Journal of Child Neurology最新文献

{"title":"Idiopathic Optic Perineuritis in a Pediatric Patient.","authors":"Cara Miller, NgocHanh H Vu, Richard B Carozza","doi":"10.1177/08830738251341771","DOIUrl":"10.1177/08830738251341771","url":null,"abstract":"<p><p>Optic perineuritis is an inflammatory disorder of the optic nerve sheath, presenting with visual deficits, dyschromatopsia, and pain with extraocular movement, often confused with optic neuritis. Most cases are believed to be idiopathic but can be associated with autoimmune, infectious, and neoplastic etiologies. Treatment involves corticosteroids, and when administered promptly has been associated with rapid recovery. Delays in treatment have been linked to poor visual outcomes. Few pediatric cases have been described. We report a teenager who presented with 2 months of unilateral visual loss and paracentral scotoma, found to have optic perineuritis. She was treated aggressively with high-dose corticosteroids, therapeutic plasma exchange, and intravenous immunoglobulin, but had limited symptomatic recovery attributable to delays in seeking treatment. Optic perineuritis is rare in children but should be included in the differential for visual deficits, especially as delayed treatment is associated with irreversible visual loss. Further studies are needed for children to better identify underlying causes and establish consistent treatment paradigms.</p>","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"906-909"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144142503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Embolic Stroke After Atrial Septal Defect Surgery in a Child.","authors":"Filippos-Paschalis Rorris, Meletios Kanakis, Maria Kontou, Tatiana Rorri, Sofia Vassilopoulou, Dimitrios Bobos, Thomas Vrachliotis, Panagiotis Papanagiotou","doi":"10.1177/08830738251332985","DOIUrl":"10.1177/08830738251332985","url":null,"abstract":"","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"900-901"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Disseminated Encephalomyelitis in Children and Adolescents: A Multicenter Retrospective Study of Relapse and Outcome.","authors":"Seda Kanmaz, Sanem Yılmaz, Nihal Olgaç Dündar, Ayşe Aksoy, Mehmet Canpolat, Hüseyin Per, İlknur Erol, Hakan Gümüş, Yasemin Özkale, Selcan Öztürk, Dilara Ece Toprak, İbrahim Öncel, Murat Özkale, Elif Nurdan Ozmansur, Hepsen Mine Serin, Gülşen Ersöz, Şeyda Besen, Gülen Gül Mert, Ayten Güleç, Sevim Şahin, Cemile Büşra Ölçülü, Ayberk Selek, Serdar Pekuz, Günce Başarır, Çağatay Günay, Didem Biçer, Zehra Filiz Kahraman, Deniz Yüksel, Meral Karadağ, Erdem Şimşek, Aycan Ünalp, Nihal Yıldız, Meltem Çobanoğulları Direk, Uluç Yiş, Hüseyin Tan, Cengiz Havalı, Aydan Değerliyurt, Mesut Güngör, Özlem Hergüner, Elif Perihan Oncel, Olcay Ünver, Sefer Kumandaş, Hale Atalay Celik, Bilge Özgör, Ali Cansu, Aslı Kübra Atasever, Ayşe Tosun, Olcay Güngör, Çetin Okuyaz, Selvinaz Edizer, Semra Hız, Esra Sarıgeçili, Hülya Kayılıoğlu, Ceren Durgun Yazgan, Gökçen Öz Tuncer, Pınar Gençpınar, Ünsal Yılmaz, Su Özgür, Hasan Tekgül, Banu Anlar","doi":"10.1177/08830738251334219","DOIUrl":"10.1177/08830738251334219","url":null,"abstract":"<p><p>ObjectivesTo evaluate the demographic, clinical, laboratory, and prognostic data of children with acute disseminated encephalomyelitis with respect to anti-myelin oligodendrocyte glycoprotein (MOG) antibody status.MethodsAcute disseminated encephalomyelitis patients (n = 245) from 24 centers followed up between 2010 and 2022 were evaluated retrospectively. The short- and long-term outcome characteristics (disease severity and course, clinical relapse, and recovery rates) were assessed. Incomplete clinical recovery was defined as modified Rankin Score ≥1 or the presence of epilepsy. Univariant and multivariant analysis were performed for outcome characteristics.ResultsThe mean age at diagnosis was 6.3 ± 3.8 (0.5-17.7) years and the median follow-up was 22 (3-132) months. The outcome characteristics were evaluated in 180 of 245 patients (73.4%) with at least 12 months' follow-up. Twenty-three patients (12.6%) relapsed. The multivariable logistic regression analysis revealed the following clinical parameters as predictors of relapse: sex, visual impairment, and ataxia at initial presentation. Incomplete clinical recovery (n = 42/180, 23.3%) was associated with the presence of seizures on admission and the need for an intensive care unit. Anti-MOG antibody positivity was not associated with an increased risk of relapse (25% vs 13.1%, <i>P</i> = .164) or incomplete clinical recovery (<i>P</i> = .511).ConclusionThe nationwide cohort presented further supports the typically monophasic nature of acute disseminated encephalomyelitis, and a high rate of complete recovery. The presence of certain symptoms in the acute period may assist the clinician in estimating the outcome.