Jaime Andrés Nieto, David Aparicio, Susan Julieth Flórez Rubio
{"title":"When 2D is not enough: 3D transesophageal echocardiography revealing a multifenestrated atrial septal defect.","authors":"Jaime Andrés Nieto, David Aparicio, Susan Julieth Flórez Rubio","doi":"10.1186/s44348-026-00103-7","DOIUrl":"https://doi.org/10.1186/s44348-026-00103-7","url":null,"abstract":"","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149238528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The longitudinal dimension of the ascending aorta: beyond diameter.","authors":"Sung Min Ko","doi":"10.1186/s44348-026-00098-1","DOIUrl":"10.1186/s44348-026-00098-1","url":null,"abstract":"","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13682122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149228050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Joel C Boudreaux, Suleman Chaudhry, Nikahat Yasmine, Saubhagya Dhakal, Honghai Zhang, Milan Sonka, Andreas Wahle, Sarah Vigmostad, Abhay B Ramachandra, William H Thiel, Loren E Smith, Jennifer Streeter, Rodrigo M Bello, Arun K Singhal
{"title":"Radiographic phenotyping of healthy and diseased aortas.","authors":"Joel C Boudreaux, Suleman Chaudhry, Nikahat Yasmine, Saubhagya Dhakal, Honghai Zhang, Milan Sonka, Andreas Wahle, Sarah Vigmostad, Abhay B Ramachandra, William H Thiel, Loren E Smith, Jennifer Streeter, Rodrigo M Bello, Arun K Singhal","doi":"10.1186/s44348-026-00086-5","DOIUrl":"https://doi.org/10.1186/s44348-026-00086-5","url":null,"abstract":"<p><strong>Background: </strong>Ascending aortic diameter guides intervention for thoracic aneurysms. Many patients with acute type A aortic dissection (ATAAD) present with ascending aortic diameters below 5.5 cm, rendering diameter an insufficient risk discriminator. This study evaluated computed tomography angiography (CTA) morphology to identify predissection radiographic features associated with ATAAD.</p><p><strong>Methods: </strong>Control (n = 50, CTA for non-aortic indications), aneurysm (n = 61, thoracic ascending aorta [TAA] ≥ 4.5 cm), and predissection (n = 13, CTA within 3 years before dissection) groups were studied. Scans were interpreted by thoracic radiologists using predefined measurements.</p><p><strong>Results: </strong>Age and sex distribution differed overall among groups (P < 0.001 and P = 0.010, respectively). The aneurysm group was older than controls, but the age difference from the predissection group was not significant (P = 0.084). Maximum TAA diameter (MaxD) was 3.11 ± 0.30, 4.96 ± 0.52, and 3.89 ± 0.60 cm in control, aneurysm, and predissection groups respectively; all predissection MaxD values were below 5.5 cm (maximum, 4.9 cm). Ascending aortic length (AAL) was elevated in both disease groups (aneurysm group, 9.03 ± 1.08 cm; predissection group, 10.73 ± 1.41 cm; P < 0.001 vs. control group, 6.38 ± 0.75 cm). The AAL/MaxD ratio differed significantly between every pair of groups (control group, 2.06 ± 0.22; aneurysm group, 1.83 ± 0.21; predissection group, 2.80 ± 0.50; all pairwise P < 0.001), reflecting disproportionate elongation in predissection aortas. Aneurysm patients demonstrated diffuse thoracic dilation, whereas predissection group patients showed predominantly ascending aortic involvement.</p><p><strong>Conclusions: </strong>In a small exploratory study, predissection aortas displayed a distinct morphological phenotype characterized by disproportionate elongation, moderate dilation, and a relatively nondilated descending aorta-distinct from the diffuse dilation of aneurysm. Ascending aortic length and the AAL/MaxD ratio may provide complementary morphological information beyond maximal diameter alone.</p>","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13660285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction: Preoperative global longitudinal strain predicts myocardial hypertrophy burden but not the magnitude of reverse remodeling after surgical aortic valve replacement in severe aortic stenosis.","authors":"Joy Wulansari Purba, Ario Soeryo Kuncoro, Rina Ariani, Estu Rudiktyo, Amiliana Mardiani Soesanto","doi":"10.1186/s44348-026-00102-8","DOIUrl":"https://doi.org/10.1186/s44348-026-00102-8","url":null,"abstract":"","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149169698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Global longitudinal strain in aortic stenosis: risk versus remodeling.","authors":"Inki Moon","doi":"10.1186/s44348-026-00101-9","DOIUrl":"10.1186/s44348-026-00101-9","url":null,"abstract":"","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13651114/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Less regurgitation without reverse remodeling: what the PROVE trial teaches us about functional tricuspid regurgitation.","authors":"Hyun-Jin Kim","doi":"10.1186/s44348-026-00100-w","DOIUrl":"10.1186/s44348-026-00100-w","url":null,"abstract":"","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13647532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149136805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association between CHA<sub>2</sub>DS<sub>2</sub>-VASc score and left atrial function by speckle-tracking echocardiography in patients with sinus rhythm.","authors":"Kareem Mahmoud, Khaled Mostafa, Sameh Bakhoum, Heba ElDeeb","doi":"10.1186/s44348-026-00090-9","DOIUrl":"10.1186/s44348-026-00090-9","url":null,"abstract":"<p><strong>Background: </strong>The CHA<sub>2</sub>DS<sub>2</sub>-VASc score is an established tool for thromboembolic risk assessment in atrial fibrillation. Individual components of the score may affect left atrial (LA) function. Speckle-tracking echocardiography (STE) enables detection of early, subtle changes in the LA. This study aimed to test whether LA function, as assessed by STE, differs among patients with sinus rhythm according to their CHA<sub>2</sub>DS<sub>2</sub>-VASc score.