Journal of Bone and Joint Surgery, American Volume最新文献

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Overcoming the Odds: "Making It"-Personally and Professionally-in Orthopaedic Surgery Residency as an International Medical Graduate. 克服困难:作为一名国际医学毕业生,在矫形外科住院实习中 "成功"--个人和职业。
IF 4.4 1区 医学
Journal of Bone and Joint Surgery, American Volume Pub Date : 2024-10-16 Epub Date: 2024-05-02 DOI: 10.2106/JBJS.24.00147
Gergo Merkely
{"title":"Overcoming the Odds: \"Making It\"-Personally and Professionally-in Orthopaedic Surgery Residency as an International Medical Graduate.","authors":"Gergo Merkely","doi":"10.2106/JBJS.24.00147","DOIUrl":"10.2106/JBJS.24.00147","url":null,"abstract":"","PeriodicalId":15273,"journal":{"name":"Journal of Bone and Joint Surgery, American Volume","volume":" ","pages":"1922-1923"},"PeriodicalIF":4.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Flaccid Myelitis: Mid-Term Clinical Course of Knee Extension Paralysis and Outcomes of Nerve Transfer. 急性弛缓性脊髓炎膝关节外展麻痹的中期临床表现和神经转移的结果
IF 4.4 1区 医学
Journal of Bone and Joint Surgery, American Volume Pub Date : 2024-10-16 Epub Date: 2024-05-30 DOI: 10.2106/JBJS.23.01268
Kazuteru Doi, Yasunori Hattori, Akio Maruyama, Abdelhakim Ezzat Marei, Sotetsu Sakamoto, Jun Sasaki, Kota Hayashi, Makimi Fujita
{"title":"Acute Flaccid Myelitis: Mid-Term Clinical Course of Knee Extension Paralysis and Outcomes of Nerve Transfer.","authors":"Kazuteru Doi, Yasunori Hattori, Akio Maruyama, Abdelhakim Ezzat Marei, Sotetsu Sakamoto, Jun Sasaki, Kota Hayashi, Makimi Fujita","doi":"10.2106/JBJS.23.01268","DOIUrl":"10.2106/JBJS.23.01268","url":null,"abstract":"<p><strong>Background: </strong>Acute flaccid myelitis (AFM) is a rare debilitating poliomyelitis-like illness characterized by the sudden onset of flaccid palsy in the extremities. The purpose of this study was to report the mid-term clinical course of knee extension in AFM and the effect of contralateral obturator nerve-to-femoral nerve transfer (CONFNT) for restoration of knee extension in AFM.</p><p><strong>Methods: </strong>Twenty-six patients with lower extremity palsy due to AFM were referred to our clinic for possible surgical reconstruction. Their median age was 4.0 years, and the first evaluation of the palsy was done at a mean of 6 months after paralysis onset. The paralysis ranged from lower limb monoplegia to quadriplegia. The clinical course of knee extension was assessed using the British Medical Research Council (MRC) grading scale and surface electromyography (EMG). Five patients with unilateral paralysis of knee extension underwent CONFNT.</p><p><strong>Results: </strong>The mean follow-up period for 19 limbs with complete paralysis of knee extension (MRC grade M0) in 13 patients who were evaluated for spontaneous recovery was 43 months. No patient who had complete paralysis of knee extension at >6 months and paralysis of the hip adductor muscle had improvement of knee extension to better than M2. Five of the original 26 patients were treated with CONFNT and followed for a mean of 61 months. Two of 5 patients had the CONFNT ≤8 months after paralysis onset and obtained M4 knee extension. Only 1 of the 3 patients with CONFNT performed approximately 12 months after paralysis onset obtained M3 knee extension; the other 2 obtained only M1 or M2 knee extension.</p><p><strong>Conclusions: </strong>The paralysis of the lower extremity in our patients with AFM was similar to that in poliomyelitis. However, in AFM, spontaneous recovery of knee extension was possible if there were signs of recovery from hip adductor paralysis up to 6 months after paralysis onset. CONFNT may enhance the recovery of knee extension and seems to be a reliable reconstruction for restoring knee extension if performed no more than 8 months after paralysis onset.</p><p><strong>Level of evidence: </strong>Therapeutic Level IV . See Instructions for Authors for a complete description of levels of evidence.</p>","PeriodicalId":15273,"journal":{"name":"Journal of Bone and Joint Surgery, American Volume","volume":" ","pages":"1876-1887"},"PeriodicalIF":4.4,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-Dose TXA Is Associated with Less Blood Loss Than Low-Dose TXA without Increased Complications in Patients with Complex Adult Spinal Deformity. 在复杂成人脊柱畸形患者中,大剂量 TXA 比小剂量 TXA 失血更少,且并发症不会增加。