</p>","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"838-851"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143967700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telemedicine for Children With Cerebral Palsy Before, During, and After the COVID-19 Pandemic: An Australian Cohort Study.","authors":"Simon P Paget, Sarah McIntyre, Amy von Huben, Kirsty Stewart, Tracey Williams, Emma Maly, Katrina Ford, Sue Woolfenden, Natasha Nassar","doi":"10.1177/08830738251339960","DOIUrl":"10.1177/08830738251339960","url":null,"abstract":"<p><p><b>Objective:</b> To examine telemedicine use in children with cerebral palsy before, during and since the COVID-19 pandemic. <b>Methods:</b> A retrospective cohort study of 1162 children with cerebral palsy (40.3% female, birth years 2005-2017), attending specialist outpatient clinics at 2 pediatric hospitals in New South Wales, Australia. We categorized outpatient visits from January 2018 to May 2023 as in-person or telemedicine and compared usage pre-, during, and post-COVID-19 periods. Neighborhood socioeconomic disadvantage and geographical remoteness were defined by residential postcode. <b>Results:</b> Of 48 896 outpatient encounters, 11 929 (24.4%) used telemedicine. Telemedicine rates increased during COVID-19 (20.2 per 100 persons/month) and declined post-COVID-19 (15.2 per 100 persons/month, <i>P</i> < .001). Neighborhood socioeconomic disadvantage was associated with higher median outpatient and telemedicine encounter rates. Regional/remote children had lower median outpatient and telemedicine rates. <b>Conclusion:</b> Telemedicine use declined since lifting of COVID-19 pandemic restrictions. Further support will be required to sustain rates and learn from pandemic experiences.</p>","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"871-881"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late-Onset Vitamin K Deficiency Resulting in Intracranial Bleeds: A Case Report and Literature Review.","authors":"Sunil Thatal, Susmin Karki, Sagar Mani Regmi, Sweta Bhandari, Rajesh Paudel","doi":"10.1177/08830738251342692","DOIUrl":"10.1177/08830738251342692","url":null,"abstract":"<p><p>We report a case of a 24-day-old male neonate who presented with multiple episodes of apnea, poor feeding, excessive crying, irritability, vomiting, and yellowish discoloration. The patient did not receive a vitamin K injection at birth, and most likely, the neonate's dietary intake was insufficient to meet vitamin K requirements for coagulation, which resulted in an intracranial hemorrhage, which ultimately resulted in the mortality of the child.</p>","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"910-914"},"PeriodicalIF":1.6,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudomonas Meningitis Revealing <i>MYD88</i> Deficiency in an Infant.","authors":"Nihal Akçay, Demet Tosun, İlyas Bingöl, Yasemin Tepe, İdan Fırat Unay","doi":"10.1177/08830738251382278","DOIUrl":"https://doi.org/10.1177/08830738251382278","url":null,"abstract":"","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"8830738251382278"},"PeriodicalIF":1.