Journal of Cardiovascular Disease Research最新文献_第7页

Intraoperative Graft Flow Measurement in off-Pump Coronary Artery Bypass Grafting Indicating Graft Revision: Our Experience of 1203 Grafts 非体外循环冠状动脉旁路移植术中移植物流量测量指示移植物修复:1203例移植物的经验

Journal of Cardiovascular Disease Research Pub Date : 2019-04-10 DOI: 10.5530/JCDR.2019.1.5

Seetharama Bhat Ps, Girish Gowda Sl, Chandana Nc, N. Manjunath, C. Manjunath

{"title":"Intraoperative Graft Flow Measurement in off-Pump Coronary Artery Bypass Grafting Indicating Graft Revision: Our Experience of 1203 Grafts","authors":"Seetharama Bhat Ps, Girish Gowda Sl, Chandana Nc, N. Manjunath, C. Manjunath","doi":"10.5530/JCDR.2019.1.5","DOIUrl":"https://doi.org/10.5530/JCDR.2019.1.5","url":null,"abstract":"Background: This study was undertaken to evaluate the use of Transit time flowmetry (TTFM) to identify the malfunctioning graft for the need of graft revision or intervention while performing Off-pump coronary artery bypass grafting (OPCAB). Methods: From July 2014-July 2018 transit time flowmetry was performed on 1206 grafts in 424 patients who underwent OPCAB. The grafts were taken as patent and acceptable if the mean graft flow was more than 20 ml/minute, Pulsatility index (PI) of < 5 and Diastolic flow (DF) more than 50% with a minimal systolic spike. The grafts which did not fulfill the above criteria were revised/appropriate intervention done after identifying the cause for graft malfunction. Results: A total of 1203 grafts were measured in 424 patients who underwent OPCAB. Out of 1203 grafts measured, 51 grafts in fours nine patients showed abnormal flowmetry reading requiring graft revision or intervention. The cause for graft malfunction was graft twisting, anastomosis stenosis, graft kinking, Lima spasm, coronary dissection, reversed vein, graft anastomosis thrombosis and retained coronary shunt. All fifty-one grafts flow returned to normal after graft revision or intervention. We had one-mortality out of forty-nine patients who had grafts revised and the mortality was not attributed to graft malfunction. Conclusion: Intraoperative evaluation of the graft flow with TTFM promptly helps in identifying the abnormal grafts before the patient becomes hemodynamically unstable. Correcting the abnormal grafts prior to chest closure leads to a reduction in mortality and morbidity which will help in improving the patient’s outcome.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":"50 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71058147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Selected Cardiometabolic Risk-factor Clusters of Urban Hypertensive Adults in Response to 72-hour ABU Radio Frequency Modulated (F.M.) Call for Free-medical Screening 城市高血压成人心脏代谢危险因子群对72小时无线射频调制(fm)的响应呼吁免费医疗检查

Journal of Cardiovascular Disease Research Pub Date : 2019-04-10 DOI: 10.5530/JCDR.2019.1.7

O. Onyemelukwe, B. Maiha, L. Ayanwuyi, T. Dahiru, N. Madugu, M. Aliyu, I. Mudashir, Rahman Khaleequr, C. Chukwumerije, U. Adamu, L. Okonkwo, I. Okpe, A. Bakari