IF 4.4 1区 医学
Journal of Bone and Joint Surgery, American Volume Pub Date : 2024-10-03 DOI: 10.2106/JBJS.23.01323
Andrew H Kim, Kevin C Mo, Andrew B Harris, Renaud Lafage, Brian J Neuman, Richard A Hostin, Alexandra Soroceanu, Han Jo Kim, Eric O Klineberg, Jeffrey L Gum, Munish C Gupta, D Kojo Hamilton, Frank Schwab, Doug Burton, Alan Daniels, Peter G Passias, Robert A Hart, Breton G Line, Christopher Ames, Virginie Lafage, Christopher I Shaffrey, Justin S Smith, Shay Bess, Lawrence Lenke, Khaled M Kebaish
{"title":"High-Dose TXA Is Associated with Less Blood Loss Than Low-Dose TXA without Increased Complications in Patients with Complex Adult Spinal Deformity.","authors":"Andrew H Kim, Kevin C Mo, Andrew B Harris, Renaud Lafage, Brian J Neuman, Richard A Hostin, Alexandra Soroceanu, Han Jo Kim, Eric O Klineberg, Jeffrey L Gum, Munish C Gupta, D Kojo Hamilton, Frank Schwab, Doug Burton, Alan Daniels, Peter G Passias, Robert A Hart, Breton G Line, Christopher Ames, Virginie Lafage, Christopher I Shaffrey, Justin S Smith, Shay Bess, Lawrence Lenke, Khaled M Kebaish","doi":"10.2106/JBJS.23.01323","DOIUrl":"https://doi.org/10.2106/JBJS.23.01323","url":null,"abstract":"<p><strong>Background: </strong>Tranexamic acid (TXA) is commonly utilized to reduce blood loss in adult spinal deformity (ASD) surgery. Despite its widespread use, there is a lack of consensus regarding the optimal dosing regimen. The aim of this study was to assess differences in blood loss and complications between high, medium, and low-dose TXA regimens among patients undergoing surgery for complex ASD.</p><p><strong>Methods: </strong>A multicenter database was retrospectively analyzed to identify 265 patients with complex ASD. Patients were separated into 3 groups by TXA regimen: (1) low dose (<20-mg/kg loading dose with ≤2-mg/kg/hr maintenance dose), (2) medium dose (20 to 50-mg/kg loading dose with 2 to 5-mg/kg/hr maintenance dose), and (3) high dose (>50-mg/kg loading dose with ≥5-mg/kg/hr maintenance dose). The measured outcomes included blood loss, complications, and red blood cell (RBC) units transfused intraoperatively and perioperatively. The multivariable analysis controlled for TXA dosing regimen, levels fused, operating room time, preoperative hemoglobin, 3-column osteotomy, and posterior interbody fusion.</p><p><strong>Results: </strong>The cohort was predominantly White (91.3%) and female (69.1%) and had a mean age of 61.6 years. Of the 265 patients, 54 (20.4%) received low-dose, 131 (49.4%) received medium-dose, and 80 (30.2%) received high-dose TXA. The median blood loss was 1,200 mL (interquartile range [IQR], 750 to 2,000). The median RBC units transfused intraoperatively was 1.0 (IQR, 0.0 to 2.0), and the median RBC units transfused perioperatively was 2.0 (IQR, 1.0 to 4.0). Compared with the high-dose group, the low-dose group had increased blood loss (by 513.0 mL; p = 0.022) as well as increased RBC units transfused intraoperatively (by 0.6 units; p < 0.001) and perioperatively (by 0.3 units; p = 0.024). The medium-dose group had increased blood loss (by 491.8 mL; p = 0.006) as well as increased RBC units transfused intraoperatively (by 0.7 units; p < 0.001) and perioperatively (by 0.5 units; p < 0.001) compared with the high-dose group.</p><p><strong>Conclusions: </strong>Patients with ASD who received high-dose intraoperative TXA had fewer RBC transfusions intraoperatively, fewer RBC transfusions perioperatively, and less blood loss than those who received low or medium-dose TXA, with no differences in the rates of seizure or thromboembolic complications.</p><p><strong>Level of evidence: </strong>Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.</p>","PeriodicalId":15273,"journal":{"name":"Journal of Bone and Joint Surgery, American Volume","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of Examination Maneuvers for Adolescent Idiopathic Scoliosis in the Telehealth Setting. 在远程医疗环境中验证青少年特发性脊柱侧凸的检查方法。
