Prevalence and trends of cancer-related daily life limitations among gastrointestinal cancer survivors.

IF 3.1 2区医学 Q2 ONCOLOGY

Journal of Cancer Survivorship Pub Date : 2025-05-24 DOI:10.1007/s11764-025-01833-1

Azza Sarfraz, Abdullah Altaf, Mujtaba Khalil, Zayed Rashid, Shahzaib Zindani, Areesh Mevawalla, Timothy M Pawlik

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引用次数: 0

Abstract

Purpose: The number of gastrointestinal (GI) cancer survivors has increased substantially due to improvements in early detection and treatment, yet long-term functional patient outcomes remain poorly characterized. We sought to quantify the burden of activity limitations (AL) and functional limitations (FL) among GI cancer survivors compared with non-GI cancer survivors and the general U.S. population, as well as identify key predictors of cancer-related limitations.

Methods: The National Health Interview Survey (NHIS), a nationally representative dataset (1997-2023), was queried to examine the prevalence and trends of cancer-related limitations among GI cancer survivors, non-GI cancer survivors, and the general U.S.

Population: Multivariable logistic regression analyses identified independent predictors of AL and FL, adjusting for demographic and socioeconomic variables.

Results: Among 5,513 GI cancer and 39,887 non-GI cancer survivors, 50.2% (Relative Risk [RR]: 1.23, 95% CI: 1.19-1.27) and 70.7% (RR: 1.07, 95% CI: 1.05-1.09) of GI cancer survivors reported AL and FL, respectively, compared with non-GI cancer survivors. The general U.S. population had a markedly lower prevalence of AL (13.5%; RR: 0.33, 95% CI: 0.33-0.34) and FL (35.7%; RR: 0.54, 95% CI: 0.53-0.54). GI cancer survivors were older (mean age: 69.1 vs. 65.3 vs. 36.1 years), more often single (8.8% vs. 8.6% vs. 28.3%), and more frequently received public insurance (75.1% vs. 68.9% vs. 27.4%) compared with non-GI cancer survivors and the general population (p < 0.05). In multivariable analysis, GI cancer survivors had 21% higher odds of AL (OR: 1.21, 95% CI: 1.11-1.32, p < 0.001) and 11% higher odds of FL (OR: 1.11, 95% CI: 1.00-1.19, p = 0.049).

Conclusions: GI cancer survivors face a significantly higher burden of functional limitations, influenced by demographic and socioeconomic factors.

Implications for cancer survivors: Addressing functional disparities through targeted rehabilitation and support services may improve long-term outcomes.

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胃肠癌幸存者中与癌症相关的日常生活限制的患病率和趋势

目的：由于早期发现和治疗的改进，胃肠道（GI）癌症幸存者的数量大幅增加，但长期功能患者的预后特征仍然很差。我们试图量化GI癌症幸存者与非GI癌症幸存者和普通美国人群相比的活动限制（AL）和功能限制（FL）的负担，并确定癌症相关限制的关键预测因素。方法：对全国健康访谈调查（NHIS），一个具有全国代表性的数据集（1997-2023）进行查询，以检查GI癌症幸存者、非GI癌症幸存者和普通美国人群中癌症相关局限性的患病率和趋势：多变量logistic回归分析确定了AL和FL的独立预测因子，并对人口统计学和社会经济变量进行了调整。结果：在5513名GI癌症和39887名非GI癌症幸存者中，与非GI癌症幸存者相比，50.2%（相对危险度[RR]: 1.23, 95% CI: 1.19-1.27）和70.7% （RR: 1.07, 95% CI: 1.05-1.09）的GI癌症幸存者分别报告AL和FL。美国一般人群的AL患病率明显较低(13.5%；RR: 0.33, 95% CI: 0.33-0.34)和FL (35.7%；Rr: 0.54, 95% ci: 0.53-0.54)。与非GI癌症幸存者和一般人群相比，GI癌症幸存者年龄更大（平均年龄：69.1岁对65.3岁对36.1岁），更常单身（8.8%对8.6%对28.3%），更频繁地接受公共保险（75.1%对68.9%对27.4%）。结论：受人口统计学和社会经济因素的影响，GI癌症幸存者面临着明显更高的功能限制负担。对癌症幸存者的启示：通过有针对性的康复和支持服务来解决功能差异可能会改善长期预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cancer Survivorship ONCOLOGY-

CiteScore

7.00

自引率

10.80%

发文量

149

审稿时长

>12 weeks

期刊介绍： Cancer survivorship is a worldwide concern. The aim of this multidisciplinary journal is to provide a global forum for new knowledge related to cancer survivorship. The journal publishes peer-reviewed papers relevant to improving the understanding, prevention, and management of the multiple areas related to cancer survivorship that can affect quality of care, access to care, longevity, and quality of life. It is a forum for research on humans (both laboratory and clinical), clinical studies, systematic and meta-analytic literature reviews, policy studies, and in rare situations case studies as long as they provide a new observation that should be followed up on to improve outcomes related to cancer survivors. Published articles represent a broad range of fields including oncology, primary care, physical medicine and rehabilitation, many other medical and nursing specialties, nursing, health services research, physical and occupational therapy, public health, behavioral medicine, psychology, social work, evidence-based policy, health economics, biobehavioral mechanisms, and qualitative analyses. The journal focuses exclusively on adult cancer survivors, young adult cancer survivors, and childhood cancer survivors who are young adults. Submissions must target those diagnosed with and treated for cancer.