{"title":"Selected Cardiometabolic Risk-factor Clusters of Urban Hypertensive Adults in Response to 72-hour ABU Radio Frequency Modulated (F.M.) Call for Free-medical Screening","authors":"O. Onyemelukwe, B. Maiha, L. Ayanwuyi, T. Dahiru, N. Madugu, M. Aliyu, I. Mudashir, Rahman Khaleequr, C. Chukwumerije, U. Adamu, L. Okonkwo, I. Okpe, A. Bakari","doi":"10.5530/JCDR.2019.1.7","DOIUrl":"https://doi.org/10.5530/JCDR.2019.1.7","url":null,"abstract":"Objective: It sought to determine the prevalence of Cardiometabolic risk factor clusters (CMRFCs) and their association with uncontrolled hypertension among urban hypertensive subjects who responded to a free health screening radio announcement. Methods: This cross-sectional epidemiologic study randomly selected 200 previously diagnosed hypertensive subjects aged ≥ 30 years. CMRFCs included hypertension in addition to obesity, prediabetes/diabetes, smoking and alcohol intake. Independent Student’s t-test determined the difference in numerical variables between sexes. Cardiometabolic risk associations were determined via Binary Logistic Regression analysis. Results: Of the 180 who met inclusion, 72.2% were females with mean age of 50.4±9.3 years. About 1 in every 4 subjects (22.2%) had diabetes of which 62.5% were undiagnosed. Almost 2 of every 5 subjects (38.9%) had prediabetes. Almost half (42.2%) had BMI ≥30 kg/m2 with central obesity identified in 78.3%. The mean SBP was 145.7±18.4 mmHg with DBP of 91.8±12.1 mmHg. Uncontrolled hypertension was found in 90.6% and 73.3% for systolic and diastolic respectively. Most (71.7%) had >1 CMRFC associated with uncontrolled systolic hypertension while almost half (42.2%) had same associated with uncontrolled diastolic hypertension. The overall mean prevalence of CMRFC was 49.6%. Significant association was found between male sex (p=0.01) and systolic/diastolic hypertension; prediabetes/diabetes (p=0.01), overweight/obesity (p=0.04) with diastolic hypertension and alcohol intake (p=0.02) with systolic hypertension. Conclusion: This study shows that there is a high prevalence of cardiometabolic risk factor clusters amongst hypertensive urban-dwellers in Northern-Nigeria. Combined overweight/obesity, prediabetes/diabetes, male sex and alcohol were significantly associated with uncontrolled hypertension.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42693068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Saccular Aneurysm of Aortic Arch at Inferior Surface 主动脉弓下表面囊状动脉瘤

Journal of Cardiovascular Disease Research Pub Date : 2019-04-10 DOI: 10.5530/JCDR.2019.1.9

Parth Solanki, J. Kothari, Devvrat Desai, K. Baria

引用次数: 0

Whole Exome Sequencing Reveals Multiple Mutations in Uncommon Genes of Familial Hypercholesterolaemia 全外显子组测序揭示家族性高胆固醇血症罕见基因的多重突变

Journal of Cardiovascular Disease Research Pub Date : 2019-04-10 DOI: 10.5530/JCDR.2019.1.2

M. Athar, F. Al-Allaf, F. Alnouri, M. Taher, A. Bouazzaoui, N. Bogari, W. Elbjeirami, H. Faidah, Z. Abduljaleel

{"title":"Whole Exome Sequencing Reveals Multiple Mutations in Uncommon Genes of Familial Hypercholesterolaemia","authors":"M. Athar, F. Al-Allaf, F. Alnouri, M. Taher, A. Bouazzaoui, N. Bogari, W. Elbjeirami, H. Faidah, Z. Abduljaleel","doi":"10.5530/JCDR.2019.1.2","DOIUrl":"https://doi.org/10.5530/JCDR.2019.1.2","url":null,"abstract":"Whole exome sequencing (WES) is an innovative, precise procedure established on the next generation sequencing \u0000and has rapidly become esteemed in medical genetics. We have used WES to study patient with suspected genetic \u0000conditions with no apparent recognizable familial hypercholesterolemia (FH). In the tested proband, multiple causative \u0000mutations were identified in LPL, EPHX2, PCSK9, APOB, ABCA1 and ABCG8 genes. The identified mutations in the LPL \u0000gene were heterozygous mutation [c.106G>A, p. (Asp36Asn)] in exon 2 and another heterozygous mutation [c.1421C>G, \u0000p.(Ser474*)] in exon 9. EPHX2 gene of the proband showed a novel heterozygous mutation [c.1644delC, p.(Pro549fs)] in \u0000exon 19. In addition, heterozygous mutations were identified in exon 1 of PCSK9 gene [c.158C>T, p.(Ala53Val)] and exon 4 \u0000of APOB [c.293C>T, p.(Thr98Ile)]. Likewise, homozygous mutations were found in exon 35 of ABCA1 gene [c.4760A>G, \u0000p.(Lys1587Arg)] and exon 13 of ABCG8 gene [c.1895T>C, p.(Val632Ala)], a common mutation highly associated with \u0000hypercholesterolemia based on the p-value by phenolyzer prioritization method. All causative mutations were validated \u0000by capillary sequencing method and confirmed the presence of homozygous and heterozygous mutations detected in \u0000the proband. All the causative mutations were functionally predicted to be deleterious including a novel frameshift and \u0000common missense mutation. Further investigations of the common mutation using Molecular dynamic (MD) simulation \u0000with solvated condition confirmed the functional and structural impact of the changes on the mutated proteins.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44523333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

