Journal of Cancer Survivorship最新文献

{"title":"Differences in COVID-19 preventive behaviors among Black and White cancer survivors in North Carolina.","authors":"Amanda Y Kong, Allison M Deal, Marah Maaita, Adrian Gerstel, Jennifer Richmond, Erin E Kent","doi":"10.1007/s11764-025-01871-9","DOIUrl":"10.1007/s11764-025-01871-9","url":null,"abstract":"<p><strong>Purpose: </strong>Engaging in COVID-19 preventive behaviors (e.g., wearing masks) can be particularly important for cancer survivors to avoid infectious disease. This cross-sectional study aimed to examine preventive behaviors of Black and White cancer survivors residing in North Carolina during the COVID-19 pandemic.</p><p><strong>Methods: </strong>From February through September 2022, we recruited 548 cancer survivors from the University of North Carolina Health Registry/Cancer Survivorship Cohort. Participants completed a retrospective survey about their COVID-preventive behaviors between March 2020 and December 2020 (Time 1) and within the last 30 days (Time 2). We examined differences and changes over time in the prevalence of behaviors by race.</p><p><strong>Results: </strong>At Time 1, Black cancer survivors had a higher prevalence of wearing gloves (adjusted prevalence ratio [aPR], 2.99; 95% CI 1.33-6.75), limiting visitors inside their homes (aPR, 1.22; 95% CI, 1.06-1.39), and avoiding public spaces, gatherings, and crowds (aPR, 1.13; 95% CI, 1.01-1.26) compared to White cancer survivors. While both Black and White cancer survivors decreased the prevalence of preventive behaviors at Time 2, White cancer survivors decreased their preventive behaviors at a greater rate than Black cancer survivors.</p><p><strong>Conclusions: </strong>Black cancer survivors took more behavioral precautions and continued them over time at a higher rate than White cancer survivors. Despite the use of individual-level COVID-related preventive measures, inequities in COVID-related morbidity and mortality persist, underscoring the need for more multi-level interventions to address COVID-related inequities.</p><p><strong>Implications for cancer survivors: </strong>State and local prioritization of equitable resource allocation to cancer survivors may improve long-term survivorship care and well-being.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"871-880"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13022956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise interventions and physical activity in adults living with and beyond blood cancer: a scoping review.","authors":"Ojbindra Kc, Moataz Ellithi, Emily Herdman, Danielle Westmark, Tanya M Wildes, Edward S Peters, Sara E Bills, Windy Alonso, Vijaya R Bhatt","doi":"10.1007/s11764-025-01822-4","DOIUrl":"10.1007/s11764-025-01822-4","url":null,"abstract":"<p><strong>Purpose: </strong>Adults living with and beyond cancer (survivors) often face physical and psychological challenges, including pain, fatigue, sleep disturbances, and depression, which impair quality of life (QOL). While exercise interventions are demonstrated to benefit survivors of solid tumors, their impact on survivors of blood cancer remains underexplored. This review evaluates the evidence regarding exercise interventions in survivors of blood cancer, focusing on intervention types, study participant characteristics, and reported outcomes.</p><p><strong>Methods: </strong>A literature search was conducted using Embase (Elsevier), Medline (EBSCO), CINAHL (EBSCO), and Scopus (Elsevier) to identify studies on exercise interventions in survivors of blood cancer published through March 15, 2024. Articles were screened based on inclusion criteria, including adults aged 18 or older who completed cancer treatment and underwent exercise interventions. Exclusion criteria included pediatric populations, active cancer treatment, study protocols, incomplete results, or non-English publications.</p><p><strong>Results: </strong>Seventeen studies were identified, including nine feasibility studies and eight randomized controlled trials. Participants, predominantly white, had a median age range of 31.5-63.5 years. Interventions, often combining aerobic and resistance exercises, were delivered three times weekly over 8-12 weeks. Feasibility studies reported adherence rates of 66-87% and retention rates of 70-95%, with improvements in QOL and physical function. Randomized controlled trials similarly demonstrated benefits in fatigue, QOL, and physical function.  CONCLUSIONS: Exercise interventions improve QOL for survivors of blood cancer, though long-term effectiveness and adherence require further study.</p><p><strong>Implications for cancer survivors: </strong>Future research should focus on diverse populations and long-term outcomes to develop tailored, accessible exercise interventions for survivors of blood cancer.