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Ocular Findings in Pediatric Patients With Neurofibromatosis Type 1.","authors":"Ulku Demir","doi":"10.1177/08830738251382296","DOIUrl":"https://doi.org/10.1177/08830738251382296","url":null,"abstract":"<p><p>PurposeEvaluation of the incidence and variability of ocular manifestations in children with neurofibromatosis type 1.MethodsIn this study, the files of 71 children aged 0-18 years with neurofibromatosis type 1 were retrospectively analyzed. Child age groups were categorized as 0-6, 7-12, and 13-18 years. In cycloplegic refractive examination, ≥-0.50 Diopter (D) values in spherical equivalents were recorded as myopia, ≥+2.0 D as hypermetropia, and ≥±1.0 D cylindrical values as astigmatism. Patients with a difference of ≥1 D in spherical or cylindrical equivalents between the 2 eyes were considered anisometropic. Amblyopia was defined as a best-corrected visual acuity ≤0.8 with Snellen chart and a difference of at least 2 lines between both eyes. The presence of 2 or more iris Lisch nodules (iris hamartoma) was considered positive.ResultsOf the 71 patients whose ocular findings were evaluated, 32 (45.1%) were boys and 39 (54.9%) were girls. According to age and gender, myopia (<i>P</i> = .878), hypermetropia (<i>P</i> = .329), myopia astigmatism (<i>P</i> = .761), hypermetropia astigmatism (<i>P</i> = .457), mixed astigmatism, anisometropia (<i>P</i> = .836), amblyopia (<i>P</i> = .551), emmetropia (<i>P</i> = .234), optic glioma (<i>P</i> = .598), strabismus (<i>P</i> = .219), and ptosis (<i>P</i> = .099) showed no significant difference (<i>P</i> > .05). A statistically significant difference was observed in the Lisch nodule, one of the ocular examination findings, according to age and gender (<i>P</i> < .05).ConclusionsPediatric patients with neurofibromatosis type 1, with common ocular manifestations, should undergo a comprehensive ophthalmologic examination. Early diagnosis and treatment are crucial for improving the clinical course of the disease and preserving vision.</p>","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"8830738251382296"},"PeriodicalIF":1.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Some Ethical Considerations for Child Neurologists in Difficult Times.","authors":"David K Urion","doi":"10.1177/08830738251382287","DOIUrl":"https://doi.org/10.1177/08830738251382287","url":null,"abstract":"","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"8830738251382287"},"PeriodicalIF":1.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bud Rowland: Courage in Times of Political Turmoil.","authors":"Alison Christy","doi":"10.1177/08830738251379561","DOIUrl":"https://doi.org/10.1177/08830738251379561","url":null,"abstract":"","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"8830738251379561"},"PeriodicalIF":1.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a Triage-Based Blunt Trauma Assessment on PECARN Recommendations and Neuroimaging Use in Pediatric Head Injury.","authors":"Cheuk Kwok, Jamie Marliere, Shaye Busse, April Taniguchi, Kamal Chavda, Andrea Rivera-Sepulveda","doi":"10.1177/08830738251378937","DOIUrl":"https://doi.org/10.1177/08830738251378937","url":null,"abstract":"<p><p>This study aimed to evaluate the impact of a triage-based blunt trauma assessment (best practice advisory) on Pediatric Emergency Care Applied Research Network (PECARN)-guided recommendations and actual head computed tomography (CT) use in children <18 years old presenting with head injury. We examined agreement between best practice advisory recommendations, PECARN risk categories, and head CT use, as well as risk factors associated with deviation from PECARN guidance. Group comparisons were analyzed by Mann-Whitney rank-sum test, Kruskal-Wallis test, Fisher exact test, or χ² test, as indicated. Best practice advisory and PECARN agreement was 47%. The best practice advisory aligned with CT use in 39% of cases, whereas PECARN aligned 73%. In children <2 years, 42% received a head CT despite a PECARN recommendation against it (<i>P</i> < .001). In children ≥2 years, 38% received a head CT against PECARN recommendations (<i>P</i> < .001). Overall agreement among best practice advisory, PECARN, and head CT use was 35%. Symptoms such as speech changes, lethargy, altered mood, and gait abnormalities were associated with deviations from PECARN. Findings suggest that although PECARN guides imaging decisions, numerous clinical factors and best practice advisory recommendations influence provider behavior, highlighting opportunities to improve decision support and reduce unnecessary CT scans.</p>","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"8830738251378937"},"PeriodicalIF":1.6,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}