New Trends in High Risk Ventricular Tachycardia Catheter Ablation 高危室性心动过速导管消融的新趋势

Journal of Cardiovascular Disease Research Pub Date : 2019-04-10 DOI: 10.5530/JCDR.2019.1.1

Zhigang Liu, B. Yasmeh, C. Verdick, Srinivas Rajsheker, A. Barone, A. Costea

{"title":"New Trends in High Risk Ventricular Tachycardia Catheter Ablation","authors":"Zhigang Liu, B. Yasmeh, C. Verdick, Srinivas Rajsheker, A. Barone, A. Costea","doi":"10.5530/JCDR.2019.1.1","DOIUrl":"https://doi.org/10.5530/JCDR.2019.1.1","url":null,"abstract":"Ventricular tachycardia (VT) is one of the major causes of sudden cardiac death (SCD). In general, VT could be managed \u0000with antiarrhythmic drugs (AADs) therapy, catheter ablation and implantable cardioverter defibrillators (ICD). While the \u0000AADs therapy and catheter ablation have been shown to reduce the recurrence of VT, only the ICD therapy is effective \u0000in aborting SCD. The recently published VANISH trial reveals that VT catheter ablation significantly decreases the rate of \u0000death, VT storm and appropriate ICD shock comparing with an escalation of AADs therapy for ischemic cardiomyopathy \u0000(ICM). However, the mapping strategies and feasibility of VT catheter ablation are often limited by the hemodynamically \u0000intolerant VT. Substrate modification strategy and percutaneous left ventricular assist device (pLVAD) are often used to \u0000overcome the hemodynamic intolerance. So far there are no large-scale randomized clinical trials comparing different \u0000mapping strategies in the setting of hemodynamically unstable VT, specifically when it comes to risk stratification for \u0000patients with hemodynamic instability. The aim of the present article is to systemically review different VT mapping \u0000strategies, the role of pLVAD in hemodynamically intolerant VT ablation with a special consideration of high risk VT.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41646062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Enlarged Ulcer-like Projection and Acute Arterial Embolism in the Lower Limbs of a Patient with Chronic Stanford Type B Aortic Dissection 慢性Stanford B型主动脉夹层患者下肢溃疡样突出和急性动脉栓塞

Journal of Cardiovascular Disease Research Pub Date : 2019-04-10 DOI: 10.5530/JCDR.2019.1.8

S. Haruta, Katsuya Suzuki, A. Honda

引用次数: 0

Tracing the Risk Factors of Heart Diseases at Al-Nasiriyah Heart Center in Iraq 伊拉克纳西里耶心脏中心心脏病危险因素的追踪

Journal of Cardiovascular Disease Research Pub Date : 2019-04-10 DOI: 10.5530/JCDR.2019.1.6

Rawaa Kamel Abd, Sameeha Naser Abd, Vinoth Raman

{"title":"Tracing the Risk Factors of Heart Diseases at Al-Nasiriyah Heart Center in Iraq","authors":"Rawaa Kamel Abd, Sameeha Naser Abd, Vinoth Raman","doi":"10.5530/JCDR.2019.1.6","DOIUrl":"https://doi.org/10.5530/JCDR.2019.1.6","url":null,"abstract":"Journal of Cardiovascular Disease Research, Vol 10, Issue 1, Jan-Mar, 2019 31 ABSTRACT Background: Heart diseases are one of the major causes for death especially in developing countries across the world. According to WHO, the deaths due to heart diseases in Iraq has reached 18.50% of total death in 2017 and Iraq has been identified as 19th rank at the international level. In our study, the heart diseases are categorized as electrical, circulatory and structural diseases. Method and Results: A Cross-sectional study was conceded out in a center for heart diseases at Al-Nasiriyah city, Thi-Qar governorate, Iraq, from 1st April to 31st May 2018. The patients who were diagnosed with heart diseases in the center were administered with a self-structured questionnaire, which explore the risk factors of heart diseases among them. A total of 80 patients (48 male and 32 female) who responded to questionnaire were included. Those who did not respond to the questionnaire were excluded. More than half of the patients (57.5%) were aged ≥ 60 and 37.5% of them were illiterate. About 65% of patients with circulatory heart diseases consumed red meat more than two times a week, however 81% of them consumed it rarely. Also, 40% of heart disease cases do not perform exercise daily. Conclusion: This study reveals that the risk of heart diseases increases with the factors such as increasing age, having fried food, avoiding fruits daily, eating red meat more than 2 times per week, physical inactivity and being a passive smoker.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49311311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Assessment of Right Ventricular Functions in Patients with Ischemic Heart Disease Before and After Percutaneous Coronary Intervention using Colored Tissue Doppler Imaging 彩色组织多普勒成像评价缺血性心脏病患者经皮冠状动脉介入治疗前后的右心室功能

