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Drug Development platform Could Provide Flexible, Fast and Targeted Antimicrobials 药物开发平台可提供灵活、快速和有针对性的抗菌素
Journal of Bioanalysis & Biomedicine Pub Date : 2021-01-01 DOI: 10.37421/1948-593X.2021.13.275
G. Reddy
{"title":"Drug Development platform Could Provide Flexible, Fast and Targeted Antimicrobials","authors":"G. Reddy","doi":"10.37421/1948-593X.2021.13.275","DOIUrl":"https://doi.org/10.37421/1948-593X.2021.13.275","url":null,"abstract":"In any case, analysts at the University of Colorado Boulder have made a stage that can foster powerful and profoundly explicit peptide nucleic corrosive treatments for use against any microorganisms inside only multi week. The work is itemized in Nature Communications Biology and could change the manner in which we react to pandemics and how we approach expanding instances of anti-infection resistance globally.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"4 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78511922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanomedicine- Impacts, Medical needs and Applications 纳米医学——影响、医疗需求和应用
Journal of Bioanalysis & Biomedicine Pub Date : 2021-01-01 DOI: 10.37421/1948-593X.2021.13.250
eep Kumar Kar
{"title":"Nanomedicine- Impacts, Medical needs and Applications","authors":"eep Kumar Kar","doi":"10.37421/1948-593X.2021.13.250","DOIUrl":"https://doi.org/10.37421/1948-593X.2021.13.250","url":null,"abstract":"Received 06 February, 2021; Accepted 20 February, 2021; Published 28 February, 2021 Nanomedicines represent subsequent era in drug innovation. Current research has demonstrated improved performance, reduced side effects, and revolutionary new treatment strategies like personalized medicine. It uses the properties developed by a cloth at its nanometric scale 10-9 m which frequently differ in terms of physics, chemistry or biology from an equivalent material at a much bigger scale.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"25 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87196145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drugs within the Western world for quite a century 毒品在西方世界存在了一个世纪
Journal of Bioanalysis & Biomedicine Pub Date : 2021-01-01 DOI: 10.37421/1948-593X.2021.13.269
H. Shirzadfar
{"title":"Drugs within the Western world for quite a century","authors":"H. Shirzadfar","doi":"10.37421/1948-593X.2021.13.269","DOIUrl":"https://doi.org/10.37421/1948-593X.2021.13.269","url":null,"abstract":"","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"252 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76905997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concise note on Molecular Epidemiology 分子流行病学简要说明
Journal of Bioanalysis & Biomedicine Pub Date : 2021-01-01 DOI: 10.37421/1948-593X.21.13.248
H. Shirzadfar
{"title":"Concise note on Molecular Epidemiology","authors":"H. Shirzadfar","doi":"10.37421/1948-593X.21.13.248","DOIUrl":"https://doi.org/10.37421/1948-593X.21.13.248","url":null,"abstract":"Received 06 January 2021; Accepted 27 January 2021; Published 30 January 2021 Molecular epidemiology is a branch of epidemiology and medical science. The study of disease transmission is a part of the study of disease transmission and clinical science that centers around the commitment of potential hereditary and ecological danger factors, recognized at the subatomic level, to the etiology, dispersion and anticipation of illness inside families and across populaces. This field has risen up out of the reconciliation of atomic science into conventional epidemiological examination. Atomic the study of disease transmission improves our comprehension of the pathogenesis of illness by recognizing explicit pathways, particles and qualities that impact the danger of creating sickness. All the more extensively, it tries to build up comprehension of how the connections between hereditary attributes and ecological openings bring about infection.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"31 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76555498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short Note on Nanotoxicology 纳米毒理学简介
Journal of Bioanalysis & Biomedicine Pub Date : 2021-01-01 DOI: 10.37421/1948-593X.2021.13.287
R. Ghosh
