Journal of Child Neurology最新文献

Knobloch Syndrome in Childhood: Neuroradiologic Findings and Clinical Correlation. 儿童Knobloch综合征：神经放射学表现和临床相关性。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-05-07 DOI: 10.1177/08830738261444228

Yanniklas Kravutske, Mateus A Esmeraldo, Stefanie Chambers, Hisham M Dahmoush, Mark R Halverson, Ana F Geraldo, Bruno P Soares

引用次数: 0

Therapeutic Courses of Presumed Intracranial Immature Teratoma Diagnosed Based on Increased Alpha-Fetoprotein. 基于甲胎蛋白增高诊断颅内未成熟畸胎瘤的治疗过程。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-05-07 DOI: 10.1177/08830738261446144

Shigeru Yamaguchi, Yukitomo Ishi, Michinari Okamoto, Sogo Oki, Ryosuke Sawaya, Hiroaki Motegi, Yukayo Terashita, Shinsuke Hirabayashi, Kentaro Nishioka, Takayuki Hashimoto, Hiromi Okada, Emi Takakuwa, Hidefumi Aoyama, Atsushi Manabe, Miki Fujimura

{"title":"Therapeutic Courses of Presumed Intracranial Immature Teratoma Diagnosed Based on Increased Alpha-Fetoprotein.","authors":"Shigeru Yamaguchi, Yukitomo Ishi, Michinari Okamoto, Sogo Oki, Ryosuke Sawaya, Hiroaki Motegi, Yukayo Terashita, Shinsuke Hirabayashi, Kentaro Nishioka, Takayuki Hashimoto, Hiromi Okada, Emi Takakuwa, Hidefumi Aoyama, Atsushi Manabe, Miki Fujimura","doi":"10.1177/08830738261446144","DOIUrl":"https://doi.org/10.1177/08830738261446144","url":null,"abstract":"Intracranial immature teratoma (ImT) is one of the non-germinomatous germ cell tumors, and elevated serum alpha-fetoprotein (AFP) value is a crucial clinical diagnostic indicator of ImT. In this retrospective study conducted among patients diagnosed with intracranial ImT, diagnostic procedures, therapeutic courses, histopathologic diagnosis, and prognosis were reviewed. Among 106 patients with intracranial germ cell tumors, 11 were diagnosed with ImT and treated since 2000. ImT was diagnosed via biopsy or based on mild or moderate serum AFP elevation of 10-500 ng/mL. Complete remission via chemoradiotherapy was achieved in only 2 patients (18%); 5 patients (45%) suffered from growing disease during treatment; and 7 patients required salvage tumor resection. The 10-year progression-free and overall survival rates were 76.2% and 87.5%, respectively. The therapeutic courses of ImT varied. Notably, cases in which treatment was applied considering ImT were highly prone to experience growing disease during treatment.","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"8830738261446144"},"PeriodicalIF":1.6,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and Electrophysiological Characteristics and Short-Term Outcomes of Pediatric Guillain-Barré Syndrome in a Latin American Intensive Care Unit. 拉丁美洲重症监护病房儿童格林-巴- <s:1>综合征的临床和电生理特征及短期预后。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-05-06 DOI: 10.1177/08830738261447158

Daniela Avila-Smirnow, Grecia Castro-Cuevas, Maite Rojas-Mckenzie, Pamela Céspedes-Fernández, Adriana Wegner-Araya

