新型5-苄基-乙酰胆碱酯的合成

Journal of Chemical Research-s Pub Date : 2022-07-01 DOI:10.1177/17475198221104183

N. R. Tshiluka, M. V. Bvumbi, Unarine Tshishonga, S. S. Mnyakeni-Moleele

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引用次数: 1

摘要

在临床使用的几种药物中发现了含有乙酰胆碱部分的化合物。本研究采用常规方法，通过四个步骤合成了乙酯和甲基-[2-(5-苄基)-2,4-二氧基咪唑烷-3-基]乙酰酯。首先，将海因酮与三种不同的苯甲醛进行Knoevenagel缩合反应，得到第二代产物，第二代产物再与乙基或甲基(溴乙酰基)丙氨酸酸酯、丁酸酯、缬氨酸酸酯和去缬氨酸酸酯反应，得到所需的低至中等产量的酯类产物。

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Synthesis of new 5-benzylidene-hydantoin esters

Compounds containing a hydantoin moiety are found in several medicines in clinical use. In this research, ethyl- and methyl-[2-(5-benzylidene)-2,4-dioxoimidazolidin-3-yl]acetyl esters are successfully synthesized over four reaction steps using conventional methods. The synthesis begins by subjecting hydantoin to a Knoevenagel condensation reaction with three different benzaldehydes to afford the penultimate products, which are further reacted with ethyl or methyl (bromoacetyl)alaninates, butanoates, valinates, and norvalinates to give the desired products as esters in low to moderate yields.

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来源期刊

Journal of Chemical Research-s 化学科学, 有机化学, 有机合成

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Chemical Research is a peer reviewed journal that publishes full-length review and research papers in all branches of experimental chemistry. The journal fills a niche by also publishing short papers, a format which favours particular types of work, e.g. the scope of new reagents or methodology, and the elucidation of the structure of novel compounds. Though welcome, short papers should not result in fragmentation of publication, they should describe a completed piece of work. The Journal is not intended as a vehicle for preliminary publications. The work must meet all the normal criteria for acceptance as regards scientific standards. Papers that contain extensive biological results or material relating to other areas of science may be diverted to more appropriate specialist journals. Areas of coverage include: Organic Chemistry; Inorganic Chemistry; Materials Chemistry; Crystallography; Computational Chemistry.