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Synthesis of new 5-benzylidene-hydantoin esters 新型5-苄基-乙酰胆碱酯的合成
Journal of Chemical Research-s Pub Date : 2022-07-01 DOI: 10.1177/17475198221104183
N. R. Tshiluka, M. V. Bvumbi, Unarine Tshishonga, S. S. Mnyakeni-Moleele
{"title":"Synthesis of new 5-benzylidene-hydantoin esters","authors":"N. R. Tshiluka, M. V. Bvumbi, Unarine Tshishonga, S. S. Mnyakeni-Moleele","doi":"10.1177/17475198221104183","DOIUrl":"https://doi.org/10.1177/17475198221104183","url":null,"abstract":"Compounds containing a hydantoin moiety are found in several medicines in clinical use. In this research, ethyl- and methyl-[2-(5-benzylidene)-2,4-dioxoimidazolidin-3-yl]acetyl esters are successfully synthesized over four reaction steps using conventional methods. The synthesis begins by subjecting hydantoin to a Knoevenagel condensation reaction with three different benzaldehydes to afford the penultimate products, which are further reacted with ethyl or methyl (bromoacetyl)alaninates, butanoates, valinates, and norvalinates to give the desired products as esters in low to moderate yields.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"117 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86173220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Novel spiroheterocycles containing a 1,3,4-thiadiazole unit: Synthesis and spectroscopic characterization 含有1,3,4-噻二唑的新型螺杂环化合物:合成与光谱表征
Journal of Chemical Research-s Pub Date : 2022-07-01 DOI: 10.1177/17475198221109503
Shaymaa K. Alazawi, M. Al-Jumaili
{"title":"Novel spiroheterocycles containing a 1,3,4-thiadiazole unit: Synthesis and spectroscopic characterization","authors":"Shaymaa K. Alazawi, M. Al-Jumaili","doi":"10.1177/17475198221109503","DOIUrl":"https://doi.org/10.1177/17475198221109503","url":null,"abstract":"We describe the preparation of a series of novel spiroheterocycles, namely 1,3,4-thiadiazole derivatives possessing an indane unit. These active heterocyclic compounds are prepared starting from thiocarbohydrazide and 2-indanone via an intermediate indan-2-thiocarbohydrazone which is used to afford the corresponding 2-(1-acetylhydrazino)-4H-acetyl-5-spiro(indano-2-yl)-1,3,4-thiadiazoline in an acidic medium. The 1,3,4-thiadiazole derivatives are obtained in good yields by reaction with aromatic carboxylic acids at reflux temperature in the presence of POCl3 as a catalyst, their structure–activity relationships are discussed and the structures of the newly synthesized derivatives are confirmed by spectroscopic techniques.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88057230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The practical acetylation of nucleosides using acetic anhydride/acetic acid as a reusable solvent 用乙酸酐/乙酸作为可重复使用的溶剂进行核苷的乙酰化
Journal of Chemical Research-s Pub Date : 2022-07-01 DOI: 10.1177/17475198221115020
Ran Xia, Chao Xia, Ying-Xing Yang, Li-Jie Liu, Lei-Shan Chen, Li-Ping Sun
{"title":"The practical acetylation of nucleosides using acetic anhydride/acetic acid as a reusable solvent","authors":"Ran Xia, Chao Xia, Ying-Xing Yang, Li-Jie Liu, Lei-Shan Chen, Li-Ping Sun","doi":"10.1177/17475198221115020","DOIUrl":"https://doi.org/10.1177/17475198221115020","url":null,"abstract":"The highly practical acetylation of free nucleosides is achieved using acetic anhydride/acetic acid as a reusable solvent and acetylating regent. A series of nucleosides, including ribosyl, deoxyribosyl, arabinosyl, acyclic and pyranosyl, and many clinical drugs were acetylated efficiently, even on large scale (200 g).","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"556 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87005588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A fluorescent chemosensor based on β-N-glycosyl and coumarin for sensing of Hg(II) ions in acetonitrile 基于β- n -糖基和香豆素的荧光化学传感器用于乙腈中Hg(II)离子的检测
Journal of Chemical Research-s Pub Date : 2022-07-01 DOI: 10.1177/17475198221109402
X. Gu, Bin Huang, Cuixia Xu, Dawei Jiang, Qiang Zhao
{"title":"A fluorescent chemosensor based on β-N-glycosyl and coumarin for sensing of Hg(II) ions in acetonitrile","authors":"X. Gu, Bin Huang, Cuixia Xu, Dawei Jiang, Qiang Zhao","doi":"10.1177/17475198221109402","DOIUrl":"https://doi.org/10.1177/17475198221109402","url":null,"abstract":"A novel fluorescent chemosensor containing a coumarin–thiourea unit and a β-N-glycosyl moiety is designed, synthesized, and characterized by 1H NMR, 13C NMR, and elemental analysis. The chemosensor can selectively and efficiently detect Hg2+ in CH3CN with a detection limit of 2.6 μM.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85920661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Analysis of certain samples of phenazine dyes from the Historical Dyestuff Collection of the Technical University Dresden by liquid chromatography–mass spectrometry 用液相色谱-质谱法分析德累斯顿工业大学历史染料收集的某些非那嗪染料样品