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"283-292"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of home-based exercise program on patients with aplastic anemia treated with allogeneic hematopoietic stem cell transplantation: a non-randomized trial.","authors":"Menghua Ye, Chenyi Xu, Xiaoxue Tan, Min Cao, Min Xu","doi":"10.1007/s11764-025-01824-2","DOIUrl":"10.1007/s11764-025-01824-2","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to assess the adherence and safety of the home-based exercise program in patients with aplastic anemia (AA) who are undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Additionally, it aims to determine whether this program can enhance patients' quality of life (QoL), alleviate fatigue, increase exercise tolerance, and reduce psychological stress.</p><p><strong>Methods: </strong>This study involved 80 patients with AA from the Hematology Department of a comprehensive tertiary hospital. All participants met the British Committee for Standards in Haematology (BCSH) diagnostic criteria, were aged 18-65 years, and had undergone allo-HSCT within the past 1-12 months. All patients were enrolled within 100 days post-transplant discharge. The control group received standard exercise nursing care, while the intervention group completed a 12-week home-based exercise program. Adherence and safety were monitored during the intervention, and QoL, fatigue level, exercise tolerance, and psychological distress were assessed at baseline (T0), week 4 (T1), week 8 (T2), and week 12 (T3).</p><p><strong>Results: </strong>Exercise adherence exceeded 70%, with no adverse events reported. Repeated measures analysis revealed that QoL scores and 6MWD increased over time for both groups. At weeks 4, 8, and 12 of the intervention, the experimental group exhibited significantly higher QoL scores and 6MWD compared to the control group, with the differences being statistically significant. Both groups demonstrated a decrease in fatigue and psychological distress scores as the intervention progressed. At weeks 4, 8, and 12, the experimental group reported significantly lower levels of fatigue and psychological distress than the control group, with these differences also reaching statistical significance and a small to moderate effect size.</p><p><strong>Conclusions: </strong>Home-based exercise is feasible for patients with AA undergoing allo-HSCT and showed an improvement in QoL, fatigue, exercise tolerance, and psychological status, which can serve as an effective adjuvant therapy during the post allo-transplant rehabilitation process.</p><p><strong>Implications for cancer survivors: </strong>This study provides a new perspective and method for the long-term rehabilitation of AA patients following allo-HSCT.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"507-519"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing NCCN distress thermometer use in real-world settings: a systematic review and thematic synthesis of the literature.","authors":"Priyal Agarwal, Pranav M Patel, Caleb Powell, Meghana Kesireddy","doi":"10.1007/s11764-025-01807-3","DOIUrl":"10.1007/s11764-025-01807-3","url":null,"abstract":"<p><strong>Purpose: </strong>This systematic review aims to examine the workflows in distress screening and referral using the NCCN distress thermometer (DT) in the US, aiming to identify key elements for flexible, organization-specific approaches.</p><p><strong>Methods: </strong>A systematic review of full-text manuscripts published from 2013 to May 2024 was conducted using MEDLINE, EMBASE, and CINAHL. Studies describing distress screening and referral protocols were included, while systematic reviews, commentaries, non-US studies, non-English publications, and studies on distress score-disease burden associations were excluded. Attributes of distress screening and referral pathways were extracted.</p><p><strong>Results: </strong>From an initial 1219 articles, 19 studies were included. Significant variability was observed in NCCN DT workflows, particularly in responder characteristics (e.g., cancer type, patient vs. caregiver). Nursing staff primarily administered screenings, varying by mode (paper vs. electronic), frequency, and location (home vs. clinic). A cut-off score of 4 or higher often triggered referrals, with some studies further stratifying distress levels for tailored follow-ups. Referral pathways included educational resources, behavioral and emotional health, social support, and rehabilitative and supportive care services. Caregiver distress screening was infrequent.</p><p><strong>Conclusion: </strong>This review underscores the variability in NCCN DT workflows and the need for customizable protocols. While standardization is desirable, some variation is essential to accommodate the differing availability of resources and personnel for effective distress screening and referral.</p><p><strong>Implications for cancer survivors: </strong>Effective distress screening and referral pathways ensure survivors receive timely psychological, emotional, and social support, improving quality of life. Integrating caregiver distress screening into workflows could amplify overall support systems, fostering holistic survivorship care. A flexible yet structured approach enhances access to tailored interventions, promoting resilience in survivors and caregivers.