用乙酸酐/乙酸作为可重复使用的溶剂进行核苷的乙酰化

Journal of Chemical Research-s Pub Date : 2022-07-01 DOI:10.1177/17475198221115020

Ran Xia, Chao Xia, Ying-Xing Yang, Li-Jie Liu, Lei-Shan Chen, Li-Ping Sun

引用次数: 0

摘要

采用乙酸酐/乙酸作为可重复使用的溶剂和乙酰化试剂，实现了高度实用的游离核苷乙酰化。一系列核苷，包括核糖基、脱氧核糖基、阿拉伯糖基、无环和吡喃糖基，以及许多临床药物被有效乙酰化，甚至大规模(200 g)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The practical acetylation of nucleosides using acetic anhydride/acetic acid as a reusable solvent

The highly practical acetylation of free nucleosides is achieved using acetic anhydride/acetic acid as a reusable solvent and acetylating regent. A series of nucleosides, including ribosyl, deoxyribosyl, arabinosyl, acyclic and pyranosyl, and many clinical drugs were acetylated efficiently, even on large scale (200 g).

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来源期刊

Journal of Chemical Research-s 化学科学, 有机化学, 有机合成

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Chemical Research is a peer reviewed journal that publishes full-length review and research papers in all branches of experimental chemistry. The journal fills a niche by also publishing short papers, a format which favours particular types of work, e.g. the scope of new reagents or methodology, and the elucidation of the structure of novel compounds. Though welcome, short papers should not result in fragmentation of publication, they should describe a completed piece of work. The Journal is not intended as a vehicle for preliminary publications. The work must meet all the normal criteria for acceptance as regards scientific standards. Papers that contain extensive biological results or material relating to other areas of science may be diverted to more appropriate specialist journals. Areas of coverage include: Organic Chemistry; Inorganic Chemistry; Materials Chemistry; Crystallography; Computational Chemistry.