Journal of Chemical Research-s Pub Date : 2022-07-01 DOI: 10.1177/17475198221109187
Oliver Reinke, S. Machill, H. Hartmann
{"title":"Analysis of certain samples of phenazine dyes from the Historical Dyestuff Collection of the Technical University Dresden by liquid chromatography–mass spectrometry","authors":"Oliver Reinke, S. Machill, H. Hartmann","doi":"10.1177/17475198221109187","DOIUrl":"https://doi.org/10.1177/17475198221109187","url":null,"abstract":"By means of liquid chromatography–mass spectrometry and other analytical methods, a variety of different samples of the phenazine dye Chrysaniline hosted in the Historical Dyestuff Collection of the Technical University Dresden and registered mostly under the trade name Phosphine have been analysed. It was found that all the dyes analysed are mixtures of compounds with different numbers of methyl groups at their phenazine core. They result, hence, from the oxidation of technical aniline that contained several amounts of isomeric toluidines and traces of dimethylanilines.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"215 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76105563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of the medium composition and product extraction for R-mandelic acid using recombinant Escherichia coli expressing Alcaligenes sp. nitrilase 利用表达Alcaligenes sp. nitrilase的重组大肠杆菌优化r -扁桃酸培养基组成及产物提取
Journal of Chemical Research-s Pub Date : 2022-07-01 DOI: 10.1177/17475198221109155
Xinhong Zhang, Fei Chang, Fucheng Zhu, Tao Xu, Yi Zhang
{"title":"Optimization of the medium composition and product extraction for R-mandelic acid using recombinant Escherichia coli expressing Alcaligenes sp. nitrilase","authors":"Xinhong Zhang, Fei Chang, Fucheng Zhu, Tao Xu, Yi Zhang","doi":"10.1177/17475198221109155","DOIUrl":"https://doi.org/10.1177/17475198221109155","url":null,"abstract":"The aim of this study is to investigate the effects of the components of the medium on nitrilase expression in recombinant Escherichia coli (E. coli), which is applied in the hydrolysis of racemic mandelonitrile (MN) to R-mandelic acid (MA). In addition, the separation of R-MA from the reaction mixture is studied. The glycerol medium is screened, and compositions are optimized in single-factor experiments. The nitrilase activity is 1.96-fold higher than before using the optimal medium containing peptone 15 g/L, yeast extract 12 g/L, NaCl 10 g/L, glycerol 15 g/L, (NH4)2SO4 5 g/L, KH2PO4 10 mM, K2HPO4·3H2O 10 mM, and MgSO4·7H2O 15 mM. During the acid-base extraction of R-MA, the optimal alkaline pH, the alkaline extractant ratio, the optimal acidic pH, the acidic extractant ratio and the amount of activated carbon are 10.0, 1:0.5 (once), 2.50, 1:2 (twice) and 1%, respectively. This study provides a basis for the industrial production of R-MA.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87657123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective oxidation of primary benzylic alcohols to aldehydes using NaNO3 under ball milling 纳米3球磨法选择性氧化伯苯醇制醛
Journal of Chemical Research-s Pub Date : 2022-07-01 DOI: 10.1177/17475198221101983
Jing-Fei Wang, Li-Yu Lu, Pu Zhang, Yujun Qin, Zhi‐Xin Guo
{"title":"Selective oxidation of primary benzylic alcohols to aldehydes using NaNO3 under ball milling","authors":"Jing-Fei Wang, Li-Yu Lu, Pu Zhang, Yujun Qin, Zhi‐Xin Guo","doi":"10.1177/17475198221101983","DOIUrl":"https://doi.org/10.1177/17475198221101983","url":null,"abstract":"A facile method for oxidation of primary benzylic alcohols to the corresponding aldehydes is reported using NaNO3/P2O5 under high-speed ball-milling conditions. This approach is clean, efficient, and exhibits broad functional group compatibility.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76663307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extensive exploration of the conformational landscapes of neutral and terminally blocked prolines in the gas phase: A density functional theory study 中性和末端阻断脯氨酸在气相构象景观的广泛探索:密度泛函理论研究
Journal of Chemical Research-s Pub Date : 2022-07-01 DOI: 10.1177/17475198221110480
Yizhou Yang, Zijing Lin
