TCH), into aquatic environments has created an urgent need for highly active and stable photocatalysts. In this study, a tourmaline-doped TiO₂ composite (TM-Ti) was synthesized via an <i>in-situ</i> sol–gel method, aiming to synergistically enhance the degradation of TCH under UV irradiation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULT</h3>\u0000 \u0000 <p>Under optimized conditions (0.25 g L⁻¹ catalyst, pH 7.1, 20 mg L⁻¹ TCH), the TM-Ti catalyst achieved a TCH removal efficiency of 61% within 60 min of irradiation, substantially higher than those of pure TiO₂ (48%) and pristine tourmaline (8%). After an extended reaction time of 8 h, the total TCH removal reached approximately 90%, with adsorption accounting for 20% and photocatalysis serving as the dominant removal mechanism (70%). The material retained over 80% of its initial activity after six consecutive cycles, confirming excellent reusability. Compared with pure TiO₂, the TM-Ti composite exhibited a narrowed bandgap (from 3.18 eV to 2.92 eV), suppressed charge recombination, and an approximately 95% larger specific surface area. Mechanistic investigations identified superoxide radicals (·O₂⁻) and holes (h⁺) as the primary reactive species, supporting an ‘adsorption-enriched photocatalysis’ mechanism. Degradation pathway analysis and biotoxicity tests further confirmed the conversion of TCH into low-toxicity compounds, with partial mineralization to CO₂.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>This study demonstrated that the strategic introduction of tourmaline synergistically enhanced TiO₂ photocatalysis, presenting a promising and sustainable strategy for treating antibiotic-contaminated water. © 2026 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"101 10","pages":"2139-2151"},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148903979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective separation of ethanol–water azeotrope using acetate-based ionic liquids: from COSMO-RS screening to process simulation","authors":"Yuxuan Xiao,&nbsp;Meijun Wu,&nbsp;Dongxiang Zhang,&nbsp;Hua Xin,&nbsp;Qinqin Zhang,&nbsp;Zhigang Zhang","doi":"10.1002/jctb.70229","DOIUrl":"https://doi.org/10.1002/jctb.70229","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>The separation of ethanol and water is challenged by the formation of a minimum-boiling azeotrope, rendering conventional distillation ineffective. Extractive distillation using ionic liquids (ILs) offers a promising alternative due to their negligible volatility and structural tunability. However, the vast number of potential cation–anion combinations necessitates a rational strategy for IL selection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Three acetate-based ILs – [N1111][Ac], [MMIM][Ac], and [EMMIM][Ac] – were identified via the conductor-like screening model for real solvents (COSMO-RS) and experimentally validated to effectively break the ethanol-water azeotrope with separation performance following [N1111][Ac] &gt; [MMIM][Ac] &gt; [EMMIM][Ac]. The NRTL (non-random two-liquid) model accurately correlated the vapor–liquid equilibrium data and quantum chemical analyses revealed that hydrogen bonding between the acetate anion and water is the primary interaction governing separation. Process simulation using [EMMIM][Ac] in a double-column extractive distillation system achieved ethanol purity exceeding 99.9 wt%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>Acetate-based ILs demonstrate high efficacy as entrainers for ethanol-water extractive distillation. The integrated methodology combining COSMO-RS, experimental validation and molecular-level analysis provided a robust framework for IL selection. These findings offer valuable insights for designing sustainable separation processes in biofuel and chemical industries. © 2026 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"101 10","pages":"2122-2138"},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sequential fed-batch fermentation as strategy for the production of drought stress tolerance-promoting compounds","authors":"Aiden Escalante,&nbsp;Tatiana Solis,&nbsp;Christian Quijia,&nbsp;Mariela Perez-Cárdenas,&nbsp;Katherine Triviño-Cepeda,&nbsp;Andrea C. Zurita-Leal,&nbsp;Ellana Boada,&nbsp;Javiera Toledo-Alarcón,&nbsp;Oscar Franchi,&nbsp;Alberto Aguirre","doi":"10.1002/jctb.70228","DOIUrl":"https://doi.org/10.1002/jctb.70228","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; BACKGROUND&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Climate change represents a critical challenge for global agriculture. Recurrent drought events associated with climate variability induce drought stress in crops, ultimately compromising productivity. Therefore, the development of effective drought adaptation strategies in agricultural systems is essential. In this context, this study evaluated a strategy for the fermentative production of bioactive compounds that enhance drought stress tolerance in lentil plants, based on two sequential fed-batch culture stages: an initial fed-batch containing endophytic fungi, followed by a second fed-batch containing rhizosphere bacteria.