</p><p><strong>Methods: </strong>This study included 150 patients with sinus rhythm. They were grouped by CHA<sub>2</sub>DS<sub>2</sub>-VASc score: low (1 for women, 0 for men), moderate (2 for women, 1 for men), and high (≥ 3 for women, ≥ 2 for men), with 50 patients per group. All participants gave written consent, provided medical histories, underwent a 12-lead electrocardiogram, and received standard echocardiography and STE.</p><p><strong>Results: </strong>The high-risk group had significantly lower LA reservoir strain (LASr) and LA conduit strain (LAScd) compared to the moderate- and low-risk groups (high vs. moderate vs. low: LASr, 33.2 ± 7.1 vs. 36.9 ± 6.1 vs. 40.6 ± 5.6; LAScd, 20.3 ± 5.7 vs. 23.5 ± 4.8 vs. 26.9 ± 3.9), with all P-values of < 0.01. Moderate-risk patients also showed lower strain values than low-risk patients. In contrast, LA maximal volume index did not differ among the groups (P = 0.536). Mediation analysis showed that the association between the score and LAScd was statistically mediated by left ventricular (LV) diastolic dysfunction (89.7%) with no significant direct association (P = 0.342). For LASr, 62.4% of the association was statistically mediated by LV diastolic dysfunction, with a residual direct statistical association remaining (β = -0.139, P = 0.008).</p><p><strong>Conclusions: </strong>Increased CHA<sub>2</sub>DS<sub>2</sub>-VASc scores correlated with reduced LASr and LAScd. The association with LAScd was mainly mediated by LV diastolic dysfunction. A direct statistical association of the score was noted with LASr, indicating possible early LA pathology. Further research should assess the clinical relevance of these echocardiographic findings for risk stratification in patients with high CHA<sub>2</sub>DS<sub>2</sub>-VASc score.</p>","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13579750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148982887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pulmonary hypertension in pregnancy: hemodynamic challenges, maternal risk, and multidisciplinary management.","authors":"Sung-A Chang","doi":"10.1186/s44348-026-00096-3","DOIUrl":"10.1186/s44348-026-00096-3","url":null,"abstract":"<p><p>Pulmonary hypertension (PH) during pregnancy remains a high-risk clinical condition because normal gestational cardiovascular adaptation may exceed the reserve of the right ventricular (RV)-pulmonary circulation unit. Pregnancy is characterized by progressive increases in plasma volume, heart rate, stroke volume, and cardiac output, together with a reduction in systemic vascular resistance. These changes become particularly hazardous during labor, delivery, and the early postpartum period, when abrupt shifts in preload, venous return, and filling pressures may precipitate RV failure, hypoxemia, arrhythmia, or circulatory collapse. However, pregnancy-related risk in PH is heterogeneous and depends on the underlying PH phenotype, pulmonary vascular disease severity, RV function, oxygenation, and access to expert multidisciplinary care. This review summarizes the hemodynamic challenges of pregnancy in women with PH, phenotype-specific maternal and fetal risks, contemporary outcome data, treatment considerations, delivery planning, and postpartum management. Particular emphasis is placed on the first 24 to 72 h postpartum as a vulnerable period of hemodynamic stress and on the role of imaging, particularly echocardiographic surveillance, in identifying maladaptive RV responses and guiding timely escalation of care.</p>","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573449/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148968867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ga Yun Kim, So-Min Lim, Dong Hyun Yang, Jong Eun Lee, Sahmin Lee, Sung-Ji Park, In-Chang Hwang, Yeonyee Elizabeth Yoon, Chi Young Shim, Hyung-Kwan Kim, Sung-Cheol Yun, Jong-Min Song, Duk-Hyun Kang