Journal of Cardiovascular Disease Research Pub Date : 2019-01-04 DOI: 10.5530/jcdr.2018.4.42

A. El-Adawy, Mahmoud Salem, Essam Mohamed Mahfoz, E. El-safty, Ayman Hamza Abdelsamad, G. Gomaa

{"title":"Assessment of Right Ventricular Functions in Patients with Ischemic Heart Disease Before and After Percutaneous Coronary Intervention using Colored Tissue Doppler Imaging","authors":"A. El-Adawy, Mahmoud Salem, Essam Mohamed Mahfoz, E. El-safty, Ayman Hamza Abdelsamad, G. Gomaa","doi":"10.5530/jcdr.2018.4.42","DOIUrl":"https://doi.org/10.5530/jcdr.2018.4.42","url":null,"abstract":"Background: Right Ventricular (RV) dysfunction considered as a predictor of mortality in patients with ischemic heart disease (IHD). Aim: This study was aimed to evaluate the impact of elective coronary artery revascularization on RV myocardial function in Egyptian patients with IHD using Colour Tissue Doppler Imaging (CTDI). Methods: The present study is prospective observational self-control study. Fifty consecutive patients with IHD were included in this study. All participants were subjected to physical examination, Electrocardiograph (ECG), Laboratory test, Transthoracic Echocardiography and color tissue Doppler Imaging. The RV myocardial performance index (MPI) and S’/RMPI index were calculated in TDI modalities parameters. Results: No significant differences were detected between the demographic characteristics of the investigated patients. Tricuspid annular plane systolic excursion (TAPSE) by echocardiographic RV function parameters was improved significantly after PCI (P=0.001). Most of RV myocardial function showed significant improvement after PCI by using PW-DTI: Early and late diastolic function: The E` and A` diastolic wave velocities were improved significantly after PCI (P= 0.003, P= 0.008 respectively), RMPI (P= 0.008) Sˋ/RIMP ratio (P=0.04). The myocardial functions showed significant improvement after PCI by using color-coded tissue Doppler; E` wave (P= 0.02), RMPI was improved significantly after PCI (P= 0.01). Conclusion: The TAPSE and Doppler tissue indices added important information to the RV functions after successful percutaneous revisualization of coronary arteries. The measurements performed by color-coded TDI derived myocardial velocities at basal, mid and apical might have added additional data describing RV function and its recovery after RV ischemia.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46299314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Role of Atherogenic Indices and Association of LPL Intron 6 Gene Polymorphism with Dyslipidemia Subtypes in the Prediction of Cardiovascular Risk 动脉粥样硬化指数及LPL内含子6基因多态性与血脂异常亚型在心血管风险预测中的作用

Journal of Cardiovascular Disease Research Pub Date : 2019-01-04 DOI: 10.5530/jcdr.2018.4.38