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"1077-1086"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medically tailored meals in lung cancer care: patient experiences from the NutriCare Clinical Trial.","authors":"Caroline E Owens, Laura Keaver, Divina Chandiramani, James McCann, Mary Kathryn Cohen, Joya Chandra, Carolyn J Presley, Jessica R Bauman, Lori Pai, Sue Daugherty, Jade Smith, Colleen Spees, Fang Fang Zhang","doi":"10.1007/s11764-025-01857-7","DOIUrl":"10.1007/s11764-025-01857-7","url":null,"abstract":"<p><strong>Purpose: </strong>To understand the perceptions and experiences of participants in NutriCare, a randomized controlled trial of medically tailored meals and nutrition counseling using medical nutrition therapy informed by motivational interviewing for patients with lung cancer.</p><p><strong>Methods: </strong>Descriptive analysis of exit surveys and thematic analysis of semi-structured interviews with 21 intervention arm (NutriCare) trial participants.</p><p><strong>Results: </strong>Most exit survey respondents reported overall satisfaction with the intervention, particularly with the nutrition counseling. In comparison, satisfaction with the medically tailored meals was more variable. Six main themes emerged from qualitative analysis: (1) convenience of medically tailored meals, (2) support navigating cancer and treatment impacts, (3) preference for fresher and more flavorful foods, (4) desire for increased food choice and meal flexibility, (5) dietitians' role in providing nutrition expertise and social support, and (6) enhanced motivation and knowledge promoting behavior change.</p><p><strong>Conclusions: </strong>Overall, participants valued the convenience of the NutriCare intervention, emphasizing the logistic ease of home-delivered meals and remote nutrition counseling during cancer treatment. Many participants felt the intervention supported their nutritional needs and overall well-being. Our findings underscore the perceived benefits of nutrition education and counseling in tandem with direct provision of food and point to a need for further research on tailoring FIM interventions for diverse patients with lung cancer.</p><p><strong>Implications for cancer survivors: </strong>Food is Medicine interventions, like NutriCare, show promise in supporting the nutrition and well-being of vulnerable patients with lung cancer, with additional benefits when combined with personalized nutrition counseling.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"787-798"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lived experience of comfort with sexuality and fertility for survivors of hematopoietic progenitor cell transplants: phenomenological study.","authors":"Lúcia Bacalhau, Patrícia Pontífice-Sousa","doi":"10.1007/s11764-025-01752-1","DOIUrl":"10.1007/s11764-025-01752-1","url":null,"abstract":"<p><strong>Introduction: </strong>Sexuality and fertility are deeply personal and fundamental aspects of human identity and quality of life. For survivors of hematopoietic stem cell transplants (HSCT), these areas can be profoundly affected by the physical, emotional, and social impacts of the treatment. Discomfort or lack of clarity regarding these issues can lead to long-term psychological distress, relationship challenges, and decreased overall well-being. Addressing this discomfort through research helps to fill a critical gap in supportive care, providing survivors with the tools and knowledge they need to navigate these challenges and enhance their post-treatment quality of life.</p><p><strong>Purpose: </strong>To grasp the scope of sexuality and fertility within the lived experiences of comfort and discomfort among allogeneic stem cell transplant survivors.</p><p><strong>Methods: </strong>We employed a qualitative approach through van Manen's phenomenology of practice. The phenomenon was revealed via phenomenological interviews, incorporating narratives and illustrative episodes that captured the lived experiences of 20 survivors. We gathered descriptions of these experiences from participants from July 2020 to May 2021. During our phenomenological reflection on these accounts, we adhered to stages like epoché, reduction, and vocative, as outlined by van Manen (van Manen 2014).</p><p><strong>Results: </strong>The exploration of comfort within the realms of sexuality and fertility yielded several themes: desire and the relationship; immunosuppression as a limitation on sexual activity; the body does not correspond to desire; the future: fertility and the couple's relationship; the challenges of disclosure and intervention.</p><p><strong>Conclusion: </strong>The findings indicate that survivors have long-term challenges with sexual expression and activity, stemming from the physical constraints of graft-versus-host disease (GVHD), perceptions of their immunosuppression, and the significance of their partnership, all of which translate into requirements for nursing care.</p><p><strong>Implications for care and support cancer survivors: </strong>Considering the experiences of these participants and the observed comfort linked to the sexuality of ASCT survivors, we can contemplate the care practices and recognize sexuality as a field of action for nurses in this context to enhance comfort for these individuals.