{"title":"Clinical and Electrophysiological Characteristics and Short-Term Outcomes of Pediatric Guillain-Barré Syndrome in a Latin American Intensive Care Unit.","authors":"Daniela Avila-Smirnow, Grecia Castro-Cuevas, Maite Rojas-Mckenzie, Pamela Céspedes-Fernández, Adriana Wegner-Araya","doi":"10.1177/08830738261447158","DOIUrl":"https://doi.org/10.1177/08830738261447158","url":null,"abstract":"Guillain-Barré syndrome (GBS) is an acute polyneuropathy with an incidence of 0.69 per 100 000 children annually. Electrophysiological variants vary geographically, with the axonal subtype more common in parts of Asia; however, pediatric data from Latin America remains limited, underscoring the need for regional studies to inform clinical management. This retrospective cohort study examined the incidence, electrophysiological variants, and clinical outcomes of children under 16 years hospitalized for GBS in an intensive care unit serving approximately 8% of the Chilean population in Santiago (2013-2023). Twenty-one patients (median age: 10 years) were included, with 11 presenting with axonal involvement and 8 with demyelinating features. Four patients required mechanical ventilation-2 in the axonal and 2 in the demyelinating group (median = 22 days, IQR = 9-43)-and 2 patients required tracheostomy. The predominance of the axonal subtype highlights critical considerations for early prognostication, critical care planning, and future inclusion in clinical trials.","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"8830738261447158"},"PeriodicalIF":1.6,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Radiologic Combination in Glutaric Aciduria Type 1. 1型戊二酸尿罕见的影像学合并。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-05-04 DOI: 10.1177/08830738261444246

Cristiano Esteves, Graça Sá, Patrícia Janeiro, Joana Coelho, Filipa Proença

引用次数: 0

Global Pediatric Stroke Epidemiology: A Systematic Review of the Literature and Meta-Analysis. 全球儿童中风流行病学：文献和荟萃分析的系统回顾。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-05-04 DOI: 10.1177/08830738261441084

Joseline Haizel-Cobbina, Stefan W Koester, Yusra Arafeh, Prabhat Poudel, Nancy Abu-Bonsrah, Nathan A Shlobin, Jeffrey Chen, Liping Du, Albert Isaacs, Michael C Dewan

{"title":"Global Pediatric Stroke Epidemiology: A Systematic Review of the Literature and Meta-Analysis.","authors":"Joseline Haizel-Cobbina, Stefan W Koester, Yusra Arafeh, Prabhat Poudel, Nancy Abu-Bonsrah, Nathan A Shlobin, Jeffrey Chen, Liping Du, Albert Isaacs, Michael C Dewan","doi":"10.1177/08830738261441084","DOIUrl":"https://doi.org/10.1177/08830738261441084","url":null,"abstract":"The global burden of stroke in children is poorly characterized. We aimed to quantify the global burden of pediatric stroke. A systematic review and meta-analysis was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The estimated birth prevalence and incidence of perinatal and overall childhood stroke was used to calculate the worldwide stroke burden by World Bank Income Groups and World Health Organization (WHO) regions. The estimated birth prevalence of perinatal stroke (regardless of type) was 21.01 per 100 000 total births and estimated childhood incidence of stroke was 3.73 per 100 000 person-years. The childhood incidence of ischemic stroke and hemorrhagic stroke was 1.30 per 100 000 person-years and 0.99 per 100 000 person-years, respectively. There is a relatively greater burden of perinatal stroke birth prevalence. Epidemiologic data on pediatric stroke is concentrated in western HIC. Coordinated efforts are needed to better understand the burden of pediatric stroke in LMIC.","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"8830738261441084"},"PeriodicalIF":1.6,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147815646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Misclassification of Abnormal Arm Movements: Paroxysmal Dystonia, Not Cervical Radiculopathy. 异常手臂运动的错误分类：阵发性肌张力障碍，而不是颈神经根病。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-05-01 Epub Date: 2026-01-07 DOI: 10.1177/08830738251408118

Audai Abudayeh, Iakiv Fishchenko

引用次数: 0

Gait Analysis in Rett Syndrome: Integrating Linear and Nonlinear Techniques. Rett综合征的步态分析：整合线性和非线性技术。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-05-01 Epub Date: 2025-09-19 DOI: 10.1177/08830738251371586