IF 4.4 1区 医学
Journal of Bone and Joint Surgery, American Volume Pub Date : 2024-10-02 DOI: 10.2106/JBJS.23.01146
Alexander R Farid, M Timothy Hresko, Semhal Ghessese, Gabriel S Linden, Stephanie Wong, Daniel Hedequist, Craig Birch, Danielle Cook, Kelsey Mikayla Flowers, Grant D Hogue
{"title":"Validation of Examination Maneuvers for Adolescent Idiopathic Scoliosis in the Telehealth Setting.","authors":"Alexander R Farid, M Timothy Hresko, Semhal Ghessese, Gabriel S Linden, Stephanie Wong, Daniel Hedequist, Craig Birch, Danielle Cook, Kelsey Mikayla Flowers, Grant D Hogue","doi":"10.2106/JBJS.23.01146","DOIUrl":"https://doi.org/10.2106/JBJS.23.01146","url":null,"abstract":"<p><strong>Background: </strong>Telehealth visits (THVs) have made it essential to adopt innovative ways to evaluate patients virtually. This study validates a novel THV approach that uses educational videos and an instructional datasheet, enabling parents to use smartphones to measure their child's scoliosis at home or in telehealth settings.</p><p><strong>Methods: </strong>We identified a prospective cohort of patients with adolescent idiopathic scoliosis (AIS) scheduled for follow-up care from March to July 2021. The angle of trunk rotation (ATR) was first measured at home by patients' guardians using instructional video guidance and a smartphone application with internal accelerometer software. The second measurement was made during a THV examination performed by caregivers with supervision by trained associates via a telehealth appointment. Lastly, the clinician measured the child's ATR during an in-person clinic visit. Intraclass correlation coefficients (ICCs) and interrater reliability were compared between in-person clinic measurements and (1) at-home and (2) THV measurements. Shoulder, lower back, and pelvic asymmetry were observed and quantified at home and virtually, and then were compared with in-person clinic evaluations using kappa values. Surveys were used to evaluate the experience of the patient/caregiver with the at-home and telehealth assessment tools.</p><p><strong>Results: </strong>Seventy-three patients were included (mean age, 14.1 years; 25% male). There was excellent agreement in the ATR measurements between THVs and in-person visits (ICC = 0.88; 95% confidence interval [CI] = 0.83 to 0.92). ATR agreement between at-home and in-person visits was also excellent, but slightly diminished (ICC = 0.76; 95% CI = 0.64 to 0.83). Agreement between THV and in-person measurements was significantly higher compared with that between at-home and in-person measurements (p = 0.04). There was poor agreement in lower back asymmetry between THV and in-person assessments (kappa = 0.37; 95% CI = 0.14 to 0.60); however, there was no significant agreement between at-home and in-person assessments (kappa = 0.06; 95% CI = -0.17 to 0.29). Patient/caregiver satisfaction surveys (n = 70) reported a median score of 4 (\"good\") for comfort with use of the technology, and a score of 3 (\"neutral\") for equivalence of THV and in-person evaluation.</p><p><strong>Conclusions: </strong>There was a high level of agreement between telehealth and in-person spine measurements, suggesting that THVs may be reliably used to evaluate AIS, thus improving access to specialized care.</p><p><strong>Level of evidence: </strong>Diagnostic Level II. See Instructions for Authors for a complete description of levels of evidence.</p>","PeriodicalId":15273,"journal":{"name":"Journal of Bone and Joint Surgery, American Volume","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AOA Critical Issues Symposium: The Disruptive Physician: Bad Apple or Toxic Tree? AOA 关键问题研讨会:破坏性医生:坏苹果还是毒树?