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"1525-1537"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143449249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of chemotherapy-induced peripheral neuropathy on physical function in pediatric cancer survivors: a systematic review.","authors":"Lynn R Tanner, Catherine Demers, Erica N Schorr, Nathan S Rosenberg, Mary C Hooke, Lucie M Turcotte, Diane Treat-Jacobson","doi":"10.1007/s11764-025-01763-y","DOIUrl":"10.1007/s11764-025-01763-y","url":null,"abstract":"<p><strong>Purpose: </strong>The majority of children, adolescents, and young adults treated with neurotoxic chemotherapy experience chemotherapy-induced peripheral neuropathy (CIPN). This side effect can cause numbness and tingling, distal weakness, and autonomic symptoms. These symptoms can lead to impaired physical function and interrupt the development of a child's motor skills. This systematic review provides an essential overview of the relationship between CIPN and physical function impairments, activity limitations, and participation restrictions in children, adolescents, and young adults with cancer.</p><p><strong>Methods: </strong>Following PRISMA guidelines, a search was conducted using the MEDLINE and CINAHL databases between 2013 and March 2024. The quality of each study was assessed using the Joanna Briggs Critical Appraisal Tools. A total of 14 studies were included.</p><p><strong>Results: </strong>This critical review demonstrated significant relationships between CIPN and measures of manual dexterity, gait, balance, motor proficiency, and health-related quality of life. These relationships were observed during treatment and persisted in many survivors years after completing treatment. Higher-level skills such as running speed, standing on one leg, and gait quality over time were more likely to be impacted than basic mobility.</p><p><strong>Conclusion: </strong>CIPN impacts multiple components of physical function and health-related quality of life in survivors of pediatric cancer. In addition to pharmacological and non-pharmacological interventions targeted at these limitations, greater understanding is needed regarding the longitudinal course of these findings with comprehensive assessments sensitive to higher-level physical function.</p><p><strong>Implications for cancer survivors: </strong>Assessment of CIPN and physical function for survivors treated with neurotoxic agents is critical to guiding supportive care interventions aimed at improving cancer survivorship.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"1631-1647"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies to improve participation in exercise programmes during chemotherapy: a modified nominal group technique.","authors":"N Kearney, D Connolly, K Bahramian, E Guinan","doi":"10.1007/s11764-025-01771-y","DOIUrl":"10.1007/s11764-025-01771-y","url":null,"abstract":"<p><strong>Purpose: </strong>Exercise can help people manage many of the side effects of chemotherapy treatment. Clear guidelines exist outlining the benefits of exercise during chemotherapy and recommended dosage; however, achieving these guidelines remains problematic. The purpose of this study is to reach an agreement on suitable strategies to improve recruitment, adherence, and retention rates to exercise programmes during chemotherapy with the involvement of key stakeholders.</p><p><strong>Methods: </strong>This study used a modified nominal group technique (NGT). Participants included individuals with a lived experience of chemotherapy and healthcare professionals working in oncology. Three workshops were carried out, two in-person and one online. The in-person workshops addressed the first four stages of the NGT, introduction, idea generation, round-robin recording, and group discussion. Voting and ranking of ideas occurred during the online workshop.</p><p><strong>Results: </strong>Nineteen individuals took part in this study, including 12 people with a lived experience of chemotherapy and seven healthcare professionals. The highest-ranked strategy to improve recruitment was to inform individuals about the benefits of exercise at the time of receiving their treatment plan, with 53% of first preference votes. Participants also agreed that direct instruction from their oncologist would have the greatest impact on successful recruitment to an exercise programme, receiving 47% of first preference votes. To enhance exercise adherence, an in-person exercise programme delivered in an exercise facility received 46% of first preference votes. Finally, 43% of participants agreed that the provision of a pedometer would support retention, and 86% of people wanted to receive weekly phone calls/check-ins.</p><p><strong>Conclusion: </strong>This study provides strategies to overcome barriers to recruitment, adherence, and retention to exercise programmes during chemotherapy, and will help to optimise participant engagement for future interventions.