Dacia Martinez Diaz, Brock Futrell, Bernhard Suter, Charles S Layne

{"title":"Gait Analysis in Rett Syndrome: Integrating Linear and Nonlinear Techniques.","authors":"Dacia Martinez Diaz, Brock Futrell, Bernhard Suter, Charles S Layne","doi":"10.1177/08830738251371586","DOIUrl":"10.1177/08830738251371586","url":null,"abstract":"Rett syndrome is a rare neurodevelopmental disorder that significantly impairs bipedal postural control and walking ability. This study quantifies the gait characteristics of 22 females with Rett syndrome (divided into 3 age groups) and compares them with age-matched neurotypical females. Bilateral sagittal plane joint angles of the hip, knee, and ankle were analyzed. Measures included joint range of motion, stride time, peak angular velocity, angle-angle diagrams, phase portrait areas, and asymmetries. Results revealed reduced joint range of motion and angular velocity in individuals with Rett syndrome, as well as greater asymmetries in gait parameters reflecting disruptions in bilateral coordination. Phase portraits and angle-angle diagrams indicated preserved coordination in proximal joints but greater variability at the ankle. Ankle movement in individuals with Rett syndrome aged 9-14 years showed a closer resemblance to Controls. These findings identify underlying lower limb motion patterns that contribute to gait deficits in Rett syndrome, guiding future targeted interventions to improve their mobility.","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"647-665"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Early Electroencephalogram to Predict Severity of Injury in Infants With Abusive Traumatic Brain Injury. 早期脑电图预测虐待性外伤性脑损伤婴儿损伤严重程度。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-05-01 Epub Date: 2025-09-26 DOI: 10.1177/08830738251377152

Natasha A Varughese, Ali Hasan, Naomi Cohen, Deja Smith, Rebekah L Clarke, Jillian Grapsy, Rana Said, Darryl Miles, Lakshmi Raman, Deepa Sirsi

{"title":"Early Electroencephalogram to Predict Severity of Injury in Infants With Abusive Traumatic Brain Injury.","authors":"Natasha A Varughese, Ali Hasan, Naomi Cohen, Deja Smith, Rebekah L Clarke, Jillian Grapsy, Rana Said, Darryl Miles, Lakshmi Raman, Deepa Sirsi","doi":"10.1177/08830738251377152","DOIUrl":"10.1177/08830738251377152","url":null,"abstract":"This study explored the hypothesis that specific electroencephalographic (EEG) findings may correlate with outcomes in children with abusive head trauma. A retrospective chart review was conducted on children <2 years of age who were hospitalized after suspected abusive head trauma between 2015 and 2021. Based on validated scoring systems, a primary analysis was performed to correlate background EEG scores against magnetic resonance imaging (MRI) scores and neurofunctional outcomes. A secondary analysis was performed to correlate seizure burden against MRI and neurofunctional outcomes. Significant positive correlations (Spearman rank) were discovered between background EEG scores and MRI scores (0.338, P = .011) as well as between background EEG scores and motor functional scores at 1-6 months (0.332, P = .017) and 7-12 months (0.386, P = .08). Seizure burden and sensory functional scores showed positive but statistically insignificant correlations. In conclusion, for children with abusive head trauma, background EEG is an early marker of prognosis whereas seizure burden requires additional study.","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"704-714"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145175638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ask-Me-3 & Going-Home-3 Education Program: Improving Communication Between Patients and Doctors in Child Neurology. Ask-Me-3和Going-Home-3教育项目：改善儿童神经病学医患沟通。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-05-01 Epub Date: 2025-09-24 DOI: 10.1177/08830738251369136