IF 4.4 1区 医学
Journal of Bone and Joint Surgery, American Volume Pub Date : 2024-10-02 DOI: 10.2106/JBJS.23.01262
Rey N Ramirez, Joel L Mayerson, Valerae O Lewis, Alan Friedman, Lisa Lattanza
{"title":"AOA Critical Issues Symposium: The Disruptive Physician: Bad Apple or Toxic Tree?","authors":"Rey N Ramirez, Joel L Mayerson, Valerae O Lewis, Alan Friedman, Lisa Lattanza","doi":"10.2106/JBJS.23.01262","DOIUrl":"https://doi.org/10.2106/JBJS.23.01262","url":null,"abstract":"<p><strong>Abstract: </strong>Disruptive physician behavior has become a common problem in medicine. Individuals who conduct themselves in a manner that could negatively affect patient care, or \"disruptive physicians,\" frequently cause stress for patients and staff, are a headache for leadership, and can require expensive remediation. We suggest that rather than \"bad apples,\" many disruptive physicians are the fruit of a \"toxic tree.\" That is, many physicians only become disruptive as a response to their environment. It is important for leaders to accurately identify the root causes of disruptive behavior in order to address the problem. In general, it is important for leaders to act prospectively, to examine events from all perspectives, to promote wellness and communication, and to identify external or systemic causes. We also discuss additional considerations for when the physician who has been labeled \"disruptive\" is a member of an underrepresented group (in orthopaedic surgery, the underrepresented groups are women and racial minorities). As a conclusion, we offer a case example of how 1 institution established a system of physician wellness to enhance prevention efforts.</p>","PeriodicalId":15273,"journal":{"name":"Journal of Bone and Joint Surgery, American Volume","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Cost-Effectiveness of Computer-Assisted Compared with Conventional Total Knee Arthroplasty: A Payer's Perspective. 计算机辅助全膝关节置换术与传统全膝关节置换术的成本效益比较:付款人的视角。
IF 4.4 1区 医学
Journal of Bone and Joint Surgery, American Volume Pub Date : 2024-09-18 Epub Date: 2024-04-25 DOI: 10.2106/JBJS.23.00555
Yao Tian, Abdalrahman G Ahmed, Annika N Hiredesai, Lynn Wei Huang, Ankita M Patel, Hassan M K Ghomrawi
{"title":"The Cost-Effectiveness of Computer-Assisted Compared with Conventional Total Knee Arthroplasty: A Payer's Perspective.","authors":"Yao Tian, Abdalrahman G Ahmed, Annika N Hiredesai, Lynn Wei Huang, Ankita M Patel, Hassan M K Ghomrawi","doi":"10.2106/JBJS.23.00555","DOIUrl":"10.2106/JBJS.23.00555","url":null,"abstract":"<p><strong>Background: </strong>Recent evidence showing that computer-assisted total knee arthroplasty (TKA) is associated with better outcomes compared with conventional TKA for patients with end-stage knee osteoarthritis has not been included in economic evaluations of computer-assisted TKA, which are needed to support coverage decisions. This study evaluated the cost-effectiveness of computer-assisted TKA from a payer's perspective, incorporating recent evidence.</p><p><strong>Methods: </strong>We compared computer-assisted TKA with conventional TKA with regard to costs (in 2022 U.S. dollars) and quality-adjusted life-years (QALYs) using Markov models for elderly patients (≥65 years of age) and patients who were not elderly (55 to 64 years of age). Costs and QALYs were estimated in the lifetime for elderly patients and in the short term for patients who were not elderly, under a bundled payment program and a Fee-for-Service program. Transition probabilities, costs, and QALYs were retrieved from the literature, a national knee arthroplasty registry, and the National Center for Health Statistics. Threshold and probabilistic sensitivity analyses were conducted to examine the robustness of key estimates used in the base-case analysis. Using projected estimates of TKA utilization, the total cost savings of performing computer-assisted TKA rather than conventional TKA were estimated.</p><p><strong>Results: </strong>Compared with conventional TKA, computer-assisted TKA was associated with higher QALYs and lower costs for both elderly patients and patients who were not elderly, regardless of payment programs, making computer-assisted TKA a favorable treatment option. Widespread adoption of computer-assisted TKA in all U.S. patients would result in an estimated total cost saving of $1 billion for payers.