{"title":"Short Note on Nanotoxicology","authors":"R. Ghosh","doi":"10.37421/1948-593X.2021.13.287","DOIUrl":"https://doi.org/10.37421/1948-593X.2021.13.287","url":null,"abstract":"","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"15 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75292078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bio analytical Procedures - Liquid Chromatography-Mass Spectrometry 生物分析方法。液相色谱-质谱法
Journal of Bioanalysis & Biomedicine Pub Date : 2021-01-01 DOI: 10.37421/1948-593X.2021.13.273
E. Mansour
{"title":"Bio analytical Procedures - Liquid Chromatography-Mass Spectrometry","authors":"E. Mansour","doi":"10.37421/1948-593X.2021.13.273","DOIUrl":"https://doi.org/10.37421/1948-593X.2021.13.273","url":null,"abstract":"","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"40 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73860548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Coronavirus Destruction (Covid-19), with High Efficacy of Magnetic Nanoparticles Containing Antiviral Drug Favipiravir/Remdesivir 含有抗病毒药物Favipiravir/Remdesivir的磁性纳米颗粒高效摧毁冠状病毒(Covid-19)
Journal of Bioanalysis & Biomedicine Pub Date : 2021-01-01 DOI: 10.37421/1948-593X.2021.13.249
Mansour Bin
{"title":"Coronavirus Destruction (Covid-19), with High Efficacy of Magnetic Nanoparticles Containing Antiviral Drug Favipiravir/Remdesivir","authors":"Mansour Bin","doi":"10.37421/1948-593X.2021.13.249","DOIUrl":"https://doi.org/10.37421/1948-593X.2021.13.249","url":null,"abstract":"Since the outbreak of coronavirus (caused by the covid-19 virus), many researchers have been working to develop an antiviral vaccine. In the meantime, I have started our research by stabilizing the biomedicines Remdesivir and Favipiravir on the substrate of magnetic nanoparticles, which took 24 hand showed over 92% stabilization. Now we want to grow Covid-19 virus in bacterial medium for half a day, then add magnetic nanoparticles containing Remdesivir and Favipiravir to the bacterial culture medium and show results of over 99% lethality of the virus with the bacterium. Magnetic nanoparticles can be a good substrate without destroying healthy cells and research is still ongoing.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"12 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72642448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nano Encapsulation of Natural Products for Chemoprevention 用于化学预防的天然产物的纳米封装
Journal of Bioanalysis & Biomedicine Pub Date : 2021-01-01 DOI: 10.37421/1948-593X.2021.13.280
eep Kumar Kar
{"title":"Nano Encapsulation of Natural Products for Chemoprevention","authors":"eep Kumar Kar","doi":"10.37421/1948-593X.2021.13.280","DOIUrl":"https://doi.org/10.37421/1948-593X.2021.13.280","url":null,"abstract":"Received 05 August 2021; Accepted 24 August 2021; Published 31 August 2021 Chemoprevention by use of natural products has arisen as a significant system that has the potential to prevent the occurrence of cancer mainly by slowing the process of carcinogenesis. Research center information upheld by a few epidemiological and some clinical investigations have approved that bioactive food components produce an expansive range of exercises that at last come full circle in dragging out the improvement time for cancer outcome. With an armamentarium of more than 1500 such compounds great hope for cancer control rest on chemoprevention. Regardless of astounding viability in preclinical settings, its appropriateness to human has met with restricted mainly due to inefficient systemic delivery and poor bioavailability of promising chemo preventive agents. In this way, novel systems are expected to improve the bioavailability and reduced perceived toxicity associated with the longterm use of potentially useful bioactive food components. We presented an original idea of 'nanochemoprevention' where nanotechnology was taken advantage of to expand the result of chemoprevention. In our examination, we revealed critical portion benefit of polylactic acid-polyethylene glycol (PLA-PEG) exemplified EGCG, a significant polyphenol from green tea (nano EGCG) over non-embodied (local) EGCG [1-3].","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"13 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86439412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Note for Regular Issue: Journal of Bioanalysis and Biomedicine (ISSN: 1948-593X) 期刊编辑说明:Journal of Bioanalysis and biomedine (ISSN: 1948-593X)