{"title":"Extensive exploration of the conformational landscapes of neutral and terminally blocked prolines in the gas phase: A density functional theory study","authors":"Yizhou Yang, Zijing Lin","doi":"10.1177/17475198221110480","DOIUrl":"https://doi.org/10.1177/17475198221110480","url":null,"abstract":"Proline is an important amino acid that plays unique roles in the structures of peptides and proteins. The conformations of proline are searched by a thorough method, generating 3888 trial structures optimized at the B97D/6-311++G** level. A total of 23 conformations are found and their structural and energetic data are presented. All the proline conformers exhibit a coplanar feature for four of the five pyrrolidine ring atoms. The coplanar rule reduces the cost of the conformational search by a factor of 40. The theoretical composition-weighted infrared spectrum provides a good explanation of the experimental results. A conformational search of capped proline yields seven unique conformers, all with trans C-termini peptide planes. The trans C-termini rule further cuts by half the cost of the conformational search of proline-containing peptides. The theoretical composition of the cis N-termini peptide bonds at room temperature is 5.5%, agreeing with the experimental estimations of 3%–10%.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72833413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the mechanism of the excellent catalytic activity of NiFe-layered double hydroxides in oxygen evolution reactions by modifying the iron content 通过改变铁的含量，探讨nife层状双氢氧化物在析氧反应中优异催化活性的机理
Journal of Chemical Research-s Pub Date : 2022-05-01 DOI: 10.1177/17475198221103519
Y. Liu, Xueyan Lei, Bing-Qing Xiong, Ji-Fang Chen, W. Zou, Z. Fu, Yalin Lu
{"title":"Exploring the mechanism of the excellent catalytic activity of NiFe-layered double hydroxides in oxygen evolution reactions by modifying the iron content","authors":"Y. Liu, Xueyan Lei, Bing-Qing Xiong, Ji-Fang Chen, W. Zou, Z. Fu, Yalin Lu","doi":"10.1177/17475198221103519","DOIUrl":"https://doi.org/10.1177/17475198221103519","url":null,"abstract":"Layered double hydroxides are very promising catalysts for water splitting, in particular NiFe-layered double hydroxide, which has attracted significant attention due to its excellent catalytic activity in oxygen evolution reactions using alkaline electrolytes. In this work, samples with different molar ratios of Ni to Fe are prepared by a typical hydrothermal method to study the effect of iron on the catalytic properties of NiFe-layered double hydroxide. All the NiFe-layered double hydroxides exhibit much better oxygen evolution reaction activity than NiOOH, while increasing the iron content slightly affects the activity, which implies that only Fe ions at some specific site contribute to the oxygen evolution reaction activity. The NiFe-layered double hydroxide with a 4:1 molar ratio of Ni to Fe shows the best oxygen evolution reaction catalytic performance, and requires only an overpotential of 176 mV to afford a current of 10 mA cm−2 in 1.0 M KOH, and exhibits a much lower Tafel slope (51 mV dec−1). This work also studies the effect of iron on the electronic structure of nickel and reveals the mechanism behind the excellent oxygen evolution reaction catalytic properties of NiFe-layered double hydroxide.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"134 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90455392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A convenient route to mono-trans polyunsaturated free fatty acids 单反式多不饱和游离脂肪酸的便捷途径
Journal of Chemical Research-s Pub Date : 2022-03-01 DOI: 10.1177/17475198221090908
Fabrizio Vetica, A. Sansone, C. Ferreri, C. Chatgilialoglu
{"title":"A convenient route to mono-trans polyunsaturated free fatty acids","authors":"Fabrizio Vetica, A. Sansone, C. Ferreri, C. Chatgilialoglu","doi":"10.1177/17475198221090908","DOIUrl":"https://doi.org/10.1177/17475198221090908","url":null,"abstract":"Trans unsaturated fatty acids in humans may be originated both from dietary supplementation and from an endogenous free-radical-catalyzed cis−trans isomerization of fatty acid residues in naturally occurring cis lipids. The latter process affords geometrical isomers and the polyunsaturated fatty acid mono-trans isomers were demonstrated to be connected with stress conditions in living organisms. Synthesis of mono-trans polyunsaturated fatty acid is useful for analytical and biological research, and in this case, the availability of free fatty acids is needed as well as the possibility of mg scale of the synthetic protocol. Herein, we report a simple synthetic route to mono-trans isomers of arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid, which includes thiyl radical-catalyzed isomerization reaction of polyunsaturated fatty acid methyl esters and fraction isolation of mono-trans mixture isomers followed by optimization of hydrolysis condition to free fatty acids and purification of each mono-trans polyunsaturated fatty acid. Our approach to mono-trans polyunsaturated fatty acids as free acids can reach the mg scale, thus fostering more applications to biochemical and biological studies.","PeriodicalId":15318,"journal":{"name":"Journal of Chemical Research-s","volume":"80 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72419516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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