</p><p><strong>Implications for cancer survivors: </strong>The involvement of key stakeholders in this study will contribute towards ensuring that future interventions are pragmatic and patient-centred.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"1729-1739"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13375752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of exercise interventions on fatigue, body composition, physical fitness, and biomarkers in breast cancer patients during and after treatment: a systematic review and meta-analysis of randomized controlled trials.","authors":"Junga Lee, YooSun Hwang","doi":"10.1007/s11764-025-01772-x","DOIUrl":"10.1007/s11764-025-01772-x","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is the leading cancer type among women, accounting for 24.5% of female cancer cases worldwide.</p><p><strong>Objective: </strong>The purpose of this study is to systematically review and conduct a meta-analysis to evaluate the effects of exercise interventions on breast cancer patients at different stages of treatment.</p><p><strong>Methods: </strong>Databases including PubMed, Cochrane Library, and Embase were searched for English-language randomized controlled trials (RCTs) published since 2000. The study included data from women aged 18 and above with breast cancer, either undergoing treatment or after treatment. Effect sizes were calculated using the standardized mean difference.</p><p><strong>Results: </strong>Out of 2845 studies, 40 met the inclusion criteria, with 17 studies focusing on patients undergoing treatment and 23 on after treatment patients. Exercise significantly reduced fatigue both undergoing (d =  - 0.20) and after treatment (d =  - 1.11). After treatment exercise interventions resulted in improvements in lean mass (d = 1.27), fat mass (d =  - 1.33), percentage body fat (d =  - 1.22), and waist circumference (d =  - 0.69). Additionally, biomarkers such as IL-6, HDL, LDL, glucose, systolic blood pressure (SBP), and diastolic blood pressure (DBP) showed improvements after treatment.</p><p><strong>Conclusions: </strong>Exercise interventions are effective in reducing fatigue and enhancing fitness while undergoing treatment and have positive effects on body composition and biomarkers after treatment. Low-to-moderate intensity exercise is recommended undergoing treatment, while moderate-to-high intensity exercise is beneficial after treatment.</p><p><strong>Implications for cancer survivors: </strong>Personalized exercise programs should be incorporated as a standard part of care in clinical settings to alleviate fatigue undergoing treatment and improve body composition and biomarkers following treatment.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"1740-1768"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of exercise interventions on functional outcomes in frail adults with a previous or current diagnosis of cancer: a systematic review and meta-analysis.","authors":"Maya El-Zahed, Lou-Anne Laura Carsault, Madison Lee Grande, Jasmin Espinoza-Alvarado, Brandon Cotton, Jordan Langille, Holly Edward, Jenna Smith-Turchyn","doi":"10.1007/s11764-025-01749-w","DOIUrl":"10.1007/s11764-025-01749-w","url":null,"abstract":"<p><strong>Purpose: </strong>Exercise improves functional outcomes in individuals with frailty and individuals with cancer, but it is unknown how exercise impacts function in individuals with both cancer and frailty. This systematic review aimed to determine if adults with cancer who are frail and participate in an exercise program have better functional outcomes compared to those who do not.</p><p><strong>Methods: </strong>Five databases (OVID Medline, Embase, CINAHL, EMCARE, and Ageline) were searched from inception to March 2024 for RCTs that investigated the impact of exercise on functional outcomes in individuals with cancer who are frail and ≥ 18 years. Title/abstract, full text review, and data extraction were done in duplicate. Cochrane ROB2 was used to assess risk of bias and GRADE for certainty of results.</p><p><strong>Results: </strong>Eleven RCTs with 1419 participants were included in this review. Meta-analysis did not find a significant difference between intervention and control groups for submaximal walking tests (95% CI 0.24 (- 0.05-0.53), Short Physical Performance Battery (95% CI - 0.50 (- 1.15-0.15)), and grip strength (95% CI 1.83 (- 0.75 to 4.41). However, positive trends emerged for those participating in exercise programs related to submaximal walking test, grip strength, sit to stand, SPPB, and TUG scores.</p><p><strong>Conclusion: </strong>There are few RCTs investigating exercise in this population, with high heterogeneity of existing interventions. This leads to low certainty in the results of the current study.</p><p><strong>Implications for cancer survivorship: </strong>Cancer survivors and patients need to be screened for frailty and be engaged in appropriate exercise. Further work should be done investigating appropriate parameters of exercise interventions for this population.</p>","PeriodicalId":15284,"journal":{"name":"Journal of Cancer Survivorship","volume":" ","pages":"1480-1498"},"PeriodicalIF":3.4,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}