Journal of Bioanalysis & Biomedicine Pub Date : 2020-01-01 DOI: 10.37421/JBABM.2020.12.239
Limin Chen
{"title":"Editorial Note for Regular Issue: Journal of Bioanalysis and Biomedicine (ISSN: 1948-593X)","authors":"Limin Chen","doi":"10.37421/JBABM.2020.12.239","DOIUrl":"https://doi.org/10.37421/JBABM.2020.12.239","url":null,"abstract":"Journal of Bioanalysis and Biomedicine has been begun in the year 2009 and it released its first volume in the same year. Till now, the journal has released 11 volumes before the completion of 2019 and is viably running its 12th Volume. Journal of Bioanalysis & Biomedicine has risen as a significant discipline of science which is multidisciplinary in nature. Various subjects such as different Pharmacotherapy, Negative consequences of Biomedicine, Molecular Epidomology, Nanomedicine, Drug Development, Toxicology, Biomarkers in toxicology, Spectroscopic and Chromatographic strategies, etc. Journal of Bioanalysis & Biomedicine is the best open access journal that expects to publish commonly complete and reliable source of information on the disclosures and advanced in this field as original articles, review articles and short communications, etc and furnish free online access to it without any constraints or some different participations to researchers around the globe. JBABM peer reviewed journal is capably upheld by universally prominent Editorial Board members. JBABM go through a single blind peer review process by competent Editorial Board in order to ensure excellence.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"208 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80535124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direct Measurement of the Intracellular Concentration of 8-Oxo-2'-Deoxyguanosine-5'-Triphosphate by LC-MS/MS LC-MS/MS直接测定细胞内8-氧-2′-脱氧鸟苷-5′-三磷酸的浓度
Journal of Bioanalysis & Biomedicine Pub Date : 2020-01-01 DOI: 10.37421/1948-593X.2020.12.237
Ting Wang, Julie Far, K. Schwartz, P. Fan, Michael O. Ports, A. Kashishian, G. Notte, A. Ray, E. Murakami
{"title":"Direct Measurement of the Intracellular Concentration of 8-Oxo-2'-Deoxyguanosine-5'-Triphosphate by LC-MS/MS","authors":"Ting Wang, Julie Far, K. Schwartz, P. Fan, Michael O. Ports, A. Kashishian, G. Notte, A. Ray, E. Murakami","doi":"10.37421/1948-593X.2020.12.237","DOIUrl":"https://doi.org/10.37421/1948-593X.2020.12.237","url":null,"abstract":"Exposure to reactive oxygen species can result in formation of oxidized nucleotides which increase the frequency of mutations, DNA damage, and cell death. MutT Homolog 1 (MTH1) is an enzyme that catalyzes removal of pyrophosphate from the highly mutagenic oxidized nucleoside triphosphate 8-oxo-2'-deoxyguanosine-5'-triphosphate (8-oxo-dGTP). Interest in MTH1 as a potential new target for cancer therapy surged due to reports of MTH1 inhibitors causing DNA damage and inducing cell death in cancer cells. However, questions have been raised about MTH1 target validation. One critical piece of information that is currently lacking is a quantitative understanding of the levels of 8-oxo-dGTP in cancer cells and the effect of MTH1 inhibition on them. In this study, we developed a sensitive and selective method to simultaneously measure the intracellular concentrations of 8-oxo guanosine nucleotides and their unmodified counterparts using liquid chromatography coupled to tandem mass spectrometry (LC-MS/ MS). An ion-pairing reversed phase liquid chromatography method using dimethylhexylamine was employed to quantify the highly polar analytes. The method was validated fit for purpose using a combination of authentic standards and cell samples. The intracellular oxo-nucleotide concentrations in human bone osteosarcoma cell line U2OS were determined using the method. We observed very low levels of 8-oxo nucleotides in untreated and hydrogen peroxide treated cells and MTH1 knockdown in these cells had minimal if any effect on 8-oxo nucleotide levels. This method will allow for a more comprehensive understanding of oxidized nucleotide detoxification pathways and MTH1 as a target for cancer therapy.","PeriodicalId":15259,"journal":{"name":"Journal of Bioanalysis & Biomedicine","volume":"220 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76971608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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