</p><p><strong>Conclusions: </strong>Compared with conventional TKA, computer-assisted TKA reduces costs to payers while providing favorable outcomes. Payers may consider providing additional payment incentives to providers for performing computer-assisted TKA, to achieve outcome improvement and cost control by facilitating widespread adoption of computer-assisted TKA.</p><p><strong>Level of evidence: </strong>Economic and Decision Analysis Level II . See Instructions for Authors for a complete description of levels of evidence.</p>","PeriodicalId":15273,"journal":{"name":"Journal of Bone and Joint Surgery, American Volume","volume":" ","pages":"1680-1687"},"PeriodicalIF":4.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Vivo Intra-Articular Antibiotic Concentrations at 24 Hours After TKA Fall Below the Minimum Inhibitory Concentration for Most Bacteria: A Randomized Study of Commercially Available Bone Cement. TKA 术后 24 小时体内关节内抗生素浓度低于大多数细菌的最低抑制浓度:对市售骨水泥的随机研究。
IF 4.4 1区 医学
Journal of Bone and Joint Surgery, American Volume Pub Date : 2024-09-18 Epub Date: 2024-07-25 DOI: 10.2106/JBJS.23.01412
Juan D Lizcano, Diana Fernández-Rodríguez, Graham S Goh, David E DeMik, Andrew J Hughes, Javad Parvizi, P Maxwell Courtney, James J Purtill, Matthew S Austin
{"title":"In Vivo Intra-Articular Antibiotic Concentrations at 24 Hours After TKA Fall Below the Minimum Inhibitory Concentration for Most Bacteria: A Randomized Study of Commercially Available Bone Cement.","authors":"Juan D Lizcano, Diana Fernández-Rodríguez, Graham S Goh, David E DeMik, Andrew J Hughes, Javad Parvizi, P Maxwell Courtney, James J Purtill, Matthew S Austin","doi":"10.2106/JBJS.23.01412","DOIUrl":"10.2106/JBJS.23.01412","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;The use of antibiotic-loaded bone cement (ALBC) to help reduce the risk of infection after primary total knee arthroplasty (TKA) is controversial. There is a paucity of in vivo data on the elution characteristics of ALBC. We aimed to determine whether the antibiotic concentrations of 2 commercially available ALBCs met the minimum inhibitory concentration (MIC) and minimum biofilm eradication concentration (MBEC) for common infecting organisms.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Forty-five patients undergoing TKA were randomized to receive 1 of the following: bone cement without antibiotic (the negative control; n = 5), a commercially available formulation containing 1 g of tobramycin (n = 20), or a commercially available formulation containing 0.5 g of gentamicin (n = 20). Intra-articular drains were placed, and fluid was collected at 4 and 24 hours postoperatively. An automated immunoassay measuring antibiotic concentration was performed, and the results were compared against published MIC and MBEC thresholds.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The ALBC treatment groups were predominantly of White (65%) or Black (32.5%) race and were 57.5% female and 42.4% male. The mean age (and standard deviation) was 72.6 ± 7.2 years in the gentamicin group and 67.6 ± 7.4 years in the tobramycin group. The mean antibiotic concentration in the tobramycin group was 55.1 ± 37.7 μg/mL at 4 hours and 19.5 ± 13.0 μg/mL at 24 hours, and the mean concentration in the gentamicin group was 38.4 ± 25.4 μg/mL at 4 hours and 17.7 ± 15.4 μg/mL at 24 hours. Time and antibiotic concentration had a negative linear correlation coefficient (r = -0.501). Most of the reference MIC levels were reached at 4 hours. However, at 24 hours, a considerable percentage of patients had concentrations below the MIC for many common pathogens, including Staphylococcus epidermidis (gentamicin: 65% to 100% of patients; tobramycin: 50% to 85%), methicillin-sensitive Staphylococcus aureus (gentamicin: 5% to 90%; tobramycin: 5% to 50%), methicillin-resistant S . aureus (gentamicin: 5% to 65%; tobramycin: 50%), Streptococcus species (gentamicin: 10% to 100%), and Cutibacterium acnes (gentamicin: 10% to 65%; tobramycin: 100%). The aforementioned ranges reflect variation in the MIC among different strains of each organism. Gentamicin concentrations reached MBEC threshold values at 4 hours only for the least virulent strains of S . aureus and Escherichia coli. Tobramycin concentrations did not reach the MBEC threshold for any of the bacteria at either time point.