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; RESULTS&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;A quadratic response surface model was successfully developed and optimized, demonstrating that a low dose combined with a high application frequency of the second fed-batch culture broth without cells maximizes stem growth efficiency. Under optimized conditions, drought-stressed lentil plants treated with the microbial broth without cells exhibited a stem growth efficiency of 48% and 92% of leaves with normal morphology, compared to untreated drought-stressed controls (7% stem growth efficiency and 37% normal leaf morphology). These findings confirm the efficacy of the produced microbial broth as a biostimulant for enhancing drought stress tolerance. The dominant bacterial genera identified in the second fed-batch were &lt;i&gt;Pseudomonas&lt;/i&gt; (52.43%), &lt;i&gt;Flavobacterium&lt;/i&gt; (40.67%), and &lt;i&gt;Sphingobium&lt;/i&gt; (5.29%). On the other hand, the dominant fungal genus in fed-batch stage 1 was &lt;i&gt;Talaromyces&lt;/i&gt; (93.6%). The positive effect on drought stress tolerance promotion observed in this study is likely associated with metabolites produced by both fungi (spiculisporic acid, citric acid, FA 9:0 + 10, FA 9:1 + 10, sebacic acid and chrysoeriol) and bacteria (ricinoleic acid, 10-hydroxydecanoic acid, 2,5-dihydroxybenzoic acid, 4-decyl-3-hydroxy-5-oxooxolane-2,3-dicarboxylic acid, chrysoeriol, ω-hydroxydodecanoic acid, &lt;i&gt;p&lt;/i&gt;-coumaric acid, and thymol-β-&lt;span&gt;d&lt;/span&gt;-glucoside) across the two fed-batch stages, as the broth from fed-batch stage 2 represents a mixture of compounds generated in both stages, and also due to previous reports in the literature indicating potential relationships between these chemical compounds and stress tolerance in plants.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; CONCLUSION&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The sequential fed-batch system employed in this study (fed-batch stage 1: endophytic fungi; fed-batch stage 2: rhizosphere bacteria) proved to be effective in generating compounds associated with enhanced drought stress tolerance in lentil plants. © 2026 Society of Chemical Industry (SCI).&lt;/p&gt;\u0000 &lt;/section&gt;","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"101 10","pages":"2104-2121"},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148903698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracellular enzymes from halophilic and halotolerant bacteria of the Atacama Desert exhibit antiproliferative activity against human cancer cell lines","authors":"Giannina Maya-Hun,&nbsp;David Medina,&nbsp;Pablo Caviedes,&nbsp;Juan A Asenjo,&nbsp;Barbara Andrews","doi":"10.1002/jctb.70223","DOIUrl":"https://doi.org/10.1002/jctb.70223","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Extremophilic microorganisms are a promising source of enzymes with potential biotechnological applications. Halophilic and halotolerant bacteria, capable of producing extracellular enzymes with various biological activities, inhabit hypersaline environments. In the present study, the effects of enzymes produced by halophilic and halotolerant bacteria isolated from hypersaline environments of the Atacama Desert on human cancer cell lines were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Five extracellular enzymatic preparations (L-asparaginase, L-glutaminase, Serine deaminase, Glycine oxidase, and Arginine deiminase) were selected, functionally enriched, and evaluated in human melanoma cell lines (RQ and DFB) and breast cancer cell line (MCF-7) using MTT viability assays and Ki-67 proliferation assays. All the enzymes reduced cell viability in a concentration-dependent manner, showing specific responses for each enzyme and cell line. Glycine oxidase had the strongest effect on melanoma cells (EC₅₀ = 47–69 IU mL⁻¹), while L-asparaginase showed comparable activity in all cell lines (EC₅₀ ≈ 100 IU mL⁻¹). Serine deaminase had cell line-dependent antiproliferative effects, while L-glutaminase and arginine deiminase showed variable responses. The patterns of Ki-67 expression in RQ and MCF-7 cells did not always correlate with viability, suggesting cytotoxic and/or cytostatic effects depending on the enzyme and cell type.