{"title":"Effect of empagliflozin with or without carvedilol on tricuspid regurgitation and right ventricular remodeling: PROVE trial.","authors":"Ga Yun Kim, So-Min Lim, Dong Hyun Yang, Jong Eun Lee, Sahmin Lee, Sung-Ji Park, In-Chang Hwang, Yeonyee Elizabeth Yoon, Chi Young Shim, Hyung-Kwan Kim, Sung-Cheol Yun, Jong-Min Song, Duk-Hyun Kang","doi":"10.1186/s44348-026-00095-4","DOIUrl":"10.1186/s44348-026-00095-4","url":null,"abstract":"<p><strong>Background: </strong>Functional tricuspid regurgitation (TR) is associated with adverse outcomes. As TR, right ventricular (RV) remodeling, and worsening TR form a vicious cycle, therapies that reverse RV remodeling and reduce TR are needed. We examined whether sustained-release carvedilol (carvedilol SR), empagliflozin, or their combination reduces RV volumes and TR severity in patients with significant functional TR.</p><p><strong>Methods: </strong>In this randomized trial with a 2 × 2 factorial design, 56 patients were assigned to carvedilol SR plus empagliflozin, carvedilol SR, empagliflozin, or placebo. The primary end point was the change in RV end-systolic volume index from baseline to 12 months. Secondary end points included changes in RV end-diastolic volume index, RV ejection fraction, vena contracta width (VCW), effective regurgitant orifice area (EROA), and regurgitant volume. Cardiac magnetic resonance imaging assessed RV volumes, and echocardiography evaluated TR severity.</p><p><strong>Results: </strong>Baseline characteristics were well balanced between treatment groups (mean age 71 ± 7 years; men 55%; diabetes 14%; atrial fibrillation 89%). Empagliflozin did not change RV volumes or RV ejection fraction. However, empagliflozin reduced VCW (1.45 mm; 95% confidence interval [CI], 0.69-2.20), EROA (0.09 cm<sup>2</sup>; 95% CI, 0.02-0.17), and regurgitant volume (10.7 mL; 95% CI, 4.2-17.2) compared with placebo. Carvedilol SR showed no significant effect on primary or secondary end points. Compared with placebo, carvedilol SR plus empagliflozin reduced VCW (- 0.78 ± 1.15 mm vs. 0.56 ± 1.45 mm, P = 0.03) but did not change other outcomes.</p><p><strong>Conclusions: </strong>Carvedilol SR, empagliflozin, or their combination showed no significant reduction in RV volumes, but empagliflozin significantly reduced TR severity in patients with functional TR.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT04345796 (PROVE trial).</p>","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13573426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148968836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stan A Benjamins, Martijn G H Vrijkorte, Leo Timmers, Benno J W M Rensing, Martin J Swaans
{"title":"Intraprocedural echocardiographic guidance in transcatheter mitral valve interventions: from procedure-specific workflows to integrated multimodal platforms.","authors":"Stan A Benjamins, Martijn G H Vrijkorte, Leo Timmers, Benno J W M Rensing, Martin J Swaans","doi":"10.1186/s44348-026-00092-7","DOIUrl":"10.1186/s44348-026-00092-7","url":null,"abstract":"<p><p>Mitral regurgitation (MR) is the most common left-sided valvular heart disease worldwide and carries significant morbidity and mortality when untreated. The expanding use of transcatheter mitral valve interventions (TMVIs), including mitral transcatheter edge-to-edge repair (M-TEER) and transcatheter mitral valve replacement (TMVR), to anatomically complex, high-risk patient populations has substantially increased the demands on intraprocedural echocardiographic guidance. Yet current consensus documents provide modality-level guidance without explicitly formalizing the divergent imaging requirements inherent to these two mechanistically distinct interventions. This state-of-the-art review synthesizes evidence on intraprocedural echocardiographic guidance for TMVIs, integrating current data on 2D and 3D transesophageal echocardiography, real-time multiplanar reconstruction (MPR), echocardiography-fluoroscopy fusion imaging, 3D intracardiac echocardiography, and artificial intelligence (AI)-assisted decision-support tools. Two fundamentally distinct imaging paradigms are identified and formalized: a leaflet-level, temporally driven framework for M-TEER and an annular-level, spatially driven framework for TMVR. These paradigms reflect divergent anatomical targets and imaging priorities, with concrete implications for workflow design, operator-echocardiographer communication, and complication avoidance. Real-time MPR serves as the geometric backbone bridging 2D temporal precision with 3D spatial clarity. AI-assisted tools provide a computational guidance layer enhancing spatial consistency and procedural reproducibility while preserving, and not replacing, expert echocardiographic judgment. Effective intraprocedural echocardiographic guidance is objective-driven rather than modality-centric. The modalities described in this review function not as interchangeable alternatives but as complementary layers of a coherent, workflow-integrated architecture. The transition toward integrated, platform-based multimodal guidance defines the trajectory of next-generation TMVI echocardiography, requiring rigorous prospective validation, protocol standardization across device platforms, and training frameworks that reflect the multimodal nature of modern structural practice.</p>","PeriodicalId":15229,"journal":{"name":"Journal of Cardiovascular Imaging","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13551723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148912154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}