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;The elution of antibiotics from commercially available ALBC decreased rapidly following TKA, and only at 4 hours postoperatively did the mean antibiotic concentrations exceed the MIC for most of the pathogens. Use of commercially available ALBC may not provide substantial antimicrobial coverage following TKA.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Level of evidence: &lt;/strong&gt;Therapeutic Level I . See Instru","PeriodicalId":15273,"journal":{"name":"Journal of Bone and Joint Surgery, American Volume","volume":" ","pages":"1664-1672"},"PeriodicalIF":4.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141758981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Gender in Health and Disease: Methods of Reporting and Interactions with Sex and Other Factors. 性别在健康和疾病中的作用:报告方法以及与性别和其他因素的相互作用。
IF 4.4 1区 医学
Journal of Bone and Joint Surgery, American Volume Pub Date : 2024-09-18 Epub Date: 2024-08-05 DOI: 10.2106/JBJS.24.00081
Londa Schiebinger
{"title":"Role of Gender in Health and Disease: Methods of Reporting and Interactions with Sex and Other Factors.","authors":"Londa Schiebinger","doi":"10.2106/JBJS.24.00081","DOIUrl":"10.2106/JBJS.24.00081","url":null,"abstract":"<p><strong>Abstract: </strong>Sex and gender are distinct terms that must be used correctly. Data regarding sex and gender may be collected using a 2-step method that separates biological sex and self-reported gender identity. The PhenX Toolkit, funded by the National Institutes of Health (NIH), is one tool that provides investigators with recommended standard data-collection protocols. Another tool is the Diversity Minimal Item Set questionnaire. Importantly, sex and gender interact: for example, pain has both biological aspects (sex differences in electrical, ischemic, thermal, pressure, and muscle pain sensitivity) and cultural aspects (gender factors in how people report pain and how physicians understand and treat pain in patients). Gender norms, identity, and relations all impact patient care. Gender norms, for instance, may influence how a person experiences pain, gender identity may influence a person's willingness to report pain, and gender relations may influence a physician's gendered expectations in relation to a patient's gendered behaviors. Clinicians may perceive women's pain to be psychological; as a result, women may receive more nonspecific diagnoses, wait longer for treatment, and receive more antidepressants and fewer analgesics than men. Research on gender-diverse people and pain is just now emerging. Resources for methods of reporting include The Lancet, Nature, and the Sex and Gender Equity in Research (SAGER) Guidelines. We must consider all relevant factors intersecting with sex and gender, including age, disabilities, educational background, ethnicity, family configuration, geographic location, race, sexuality, social and economic status, sustainability, and more.</p>","PeriodicalId":15273,"journal":{"name":"Journal of Bone and Joint Surgery, American Volume","volume":" ","pages":"1713-1717"},"PeriodicalIF":4.4,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of Institutional Review Boards in Improving the Inclusion of Sex and Gender as Variables in Clinical Research. 机构审查委员会在改善将性和性别作为变量纳入临床研究中的作用》(The Role of Institutional Review Boards in Improving the Inclusion of Sex and Gender as Variables in Clinical Research.
IF 4.4 1区 医学
Journal of Bone and Joint Surgery, American Volume Pub Date : 2024-09-18 Epub Date: 2024-08-01 DOI: 10.2106/JBJS.24.00211
Barbara E Bierer
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引用次数: 0
What Are Social Determinants of Health and Why Should They Matter to an Orthopaedic Surgeon? 什么是健康的社会决定因素,为什么它们对矫形外科医生很重要?
IF 4.4 1区 医学
Journal of Bone and Joint Surgery, American Volume Pub Date : 2024-09-18 Epub Date: 2024-04-18 DOI: 10.2106/JBJS.23.01114
Samantha S Meacock, Irfan A Khan, Alexandra L Hohmann, Anna Cohen-Rosenblum, Chad A Krueger, James J Purtill, Yale A Fillingham
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引用次数: 0
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