Pusapati Madan Ranjit, G. Guntuku, R. Pothineni

{"title":"Role of Atherogenic Indices and Association of LPL Intron 6 Gene Polymorphism with Dyslipidemia Subtypes in the Prediction of Cardiovascular Risk","authors":"Pusapati Madan Ranjit, G. Guntuku, R. Pothineni","doi":"10.5530/jcdr.2018.4.38","DOIUrl":"https://doi.org/10.5530/jcdr.2018.4.38","url":null,"abstract":"Background and Objectives: Dyslipidemia is renowned as a prominent risk factor for development of atherosclerosis and other Cardiovascular disease. The Aim study to estimation of lipid profile and predict the cardiovascular risk among the dyslipidemia subtypes and also determine the association of LPL intron 6 C >T (rs285) gene Polymorphism in dyslipidemia subtypes. Methods: A total number of 258 subjects were participated in our study, in which 129 members were with elevated lipid profile considered as cases and 129 numbers with normal lipids considered as control subjects. Among the 129 cases, they are further divided into dyslipidemia subtypes. All the sample were further used for analysis of lipid profile and determined the gene Polymorphism by RFLP. Results: In our study observed, elevated levels of lipid profile [TC (241.53±6.45), TGs (295.40±28.31), LDL-c (143.69±7.05), VLDL-c (59.08±5.66) and lower levels of HDL-c (39.70± 1.23) and higher values atherogenic indices in combined lipidemia type than the other types and controls. In genotype analysis was not showed significant association of intron 6 C >T gene polymorphisma in both hypercholesterolemia [odd’s ratio: 0.77(0.33-1.79); 0.18(0.05-0.62); χ2 p: 0.025] and hyperlipidemia [odd’s ratio: 0.40 (0.14-1.12); 0.82 (0.33-2.03); χ2 p: 0.177] cases compared with control subjects. But observed, higher risk with CT and CC genotypes in both hypertriglyceridemia and combined dyslipidemia cases. In combined lipidema cases the comparison of lipid profile of genotypes, CC genotypes showed significantly elevated triglycrides (349.5±39.49; p<0.05) and VLDL-c (69.91±7.898; p<0.05) than CT genotypes. Conclusion: Combined lipidemia is one of the major forms of dyslipidemia and atherogenic indices are used as strong predictors to assess the cardiovascular risk in the clinical practices. In case genotype analysis, LPL intron 6 C >T gene Polymorphism may be associated with elevated levels of triglycrdies and VLDL-c.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48512369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systolic and Diastolic Epicardial Adipose Tissue Thickness in Non-Dialysis Dependent Chronic Kidney Disease Patients: Technique, Correlates and Cardiovascular Outcomes (The EAT CKD study) 非透析依赖性慢性肾脏病患者的收缩和舒张心外膜脂肪组织厚度：技术、相关性和心血管结果（EAT CKD研究）

Journal of Cardiovascular Disease Research Pub Date : 2019-01-04 DOI: 10.5530/jcdr.2018.4.40

B. Verma, J. S. Bishnoi, A. Mishra, Amrita Singh, Manu Kumar, A. K. Saxena

{"title":"Systolic and Diastolic Epicardial Adipose Tissue Thickness in Non-Dialysis Dependent Chronic Kidney Disease Patients: Technique, Correlates and Cardiovascular Outcomes (The EAT CKD study)","authors":"B. Verma, J. S. Bishnoi, A. Mishra, Amrita Singh, Manu Kumar, A. K. Saxena","doi":"10.5530/jcdr.2018.4.40","DOIUrl":"https://doi.org/10.5530/jcdr.2018.4.40","url":null,"abstract":"Background: Epicardial adipose tissue (EAT) has been related to increased cardiovascular risk in chronic kidney disease patients. However, prospective studies of EAT thickness in prediction of cardiovascular events in CKD patients are lacking. Moreover, there are inconsistencies in literature regarding cut-off of EAT thickness, standard technique and phase of measurement. Objectives: This study was undertaken to compare systolic and diastolic EAT thickness in prediction of CV events in non-dialysis dependent CKD patients. Methods: In this prospective, observational study, transthoracic echocardiography (TTE) was used to assess systolic and diastolic EAT thickness in 210 consecutive non-dialysis dependent CKD patients and followed up for at least one year for pre-defined end-points. Results: The mean systolic and diastolic EAT thickness in the CKD group (5.6±1.2mm and 4.2±1.1mm) was significantly higher than the non-CKD participants (4.3±1.0mm and 3.1±1.1mm), both P<0.001. Interclass correlation coefficient (ICC) agreement on measurements were 0.93 (95% CI: 0.79-0.98) for systolic EAT and 0.91 (95% CI: 0.74-0.97) for diastolic EAT. On multivariate linear regression analysis, only e-GFR remained as independent predictor of both systolic and diastolic EAT thickness. Receiver operating characteristics (ROC) analysis showed that diastolic EAT thickness of 5mm and systolic EAT thickness of 3.8mm had similar sensitivity (88% versus 87%, respectively) and specificity (72% versus 74%, respectively) to predict CV events in CKD patients. Conclusion: Both systolic and diastolic EAT thickness are significantly increased in CKD patients and can be used in CV risk stratification with similar sensitivity and specificity albeit with different cut-offs.","PeriodicalId":15222,"journal":{"name":"Journal of Cardiovascular Disease Research","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45558455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1