Sharoon Qaiser, Kimberly S Jones, Anna Thamann, Matthew Stowe

{"title":"Ask-Me-3 & Going-Home-3 Education Program: Improving Communication Between Patients and Doctors in Child Neurology.","authors":"Sharoon Qaiser, Kimberly S Jones, Anna Thamann, Matthew Stowe","doi":"10.1177/08830738251369136","DOIUrl":"10.1177/08830738251369136","url":null,"abstract":"BackgroundEffective communication between physicians and caregivers is essential to high-quality pediatric care. Communication failures contribute to suboptimal outcomes, caregiver dissatisfaction, and increased health care use. Children with neurologic conditions often require complex and prolonged hospitalizations, increasing the risk of communication breakdowns.ObjectiveTo improve communication during hospitalization and at discharge, we developed and implemented a 2-part bedside communication tool-Ask-Me-3 & Going-Home-3-and evaluated its association with Press Ganey patient satisfaction scores.MethodsThis 6-month quality improvement (QI) initiative took place in a tertiary children's hospital where child neurology served as the primary admitting service. Physicians were trained to use a laminated, dual-phase communication tool during rounds and at discharge. Caregivers used this reference to track understanding. Monthly Press Ganey communication scores were tracked pre- and post-implementation and visualized using a run chart to assess trends. No formal statistical testing was performed, consistent with QI methodology.ResultsFrom March to August 2023, baseline communication scores averaged 82.0% to 83.5%, below the institutional benchmark of 83.9%. Following implementation (September 2023-March 2024), scores improved to 84.5% to 85.2%, exceeding both institutional and departmental goals. A run chart indicated a sustained upward trend. The internal caregiver survey (n = 98) demonstrated >95% satisfaction with communication during the initial implementation month.ConclusionAsk-Me-3 & Going-Home-3 is a feasible and low-cost tool associated with improved caregiver-reported satisfaction. It enhances communication at both admission and discharge in hospitalized child neurology patients. Further multicenter studies are needed to evaluate generalizability and long-term impact.","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"700-703"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual Recovery and Neurological Stabilization Following Miglustat Treatment in Pediatric CLN3 Disease. 小儿CLN3疾病米卢司他治疗后的视力恢复和神经系统稳定。

IF 1.6 4区医学

Journal of Child Neurology Pub Date : 2026-05-01 Epub Date: 2025-09-18 DOI: 10.1177/08830738251374538

Alice E Dutton, Ineka T Whiteman, Michael M Jones, Katie E Geering, Soheil Afshar, Alexandra M Johnson, John R Grigg

{"title":"Visual Recovery and Neurological Stabilization Following Miglustat Treatment in Pediatric CLN3 Disease.","authors":"Alice E Dutton, Ineka T Whiteman, Michael M Jones, Katie E Geering, Soheil Afshar, Alexandra M Johnson, John R Grigg","doi":"10.1177/08830738251374538","DOIUrl":"10.1177/08830738251374538","url":null,"abstract":"Neuronal ceroid lipofuscinosis type 3 (CLN3) disease is a rare, life-limiting pediatric neurodegenerative disorder with no approved disease-modifying therapy. We conducted a prospective case report from October 2023 to April 2025 involving two female siblings with genetically confirmed CLN3 disease (homozygous for the common 1 kb deletion). Both patients were treated with oral, weight-based miglustat for 18 months. Miglustat was supplied as off-label use in the absence of a therapeutic alternative for this severe neurodegenerative disorder. Clinical outcomes were assessed using comprehensive ophthalmologic evaluation, the Unified Batten Disease Rating Scale (UBDRS), and the Vineland Adaptive Behavior Scales, Third Edition (Vineland-3). At the time of report, patients were aged 13 and 10 years. Both had been diagnosed at age 7 years and commenced miglustat at ages 11 and 9 years, respectively. Over the treatment period, both patients demonstrated improvement in visual acuity and clinical stabilization on the Unified Batten Disease Rating Scale. One patient showed measurable improvement in adaptive functioning as assessed by Vineland-3. No significant adverse effects were reported. These preliminary findings suggest potential short-term clinical benefit of miglustat in pediatric patients with CLN3 disease, particularly when initiated early in the disease course. Further studies involving larger cohorts and longer follow-up are warranted to evaluate the safety and long-term efficacy of miglustat in this population.","PeriodicalId":15319,"journal":{"name":"Journal of Child Neurology","volume":" ","pages":"636-646"},"PeriodicalIF":1.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0