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>Extracellular enzymes produced by halophilic and halotolerant bacteria from hypersaline environments showed antiproliferative activity in human cancer cell lines <i>in vitro</i>, exhibiting canonical and non-canonical behaviors depending on the enzyme and cell type. These findings highlight hypersaline ecosystems such as the Atacama Desert as promising sources of microbial enzymes with potential biotechnological applications. © 2026 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"101 10","pages":"2051-2061"},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148903878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micropollutant removal from agricultural drainage waters by nanofiltration and reverse osmosis processes","authors":"Burak Aslancan Pak,&nbsp;Yamaç Bal,&nbsp;Emir Kasım Demir,&nbsp;Baraa Ahmed Hatib,&nbsp;Barış Güzel,&nbsp;Oltan Canlı,&nbsp;Elmas Eva Öktem,&nbsp;Alper Bayrakdar,&nbsp;Erkan Sahinkaya","doi":"10.1002/jctb.70219","DOIUrl":"https://doi.org/10.1002/jctb.70219","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>The recovery of agricultural drainage water is crucial for sustainable irrigation, but the presence of pesticides and salinity poses significant obstacles to recovery. This study aimed to evaluate the performance of nanofiltration (NF) and reverse osmosis (RO) membranes (NF270, NF90, BW30) in the treatment of synthetic drainage water and, in particular, to elucidate their pesticide rejection mechanisms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>NF90 and BW30 membranes demonstrated exceptionally high rejection performance (&gt;88%) in the presence of five selected pesticides and salt. Conversely, the NF270 membrane exhibited comparably lower rejection performances, especially for atrazine and imidacloprid. The rejection performance of the membranes was also impacted by the mode of filtration due to different hydrodynamic conditions; the rejection performance improved in the cross-flow mode of operation. This improvement is attributed to the mitigation of concentration polarization. Process modelling confirmed that a full-scale RO system could produce high-quality irrigation water with a temperature-dependent specific energy consumption of 0.59 kWh m⁻³ at 20 °C.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>While dense membranes offer robust barrier properties, hydrodynamic control is critical for maximizing the performance of loose NF membranes against hydrophobic micropollutants. These findings demonstrate that advanced membrane technologies (NF and RO) can be safely used for recovering pesticide- and salt-bearing agricultural drainage water, which is important to mitigate global water scarcity. © 2026 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"101 10","pages":"2036-2050"},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148903879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of manganese ferrite nanoparticles as capable magnetic nano-sorbent for selective and effective removal of active pharmaceutical ingredients: single and binary adsorptive applications","authors":"Tuba Dedecan,&nbsp;Hazan Karaduman,&nbsp;Nilay Baylan,&nbsp;İsmail İnci","doi":"10.1002/jctb.70226","DOIUrl":"https://doi.org/10.1002/jctb.70226","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>The increasing occurrence of active pharmaceutical ingredients (APIs) in aquatic environments poses risks to ecosystems and human health, underscoring the necessity for effective removal strategies. This study involved the synthesis of manganese ferrite (MnFe₂O₄) nanoparticles (MFO-NPs) through a controlled co-precipitation method and characterized X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and Brunauer–Emmett–Teller surface area analysis. The adsorptive performance of MFO-NPs has been evaluated for the removal of quetiapine and lansoprazole as APIs from an aquatic environment under varying operational parameters, including pH, MFO-NP dosage, calcination temperature, contact time, and initial API concentration. Kinetic, isotherm, and thermodynamic modeling studies were also performed to clarify the adsorption behavior. Additionally, binary adsorption trials of lansoprazole and quetiapine, as well as regeneration experiments, have been performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>The maximum adsorption performance values, adsorption capacity and adsorption percentage of synthesized MFO-NPs for lansoprazole and quetiapine were determined to be 34.23 mg g⁻¹, 89% and 32.32 mg g⁻¹, 81%, respectively. In the binary adsorption system, the adsorption capacities of both quetiapine and lansoprazole decreased compared with their corresponding single adsorption system. These findings indicate that quetiapine and lansoprazole may compete for available adsorption sites on the MFO-NP surface, with quetiapine exhibiting a relatively greater affinity under binary conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>This work highlights MFO-NPs as a promising and capable magnetic nano-sorbent for water purification applications targeting pharmaceutical pollutants in single or multiple adsorption systems. © 2026 Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"101 10","pages":"2085-2103"},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of bioactive compounds extraction from Rosa canina L. pseudofruit through the action of two hydrolytic enzyme preparations","authors":"Zafeiria Lemoni,&nbsp;Styliani Kalantzi,&nbsp;Theopisti Lymperopoulou,&nbsp;Andromachi Tzani,&nbsp;Georgios Stavropoulos,&nbsp;Anastasia Detsi,&nbsp;Diomi Mamma","doi":"10.1002/jctb.70075","DOIUrl":"https://doi.org/10.1002/jctb.70075","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKROUND</h3>\u0000 \u0000 <p>The pseudo-fruit of <i>Rosa canina L</i>. is a rich source of bioactive compounds with antioxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-aging, and antimicrobial activities. The aim of the present study is the optimization of a green process based on the action of two hydrolytic enzyme preparations, namely Pectinex® Ultra Color (pectinolytic) and Viscoferm® (hemicellulolytic), for the extraction of bioactive compounds from the pseudo-fruit of <i>Rosa canina L</i>. of Greek origin. A Box–Behnken Design (BBD) was employed to optimize extraction conditions by evaluating the effects of enzyme loadings and extraction time on total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity. The optimum extract was evaluated for its biological activities, anti-aging (inhibition of tyrosinase activity), antidiabetic (inhibition of α-glucosidase and α-amylase activity), and for its antibacterial activity against <i>Escherichia coli</i> cells.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>The optimal conditions were determined using Derringer's desirability function and were found at 0.59% v/v Pectinex® Ultra color, 0.51% v/v Viscoferm®, and approximately 97 min (96.23 min) extraction time. The optimum extract yielded 123.22 ± 2.50 mg GAE/g DW TPC, 49.13 ± 0.92 mg CAE/g DW TFC, and exhibited antioxidant activity with an IC₅₀ of 0.98 ± 0.02μL_extract/mL. The biological activities of the extracts revealed strong inhibition of <i>E. coli</i> growth, moderate α-glucosidase inhibition, and weak tyrosinase inhibition and α-amylase inhibition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>The proposed process offers a rapid approach for the effective extraction of bioactive compounds from the pseudofruit of <i>Rosa canina L</i>., with promising biological activities, thus demonstrating its potential for applications in various industries. © 2025 The Author(s). <i>Journal of Chemical Technology and Biotechnology</i> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"101 10","pages":"1954-1967"},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jctb.70075","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanostructured lipid carriers and natural deep eutectic solvents: a highly advantageous combination for the encapsulation of curcumin","authors":"Kyriaki Safari,&nbsp;Ioanna Pitterou,&nbsp;Marianthi Miliaronikolaki,&nbsp;Nikolaos Paraskevopoulos,&nbsp;Andromachi Tzani,&nbsp;Anastasia Detsi","doi":"10.1002/jctb.70122","DOIUrl":"https://doi.org/10.1002/jctb.70122","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> BACKGROUND</h3>\u0000 \u0000 <p>Curcumin is a naturally derived polyphenol known for its potent biological properties. Its therapeutic potential, however, is hindered by low bioavailability. Nanostructured lipid carriers (NLCs) have emerged as advanced delivery systems to overcome such limitations. Natural deep eutectic solvents (NADESs) have garnered attention as green alternatives to conventional solvents with potential applications in drug delivery. In this context, this study explores the encapsulation of curcumin in NLCs incorporating a hydrophobic NADES (hNADES) as a multifunctional component, serving both as an alternative to conventional liquid lipids in the NLC formulation and as a green solvent for curcumin.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> RESULTS</h3>\u0000 \u0000 <p>Curcumin exhibited satisfactory solubility in the hNADES (1.17 mg/mL at 25 °C; 4.79 mg/mL at 70 °C). The hNADES was successfully incorporated as the liquid lipid in curcumin-loaded NLCs (CUR-NLCs). The preparation of CUR-NLCs was optimized through a Box–Behnken design. The CUR-NLCs obtained <i>via</i> the optimized process had a size of 227.8 ± 17.4 nm, PDI of 0.318 ± 0.032, and ζ-potential of −39.1 ± 2.3 mV. Encapsulation efficiency was 79.1 ± 0.9%, and process yield was 86.8 ± 1.1%. The ability of CUR-NLCs to scavenge the DPPH free radical reached 42.4 ± 0.4% at 120 min, whereas free curcumin showed 15.3 ± 0.2%. Photoprotective performance also improved, with CUR-NLCs exhibiting Sun Protection Factor (SPF) values up to 8.28 ± 0.02 and providing an SPF boost of 33.7% when incorporated into a base sunscreen.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> CONCLUSION</h3>\u0000 \u0000 <p>The findings highlight the successful use of a hydrophobic NADES as a multifunctional liquid lipid component in the design of NLCs for curcumin encapsulation, underscoring the potential of hNADESs in the development of advanced lipid-based formulations. © 2025 The Author(s). <i>Journal of Chemical Technology and Biotechnology</i> published by John Wiley &amp; Sons Ltd on behalf of Society of Chemical Industry (SCI).</p>\u0000 </section>\u0000 </div>","PeriodicalId":15335,"journal":{"name":"Journal of chemical technology and biotechnology","volume":"101 10","pages":"1980-1999"},"PeriodicalIF":2.7,"publicationDate":"2026-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/jctb.70122","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148904372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}